hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_14744.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| KSR1 | Kinase suppressor of Ras 1 (EC 2.7.11.1) | 5 | UniProt NCBI |
| MAP2K1 | Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1) | 5 | UniProt NCBI |
| KSR2 | Kinase suppressor of Ras 2 (hKSR2) (EC 2.7.11.1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-6802948 | 1.89440469306e-06 | 1.0 | MAP2K1 KSR1 KSR2 | Signaling by high-kinase activity BRAF mutants |
| REAC:R-HSA-5674135 | 2.79214721263e-06 | 1.0 | MAP2K1 KSR1 KSR2 | MAP2K and MAPK activation |
| REAC:R-HSA-9656223 | 3.05391101381e-06 | 1.0 | MAP2K1 KSR1 KSR2 | Signaling by RAF1 mutants |
| CORUM:5921 | 3.41752350426e-06 | 0.666666666667 | MAP2K1 KSR1 | KSR1-BRAF-MEK complex |
| REAC:R-HSA-6802949 | 3.93625566272e-06 | 1.0 | MAP2K1 KSR1 KSR2 | Signaling by RAS mutants |
| REAC:R-HSA-9649948 | 3.93625566272e-06 | 1.0 | MAP2K1 KSR1 KSR2 | Signaling downstream of RAS mutants |
| REAC:R-HSA-6802955 | 3.93625566272e-06 | 1.0 | MAP2K1 KSR1 KSR2 | Paradoxical activation of RAF signaling by kinase inactive BRAF |
| REAC:R-HSA-6802946 | 3.93625566272e-06 | 1.0 | MAP2K1 KSR1 KSR2 | Signaling by moderate kinase activity BRAF mutants |
| CORUM:5920 | 1.02521027753e-05 | 0.666666666667 | MAP2K1 KSR1 | KSR1-RAF1-MEK complex |
| REAC:R-HSA-6802952 | 1.29342113526e-05 | 1.0 | MAP2K1 KSR1 KSR2 | Signaling by BRAF and RAF1 fusions |
| CORUM:5877 | 2.05032700758e-05 | 0.666666666667 | MAP2K1 KSR1 | MAP2K1-BRAF-RAF1-YWHAE-KSR1 complex |
| REAC:R-HSA-6802957 | 2.66686453773e-05 | 1.0 | MAP2K1 KSR1 KSR2 | Oncogenic MAPK signaling |
| WP:WP4223 | 4.02049202459e-05 | 1.0 | MAP2K1 KSR1 KSR2 | Ras signaling |
| KEGG:04014 | 5.33562348015e-05 | 1.0 | MAP2K1 KSR1 KSR2 | Ras signaling pathway |
| WP:WP4928 | 0.000103023242897 | 0.666666666667 | MAP2K1 KSR1 | MAPK pathway in congenital thyroid cancer |
| REAC:R-HSA-5673001 | 0.000740957667713 | 1.0 | MAP2K1 KSR1 KSR2 | RAF/MAP kinase cascade |
| REAC:R-HSA-5684996 | 0.000783695624229 | 1.0 | MAP2K1 KSR1 KSR2 | MAPK1/MAPK3 signaling |
| REAC:R-HSA-5683057 | 0.00118616050146 | 1.0 | MAP2K1 KSR1 KSR2 | MAPK family signaling cascades |
| REAC:R-HSA-5673000 | 0.00296224002415 | 0.666666666667 | MAP2K1 KSR1 | RAF activation |
| WP:WP231 | 0.0039339723602 | 0.666666666667 | KSR2 KSR1 | TNF alpha signaling pathway |
| REAC:R-HSA-5663202 | 0.00393910426879 | 1.0 | MAP2K1 KSR1 KSR2 | Diseases of signal transduction by growth factor receptors and second messengers |
| REAC:R-HSA-5675221 | 0.00478550282195 | 0.666666666667 | MAP2K1 KSR1 | Negative regulation of MAPK pathway |
| WP:WP2380 | 0.00845205977617 | 0.666666666667 | MAP2K1 KSR1 | Brain derived neurotrophic factor BDNF signaling pathway |
| CORUM:5918 | 0.0249718442456 | 0.333333333333 | KSR1 | KSR1 homo-oligomer complex |
| CORUM:5872 | 0.0499402709677 | 0.333333333333 | MAP2K1 | BRAF-MAP2K1-MAP2K2-YWHAE complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MAP2K1 | KSR2 | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MAP2K1 | KSR1 | 0.801 | 0.108 | hein_WMM hein () |
Related Complexes
| Genename | Complexes |
|---|---|
| KSR1 | huMAP3_03322.1 huMAP3_04917.1 huMAP3_07588.1 huMAP3_14744.1 huMAP3_15194.1 |
| MAP2K1 | huMAP3_00685.1 huMAP3_14744.1 |
| KSR2 | huMAP3_00685.1 huMAP3_14744.1 |