hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14663.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NCAPH | Condensin complex subunit 2 (Barren homolog protein 1) (Chromosome-associated protein H) (hCAP-H) (Non-SMC condensin I complex subunit H) (XCAP-H homolog) | 5 | UniProt NCBI |
| GPR137B | Integral membrane protein GPR137B (Transmembrane 7 superfamily member 1 protein) | 5 | UniProt NCBI |
| KLKB1 | Plasma kallikrein (EC 3.4.21.34) (Fletcher factor) (Kininogenin) (Plasma prekallikrein) (PKK) [Cleaved into: Plasma kallikrein heavy chain; Plasma kallikrein light chain] | 5 | UniProt NCBI |
| TRIM38 | E3 ubiquitin-protein ligase TRIM38 (EC 2.3.2.27) (RING finger protein 15) (Tripartite motif-containing protein 38) (Zinc finger protein RoRet) | 5 | UniProt NCBI |
| TYK2 | Non-receptor tyrosine-protein kinase TYK2 (EC 2.7.10.2) | 5 | UniProt NCBI |
| NCAPD3 | Condensin-2 complex subunit D3 (Non-SMC condensin II complex subunit D3) (hCAP-D3) | 5 | UniProt NCBI |
| NCAPD2 | Condensin complex subunit 1 (Chromosome condensation-related SMC-associated protein 1) (Chromosome-associated protein D2) (hCAP-D2) (Non-SMC condensin I complex subunit D2) (XCAP-D2 homolog) | 5 | UniProt NCBI |
| NCAPH2 | Condensin-2 complex subunit H2 (Chromosome-associated protein H2) (hCAP-H2) (Kleisin-beta) (Non-SMC condensin II complex subunit H2) | 5 | UniProt NCBI |
| NCAPG2 | Condensin-2 complex subunit G2 (Chromosome-associated protein G2) (CAP-G2) (hCAP-G2) (Leucine zipper protein 5) (Non-SMC condensin II complex subunit G2) | 5 | UniProt NCBI |
| DUS3L | tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like (EC 1.3.1.89) (mRNA-dihydrouridine synthase DUS3L) (EC 1.3.1.-) (tRNA-dihydrouridine synthase 3-like) | 5 | UniProt NCBI |
| SMC4 | Structural maintenance of chromosomes protein 4 (SMC protein 4) (SMC-4) (Chromosome-associated polypeptide C) (hCAP-C) (XCAP-C homolog) | 5 | UniProt NCBI |
| ARPC1A | Actin-related protein 2/3 complex subunit 1A (SOP2-like protein) | 4 | UniProt NCBI |
| NCAPG | Condensin complex subunit 3 (Chromosome-associated protein G) (Condensin subunit CAP-G) (hCAP-G) (Melanoma antigen NY-MEL-3) (Non-SMC condensin I complex subunit G) (XCAP-G homolog) | 5 | UniProt NCBI |
| SMC2 | Structural maintenance of chromosomes protein 2 (SMC protein 2) (SMC-2) (Chromosome-associated protein E) (hCAP-E) (XCAP-E homolog) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0000796 | 1.24885120777e-21 | 0.615384615385 | NCAPG NCAPH2 NCAPH NCAPD2 NCAPG2 NCAPD3 SMC4 SMC2 | condensin complex |
| GO:1905821 | 1.24885120777e-21 | 0.615384615385 | NCAPG NCAPH2 NCAPH NCAPD2 NCAPG2 NCAPD3 SMC4 SMC2 | positive regulation of chromosome condensation |
| GO:0060623 | 5.61641098591e-20 | 0.615384615385 | NCAPG NCAPH2 NCAPH NCAPD2 NCAPG2 NCAPD3 SMC4 SMC2 | regulation of chromosome condensation |
| GO:0051984 | 3.85799522562e-15 | 0.615384615385 | NCAPG NCAPH2 NCAPH NCAPD2 NCAPG2 NCAPD3 SMC4 SMC2 | positive regulation of chromosome segregation |
| GO:1905820 | 3.85799522562e-15 | 0.615384615385 | NCAPG NCAPH2 NCAPH NCAPD2 NCAPG2 NCAPD3 SMC4 SMC2 | positive regulation of chromosome separation |
| GO:0030261 | 7.26063032364e-15 | 0.615384615385 | NCAPG NCAPH2 NCAPH NCAPD2 NCAPG2 NCAPD3 SMC4 SMC2 | chromosome condensation |
| CORUM:167 | 1.302095624e-14 | 0.384615384615 | NCAPG NCAPD2 SMC2 NCAPH SMC4 | Condensin I complex |
| CORUM:160 | 1.302095624e-14 | 0.384615384615 | NCAPD3 SMC4 SMC2 NCAPH2 NCAPG2 | Condensin II |
| CORUM:157 | 1.302095624e-14 | 0.384615384615 | NCAPG NCAPD2 SMC2 NCAPH SMC4 | Condensin I complex |
| CORUM:10 | 1.302095624e-14 | 0.384615384615 | NCAPG NCAPD2 SMC2 NCAPH SMC4 | Condensin I complex |
| GO:0007076 | 1.95096571556e-14 | 0.538461538462 | NCAPG NCAPH2 NCAPH NCAPD2 SMC2 NCAPD3 SMC4 | mitotic chromosome condensation |
| CORUM:159 | 7.80900880046e-14 | 0.384615384615 | NCAPG NCAPD2 SMC2 NCAPH SMC4 | Condensin I-PARP-1-XRCC1 complex |
| GO:0000794 | 3.22115675502e-13 | 0.615384615385 | NCAPG NCAPH2 NCAPH NCAPD2 NCAPG2 NCAPD3 SMC4 SMC2 | condensed nuclear chromosome |
| GO:1905818 | 7.04716953622e-12 | 0.615384615385 | NCAPG NCAPH2 NCAPH NCAPD2 NCAPG2 NCAPD3 SMC4 SMC2 | regulation of chromosome separation |
| GO:0051304 | 1.46586962489e-11 | 0.615384615385 | NCAPG NCAPH2 NCAPH NCAPD2 NCAPG2 NCAPD3 SMC4 SMC2 | chromosome separation |
| REAC:R-HSA-2514853 | 2.91765764776e-11 | 0.384615384615 | NCAPG NCAPD2 SMC2 NCAPH SMC4 | Condensation of Prometaphase Chromosomes |
| GO:2001252 | 3.38047268841e-10 | 0.615384615385 | NCAPG NCAPH2 NCAPH NCAPD2 NCAPG2 NCAPD3 SMC4 SMC2 | positive regulation of chromosome organization |
| GO:0051983 | 9.46771828758e-10 | 0.615384615385 | NCAPG NCAPH2 NCAPH NCAPD2 NCAPG2 NCAPD3 SMC4 SMC2 | regulation of chromosome segregation |
| GO:0000070 | 1.11829601434e-08 | 0.615384615385 | NCAPG NCAPH2 NCAPH NCAPD2 NCAPG2 NCAPD3 SMC4 SMC2 | mitotic sister chromatid segregation |
| GO:0000228 | 2.00502393521e-08 | 0.615384615385 | NCAPG NCAPH2 NCAPH NCAPD2 NCAPG2 NCAPD3 SMC4 SMC2 | nuclear chromosome |
| GO:0090068 | 3.6072252942e-08 | 0.615384615385 | NCAPG NCAPH2 NCAPH NCAPD2 NCAPG2 NCAPD3 SMC4 SMC2 | positive regulation of cell cycle process |
| GO:0000819 | 6.48840857751e-08 | 0.615384615385 | NCAPG NCAPH2 NCAPH NCAPD2 NCAPG2 NCAPD3 SMC4 SMC2 | sister chromatid segregation |
| REAC:R-HSA-68886 | 7.04621230821e-08 | 0.615384615385 | NCAPG NCAPH2 NCAPH NCAPD2 NCAPG2 NCAPD3 SMC4 SMC2 | M Phase |
| GO:0000793 | 7.61425602554e-08 | 0.615384615385 | NCAPG NCAPH2 NCAPH NCAPD2 NCAPG2 NCAPD3 SMC4 SMC2 | condensed chromosome |
| GO:0140014 | 1.73961269575e-07 | 0.615384615385 | NCAPG NCAPH2 NCAPH NCAPD2 NCAPG2 NCAPD3 SMC4 SMC2 | mitotic nuclear division |
| GO:0033044 | 2.07492473552e-07 | 0.615384615385 | NCAPG NCAPH2 NCAPH NCAPD2 NCAPG2 NCAPD3 SMC4 SMC2 | regulation of chromosome organization |
| GO:0098813 | 3.01717781146e-07 | 0.615384615385 | NCAPG NCAPH2 NCAPH NCAPD2 NCAPG2 NCAPD3 SMC4 SMC2 | nuclear chromosome segregation |
| GO:0045787 | 3.1189279602e-07 | 0.615384615385 | NCAPG NCAPH2 NCAPH NCAPD2 NCAPG2 NCAPD3 SMC4 SMC2 | positive regulation of cell cycle |
| REAC:R-HSA-2299718 | 3.37271221421e-07 | 0.384615384615 | NCAPD3 SMC4 SMC2 NCAPH2 NCAPG2 | Condensation of Prophase Chromosomes |
| REAC:R-HSA-69278 | 8.0111264725e-07 | 0.615384615385 | NCAPG NCAPH2 NCAPH NCAPD2 NCAPG2 NCAPD3 SMC4 SMC2 | Cell Cycle, Mitotic |
| GO:0000280 | 2.49818117866e-06 | 0.615384615385 | NCAPG NCAPH2 NCAPH NCAPD2 NCAPG2 NCAPD3 SMC4 SMC2 | nuclear division |
| GO:0007059 | 3.05249157424e-06 | 0.615384615385 | NCAPG NCAPH2 NCAPH NCAPD2 NCAPG2 NCAPD3 SMC4 SMC2 | chromosome segregation |
| REAC:R-HSA-1640170 | 4.08187670003e-06 | 0.615384615385 | NCAPG NCAPH2 NCAPH NCAPD2 NCAPG2 NCAPD3 SMC4 SMC2 | Cell Cycle |
| GO:0048285 | 6.34205868369e-06 | 0.615384615385 | NCAPG NCAPH2 NCAPH NCAPD2 NCAPG2 NCAPD3 SMC4 SMC2 | organelle fission |
| REAC:R-HSA-68875 | 1.24423681179e-05 | 0.384615384615 | NCAPD3 SMC4 SMC2 NCAPH2 NCAPG2 | Mitotic Prophase |
| GO:0010638 | 1.42803209745e-05 | 0.615384615385 | NCAPG NCAPH2 NCAPH NCAPD2 NCAPG2 NCAPD3 SMC4 SMC2 | positive regulation of organelle organization |
| GO:0010032 | 2.74903317479e-05 | 0.230769230769 | NCAPD3 NCAPH2 NCAPD2 | meiotic chromosome condensation |
| CORUM:5239 | 4.10333215354e-05 | 0.153846153846 | SMC4 SMC2 | CAP(C)-CAP(E) complex |
| GO:0051276 | 0.000101400360255 | 0.615384615385 | NCAPG NCAPH2 NCAPH NCAPD2 NCAPG2 NCAPD3 SMC4 SMC2 | chromosome organization |
| CORUM:353 | 0.00012303818858 | 0.153846153846 | SMC4 SMC2 | DNA ligase IV-condensin complex |
| REAC:R-HSA-68877 | 0.00012951040666 | 0.384615384615 | NCAPG NCAPD2 SMC2 NCAPH SMC4 | Mitotic Prometaphase |
| GO:0010564 | 0.000217529400513 | 0.615384615385 | NCAPG NCAPH2 NCAPH NCAPD2 NCAPG2 NCAPD3 SMC4 SMC2 | regulation of cell cycle process |
| GO:1903047 | 0.000402575460606 | 0.615384615385 | NCAPG NCAPH2 NCAPH NCAPD2 NCAPG2 NCAPD3 SMC4 SMC2 | mitotic cell cycle process |
| CORUM:49 | 0.0008595398098 | 0.153846153846 | SMC4 SMC2 | DNMT3B complex |
| GO:0000278 | 0.00178123579601 | 0.615384615385 | NCAPG NCAPH2 NCAPH NCAPD2 NCAPG2 NCAPD3 SMC4 SMC2 | mitotic cell cycle |
| GO:0051130 | 0.00288196909591 | 0.615384615385 | NCAPG NCAPH2 NCAPH NCAPD2 NCAPG2 NCAPD3 SMC4 SMC2 | positive regulation of cellular component organization |
| GO:0051726 | 0.00466096191784 | 0.615384615385 | NCAPG NCAPH2 NCAPH NCAPD2 NCAPG2 NCAPD3 SMC4 SMC2 | regulation of cell cycle |
| GO:0033043 | 0.00961335538286 | 0.615384615385 | NCAPG NCAPH2 NCAPH NCAPD2 NCAPG2 NCAPD3 SMC4 SMC2 | regulation of organelle organization |
| GO:0005694 | 0.016278404599 | 0.692307692308 | NCAPG NCAPH2 SMC2 NCAPH NCAPD2 NCAPG2 NCAPD3 SMC4 ARPC1A | chromosome |
| GO:0022402 | 0.0188869246022 | 0.615384615385 | NCAPG NCAPH2 NCAPH NCAPD2 NCAPG2 NCAPD3 SMC4 SMC2 | cell cycle process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| NCAPH2 | NCAPD3 | 1.0 | 0.184 |
| NCAPH2 | NCAPG2 | 1.0 | 0.215333333333 |
| NCAPD3 | NCAPG2 | 1.0 | 0.598 |
| NCAPH2 | SMC4 | 1.0 | 0.246 |
| SMC2 | SMC4 | 0.999 | 0.926 |
| NCAPH | NCAPG | 0.999 | 0.954 |
| NCAPG2 | SMC4 | 0.999 | 0.224 |
| NCAPH2 | SMC2 | 0.998 | 0.098 |
| NCAPH | NCAPD2 | 0.998 | 0.944 |
| NCAPG | NCAPD2 | 0.998 | 0.964 |
| NCAPG2 | SMC2 | 0.997 | 0.19 |
| NCAPH2 | NCAPG | 0.994 | 0.152 |
| NCAPD3 | SMC4 | 0.993 | 0.16 |
| SMC2 | NCAPG | 0.991 | 0.912 |
| NCAPG2 | NCAPG | 0.991 | 0.194 |
| NCAPD3 | SMC2 | 0.99 | 0.136 |
| NCAPD3 | NCAPG | 0.987 | 0.224 |
| NCAPH | NCAPD3 | 0.986 | 0.12 |
| NCAPH | SMC4 | 0.985 | 0.86 |
| NCAPH | NCAPG2 | 0.983 | 0.162 |
| NCAPH2 | NCAPH | 0.982 | 0.144 |
| NCAPH | SMC2 | 0.981 | 0.84 |
| SMC2 | NCAPD2 | 0.981 | 0.93 |
| SMC4 | NCAPD2 | 0.977 | 0.95 |
| NCAPD2 | ARPC1A | 0.976 | 0.06 |
| SMC4 | NCAPG | 0.974 | 0.916 |
| NCAPG | ARPC1A | 0.971 | 0.064 |
| NCAPH | ARPC1A | 0.965 | 0.088 |
| TYK2 | NCAPH2 | 0.963 | 0.136 |
| NCAPD3 | NCAPD2 | 0.96 | 0.158 |
| GPR137B | SMC4 | 0.957 | |
| DUS3L | NCAPH2 | 0.954 | 0.14 |
| NCAPH2 | NCAPD2 | 0.94 | 0.116 |
| NCAPH | GPR137B | 0.928 | |
| KLKB1 | NCAPH | 0.919 | |
| NCAPG2 | NCAPD2 | 0.911 | 0.116 |
| GPR137B | NCAPD2 | 0.828 | |
| TRIM38 | SMC2 | 0.811 | 0.044 |
| GPR137B | SMC2 | 0.78 | |
| GPR137B | NCAPG | 0.367 | |
| TYK2 | NCAPD3 | 0.272 | 0.1 |
| TYK2 | SMC2 | 0.234 | 0.108 |
| TYK2 | NCAPG2 | 0.159 | 0.09 |
| DUS3L | NCAPG2 | 0.117 | 0.078 |
| DUS3L | SMC4 | 0.102 | 0.062 |
| DUS3L | SMC2 | 0.097 | 0.024 |
| TYK2 | NCAPG | 0.059 | 0.164 |
| TYK2 | NCAPD2 | 0.055 | 0.192 |
| DUS3L | NCAPG | 0.044 | 0.048 |
| TYK2 | SMC4 | 0.039 | 0.142 |
| DUS3L | NCAPD2 | 0.033 | 0.10725 |
| DUS3L | NCAPD3 | 0.029 | 0.11 |
| DUS3L | NCAPH | 0.026 | 0.044 |
| DUS3L | TYK2 | 0.022 | 0.066 |
| KLKB1 | SMC4 | 0.015 | |
| TRIM38 | ARPC1A | 0.013 | 0.122 |
| DUS3L | ARPC1A | 0.013 | 0.062 |
| TRIM38 | NCAPG | 0.011 | 0.04 |
| TYK2 | NCAPH | 0.011 | 0.108 |
| TRIM38 | SMC4 | 0.01 | 0.052 |
| TRIM38 | NCAPH | 0.009 | 0.068 |
| KLKB1 | NCAPD3 | 0.009 | |
| KLKB1 | ARPC1A | 0.007 | |
| KLKB1 | SMC2 | 0.006 | |
| TYK2 | ARPC1A | 0.002 | 0.11 |
| NCAPH2 | ARPC1A | 0.002 | 0.11 |
| NCAPG2 | ARPC1A | 0.002 | 0.062 |
| SMC2 | ARPC1A | 0.002 | 0.122 |
| NCAPD3 | ARPC1A | 0.001 | 0.038 |
| SMC4 | ARPC1A | 0.0 | 0.062 |
Related Complexes