hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14727.1
Complex Portal: CPX-11649
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| USP25 | Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (USP on chromosome 21) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25) | 5 | UniProt NCBI |
| BTBD9 | BTB/POZ domain-containing protein 9 | 5 | UniProt NCBI |
| MTURN | Maturin (Maturin neural progenitor differentiation regulator protein homolog) (Protein Ells1) | 5 | UniProt NCBI |
| KCTD13 | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 (hBACURD1) (BTB/POZ domain-containing protein KCTD13) (Polymerase delta-interacting protein 1) (TNFAIP1-like protein) | 5 | UniProt NCBI |
| TNFAIP1 | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (hBACURD2) (BTB/POZ domain-containing protein TNFAIP1) (Protein B12) (Tumor necrosis factor, alpha-induced protein 1, endothelial) | 5 | UniProt NCBI |
| DCUN1D2 | DCN1-like protein 2 (DCNL2) (DCUN1 domain-containing protein 2) (Defective in cullin neddylation protein 1-like protein 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9696270 | 0.019003715544 | 0.333333333333 | KCTD13 TNFAIP1 | RND2 GTPase cycle |
| REAC:R-HSA-9696264 | 0.0200002568185 | 0.333333333333 | KCTD13 TNFAIP1 | RND3 GTPase cycle |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TNFAIP1 | KCTD13 | 1.0 |
mutually_exclusive (Q9H3F6)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| BTBD9 | KCTD13 | 0.963 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| MTURN | TNFAIP1 | 0.96 | 0.082 |
structurally_consistent (Q9H3F6)
|
bioplex3_HEK293 bioplex3_WMM WMM_only |
| USP25 | BTBD9 | 0.911 | 0.184 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| USP25 | TNFAIP1 | 0.894 | 0.126 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| DCUN1D2 | USP25 | 0.883 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| TNFAIP1 | BTBD9 | 0.816 | 0.104 | bioplex_WMM bioplex3_WMM WMM_only | |
| MTURN | KCTD13 | 0.759 |
structurally_consistent (Q9H3F6)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| MTURN | BTBD9 | 0.632 | 0.084 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| USP25 | KCTD13 | 0.25 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes