hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14671.1
Complex Portal: CPX-10676
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TEAD4 | Transcriptional enhancer factor TEF-3 (TEA domain family member 4) (TEAD-4) (Transcription factor 13-like 1) (Transcription factor RTEF-1) | 5 | UniProt NCBI |
| IRF2 | Interferon regulatory factor 2 (IRF-2) | 5 | UniProt NCBI |
| IRF2BPL | Probable E3 ubiquitin-protein ligase IRF2BPL (EC 2.3.2.27) (Enhanced at puberty protein 1) (Interferon regulatory factor 2-binding protein-like) | 5 | UniProt NCBI |
| WWTR1 | WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif) | 5 | UniProt NCBI |
| TEAD2 | Transcriptional enhancer factor TEF-4 (TEA domain family member 2) (TEAD-2) | 5 | UniProt NCBI |
| TEAD3 | Transcriptional enhancer factor TEF-5 (DTEF-1) (TEA domain family member 3) (TEAD-3) | 5 | UniProt NCBI |
| CTSS | Cathepsin S (EC 3.4.22.27) | 5 | UniProt NCBI |
| TEAD1 | Transcriptional enhancer factor TEF-1 (NTEF-1) (Protein GT-IIC) (TEA domain family member 1) (TEAD-1) (Transcription factor 13) (TCF-13) | 5 | UniProt NCBI |
| IRF2BP1 | Interferon regulatory factor 2-binding protein 1 (IRF-2-binding protein 1) (IRF-2BP1) (Probable E3 ubiquitin-protein ligase IRF2BP1) (EC 2.3.2.27) (Probable RING-type E3 ubiquitin transferase IRF2BP1) | 5 | UniProt NCBI |
| IRF2BP2 | Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2) | 5 | UniProt NCBI |
| VGLL4 | Transcription cofactor vestigial-like protein 4 (Vgl-4) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8951671 | 3.00907593977e-13 | 0.555555555556 | TEAD2 TEAD4 TEAD1 TEAD3 WWTR1 | RUNX3 regulates YAP1-mediated transcription |
| REAC:R-HSA-2032785 | 4.25180971524e-12 | 0.555555555556 | TEAD2 TEAD4 TEAD1 TEAD3 WWTR1 | YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| WP:WP4537 | 2.39972521199e-11 | 0.555555555556 | TEAD2 TEAD4 TEAD1 TEAD3 WWTR1 | Hippo YAP signaling |
| KEGG:04392 | 7.5100067915e-11 | 0.555555555556 | TEAD2 TEAD4 TEAD1 TEAD3 WWTR1 | Hippo signaling pathway - multiple species |
| WP:WP4541 | 5.1720022888e-10 | 0.666666666667 | WWTR1 TEAD2 TEAD3 VGLL4 TEAD4 TEAD1 | Hippo Merlin signaling dysregulation |
| WP:WP4534 | 1.35146253623e-09 | 0.555555555556 | TEAD2 TEAD4 TEAD1 TEAD3 WWTR1 | Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms |
| GO:0035329 | 1.61916207817e-09 | 0.666666666667 | WWTR1 TEAD2 TEAD3 VGLL4 TEAD4 TEAD1 | hippo signaling |
| WP:WP3967 | 1.09748439577e-08 | 0.444444444444 | TEAD1 TEAD4 TEAD3 TEAD2 | miR 509 3p alteration of YAP1 ECM axis |
| CORUM:6848 | 1.31072783286e-08 | 0.333333333333 | IRF2BP2 IRF2BPL IRF2BP1 | IRF2BP2-IRF2BP1-IRF2BPL complex |
| WP:WP4533 | 1.84421026031e-08 | 0.444444444444 | TEAD1 TEAD4 TEAD3 TEAD2 | Transcription co factors SKI and SKIL protein partners |
| WP:WP4540 | 5.55044716132e-08 | 0.555555555556 | TEAD2 TEAD4 TEAD1 TEAD3 WWTR1 | Hippo signaling regulation pathways |
| WP:WP4542 | 1.42712411928e-07 | 0.444444444444 | TEAD1 TEAD4 TEAD3 TEAD2 | Leukocyte intrinsic Hippo pathway functions |
| REAC:R-HSA-8878159 | 2.066888518e-07 | 0.555555555556 | TEAD2 TEAD4 TEAD1 TEAD3 WWTR1 | Transcriptional regulation by RUNX3 |
| KEGG:04390 | 5.7296898425e-07 | 0.555555555556 | TEAD2 TEAD4 TEAD1 TEAD3 WWTR1 | Hippo signaling pathway |
| WP:WP5087 | 1.87719273313e-06 | 0.666666666667 | WWTR1 TEAD2 TEAD3 VGLL4 TEAD4 TEAD1 | Pleural mesothelioma |
| REAC:R-HSA-9796292 | 0.00286935042585 | 0.222222222222 | TEAD4 TEAD2 | Formation of axial mesoderm |
| GO:0006355 | 0.00303795876717 | 1.0 | WWTR1 TEAD2 TEAD1 VGLL4 IRF2BP1 IRF2BPL TEAD4 IRF2BP2 TEAD3 | regulation of DNA-templated transcription |
| GO:2001141 | 0.00320804197401 | 1.0 | WWTR1 TEAD2 TEAD1 VGLL4 IRF2BP1 IRF2BPL TEAD4 IRF2BP2 TEAD3 | regulation of RNA biosynthetic process |
| GO:0006351 | 0.00465537895398 | 1.0 | WWTR1 TEAD2 TEAD1 VGLL4 IRF2BP1 IRF2BPL TEAD4 IRF2BP2 TEAD3 | DNA-templated transcription |
| GO:0032774 | 0.00512577137556 | 1.0 | WWTR1 TEAD2 TEAD1 VGLL4 IRF2BP1 IRF2BPL TEAD4 IRF2BP2 TEAD3 | RNA biosynthetic process |
| GO:0051252 | 0.00831592797017 | 1.0 | WWTR1 TEAD2 TEAD1 VGLL4 IRF2BP1 IRF2BPL TEAD4 IRF2BP2 TEAD3 | regulation of RNA metabolic process |
| GO:0006357 | 0.0145554752998 | 0.888888888889 | WWTR1 TEAD2 TEAD1 IRF2BP1 IRF2BPL TEAD4 IRF2BP2 TEAD3 | regulation of transcription by RNA polymerase II |
| GO:0034654 | 0.0158700258372 | 1.0 | WWTR1 TEAD2 TEAD1 VGLL4 IRF2BP1 IRF2BPL TEAD4 IRF2BP2 TEAD3 | nucleobase-containing compound biosynthetic process |
| REAC:R-HSA-9619665 | 0.0166738379974 | 0.222222222222 | WWTR1 TEAD1 | EGR2 and SOX10-mediated initiation of Schwann cell myelination |
| GO:0018130 | 0.0187008801665 | 1.0 | WWTR1 TEAD2 TEAD1 VGLL4 IRF2BP1 IRF2BPL TEAD4 IRF2BP2 TEAD3 | heterocycle biosynthetic process |
| GO:0019438 | 0.0188805671311 | 1.0 | WWTR1 TEAD2 TEAD1 VGLL4 IRF2BP1 IRF2BPL TEAD4 IRF2BP2 TEAD3 | aromatic compound biosynthetic process |
| GO:0019219 | 0.0189408029 | 1.0 | WWTR1 TEAD2 TEAD1 VGLL4 IRF2BP1 IRF2BPL TEAD4 IRF2BP2 TEAD3 | regulation of nucleobase-containing compound metabolic process |
| GO:0006366 | 0.0221609176661 | 0.888888888889 | WWTR1 TEAD2 TEAD1 IRF2BP1 IRF2BPL TEAD4 IRF2BP2 TEAD3 | transcription by RNA polymerase II |
| GO:1901362 | 0.0245018387601 | 1.0 | WWTR1 TEAD2 TEAD1 VGLL4 IRF2BP1 IRF2BPL TEAD4 IRF2BP2 TEAD3 | organic cyclic compound biosynthetic process |
| REAC:R-HSA-212436 | 0.0395263988284 | 0.555555555556 | TEAD2 TEAD4 TEAD1 TEAD3 WWTR1 | Generic Transcription Pathway |
| CORUM:6652 | 0.0499842271994 | 0.111111111111 | WWTR1 | WWTR1 homodimer |
| CORUM:7062 | 0.0499842271994 | 0.111111111111 | WWTR1 | NFAT5-WWTR1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| IRF2BP1 | IRF2BP2 | 1.0 | 0.082 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| TEAD2 | TEAD1 | 1.0 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| IRF2BPL | IRF2BP1 | 1.0 | 0.274 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| WWTR1 | TEAD1 | 1.0 | 0.15 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| VGLL4 | TEAD3 | 1.0 | 0.066 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| VGLL4 | IRF2BPL | 0.999 | 0.064 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| WWTR1 | TEAD4 | 0.999 | 0.078 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| IRF2BPL | IRF2BP2 | 0.999 | 0.074 | bioplex_WMM bioplex3_WMM Malo fraction | |
| VGLL4 | IRF2BP2 | 0.999 | 0.088 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| VGLL4 | IRF2BP1 | 0.999 | 0.166 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| WWTR1 | TEAD2 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| TEAD4 | TEAD1 | 0.999 | 0.38 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TEAD2 | TEAD4 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| TEAD3 | WWTR1 | 0.997 | 0.136 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| IRF2 | CTSS | 0.995 | 0.266 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| IRF2BPL | IRF2 | 0.995 | 0.106 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| IRF2BP2 | IRF2 | 0.993 | 0.09 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| VGLL4 | TEAD1 | 0.991 | 0.136 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| VGLL4 | TEAD4 | 0.99 | 0.11 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TEAD3 | TEAD1 | 0.925 | 0.254 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| TEAD3 | TEAD2 | 0.902 | bioplex3_WMM WMM_only | ||
| TEAD3 | IRF2BPL | 0.884 | 0.022 | bioplex_WMM bioplex3_WMM WMM_only | |
| TEAD3 | IRF2BP1 | 0.878 | 0.05 | bioplex_WMM bioplex3_WMM WMM_only | |
| TEAD3 | IRF2BP2 | 0.853 | 0.128 | bioplex_WMM bioplex3_WMM WMM_only | |
| IRF2BP1 | IRF2 | 0.838 | 0.13 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| TEAD3 | TEAD4 | 0.829 | 0.21 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| IRF2BPL | CTSS | 0.502 | 0.104 | bioplex_WMM bioplex3_WMM WMM_only | |
| VGLL4 | TEAD2 | 0.378 |
mutually_exclusive (P28347)
|
bioplex_WMM bioplex3_WMM WMM_only | |
| IRF2BP2 | CTSS | 0.35 | 0.036 | bioplex_WMM bioplex3_WMM WMM_only | |
| IRF2BP1 | CTSS | 0.333 | 0.09 | bioplex_WMM bioplex3_WMM WMM_only | |
| VGLL4 | WWTR1 | 0.215 | 0.094 |
mutually_exclusive (Q99594)
|
bioplex_WMM bioplex3_WMM WMM_only |
| IRF2BPL | TEAD4 | 0.188 | 0.028 | bioplex_WMM bioplex3_WMM WMM_only | |
| IRF2BPL | TEAD1 | 0.188 | 0.046 | bioplex_WMM bioplex3_WMM WMM_only | |
| IRF2BP1 | TEAD4 | 0.17 | 0.052 | bioplex_WMM bioplex3_WMM WMM_only | |
| IRF2BP1 | TEAD1 | 0.163 | 0.064 | bioplex_WMM bioplex3_WMM WMM_only | |
| IRF2BP2 | TEAD1 | 0.14 | 0.056 | bioplex_WMM bioplex3_WMM WMM_only | |
| IRF2BP2 | TEAD4 | 0.109 | 0.124 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes