hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_14708.1

Complex Portal: CPX-17295

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
BMPR1B	Bone morphogenetic protein receptor type-1B (BMP type-1B receptor) (BMPR-1B) (EC 2.7.11.30) (CD antigen CDw293)	5	UniProt NCBI
RRAGD	Ras-related GTP-binding protein D (Rag D) (RagD) (EC 3.6.5.-)	5	UniProt NCBI
INPP5F	Phosphatidylinositide phosphatase SAC2 (EC 3.1.3.25) (Inositol polyphosphate 5-phosphatase F) (Sac domain-containing inositol phosphatase 2) (Sac domain-containing phosphoinositide 4-phosphatase 2) (hSAC2)	5	UniProt NCBI
KDF1	Keratinocyte differentiation factor 1	5	UniProt NCBI
SLC38A9	Neutral amino acid transporter 9 (Solute carrier family 38 member 9) (Up-regulated in lung cancer 11)	5	UniProt NCBI
LAMTOR2	Ragulator complex protein LAMTOR2 (Endosomal adaptor protein p14) (Late endosomal/lysosomal Mp1-interacting protein) (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2) (Mitogen-activated protein-binding protein-interacting protein) (MAPBP-interacting protein) (Roadblock domain-containing protein 3)	5	UniProt NCBI
LAMTOR1	Ragulator complex protein LAMTOR1 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1) (Lipid raft adaptor protein p18) (Protein associated with DRMs and endosomes) (p27Kip1-releasing factor from RhoA) (p27RF-Rho)	5	UniProt NCBI
BIRC5	Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor 4) (Apoptosis inhibitor survivin)	5	UniProt NCBI
RRAGC	Ras-related GTP-binding protein C (Rag C) (RagC) (EC 3.6.5.-) (GTPase-interacting protein 2) (TIB929)	5	UniProt NCBI
RRAGA	Ras-related GTP-binding protein A (Rag A) (RagA) (EC 3.6.5.-) (Adenovirus E3 14.7 kDa-interacting protein 1) (FIP-1)	5	UniProt NCBI
LAMTOR4	Ragulator complex protein LAMTOR4 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4) [Cleaved into: Ragulator complex protein LAMTOR4, N-terminally processed]	5	UniProt NCBI
LAMTOR3	Ragulator complex protein LAMTOR3 (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3) (MEK-binding partner 1) (Mp1) (Mitogen-activated protein kinase kinase 1-interacting protein 1) (Mitogen-activated protein kinase scaffold protein 1)	5	UniProt NCBI
LAMTOR5	Ragulator complex protein LAMTOR5 (Hepatitis B virus X-interacting protein) (HBV X-interacting protein) (HBX-interacting protein) (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5)	5	UniProt NCBI
RRAGB	Ras-related GTP-binding protein B (Rag B) (RagB) (EC 3.6.5.-)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-166208	4.49900085802e-24	0.714285714286	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGD RRAGC LAMTOR5 RRAGB LAMTOR2	mTORC1-mediated signalling
REAC:R-HSA-380972	4.58903858367e-23	0.714285714286	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGD RRAGC LAMTOR5 RRAGB LAMTOR2	Energy dependent regulation of mTOR by LKB1-AMPK
REAC:R-HSA-165159	2.56085507038e-21	0.714285714286	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGD RRAGC LAMTOR5 RRAGB LAMTOR2	MTOR signalling
REAC:R-HSA-9639288	4.44073462828e-20	0.714285714286	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGD RRAGC LAMTOR5 RRAGB LAMTOR2	Amino acids regulate mTORC1
GO:0071230	5.34090722605e-20	0.714285714286	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGD RRAGC LAMTOR5 RRAGB LAMTOR2	cellular response to amino acid stimulus
REAC:R-HSA-8943724	9.82470511715e-20	0.714285714286	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGD RRAGC LAMTOR5 RRAGB LAMTOR2	Regulation of PTEN gene transcription
GO:1990877	1.31033635192e-19	0.571428571429	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGC LAMTOR5 LAMTOR2	FNIP-folliculin RagC/D GAP
GO:0071229	1.41770299306e-19	0.714285714286	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGD RRAGC LAMTOR5 RRAGB LAMTOR2	cellular response to acid chemical
GO:0043200	2.58619209679e-19	0.714285714286	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGD RRAGC LAMTOR5 RRAGB LAMTOR2	response to amino acid
GO:1902773	4.8028121718e-19	0.571428571429	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGC LAMTOR5 LAMTOR2	GTPase activator complex
GO:0001101	7.79187770436e-19	0.714285714286	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGD RRAGC LAMTOR5 RRAGB LAMTOR2	response to acid chemical
REAC:R-HSA-5628897	3.25976814779e-18	0.714285714286	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGD RRAGC LAMTOR5 RRAGB LAMTOR2	TP53 Regulates Metabolic Genes
GO:1904263	4.16727613944e-18	0.714285714286	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGD RRAGC LAMTOR5 RRAGB LAMTOR2	positive regulation of TORC1 signaling
GO:0150005	3.7393574544e-17	0.571428571429	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGC LAMTOR5 LAMTOR2	enzyme activator complex
GO:0032008	7.2351112125e-17	0.714285714286	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGD RRAGC LAMTOR5 RRAGB LAMTOR2	positive regulation of TOR signaling
REAC:R-HSA-1632852	4.30817440635e-16	0.714285714286	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGD RRAGC LAMTOR5 RRAGB LAMTOR2	Macroautophagy
KEGG:04150	4.48390191263e-16	0.714285714286	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGD RRAGC LAMTOR5 RRAGB LAMTOR2	mTOR signaling pathway
REAC:R-HSA-6807070	8.78652072999e-16	0.714285714286	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGD RRAGC LAMTOR5 RRAGB LAMTOR2	PTEN Regulation
GO:1903432	1.25839056604e-15	0.714285714286	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGD RRAGC LAMTOR5 RRAGB LAMTOR2	regulation of TORC1 signaling
REAC:R-HSA-9612973	1.37554539939e-15	0.714285714286	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGD RRAGC LAMTOR5 RRAGB LAMTOR2	Autophagy
GO:0038202	2.04289116257e-15	0.714285714286	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGD RRAGC LAMTOR5 RRAGB LAMTOR2	TORC1 signaling
REAC:R-HSA-9711097	3.18605743965e-15	0.714285714286	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGD RRAGC LAMTOR5 RRAGB LAMTOR2	Cellular response to starvation
GO:0071986	1.11047990931e-14	0.428571428571	LAMTOR4 LAMTOR1 SLC38A9 LAMTOR2 LAMTOR5 LAMTOR3	Ragulator complex
GO:0032006	6.49839868437e-14	0.714285714286	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGD RRAGC LAMTOR5 RRAGB LAMTOR2	regulation of TOR signaling
REAC:R-HSA-3700989	8.28232660086e-14	0.785714285714	LAMTOR4 RRAGC LAMTOR1 BIRC5 RRAGA SLC38A9 RRAGD LAMTOR3 LAMTOR5 RRAGB LAMTOR2	Transcriptional Regulation by TP53
GO:0031929	1.961843381e-13	0.714285714286	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGD RRAGC LAMTOR5 RRAGB LAMTOR2	TOR signaling
REAC:R-HSA-1257604	2.03936619621e-13	0.714285714286	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGD RRAGC LAMTOR5 RRAGB LAMTOR2	PIP3 activates AKT signaling
REAC:R-HSA-9006925	8.55766120033e-13	0.714285714286	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGD RRAGC LAMTOR5 RRAGB LAMTOR2	Intracellular signaling by second messengers
CORUM:6888	3.74981302983e-11	0.357142857143	LAMTOR1 LAMTOR5 LAMTOR3 LAMTOR2 LAMTOR4	v-ATPase-Ragulator-AXIN/LKB1-AMPK complex
GO:0032045	2.99461549368e-10	0.428571428571	LAMTOR4 LAMTOR1 SLC38A9 LAMTOR2 LAMTOR5 LAMTOR3	guanyl-nucleotide exchange factor complex
GO:0071417	1.56948034315e-09	0.714285714286	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGD RRAGC LAMTOR5 RRAGB LAMTOR2	cellular response to organonitrogen compound
GO:1901699	5.58195543241e-09	0.714285714286	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGD RRAGC LAMTOR5 RRAGB LAMTOR2	cellular response to nitrogen compound
REAC:R-HSA-212436	1.61225453306e-08	0.785714285714	LAMTOR4 RRAGC LAMTOR1 BIRC5 RRAGA SLC38A9 RRAGD LAMTOR3 LAMTOR5 RRAGB LAMTOR2	Generic Transcription Pathway
REAC:R-HSA-2262752	1.93974804421e-08	0.714285714286	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGD RRAGC LAMTOR5 RRAGB LAMTOR2	Cellular responses to stress
REAC:R-HSA-8953897	2.13334492431e-08	0.714285714286	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGD RRAGC LAMTOR5 RRAGB LAMTOR2	Cellular responses to stimuli
GO:1990131	2.63389436402e-08	0.285714285714	RRAGB RRAGD RRAGA RRAGC	Gtr1-Gtr2 GTPase complex
GO:0010243	3.79119983798e-08	0.714285714286	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGD RRAGC LAMTOR5 RRAGB LAMTOR2	response to organonitrogen compound
GO:1902533	4.86335172901e-08	0.785714285714	LAMTOR4 RRAGC LAMTOR1 BIRC5 RRAGA SLC38A9 RRAGD LAMTOR3 LAMTOR5 RRAGB LAMTOR2	positive regulation of intracellular signal transduction
REAC:R-HSA-73857	5.29874402862e-08	0.785714285714	LAMTOR4 RRAGC LAMTOR1 BIRC5 RRAGA SLC38A9 RRAGD LAMTOR3 LAMTOR5 RRAGB LAMTOR2	RNA Polymerase II Transcription
GO:0005765	1.1119075982e-07	0.642857142857	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGC LAMTOR5 RRAGB LAMTOR2	lysosomal membrane
GO:0098852	1.1119075982e-07	0.642857142857	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGC LAMTOR5 RRAGB LAMTOR2	lytic vacuole membrane
GO:1901698	1.55996753338e-07	0.714285714286	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGD RRAGC LAMTOR5 RRAGB LAMTOR2	response to nitrogen compound
GO:0023056	1.86742077536e-07	0.857142857143	LAMTOR4 RRAGC LAMTOR1 BIRC5 RRAGA INPP5F RRAGD LAMTOR3 LAMTOR5 SLC38A9 RRAGB LAMTOR2	positive regulation of signaling
REAC:R-HSA-74160	2.05484653639e-07	0.785714285714	LAMTOR4 RRAGC LAMTOR1 BIRC5 RRAGA SLC38A9 RRAGD LAMTOR3 LAMTOR5 RRAGB LAMTOR2	Gene expression (Transcription)
GO:0005774	2.21844490159e-07	0.642857142857	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGC LAMTOR5 RRAGB LAMTOR2	vacuolar membrane
GO:0000323	3.45187798173e-07	0.714285714286	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGD RRAGC LAMTOR5 RRAGB LAMTOR2	lytic vacuole
GO:0005764	3.45187798173e-07	0.714285714286	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGD RRAGC LAMTOR5 RRAGB LAMTOR2	lysosome
GO:0071495	3.8456402197e-07	0.785714285714	LAMTOR4 RRAGD BMPR1B SLC38A9 RRAGA LAMTOR3 RRAGC LAMTOR5 LAMTOR1 RRAGB LAMTOR2	cellular response to endogenous stimulus
GO:0005773	8.98391450336e-07	0.714285714286	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGD RRAGC LAMTOR5 RRAGB LAMTOR2	vacuole
REAC:R-HSA-162582	9.4233120148e-07	0.857142857143	LAMTOR4 RRAGC BMPR1B BIRC5 RRAGA SLC38A9 RRAGD LAMTOR3 LAMTOR5 LAMTOR1 RRAGB LAMTOR2	Signal Transduction
GO:0009719	9.74770041349e-07	0.785714285714	LAMTOR4 RRAGD BMPR1B SLC38A9 RRAGA LAMTOR3 RRAGC LAMTOR5 LAMTOR1 RRAGB LAMTOR2	response to endogenous stimulus
GO:1901701	1.38103922738e-06	0.714285714286	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGD RRAGC LAMTOR5 RRAGB LAMTOR2	cellular response to oxygen-containing compound
WP:WP1471	2.80088414036e-06	0.285714285714	RRAGB RRAGD RRAGA RRAGC	Target of rapamycin signaling
GO:0009967	3.39478998969e-06	0.785714285714	LAMTOR4 RRAGC LAMTOR1 BIRC5 RRAGA SLC38A9 RRAGD LAMTOR3 LAMTOR5 RRAGB LAMTOR2	positive regulation of signal transduction
GO:0010647	8.57717292935e-06	0.785714285714	LAMTOR4 RRAGC LAMTOR1 BIRC5 RRAGA SLC38A9 RRAGD LAMTOR3 LAMTOR5 RRAGB LAMTOR2	positive regulation of cell communication
GO:1901700	1.22337165969e-05	0.714285714286	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGD RRAGC LAMTOR5 RRAGB LAMTOR2	response to oxygen-containing compound
GO:1902531	1.89004677178e-05	0.785714285714	LAMTOR4 RRAGC LAMTOR1 BIRC5 RRAGA SLC38A9 RRAGD LAMTOR3 LAMTOR5 RRAGB LAMTOR2	regulation of intracellular signal transduction
GO:0061462	3.7321184062e-05	0.357142857143	LAMTOR1 LAMTOR5 LAMTOR4 RRAGA RRAGC	protein localization to lysosome
GO:0035556	4.39124996937e-05	0.857142857143	LAMTOR4 RRAGC LAMTOR1 BIRC5 RRAGA INPP5F RRAGD LAMTOR3 LAMTOR5 SLC38A9 RRAGB LAMTOR2	intracellular signal transduction
CORUM:5226	4.44741811353e-05	0.142857142857	LAMTOR2 LAMTOR3	p14-Mp1-ERK2 complex
CORUM:5222	0.000133349500201	0.142857142857	LAMTOR2 LAMTOR3	p14-Mp1-MEK1 complex
GO:0009966	0.000200494963382	0.857142857143	LAMTOR4 RRAGC LAMTOR1 BIRC5 RRAGA INPP5F RRAGD LAMTOR3 LAMTOR5 SLC38A9 RRAGB LAMTOR2	regulation of signal transduction
GO:0071310	0.000201260039956	0.714285714286	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGD RRAGC LAMTOR5 RRAGB LAMTOR2	cellular response to organic substance
GO:0048584	0.000243133130724	0.785714285714	LAMTOR4 RRAGC LAMTOR1 BIRC5 RRAGA SLC38A9 RRAGD LAMTOR3 LAMTOR5 RRAGB LAMTOR2	positive regulation of response to stimulus
GO:0005085	0.000263394184854	0.428571428571	LAMTOR4 LAMTOR1 SLC38A9 LAMTOR2 LAMTOR5 LAMTOR3	guanyl-nucleotide exchange factor activity
WP:WP5224	0.000277667759616	0.285714285714	RRAGB RRAGD RRAGA RRAGC	2q37 copy number variation syndrome
GO:0072665	0.000300130459659	0.357142857143	LAMTOR1 LAMTOR5 LAMTOR4 RRAGA RRAGC	protein localization to vacuole
GO:0031902	0.000391107232434	0.357142857143	LAMTOR1 LAMTOR5 LAMTOR3 LAMTOR2 LAMTOR4	late endosome membrane
GO:0023051	0.000595213969014	0.857142857143	LAMTOR4 RRAGC LAMTOR1 BIRC5 RRAGA INPP5F RRAGD LAMTOR3 LAMTOR5 SLC38A9 RRAGB LAMTOR2	regulation of signaling
GO:0010646	0.000604542757892	0.857142857143	LAMTOR4 RRAGC LAMTOR1 BIRC5 RRAGA INPP5F RRAGD LAMTOR3 LAMTOR5 SLC38A9 RRAGB LAMTOR2	regulation of cell communication
KEGG:04140	0.000639806742866	0.285714285714	RRAGB RRAGD RRAGA RRAGC	Autophagy - animal
GO:0005770	0.000860381288202	0.428571428571	LAMTOR4 LAMTOR1 SLC38A9 LAMTOR2 LAMTOR5 LAMTOR3	late endosome
GO:1905360	0.00152452693808	0.285714285714	RRAGB RRAGD RRAGA RRAGC	GTPase complex
GO:0048518	0.00154296535495	1.0	RRAGB LAMTOR4 RRAGC BMPR1B SLC38A9 RRAGA INPP5F RRAGD LAMTOR3 LAMTOR5 LAMTOR1 KDF1 BIRC5 LAMTOR2	positive regulation of biological process
GO:0010033	0.00205572737879	0.714285714286	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGD RRAGC LAMTOR5 RRAGB LAMTOR2	response to organic substance
KEGG:05131	0.00279222396237	0.285714285714	RRAGB RRAGD RRAGA RRAGC	Shigellosis
GO:0098588	0.00300903618317	0.714285714286	LAMTOR4 RRAGC LAMTOR1 INPP5F SLC38A9 RRAGA LAMTOR3 LAMTOR5 RRAGB LAMTOR2	bounding membrane of organelle
GO:0034198	0.00318175191918	0.285714285714	RRAGB RRAGD RRAGA RRAGC	cellular response to amino acid starvation
GO:1990928	0.00383717232873	0.285714285714	RRAGB RRAGD RRAGA RRAGC	response to amino acid starvation
GO:0048583	0.00490011895477	0.857142857143	LAMTOR4 RRAGC LAMTOR1 BIRC5 RRAGA INPP5F RRAGD LAMTOR3 LAMTOR5 SLC38A9 RRAGB LAMTOR2	regulation of response to stimulus
GO:0007165	0.00626107412934	0.928571428571	LAMTOR4 RRAGC BMPR1B SLC38A9 RRAGA INPP5F RRAGD LAMTOR3 LAMTOR5 LAMTOR1 RRAGB BIRC5 LAMTOR2	signal transduction
GO:0070887	0.00632079438653	0.714285714286	LAMTOR4 RRAGA LAMTOR1 SLC38A9 LAMTOR3 RRAGD RRAGC LAMTOR5 RRAGB LAMTOR2	cellular response to chemical stimulus
GO:0031669	0.0140841279252	0.357142857143	RRAGB RRAGD RRAGC RRAGA LAMTOR1	cellular response to nutrient levels
GO:0048522	0.015902461252	0.928571428571	RRAGB LAMTOR4 RRAGC BMPR1B SLC38A9 RRAGA BIRC5 RRAGD LAMTOR3 LAMTOR5 LAMTOR1 KDF1 LAMTOR2	positive regulation of cellular process
GO:0023052	0.0171477463554	0.928571428571	LAMTOR4 RRAGC BMPR1B SLC38A9 RRAGA INPP5F RRAGD LAMTOR3 LAMTOR5 LAMTOR1 RRAGB BIRC5 LAMTOR2	signaling
GO:0031668	0.0184619913056	0.357142857143	RRAGB RRAGD RRAGC RRAGA LAMTOR1	cellular response to extracellular stimulus
GO:0060090	0.0196390765426	0.571428571429	LAMTOR4 RRAGC LAMTOR1 RRAGA LAMTOR3 RRAGD LAMTOR5 LAMTOR2	molecular adaptor activity
GO:0007154	0.0200399845293	0.928571428571	LAMTOR4 RRAGC BMPR1B SLC38A9 RRAGA INPP5F RRAGD LAMTOR3 LAMTOR5 LAMTOR1 RRAGB BIRC5 LAMTOR2	cell communication
GO:0010008	0.0201416682419	0.428571428571	LAMTOR4 LAMTOR1 INPP5F LAMTOR2 LAMTOR5 LAMTOR3	endosome membrane
GO:0010507	0.0232917470649	0.285714285714	RRAGB RRAGD RRAGA RRAGC	negative regulation of autophagy
GO:0051641	0.024060212492	0.785714285714	LAMTOR4 RRAGC LAMTOR1 BIRC5 RRAGA INPP5F RRAGD LAMTOR3 LAMTOR5 RRAGB LAMTOR2	cellular localization
GO:0060589	0.0242608112297	0.428571428571	LAMTOR4 LAMTOR1 SLC38A9 LAMTOR2 LAMTOR5 LAMTOR3	nucleoside-triphosphatase regulator activity
GO:0030695	0.0242608112297	0.428571428571	LAMTOR4 LAMTOR1 SLC38A9 LAMTOR2 LAMTOR5 LAMTOR3	GTPase regulator activity
GO:0071496	0.0455900426014	0.357142857143	RRAGB RRAGD RRAGC RRAGA LAMTOR1	cellular response to external stimulus
GO:0051020	0.0467055946247	0.357142857143	RRAGB RRAGD RRAGC BIRC5 LAMTOR1	GTPase binding
CORUM:2580	0.0499958217778	0.0714285714286	BIRC5	Survivin homodimer complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
LAMTOR1	LAMTOR4	1.0	0.916
LAMTOR1	RRAGA	1.0	0.254
LAMTOR2	LAMTOR1	1.0	0.872
LAMTOR2	LAMTOR5	0.999	0.516	mutually_exclusive (Q5VZM2)
RRAGC	RRAGB	0.999	0.536
RRAGC	RRAGA	0.999	0.207777777778
RRAGD	RRAGA	0.999
RRAGA	LAMTOR5	0.999	0.276
SLC38A9	RRAGA	0.999	0.128
RRAGD	RRAGB	0.999
LAMTOR2	LAMTOR3	0.999	0.944	mutually_exclusive (Q5VZM2)
RRAGD	LAMTOR5	0.999
RRAGC	LAMTOR1	0.998	0.262	mutually_exclusive (Q9NQL2)
LAMTOR4	LAMTOR5	0.998	0.582	mutually_exclusive (Q5VZM2)
LAMTOR4	LAMTOR3	0.998	0.912
LAMTOR2	LAMTOR4	0.998	0.836	mutually_exclusive (Q5VZM2)
RRAGB	LAMTOR4	0.998	0.34	structurally_consistent (dimer)
LAMTOR1	LAMTOR3	0.998	0.816
SLC38A9	LAMTOR1	0.998	0.250911392405
RRAGC	LAMTOR2	0.998	0.112
SLC38A9	LAMTOR3	0.997	0.134
RRAGC	LAMTOR4	0.997	0.164
SLC38A9	LAMTOR2	0.997	0.194
LAMTOR1	LAMTOR5	0.997	0.696	structurally_consistent (dimer)
RRAGD	LAMTOR4	0.997
RRAGC	LAMTOR3	0.997	0.224
LAMTOR3	LAMTOR5	0.997	0.332
RRAGD	LAMTOR3	0.996
SLC38A9	LAMTOR4	0.996	0.092
SLC38A9	LAMTOR5	0.995	0.15
RRAGC	LAMTOR5	0.995	0.124
RRAGD	LAMTOR1	0.994		structurally_consistent (dimer)
RRAGA	LAMTOR3	0.994	0.14
RRAGB	LAMTOR1	0.992	0.188
RRAGB	LAMTOR3	0.992	0.232	structurally_consistent (dimer)
LAMTOR2	RRAGA	0.99	0.144	mutually_exclusive (Q5VZM2)
RRAGA	LAMTOR4	0.988	0.266
BIRC5	LAMTOR4	0.986	0.046
LAMTOR5	INPP5F	0.985	0.028	structurally_consistent (dimer)
SLC38A9	RRAGC	0.984	0.046
LAMTOR1	BMPR1B	0.978
SLC38A9	RRAGB	0.973	0.078
RRAGC	RRAGD	0.973		structurally_consistent (dimer)
RRAGB	LAMTOR2	0.971	0.176	structurally_consistent (dimer)
RRAGD	LAMTOR2	0.965
SLC38A9	RRAGD	0.959
RRAGB	LAMTOR5	0.923	0.134	structurally_consistent (dimer)
RRAGD	KDF1	0.911
BIRC5	LAMTOR5	0.886	0.038	structurally_consistent (dimer)
RRAGA	BMPR1B	0.73
RRAGD	BMPR1B	0.715
LAMTOR5	BMPR1B	0.676
RRAGB	BMPR1B	0.665
RRAGD	INPP5F	0.638
RRAGB	RRAGA	0.634	0.348	structurally_consistent (dimer)
RRAGA	INPP5F	0.604	0.04
RRAGB	KDF1	0.589
RRAGC	INPP5F	0.431	0.0601025641026
SLC38A9	INPP5F	0.356	0.04
SLC38A9	BMPR1B	0.343
RRAGC	BMPR1B	0.343
LAMTOR2	INPP5F	0.332	0.044
LAMTOR4	INPP5F	0.332	0.018
LAMTOR4	BMPR1B	0.32
LAMTOR2	BMPR1B	0.32
LAMTOR3	BMPR1B	0.182
LAMTOR1	INPP5F	0.149	0.052	mutually_exclusive (O43504)
LAMTOR3	INPP5F	0.149	0.026
LAMTOR2	KDF1	0.028
LAMTOR1	KDF1	0.019
LAMTOR3	KDF1	0.015

Related Complexes

Genename	Complexes
BMPR1B	huMAP3_03945.1 huMAP3_06169.1 huMAP3_10047.1 huMAP3_10694.1 huMAP3_14108.1 huMAP3_14708.1
RRAGD	huMAP3_01903.1 huMAP3_02963.1 huMAP3_05542.1 huMAP3_08350.1 huMAP3_10848.1 huMAP3_14108.1 huMAP3_14708.1 huMAP3_14711.1
INPP5F	huMAP3_12921.1 huMAP3_14708.1
KDF1	huMAP3_13851.1 huMAP3_14108.1 huMAP3_14708.1 huMAP3_14711.1
SLC38A9	huMAP3_00620.1 huMAP3_02963.1 huMAP3_05542.1 huMAP3_08350.1 huMAP3_10848.1 huMAP3_11349.1 huMAP3_14108.1 huMAP3_14708.1
LAMTOR2	huMAP3_02963.1 huMAP3_05542.1 huMAP3_08350.1 huMAP3_12042.1 huMAP3_14108.1 huMAP3_14708.1
LAMTOR1	huMAP3_02963.1 huMAP3_03143.1 huMAP3_05542.1 huMAP3_08350.1 huMAP3_10047.1 huMAP3_14108.1 huMAP3_14708.1
BIRC5	huMAP3_00111.1 huMAP3_00910.1 huMAP3_00946.1 huMAP3_01130.1 huMAP3_04346.1 huMAP3_08157.1 huMAP3_08415.1 huMAP3_11479.1 huMAP3_12277.1 huMAP3_12835.1 huMAP3_14108.1 huMAP3_14708.1
RRAGC	huMAP3_00620.1 huMAP3_02963.1 huMAP3_05542.1 huMAP3_08350.1 huMAP3_10848.1 huMAP3_11349.1 huMAP3_14108.1 huMAP3_14708.1
RRAGA	huMAP3_03271.1 huMAP3_05542.1 huMAP3_08350.1 huMAP3_14108.1 huMAP3_14708.1
LAMTOR4	huMAP3_03271.1 huMAP3_05542.1 huMAP3_08350.1 huMAP3_11173.1 huMAP3_14108.1 huMAP3_14708.1
LAMTOR3	huMAP3_03271.1 huMAP3_05542.1 huMAP3_08350.1 huMAP3_14108.1 huMAP3_14708.1
LAMTOR5	huMAP3_03271.1 huMAP3_05542.1 huMAP3_08350.1 huMAP3_14108.1 huMAP3_14708.1 huMAP3_15175.1
RRAGB	huMAP3_01903.1 huMAP3_03271.1 huMAP3_05542.1 huMAP3_10848.1 huMAP3_11349.1 huMAP3_14108.1 huMAP3_14708.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_14708.1

Complex Portal: CPX-17295