hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_14743.1
Complex Portal: CPX-14896
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TRIT1 | tRNA dimethylallyltransferase (EC 2.5.1.75) (Isopentenyl-diphosphate:tRNA isopentenyltransferase) (IPP transferase) (IPPT) (hGRO1) (tRNA isopentenyltransferase 1) (IPTase) | 5 | UniProt NCBI |
| TBL1Y | F-box-like/WD repeat-containing protein TBL1Y (Transducin beta-like protein 1Y) (Transducin-beta-like protein 1, Y-linked) | 5 | UniProt NCBI |
| MT-ND3 | NADH-ubiquinone oxidoreductase chain 3 (EC 7.1.1.2) (NADH dehydrogenase subunit 3) | 5 | UniProt NCBI |
| TRMT5 | tRNA (guanine(37)-N1)-methyltransferase (EC 2.1.1.228) (M1G-methyltransferase) (tRNA [GM37] methyltransferase) (tRNA methyltransferase 5 homolog) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0011923 | 0.000517504387705 | 0.75 | TRIT1 MT-ND3 TRMT5 | Decreased activity of mitochondrial complex I |
| HP:0008972 | 0.00155250227532 | 0.75 | TRIT1 MT-ND3 TRMT5 | Decreased activity of mitochondrial respiratory chain |
| HP:0011922 | 0.00170351843773 | 0.75 | TRIT1 MT-ND3 TRMT5 | Abnormal activity of mitochondrial respiratory chain |
| HP:0003287 | 0.00398314090359 | 0.75 | TRIT1 MT-ND3 TRMT5 | Abnormality of mitochondrial metabolism |
| HP:0012103 | 0.0058618765749 | 0.75 | TRIT1 MT-ND3 TRMT5 | Abnormality of the mitochondrion |
| REAC:R-HSA-6782315 | 0.0068064250699 | 0.5 | TRIT1 TRMT5 | tRNA modification in the nucleus and cytosol |
| REAC:R-HSA-72306 | 0.0492961191682 | 0.5 | TRIT1 TRMT5 | tRNA processing |
| HP:0008347 | 0.049422876951 | 0.5 | TRIT1 TRMT5 | Decreased activity of mitochondrial complex IV |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TRIT1 | TBL1Y | 0.902 | bioplex3_WMM WMM_only | ||
| MT-ND3 | TRIT1 | 0.902 | 0.148 | bioplex3_WMM WMM_only | |
| MT-ND3 | TBL1Y | 0.902 | bioplex3_WMM WMM_only | ||
| TRMT5 | TRIT1 | 0.801 | 0.1 | bioplex3_WMM youn_WMM WMM_only |
Related Complexes