hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_14734.1
Complex Portal: CPX-23845
Confidence: Medium  
ProteinsGenename | Protein Name | Uniprot Annotation Score | Links |
---|---|---|---|
ZNF597 | Zinc finger protein 597 | 5 | UniProt   NCBI |
SMC5 | Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5) | 5 | UniProt   NCBI |
EID3 | EP300-interacting inhibitor of differentiation 3 (EID-3) (E1A-like inhibitor of differentiation 3) (EID-1-like inhibitor of differentiation 3) (Non-structural maintenance of chromosomes element 4 homolog B) (NS4EB) (Non-SMC element 4 homolog B) | 5 | UniProt   NCBI |
NSMCE1 | Non-structural maintenance of chromosomes element 1 homolog (Non-SMC element 1 homolog) (EC 2.3.2.27) | 5 | UniProt   NCBI |
SMC6 | Structural maintenance of chromosomes protein 6 (SMC protein 6) (SMC-6) (hSMC6) | 5 | UniProt   NCBI |
ZNF200 | Zinc finger protein 200 | 3 | UniProt   NCBI |
NSMCE2 | E3 SUMO-protein ligase NSE2 (EC 2.3.2.-) (E3 SUMO-protein transferase NSE2) (MMS21 homolog) (hMMS21) (Non-structural maintenance of chromosomes element 2 homolog) (Non-SMC element 2 homolog) | 5 | UniProt   NCBI |
UBE2A | Ubiquitin-conjugating enzyme E2 A (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme A) (RAD6 homolog A) (HR6A) (hHR6A) (Ubiquitin carrier protein A) (Ubiquitin-protein ligase A) | 5 | UniProt   NCBI |
SLF2 | SMC5-SMC6 complex localization factor protein 2 (Smc5/6 localization factor 1) | 5 | UniProt   NCBI |
NSMCE3 | Non-structural maintenance of chromosomes element 3 homolog (Non-SMC element 3 homolog) (Hepatocellular carcinoma-associated protein 4) (MAGE-G1 antigen) (Melanoma-associated antigen G1) (Necdin-like protein 2) | 5 | UniProt   NCBI |
SLF1 | SMC5-SMC6 complex localization factor protein 1 (Ankyrin repeat domain-containing protein 32) (BRCT domain-containing protein 1) (Smc5/6 localization factor 1) | 5 | UniProt   NCBI |
UBE2B | Ubiquitin-conjugating enzyme E2 B (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme B) (RAD6 homolog B) (HR6B) (hHR6B) (Ubiquitin carrier protein B) (Ubiquitin-conjugating enzyme E2-17 kDa) (Ubiquitin-protein ligase B) | 5 | UniProt   NCBI |
ANKDD1A | Ankyrin repeat and death domain-containing protein 1A | 3 | UniProt   NCBI |
RAD18 | E3 ubiquitin-protein ligase RAD18 (EC 2.3.2.27) (Postreplication repair protein RAD18) (hHR18) (hRAD18) (RING finger protein 73) (RING-type E3 ubiquitin transferase RAD18) | 5 | UniProt   NCBI |
ESAM | Endothelial cell-selective adhesion molecule | 5 | UniProt   NCBI |
NSMCE4A | Non-structural maintenance of chromosomes element 4 homolog A (NS4EA) (Non-SMC element 4 homolog A) | 5 | UniProt   NCBI |
CD8A | T-cell surface glycoprotein CD8 alpha chain (T-lymphocyte differentiation antigen T8/Leu-2) (CD antigen CD8a) | 5 | UniProt   NCBI |
SIMC1 | SUMO-interacting motif-containing protein 1 (Platform element for inhibition of autolytic degradation) | 5 | UniProt   NCBI |
MPHOSPH8 | M-phase phosphoprotein 8 (Two hybrid-associated protein 3 with RanBPM) (Twa3) | 5 | UniProt   NCBI |
TASOR2 | Protein TASOR 2 | 5 | UniProt   NCBI |
Enrichments
Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
---|---|---|---|---|
  GO:0030915 | 1.00419833606e-22 | 0.45 | SMC6 NSMCE1 SMC5 SLF1 SLF2 NSMCE4A EID3 NSMCE2 NSMCE3 | Smc5-Smc6 complex |
  GO:0140588 | 1.00351768677e-21 | 0.45 | SMC6 NSMCE1 SMC5 SLF1 SLF2 NSMCE4A EID3 NSMCE2 NSMCE3 | chromatin looping |
  GO:0106068 | 7.16056970181e-20 | 0.45 | SMC6 NSMCE1 SMC5 SLF1 SLF2 NSMCE4A EID3 NSMCE2 NSMCE3 | SUMO ligase complex |
  WP:WP5407 | 6.33211987203e-14 | 0.4 | SMC6 NSMCE1 SMC5 SLF1 SLF2 EID3 NSMCE2 NSMCE3 | 15q11q13 copy number variation |
  GO:0016925 | 6.18878121676e-13 | 0.45 | SMC6 NSMCE1 SMC5 SLF1 SLF2 NSMCE4A EID3 NSMCE2 NSMCE3 | protein sumoylation |
  GO:0032204 | 1.79564106719e-10 | 0.45 | SMC6 NSMCE1 SMC5 SLF1 SLF2 NSMCE4A EID3 NSMCE2 NSMCE3 | regulation of telomere maintenance |
  GO:0018205 | 7.70627896787e-10 | 0.45 | SMC6 NSMCE1 SMC5 SLF1 SLF2 NSMCE4A EID3 NSMCE2 NSMCE3 | peptidyl-lysine modification |
  REAC:R-HSA-3108214 | 1.07932406176e-09 | 0.35 | SMC6 NSMCE1 SMC5 NSMCE4A NSMCE3 NSMCE2 EID3 | SUMOylation of DNA damage response and repair proteins |
  GO:0000723 | 4.88551907573e-09 | 0.45 | SMC6 NSMCE1 SMC5 SLF1 SLF2 NSMCE4A EID3 NSMCE2 NSMCE3 | telomere maintenance |
  GO:0000781 | 5.54849481035e-09 | 0.45 | SMC6 NSMCE1 SMC5 SLF1 SLF2 NSMCE4A EID3 NSMCE2 NSMCE3 | chromosome, telomeric region |
  GO:0033044 | 6.44330038334e-09 | 0.5 | SMC6 NSMCE1 SMC5 SLF1 MPHOSPH8 SLF2 NSMCE4A EID3 NSMCE2 NSMCE3 | regulation of chromosome organization |
  GO:0006281 | 7.53126533767e-09 | 0.6 | SMC6 NSMCE1 SLF2 SLF1 RAD18 SMC5 NSMCE4A EID3 UBE2B NSMCE2 UBE2A NSMCE3 | DNA repair |
  GO:0000724 | 1.21657062141e-08 | 0.45 | SMC6 NSMCE1 SMC5 SLF1 SLF2 NSMCE4A EID3 NSMCE2 NSMCE3 | double-strand break repair via homologous recombination |
  GO:0000725 | 1.52828498646e-08 | 0.45 | SMC6 NSMCE1 SMC5 SLF1 SLF2 NSMCE4A EID3 NSMCE2 NSMCE3 | recombinational repair |
  GO:0032200 | 2.78015485312e-08 | 0.45 | SMC6 NSMCE1 SMC5 SLF1 SLF2 NSMCE4A EID3 NSMCE2 NSMCE3 | telomere organization |
  GO:0006259 | 5.43589003362e-08 | 0.65 | SMC6 NSMCE1 SLF2 SLF1 MPHOSPH8 RAD18 SMC5 NSMCE4A EID3 UBE2B NSMCE2 UBE2A NSMCE3 | DNA metabolic process |
  GO:0032446 | 7.55591252179e-08 | 0.6 | SMC6 NSMCE1 SLF2 SLF1 RAD18 SMC5 NSMCE4A EID3 UBE2B NSMCE2 UBE2A NSMCE3 | protein modification by small protein conjugation |
  GO:0000793 | 1.23956532917e-07 | 0.45 | SMC6 NSMCE1 SMC5 SLF1 SLF2 NSMCE4A EID3 NSMCE2 NSMCE3 | condensed chromosome |
  GO:0006325 | 1.54109200441e-07 | 0.55 | SMC6 NSMCE1 SLF2 SLF1 MPHOSPH8 SMC5 NSMCE4A EID3 NSMCE2 UBE2A NSMCE3 | chromatin organization |
  GO:0070647 | 2.41782732234e-07 | 0.6 | SMC6 NSMCE1 SLF2 SLF1 RAD18 SMC5 NSMCE4A EID3 UBE2B NSMCE2 UBE2A NSMCE3 | protein modification by small protein conjugation or removal |
  REAC:R-HSA-3108232 | 3.23138118558e-07 | 0.35 | SMC6 NSMCE1 SMC5 NSMCE4A NSMCE3 NSMCE2 EID3 | SUMO E3 ligases SUMOylate target proteins |
  REAC:R-HSA-2990846 | 4.01992199418e-07 | 0.35 | SMC6 NSMCE1 SMC5 NSMCE4A NSMCE3 NSMCE2 EID3 | SUMOylation |
  GO:0043687 | 5.2246615053e-07 | 0.6 | SMC6 NSMCE1 SLF2 SLF1 RAD18 SMC5 NSMCE4A EID3 UBE2B NSMCE2 UBE2A NSMCE3 | post-translational protein modification |
  GO:0006310 | 6.9461798438e-07 | 0.45 | SMC6 NSMCE1 SMC5 SLF1 SLF2 NSMCE4A EID3 NSMCE2 NSMCE3 | DNA recombination |
  GO:0071824 | 7.56331143553e-07 | 0.55 | SMC6 NSMCE1 SLF2 SLF1 MPHOSPH8 SMC5 NSMCE4A EID3 NSMCE2 UBE2A NSMCE3 | protein-DNA complex organization |
  GO:0006974 | 7.91547223304e-07 | 0.6 | SMC6 NSMCE1 SLF2 SLF1 RAD18 SMC5 NSMCE4A EID3 UBE2B NSMCE2 UBE2A NSMCE3 | DNA damage response |
  GO:0006302 | 1.54309846203e-06 | 0.45 | SMC6 NSMCE1 SMC5 SLF1 SLF2 NSMCE4A EID3 NSMCE2 NSMCE3 | double-strand break repair |
  GO:0034184 | 1.90892139407e-06 | 0.2 | SLF2 SMC5 SLF1 NSMCE2 | positive regulation of maintenance of mitotic sister chromatid cohesion |
  GO:0034093 | 1.90892139407e-06 | 0.2 | SLF2 SMC5 SLF1 NSMCE2 | positive regulation of maintenance of sister chromatid cohesion |
  GO:1990234 | 1.993129792e-06 | 0.6 | SMC6 NSMCE1 SLF2 SLF1 RAD18 SMC5 NSMCE4A EID3 UBE2B NSMCE2 UBE2A NSMCE3 | transferase complex |
  GO:0051052 | 2.2460829595e-06 | 0.5 | SMC6 NSMCE1 SMC5 SLF1 MPHOSPH8 SLF2 NSMCE4A EID3 NSMCE2 NSMCE3 | regulation of DNA metabolic process |
  GO:0098687 | 6.83356346031e-06 | 0.45 | SMC6 NSMCE1 SMC5 SLF1 SLF2 NSMCE4A EID3 NSMCE2 NSMCE3 | chromosomal region |
  GO:0051276 | 1.41847631595e-05 | 0.5 | SMC6 NSMCE1 SMC5 SLF1 MPHOSPH8 SLF2 NSMCE4A EID3 NSMCE2 NSMCE3 | chromosome organization |
  GO:0034091 | 1.59928316967e-05 | 0.2 | SLF2 SMC5 SLF1 NSMCE2 | regulation of maintenance of sister chromatid cohesion |
  GO:0034182 | 1.59928316967e-05 | 0.2 | SLF2 SMC5 SLF1 NSMCE2 | regulation of maintenance of mitotic sister chromatid cohesion |
  GO:0045876 | 1.59928316967e-05 | 0.2 | SLF2 SMC5 SLF1 NSMCE2 | positive regulation of sister chromatid cohesion |
  GO:0034086 | 9.04353315882e-05 | 0.2 | SLF2 SMC5 SLF1 NSMCE2 | maintenance of sister chromatid cohesion |
  GO:0034088 | 9.04353315882e-05 | 0.2 | SLF2 SMC5 SLF1 NSMCE2 | maintenance of mitotic sister chromatid cohesion |
  GO:0005694 | 0.000107612751444 | 0.65 | SMC6 NSMCE1 SLF2 SLF1 MPHOSPH8 RAD18 SMC5 NSMCE4A EID3 UBE2B NSMCE2 UBE2A NSMCE3 | chromosome |
  GO:0033043 | 0.000223244473066 | 0.55 | SMC6 NSMCE1 SMC5 SLF1 MPHOSPH8 SLF2 NSMCE4A EID3 NSMCE2 ESAM NSMCE3 | regulation of organelle organization |
  GO:0007063 | 0.00029997578462 | 0.2 | SLF2 SMC5 SLF1 NSMCE2 | regulation of sister chromatid cohesion |
  REAC:R-HSA-597592 | 0.000456829711776 | 0.5 | SMC6 NSMCE1 RAD18 SMC5 NSMCE4A EID3 UBE2B NSMCE2 UBE2A NSMCE3 | Post-translational protein modification |
  GO:0033554 | 0.000685878619134 | 0.6 | SMC6 NSMCE1 SLF2 SLF1 RAD18 SMC5 NSMCE4A EID3 UBE2B NSMCE2 UBE2A NSMCE3 | cellular response to stress |
  GO:0018193 | 0.000932066458543 | 0.45 | SMC6 NSMCE1 SMC5 SLF1 SLF2 NSMCE4A EID3 NSMCE2 NSMCE3 | peptidyl-amino acid modification |
  GO:0016605 | 0.001717689012 | 0.25 | SLF2 SMC5 NSMCE2 SIMC1 SMC6 | PML body |
  GO:0007064 | 0.00219269733138 | 0.2 | SLF2 SMC5 SLF1 NSMCE2 | mitotic sister chromatid cohesion |
  GO:0035861 | 0.00242691357521 | 0.25 | SLF2 SMC5 SLF1 RAD18 SMC6 | site of double-strand break |
  GO:1902494 | 0.00462431159894 | 0.6 | SMC6 NSMCE1 SLF2 SLF1 RAD18 SMC5 NSMCE4A EID3 UBE2B NSMCE2 UBE2A NSMCE3 | catalytic complex |
  GO:0090068 | 0.0065497684166 | 0.3 | SMC6 SMC5 SLF1 SLF2 RAD18 NSMCE2 | positive regulation of cell cycle process |
  REAC:R-HSA-392499 | 0.00876215450567 | 0.5 | SMC6 NSMCE1 RAD18 SMC5 NSMCE4A EID3 UBE2B NSMCE2 UBE2A NSMCE3 | Metabolism of proteins |
  GO:0090734 | 0.0106999738176 | 0.25 | SLF2 SMC5 SLF1 RAD18 SMC6 | site of DNA damage |
  GO:0043933 | 0.0114947767387 | 0.6 | SMC6 NSMCE1 SLF2 SLF1 MPHOSPH8 ESAM SMC5 NSMCE4A EID3 NSMCE2 UBE2A NSMCE3 | protein-containing complex organization |
  GO:2001252 | 0.0123726406211 | 0.25 | SLF2 SMC5 SLF1 MPHOSPH8 NSMCE2 | positive regulation of chromosome organization |
  REAC:R-HSA-8866654 | 0.0161466146549 | 0.15 | UBE2B UBE2A RAD18 | E3 ubiquitin ligases ubiquitinate target proteins |
  GO:0000722 | 0.0179543561972 | 0.15 | SMC5 NSMCE2 SMC6 | telomere maintenance via recombination |
  GO:0007062 | 0.0200514185326 | 0.2 | SLF2 SMC5 SLF1 NSMCE2 | sister chromatid cohesion |
  GO:0045787 | 0.0316682718749 | 0.3 | SMC6 SMC5 SLF1 SLF2 RAD18 NSMCE2 | positive regulation of cell cycle |
  GO:0043412 | 0.0337266653833 | 0.65 | SMC6 NSMCE1 SLF2 SLF1 MPHOSPH8 RAD18 SMC5 NSMCE4A EID3 UBE2B NSMCE2 UBE2A NSMCE3 | macromolecule modification |
  GO:0031625 | 0.0365321654337 | 0.3 | SMC6 SLF1 SLF2 RAD18 UBE2B UBE2A | ubiquitin protein ligase binding |
  REAC:R-HSA-8852135 | 0.0414681934151 | 0.15 | UBE2B UBE2A RAD18 | Protein ubiquitination |
Edges
Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap |
---|---|---|---|---|
 SMC6 |  NSMCE3 | 1.0 | 0.896           |          |
 NSMCE1 |  SMC5 | 1.0 | 0.292           |          |
 SMC6 |  NSMCE1 | 1.0 | 0.34           |          |
 NSMCE3 |  NSMCE1 | 1.0 | 0.576           |          |
 SMC6 |  SMC5 | 1.0 | 0.854           |          |
 NSMCE3 |  SMC5 | 1.0 | 0.508           |          |
 NSMCE3 |  NSMCE4A | 1.0 | 0.648           |          |
 NSMCE3 |  NSMCE2 | 1.0 | 0.362           |          |
 NSMCE1 |  NSMCE2 | 1.0 | 0.522           |          |
 SLF2 |  SLF1 | 1.0 |            |          |
 RAD18 |  SLF1 | 1.0 |            |          |
 NSMCE4A |  NSMCE1 | 0.999 | 0.494           |          |
 ZNF597 |  TASOR2 | 0.999 |            |          |
 NSMCE3 |  EID3 | 0.999 |            |          |
 SMC5 |  NSMCE2 | 0.999 | 0.252           |          |
 CD8A |  SLF1 | 0.999 |            |          |
 RAD18 |  UBE2A | 0.999 | 0.108           |
structurally_consistent (dimer)        
|
 SMC6 |  NSMCE2 | 0.999 | 0.32           |          |
 ZNF597 |  SMC6 | 0.999 |            |          |
 ZNF597 |  NSMCE2 | 0.999 |            |          |
 TASOR2 |  MPHOSPH8 | 0.999 | 0.086           |          |
 ZNF597 |  SMC5 | 0.999 |            |          |
 SMC6 |  NSMCE4A | 0.999 | 0.404           |          |
 ZNF597 |  MPHOSPH8 | 0.999 |            |          |
 ZNF597 |  NSMCE3 | 0.998 |            |          |
 SLF2 |  RAD18 | 0.998 |            |          |
 TASOR2 |  ZNF200 | 0.998 |            |          |
 ZNF597 |  NSMCE1 | 0.997 |            |          |
 ZNF597 |  NSMCE4A | 0.997 |            |          |
 SLF2 |  NSMCE3 | 0.997 |            |          |
 ZNF597 |  ANKDD1A | 0.995 |            |          |
 NSMCE4A |  SMC5 | 0.994 | 0.47           |          |
 NSMCE1 |  EID3 | 0.993 |            |          |
 NSMCE4A |  NSMCE2 | 0.992 | 0.402           |          |
 SLF2 |  SMC6 | 0.991 |            |          |
 SMC6 |  EID3 | 0.99 |            |          |
 SLF2 |  NSMCE4A | 0.988 |            |          |
 SIMC1 |  NSMCE1 | 0.987 | 0.144           |          |
 SIMC1 |  NSMCE3 | 0.983 | 0.1           |          |
 SMC5 |  EID3 | 0.983 |            |          |
 SLF2 |  NSMCE1 | 0.98 |            |          |
 SLF2 |  UBE2A | 0.979 |            |          |
 SLF2 |  SMC5 | 0.979 |            |          |
 SIMC1 |  SLF2 | 0.972 |            |          |
 UBE2B |  UBE2A | 0.97 | 0.16           |
mutually_exclusive (Q9NS91)        
structurally_consistent (dimer)         |
 RAD18 |  UBE2B | 0.965 | 0.102           |
mutually_exclusive (P49459)        
structurally_consistent (dimer)         |
 SLF2 |  NSMCE2 | 0.958 |            |          |
 RAD18 |  SMC6 | 0.95 | 0.326           |          |
 MPHOSPH8 |  NSMCE4A | 0.941 | 0.184           |          |
 EID3 |  NSMCE2 | 0.938 |            |          |
 SIMC1 |  NSMCE2 | 0.937 | 0.19           |          |
 MPHOSPH8 |  NSMCE2 | 0.932 | 0.116           |          |
 MPHOSPH8 |  NSMCE3 | 0.932 | 0.106           |          |
 MPHOSPH8 |  SMC6 | 0.932 | 0.068           |          |
 MPHOSPH8 |  SMC5 | 0.932 | 0.064           |          |
 SLF2 |  CD8A | 0.931 |            |          |
 MPHOSPH8 |  ESAM | 0.924 | 0.054           |          |
 SLF1 |  NSMCE4A | 0.922 |            |          |
 TASOR2 |  NSMCE3 | 0.908 | 0.064           |          |
 SIMC1 |  SMC5 | 0.904 | 0.15           |          |
 TASOR2 |  SMC5 | 0.901 | 0.094           |          |
 TASOR2 |  NSMCE2 | 0.894 | 0.08           |          |
 SIMC1 |  SMC6 | 0.893 | 0.098           |          |
 ANKDD1A |  MPHOSPH8 | 0.892 |            |          |
 TASOR2 |  SMC6 | 0.885 | 0.078           |          |
 SLF1 |  SMC6 | 0.884 |            |          |
 MPHOSPH8 |  NSMCE1 | 0.878 | 0.188           |          |
 TASOR2 |  NSMCE1 | 0.827 | 0.166           |          |
 TASOR2 |  NSMCE4A | 0.827 | 0.15           |          |
 RAD18 |  NSMCE1 | 0.812 | 0.232           |          |
 RAD18 |  NSMCE3 | 0.805 | 0.13           |          |
 RAD18 |  NSMCE4A | 0.782 | 0.102           |          |
 ANKDD1A |  NSMCE2 | 0.768 |            |          |
 RAD18 |  CD8A | 0.72 |            |          |
 SIMC1 |  NSMCE4A | 0.712 | 0.126           |          |
 UBE2A |  NSMCE3 | 0.708 | 0.058           |          |
 UBE2A |  SMC6 | 0.639 | 0.118           |          |
 SLF1 |  SMC5 | 0.579 |            |          |
 ANKDD1A |  SMC6 | 0.478 |            |          |
 ANKDD1A |  SMC5 | 0.478 |            |          |
 SLF1 |  NSMCE3 | 0.423 |            |          |
 SLF1 |  NSMCE1 | 0.423 |            |          |
 ANKDD1A |  NSMCE1 | 0.418 |            |          |
 ZNF597 |  ZNF200 | 0.415 |            |          |
 ANKDD1A |  NSMCE3 | 0.401 |            |          |
 ANKDD1A |  NSMCE4A | 0.388 |            |          |
 ANKDD1A |  TASOR2 | 0.388 |            |          |
 RAD18 |  SMC5 | 0.293 | 0.324           |          |
 ZNF200 |  MPHOSPH8 | 0.278 |            |          |
 UBE2A |  SLF1 | 0.192 |            |          |
 RAD18 |  NSMCE2 | 0.112 | 0.276           |          |
 UBE2A |  NSMCE4A | 0.095 | 0.076           |          |
 UBE2A |  NSMCE1 | 0.079 | 0.116           |          |
 UBE2A |  SMC5 | 0.067 | 0.066           |          |
 UBE2A |  NSMCE2 | 0.067 | 0.18           |          |
 SIMC1 |  UBE2A | 0.063 | 0.164           |          |
 SLF1 |  NSMCE2 | 0.048 |            |          |
 SIMC1 |  RAD18 | 0.028 | 0.164           |          |
 CD8A |  NSMCE4A | 0.027 |            |          |
 SLF2 |  TASOR2 | 0.022 |            |          |
 SLF1 |  TASOR2 | 0.015 |            |          |
 RAD18 |  TASOR2 | 0.012 | 0.152           |          |
Related Complexes