hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14676.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| IGFBP4 | Insulin-like growth factor-binding protein 4 (IBP-4) (IGF-binding protein 4) (IGFBP-4) | 5 | UniProt NCBI |
| NOTCH3 | Neurogenic locus notch homolog protein 3 (Notch 3) [Cleaved into: Notch 3 extracellular truncation; Notch 3 intracellular domain] | 5 | UniProt NCBI |
| MAML1 | Mastermind-like protein 1 (Mam-1) | 5 | UniProt NCBI |
| ZNF783 | Zinc finger protein 783 | 5 | UniProt NCBI |
| WNT10A | Protein Wnt-10a | 5 | UniProt NCBI |
| CCN6 | Cellular communication network factor 6 (CCN family member 6) (WNT1-inducible-signaling pathway protein 3) (WISP-3) | 5 | UniProt NCBI |
| PASK | PAS domain-containing serine/threonine-protein kinase (PAS-kinase) (PASKIN) (hPASK) (EC 2.7.11.1) | 5 | UniProt NCBI |
| NOTCH1 | Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)] | 5 | UniProt NCBI |
| RBPJ | Recombining binding protein suppressor of hairless (CBF-1) (J kappa-recombination signal-binding protein) (RBP-J kappa) (RBP-J) (RBP-JK) (Renal carcinoma antigen NY-REN-30) | 5 | UniProt NCBI |
| NOTCH2 | Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)] | 5 | UniProt NCBI |
| WNT2 | Protein Wnt-2 (Int-1-like protein 1) (Int-1-related protein) (IRP) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP3845 | 5.17322498575e-11 | 0.5 | RBPJ NOTCH1 NOTCH2 NOTCH3 MAML1 | Canonical and non canonical Notch signaling |
| REAC:R-HSA-350054 | 2.87272883513e-10 | 0.5 | RBPJ NOTCH1 NOTCH2 NOTCH3 MAML1 | Notch-HLH transcription pathway |
| WP:WP4787 | 2.01243328924e-09 | 0.6 | NOTCH2 WNT2 WNT10A NOTCH1 RBPJ NOTCH3 | Osteoblast differentiation and related diseases |
| KEGG:04330 | 3.8650418957e-09 | 0.5 | RBPJ NOTCH1 NOTCH2 NOTCH3 MAML1 | Notch signaling pathway |
| WP:WP61 | 4.79720648579e-09 | 0.5 | RBPJ NOTCH1 NOTCH2 NOTCH3 MAML1 | Notch signaling pathway |
| KEGG:05165 | 7.12567373092e-09 | 0.7 | NOTCH2 NOTCH1 WNT10A MAML1 WNT2 RBPJ NOTCH3 | Human papillomavirus infection |
| WP:WP4239 | 9.71588010752e-09 | 0.6 | NOTCH2 WNT2 WNT10A NOTCH1 RBPJ NOTCH3 | Epithelial to mesenchymal transition in colorectal cancer |
| CORUM:2897 | 1.68385473419e-08 | 0.3 | NOTCH1 MAML1 RBPJ | RBPJ-NOTCH1-MAML1 complex |
| CORUM:2890 | 1.68385473419e-08 | 0.3 | NOTCH1 MAML1 RBPJ | RBPJ-NOTCH1-MAML1 complex |
| CORUM:3113 | 1.68385473419e-08 | 0.3 | NOTCH1 MAML1 RBPJ | RBPJ-NOTCH1-MAML1 complex |
| KEGG:04658 | 3.60915674392e-08 | 0.5 | RBPJ NOTCH1 NOTCH2 NOTCH3 MAML1 | Th1 and Th2 cell differentiation |
| REAC:R-HSA-9013695 | 3.63057874925e-08 | 0.4 | NOTCH2 NOTCH1 MAML1 RBPJ | NOTCH4 Intracellular Domain Regulates Transcription |
| REAC:R-HSA-9013508 | 1.28653942882e-07 | 0.4 | RBPJ NOTCH1 NOTCH3 MAML1 | NOTCH3 Intracellular Domain Regulates Transcription |
| REAC:R-HSA-1912408 | 1.98451547866e-07 | 0.5 | RBPJ NOTCH1 NOTCH2 NOTCH3 MAML1 | Pre-NOTCH Transcription and Translation |
| REAC:R-HSA-5083630 | 2.22806969851e-07 | 0.3 | NOTCH1 NOTCH3 NOTCH2 | Defective LFNG causes SCDO3 |
| REAC:R-HSA-1912422 | 5.2583207726e-07 | 0.5 | RBPJ NOTCH1 NOTCH2 NOTCH3 MAML1 | Pre-NOTCH Expression and Processing |
| REAC:R-HSA-1912399 | 5.56817285598e-07 | 0.3 | NOTCH1 NOTCH3 NOTCH2 | Pre-NOTCH Processing in the Endoplasmic Reticulum |
| KEGG:05224 | 5.61017394541e-07 | 0.5 | NOTCH2 WNT10A WNT2 NOTCH3 NOTCH1 | Breast cancer |
| WP:WP268 | 6.34019510892e-07 | 0.4 | NOTCH2 NOTCH1 NOTCH3 MAML1 | Notch signaling |
| WP:WP4262 | 1.38398941122e-06 | 0.5 | NOTCH2 WNT10A WNT2 NOTCH3 NOTCH1 | Breast cancer pathway |
| REAC:R-HSA-2197563 | 1.94746021672e-06 | 0.3 | NOTCH2 MAML1 RBPJ | NOTCH2 intracellular domain regulates transcription |
| REAC:R-HSA-9012852 | 2.17048260795e-06 | 0.4 | RBPJ NOTCH1 NOTCH3 MAML1 | Signaling by NOTCH3 |
| WP:WP3971 | 2.71781665291e-06 | 0.3 | NOTCH1 NOTCH3 NOTCH2 | OSX and miRNAs in tooth development |
| CORUM:2639 | 3.69251717673e-06 | 0.3 | NOTCH1 MAML1 RBPJ | HES1 promoter-Notch enhancer complex |
| REAC:R-HSA-210744 | 9.16769422079e-06 | 0.3 | NOTCH1 MAML1 RBPJ | Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells |
| REAC:R-HSA-8941856 | 9.16769422079e-06 | 0.3 | NOTCH1 MAML1 RBPJ | RUNX3 regulates NOTCH signaling |
| GO:0002193 | 1.15344049292e-05 | 0.3 | NOTCH1 MAML1 RBPJ | MAML1-RBP-Jkappa- ICN1 complex |
| GO:0007221 | 1.15344049292e-05 | 0.3 | NOTCH1 MAML1 RBPJ | positive regulation of transcription of Notch receptor target |
| WP:WP2064 | 1.22306700697e-05 | 0.4 | NOTCH2 NOTCH1 NOTCH3 RBPJ | Neural crest differentiation |
| REAC:R-HSA-9013694 | 2.84022707524e-05 | 0.4 | NOTCH2 NOTCH1 MAML1 RBPJ | Signaling by NOTCH4 |
| REAC:R-HSA-157118 | 2.90156143749e-05 | 0.5 | RBPJ NOTCH1 NOTCH2 NOTCH3 MAML1 | Signaling by NOTCH |
| CORUM:2946 | 3.07577115383e-05 | 0.2 | NOTCH1 RBPJ | YY1-Notch1-RBP-Jkappa complex |
| CORUM:2907 | 3.07577115383e-05 | 0.2 | NOTCH1 RBPJ | RBP-Jkappa-Notch1 complex |
| REAC:R-HSA-1912420 | 3.77006103587e-05 | 0.3 | NOTCH1 NOTCH3 NOTCH2 | Pre-NOTCH Processing in Golgi |
| REAC:R-HSA-9793380 | 4.52244707165e-05 | 0.3 | NOTCH1 MAML1 RBPJ | Formation of paraxial mesoderm |
| GO:0007219 | 6.84879862683e-05 | 0.5 | RBPJ NOTCH1 NOTCH2 NOTCH3 MAML1 | Notch signaling pathway |
| REAC:R-HSA-1980145 | 0.000111932688205 | 0.3 | NOTCH2 MAML1 RBPJ | Signaling by NOTCH2 |
| REAC:R-HSA-186712 | 0.000127150506262 | 0.3 | NOTCH1 MAML1 RBPJ | Regulation of beta-cell development |
| KEGG:05200 | 0.000289324227938 | 0.5 | NOTCH2 WNT10A WNT2 NOTCH3 NOTCH1 | Pathways in cancer |
| REAC:R-HSA-9758941 | 0.000427697670043 | 0.3 | NOTCH1 MAML1 RBPJ | Gastrulation |
| REAC:R-HSA-2122947 | 0.000543255465432 | 0.3 | NOTCH1 MAML1 RBPJ | NOTCH1 Intracellular Domain Regulates Transcription |
| REAC:R-HSA-3906995 | 0.000630778022304 | 0.3 | NOTCH1 NOTCH3 NOTCH2 | Diseases associated with O-glycosylation of proteins |
| REAC:R-HSA-2644602 | 0.000889345061537 | 0.3 | NOTCH1 MAML1 RBPJ | Signaling by NOTCH1 PEST Domain Mutants in Cancer |
| REAC:R-HSA-2644603 | 0.000889345061537 | 0.3 | NOTCH1 MAML1 RBPJ | Signaling by NOTCH1 in Cancer |
| REAC:R-HSA-2644606 | 0.000889345061537 | 0.3 | NOTCH1 MAML1 RBPJ | Constitutive Signaling by NOTCH1 PEST Domain Mutants |
| REAC:R-HSA-2894858 | 0.000889345061537 | 0.3 | NOTCH1 MAML1 RBPJ | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer |
| REAC:R-HSA-2894862 | 0.000889345061537 | 0.3 | NOTCH1 MAML1 RBPJ | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| WP:WP2840 | 0.000969904252276 | 0.3 | NOTCH1 RBPJ NOTCH2 | Hair follicle development cytodifferentiation part 3 of 3 |
| KEGG:01522 | 0.000999860604288 | 0.3 | NOTCH1 NOTCH3 NOTCH2 | Endocrine resistance |
| WP:WP4674 | 0.00121330267742 | 0.3 | NOTCH1 MAML1 NOTCH2 | Head and neck squamous cell carcinoma |
| WP:WP4147 | 0.00148927061823 | 0.2 | NOTCH1 RBPJ | PTF1A related regulatory pathway |
| REAC:R-HSA-1980143 | 0.00177533901832 | 0.3 | NOTCH1 MAML1 RBPJ | Signaling by NOTCH1 |
| KEGG:04919 | 0.00209899304276 | 0.3 | NOTCH1 NOTCH3 NOTCH2 | Thyroid hormone signaling pathway |
| HP:0001231 | 0.00305899240526 | 0.4 | NOTCH2 WNT10A RBPJ NOTCH1 | Abnormal fingernail morphology |
| WP:WP3678 | 0.00322204466284 | 0.2 | NOTCH1 WNT2 | Amplification and expansion of oncogenic pathways as metastatic traits |
| HP:0001798 | 0.00520371988663 | 0.3 | WNT10A RBPJ NOTCH1 | Anonychia |
| HP:0010760 | 0.00582350189537 | 0.3 | NOTCH1 RBPJ NOTCH2 | Absent toe |
| KEGG:05206 | 0.00583642418014 | 0.3 | NOTCH1 NOTCH3 NOTCH2 | MicroRNAs in cancer |
| REAC:R-HSA-8878159 | 0.00593049755213 | 0.3 | NOTCH1 MAML1 RBPJ | Transcriptional regulation by RUNX3 |
| GO:0003205 | 0.00730022803694 | 0.4 | NOTCH2 NOTCH1 MAML1 RBPJ | cardiac chamber development |
| HP:0008386 | 0.00874829102906 | 0.4 | NOTCH2 WNT10A RBPJ NOTCH1 | Aplasia/Hypoplasia of the nails |
| GO:0003177 | 0.00936146543831 | 0.3 | NOTCH1 RBPJ NOTCH2 | pulmonary valve development |
| REAC:R-HSA-3781865 | 0.0122114640727 | 0.3 | NOTCH1 NOTCH3 NOTCH2 | Diseases of glycosylation |
| WP:WP5269 | 0.0166734771023 | 0.2 | NOTCH1 RBPJ | Genetic causes of porto sinusoidal vascular disease |
| REAC:R-HSA-162582 | 0.0190896791054 | 0.7 | NOTCH2 NOTCH1 WNT10A MAML1 WNT2 RBPJ NOTCH3 | Signal Transduction |
| WP:WP4331 | 0.0203472698002 | 0.2 | NOTCH1 NOTCH3 | Neovascularisation processes |
| HP:0001269 | 0.0209309049474 | 0.3 | NOTCH1 NOTCH3 RBPJ | Hemiparesis |
| HP:0001799 | 0.0226469783291 | 0.2 | WNT10A NOTCH2 | Short nail |
| GO:0048738 | 0.0227360626478 | 0.4 | NOTCH2 NOTCH1 MAML1 RBPJ | cardiac muscle tissue development |
| WP:WP4150 | 0.0229969481751 | 0.2 | WNT10A WNT2 | Wnt signaling in kidney disease |
| WP:WP2848 | 0.0243817991122 | 0.2 | NOTCH1 WNT2 | Pluripotent stem cell differentiation pathway |
| GO:0014706 | 0.0275647597214 | 0.4 | NOTCH2 NOTCH1 MAML1 RBPJ | striated muscle tissue development |
| REAC:R-HSA-3238698 | 0.0302795201711 | 0.2 | WNT10A WNT2 | WNT ligand biogenesis and trafficking |
| KEGG:05217 | 0.0309042548689 | 0.2 | WNT10A WNT2 | Basal cell carcinoma |
| HP:0009882 | 0.0342690801014 | 0.3 | NOTCH1 RBPJ NOTCH2 | Short distal phalanx of finger |
| HP:0009835 | 0.0397152677732 | 0.3 | NOTCH1 RBPJ NOTCH2 | Aplasia/Hypoplasia of the distal phalanges of the hand |
| HP:0001991 | 0.0408686292444 | 0.3 | NOTCH1 RBPJ NOTCH2 | Aplasia/Hypoplasia of toe |
| HP:0006493 | 0.0418434633702 | 0.4 | NOTCH2 CCN6 RBPJ NOTCH1 | Aplasia/hypoplasia involving bones of the lower limbs |
| HP:0030966 | 0.049564177707 | 0.3 | NOTCH1 RBPJ NOTCH2 | Abnormal pulmonary artery morphology |
| CORUM:2947 | 0.0499436884912 | 0.1 | NOTCH1 | YY1-Notch1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MAML1 | RBPJ | 0.998 | 0.076 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| RBPJ | NOTCH2 | 0.996 | 0.046 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| WNT2 | NOTCH1 | 0.988 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| NOTCH3 | WNT10A | 0.987 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MAML1 | NOTCH2 | 0.986 | 0.124 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| NOTCH1 | NOTCH2 | 0.981 | 0.096 | hein_WMM bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| NOTCH1 | RBPJ | 0.98 | 0.084 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| NOTCH3 | NOTCH1 | 0.98 | 0.166 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| MAML1 | NOTCH1 | 0.979 | 0.166 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| NOTCH3 | NOTCH2 | 0.979 | 0.16 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| CCN6 | NOTCH1 | 0.972 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| WNT10A | NOTCH2 | 0.964 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CCN6 | NOTCH2 | 0.963 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| WNT10A | NOTCH1 | 0.962 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| WNT2 | NOTCH2 | 0.948 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| IGFBP4 | NOTCH2 | 0.941 | 0.046 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| IGFBP4 | NOTCH1 | 0.933 | 0.086 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| WNT2 | PASK | 0.919 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CCN6 | PASK | 0.912 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ZNF783 | NOTCH2 | 0.889 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| WNT10A | PASK | 0.849 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| NOTCH3 | RBPJ | 0.76 | 0.126 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| NOTCH1 | PASK | 0.498 | 0.068 | bioplex3_WMM WMM_only |
| NOTCH3 | MAML1 | 0.186 | 0.174 | bioplex_WMM bioplex3_WMM WMM_only |
| NOTCH2 | PASK | 0.127 | 0.066 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
| NOTCH3 | ZNF783 | 0.093 | bioplex3_WMM WMM_only | |
| NOTCH3 | PASK | 0.069 | 0.166 | bioplex_WMM bioplex3_WMM WMM_only |
| ZNF783 | NOTCH1 | 0.044 | bioplex3_WMM WMM_only | |
| RBPJ | PASK | 0.012 | 0.092 | gupta_WMM WMM_only |
| MAML1 | PASK | 0.003 | 0.166 | youn_WMM WMM_only |
Related Complexes