hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_14749.1

Complex Portal: CPX-15294

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
BABAM1	BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex)	5	UniProt NCBI
ABRAXAS1	BRCA1-A complex subunit Abraxas 1 (Coiled-coil domain-containing protein 98) (Protein FAM175A)	5	UniProt NCBI
SHMT2	Serine hydroxymethyltransferase, mitochondrial (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase)	5	UniProt NCBI
PAGE4	P antigen family member 4 (PAGE-4) (G antigen family C member 1) (PAGE-1)	5	UniProt NCBI
C9orf85	Uncharacterized protein C9orf85	2	UniProt NCBI
TNKS	Poly [ADP-ribose] polymerase tankyrase-1 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (Poly [ADP-ribose] polymerase 5A) (Protein poly-ADP-ribosyltransferase tankyrase-1) (EC 2.4.2.-) (TNKS-1) (TRF1-interacting ankyrin-related ADP-ribose polymerase) (Tankyrase I) (Tankyrase-1) (TANK1)	5	UniProt NCBI
GMDS	GDP-mannose 4,6 dehydratase (EC 4.2.1.47) (GDP-D-mannose dehydratase) (GMD)	5	UniProt NCBI
BRCC3	Lys-63-specific deubiquitinase BRCC36 (EC 3.4.19.-) (BRCA1-A complex subunit BRCC36) (BRCA1/BRCA2-containing complex subunit 3) (BRCA1/BRCA2-containing complex subunit 36) (BRISC complex subunit BRCC36)	5	UniProt NCBI
BABAM2	BRISC and BRCA1-A complex member 2 (BRCA1-A complex subunit BRE) (BRCA1/BRCA2-containing complex subunit 45) (Brain and reproductive organ-expressed protein)	5	UniProt NCBI
ABRAXAS2	BRISC complex subunit Abraxas 2 (Abraxas brother protein 1) (Protein FAM175B)	5	UniProt NCBI
TNKS2	Poly [ADP-ribose] polymerase tankyrase-2 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 6) (ARTD6) (Poly [ADP-ribose] polymerase 5B) (Protein poly-ADP-ribosyltransferase tankyrase-2) (EC 2.4.2.-) (TNKS-2) (TRF1-interacting ankyrin-related ADP-ribose polymerase 2) (Tankyrase II) (Tankyrase-2) (TANK2) (Tankyrase-like protein) (Tankyrase-related protein)	5	UniProt NCBI
UIMC1	BRCA1-A complex subunit RAP80 (Receptor-associated protein 80) (Retinoid X receptor-interacting protein 110) (Ubiquitin interaction motif-containing protein 1)	5	UniProt NCBI
FCHSD2	F-BAR and double SH3 domains protein 2 (Carom) (Protein nervous wreck 1) (NWK1) (SH3 multiple domains protein 3)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-5689901	1.29460207433e-11	0.461538461538	BRCC3 BABAM2 UIMC1 BABAM1 ABRAXAS1 ABRAXAS2	Metalloprotease DUBs
GO:0070552	6.95001783241e-11	0.384615384615	SHMT2 BABAM2 ABRAXAS2 BABAM1 BRCC3	BRISC complex
GO:0070531	6.48076439894e-10	0.384615384615	UIMC1 ABRAXAS1 BABAM2 BABAM1 BRCC3	BRCA1-A complex
REAC:R-HSA-5688426	2.07360370435e-09	0.615384615385	BABAM2 UIMC1 TNKS ABRAXAS2 ABRAXAS1 BRCC3 TNKS2 BABAM1	Deubiquitination
KEGG:03440	8.58637063478e-09	0.384615384615	UIMC1 ABRAXAS1 BABAM2 BABAM1 BRCC3	Homologous recombination
REAC:R-HSA-5693571	3.67216661465e-07	0.384615384615	UIMC1 ABRAXAS1 BABAM2 BABAM1 BRCC3	Nonhomologous End-Joining (NHEJ)
REAC:R-HSA-5693565	7.99996289757e-07	0.384615384615	UIMC1 ABRAXAS1 BABAM2 BABAM1 BRCC3	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
REAC:R-HSA-5693606	8.59304035409e-07	0.384615384615	UIMC1 ABRAXAS1 BABAM2 BABAM1 BRCC3	DNA Double Strand Break Response
WP:WP5380	1.58754653326e-06	0.384615384615	UIMC1 ABRAXAS1 BABAM2 BABAM1 BRCC3	5q35 copy number variation
GO:0007095	1.63270560884e-06	0.384615384615	UIMC1 ABRAXAS1 BABAM2 BABAM1 BRCC3	mitotic G2 DNA damage checkpoint signaling
REAC:R-HSA-69473	2.25377550048e-06	0.384615384615	UIMC1 ABRAXAS1 BABAM2 BABAM1 BRCC3	G2/M DNA damage checkpoint
REAC:R-HSA-5693607	2.67702624726e-06	0.384615384615	UIMC1 ABRAXAS1 BABAM2 BABAM1 BRCC3	Processing of DNA double-strand break ends
REAC:R-HSA-5693567	1.2963637311e-05	0.384615384615	UIMC1 ABRAXAS1 BABAM2 BABAM1 BRCC3	HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
GO:0044818	1.5590429161e-05	0.384615384615	UIMC1 ABRAXAS1 BABAM2 BABAM1 BRCC3	mitotic G2/M transition checkpoint
REAC:R-HSA-5693538	1.64678328875e-05	0.384615384615	UIMC1 ABRAXAS1 BABAM2 BABAM1 BRCC3	Homology Directed Repair
GO:0051054	2.26122911134e-05	0.538461538462	BABAM2 UIMC1 BABAM1 ABRAXAS1 BRCC3 TNKS2 TNKS	positive regulation of DNA metabolic process
REAC:R-HSA-597592	2.98907719811e-05	0.692307692308	BABAM2 UIMC1 BRCC3 ABRAXAS1 GMDS ABRAXAS2 BABAM1 TNKS2 TNKS	Post-translational protein modification
GO:0031593	3.583781251e-05	0.384615384615	ABRAXAS1 UIMC1 ABRAXAS2 BRCC3 BABAM2	polyubiquitin modification-dependent protein binding
GO:0010972	3.94035651018e-05	0.384615384615	UIMC1 ABRAXAS1 BABAM2 BABAM1 BRCC3	negative regulation of G2/M transition of mitotic cell cycle
CORUM:7114	4.10333215354e-05	0.153846153846	SHMT2 ABRAXAS2	ABRAXAS2-SHMT2 complex
REAC:R-HSA-5693532	4.54466258455e-05	0.384615384615	UIMC1 ABRAXAS1 BABAM2 BABAM1 BRCC3	DNA Double-Strand Break Repair
REAC:R-HSA-69481	4.69006047638e-05	0.384615384615	UIMC1 ABRAXAS1 BABAM2 BABAM1 BRCC3	G2/M Checkpoints
GO:1902750	4.73835429563e-05	0.384615384615	UIMC1 ABRAXAS1 BABAM2 BABAM1 BRCC3	negative regulation of cell cycle G2/M phase transition
CORUM:1219	0.00012303818858	0.153846153846	TNKS TNKS2	Tankyrin 1-tankyrin 2-TRF1 complex
GO:0044773	0.000136151821387	0.384615384615	UIMC1 ABRAXAS1 BABAM2 BABAM1 BRCC3	mitotic DNA damage checkpoint signaling
GO:0070536	0.000165040423252	0.307692307692	SHMT2 ABRAXAS2 BRCC3 BABAM2	protein K63-linked deubiquitination
GO:0044774	0.000180882628253	0.384615384615	UIMC1 ABRAXAS1 BABAM2 BABAM1 BRCC3	mitotic DNA integrity checkpoint signaling
REAC:R-HSA-5545619	0.000199560962658	0.153846153846	TNKS TNKS2	XAV939 stabilizes AXIN
CORUM:2786	0.000245952888523	0.153846153846	ABRAXAS1 UIMC1	BRCA1 A complex
GO:0010389	0.000286779915289	0.384615384615	UIMC1 ABRAXAS1 BABAM2 BABAM1 BRCC3	regulation of G2/M transition of mitotic cell cycle
GO:0010212	0.000366472005037	0.384615384615	UIMC1 ABRAXAS1 BABAM2 BABAM1 BRCC3	response to ionizing radiation
CORUM:5400	0.00040971577212	0.153846153846	BRCC3 BABAM2	BRCC complex
GO:1902749	0.000489895803248	0.384615384615	UIMC1 ABRAXAS1 BABAM2 BABAM1 BRCC3	regulation of cell cycle G2/M phase transition
REAC:R-HSA-392499	0.000501379658429	0.692307692308	BABAM2 UIMC1 BRCC3 ABRAXAS1 GMDS ABRAXAS2 BABAM1 TNKS2 TNKS	Metabolism of proteins
REAC:R-HSA-69620	0.000758787221553	0.384615384615	UIMC1 ABRAXAS1 BABAM2 BABAM1 BRCC3	Cell Cycle Checkpoints
GO:0051052	0.00106551008877	0.538461538462	BABAM2 UIMC1 BABAM1 ABRAXAS1 BRCC3 TNKS2 TNKS	regulation of DNA metabolic process
GO:0000077	0.00112137749506	0.384615384615	UIMC1 ABRAXAS1 BABAM2 BABAM1 BRCC3	DNA damage checkpoint signaling
REAC:R-HSA-73894	0.00119308541356	0.384615384615	UIMC1 ABRAXAS1 BABAM2 BABAM1 BRCC3	DNA Repair
GO:0000086	0.00129097462355	0.384615384615	UIMC1 ABRAXAS1 BABAM2 BABAM1 BRCC3	G2/M transition of mitotic cell cycle
GO:0010948	0.00133190143794	0.461538461538	BABAM2 UIMC1 BABAM1 ABRAXAS1 BRCC3 TNKS	negative regulation of cell cycle process
GO:0031570	0.00169128014251	0.384615384615	UIMC1 ABRAXAS1 BABAM2 BABAM1 BRCC3	DNA integrity checkpoint signaling
GO:0044839	0.00200894089825	0.384615384615	UIMC1 ABRAXAS1 BABAM2 BABAM1 BRCC3	cell cycle G2/M phase transition
GO:0045739	0.00209532461544	0.384615384615	UIMC1 ABRAXAS1 BABAM2 BABAM1 BRCC3	positive regulation of DNA repair
GO:0007093	0.00247088992352	0.384615384615	UIMC1 ABRAXAS1 BABAM2 BABAM1 BRCC3	mitotic cell cycle checkpoint signaling
WP:WP4016	0.00452312379864	0.230769230769	ABRAXAS1 BRCC3 UIMC1	DNA IR damage and cellular response via ATR
GO:1901991	0.00523053993714	0.384615384615	UIMC1 ABRAXAS1 BABAM2 BABAM1 BRCC3	negative regulation of mitotic cell cycle phase transition
GO:0045786	0.00562688830749	0.461538461538	BABAM2 UIMC1 BABAM1 ABRAXAS1 BRCC3 TNKS	negative regulation of cell cycle
GO:0042770	0.00708282257091	0.384615384615	UIMC1 ABRAXAS1 BABAM2 BABAM1 BRCC3	signal transduction in response to DNA damage
GO:0140030	0.00805724695291	0.384615384615	ABRAXAS1 UIMC1 ABRAXAS2 BRCC3 BABAM2	modification-dependent protein binding
GO:0000075	0.0100164432278	0.384615384615	UIMC1 ABRAXAS1 BABAM2 BABAM1 BRCC3	cell cycle checkpoint signaling
GO:1903047	0.0128330677559	0.538461538462	BABAM2 UIMC1 TNKS ABRAXAS2 ABRAXAS1 BRCC3 BABAM1	mitotic cell cycle process
WP:WP3645	0.0129505034666	0.153846153846	TNKS TNKS2	NAD biosynthetic pathways
GO:0045930	0.016823696856	0.384615384615	UIMC1 ABRAXAS1 BABAM2 BABAM1 BRCC3	negative regulation of mitotic cell cycle
GO:0016579	0.0187164254851	0.307692307692	SHMT2 ABRAXAS2 BRCC3 BABAM2	protein deubiquitination
GO:0006282	0.0243096394976	0.384615384615	UIMC1 ABRAXAS1 BABAM2 BABAM1 BRCC3	regulation of DNA repair
GO:0140861	0.0264201745208	0.230769230769	UIMC1 BABAM1 BRCC3	DNA repair-dependent chromatin remodeling
GO:0080135	0.0278294642952	0.461538461538	BABAM2 UIMC1 BABAM1 PAGE4 ABRAXAS1 BRCC3	regulation of cellular response to stress
GO:1901988	0.0289303876449	0.384615384615	UIMC1 ABRAXAS1 BABAM2 BABAM1 BRCC3	negative regulation of cell cycle phase transition
GO:0070646	0.0420891142594	0.307692307692	SHMT2 ABRAXAS2 BRCC3 BABAM2	protein modification by small protein removal
REAC:R-HSA-1640170	0.0437584916562	0.384615384615	UIMC1 ABRAXAS1 BABAM2 BABAM1 BRCC3	Cell Cycle
GO:0000278	0.046537776738	0.538461538462	BABAM2 UIMC1 TNKS ABRAXAS2 ABRAXAS1 BRCC3 BABAM1	mitotic cell cycle
GO:0140513	0.0478748528772	0.615384615385	BABAM2 UIMC1 BABAM1 SHMT2 ABRAXAS1 ABRAXAS2 BRCC3 TNKS	nuclear protein-containing complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
BABAM1	BABAM2	1.0	0.45	structurally_consistent (dimer)
BABAM1	ABRAXAS2	1.0	0.334
BABAM1	BRCC3	1.0	0.316
BABAM1	SHMT2	1.0	0.044
BRCC3	ABRAXAS2	1.0	0.372
SHMT2	BRCC3	0.999	0.122482269504
TNKS	TNKS2	0.999
BABAM1	UIMC1	0.999	0.118
BRCC3	BABAM2	0.998	0.802
GMDS	TNKS2	0.998
BABAM1	ABRAXAS1	0.998	0.304	structurally_consistent (Q9NXR7)
GMDS	TNKS	0.998	0.052
TNKS2	BABAM1	0.998
SHMT2	ABRAXAS2	0.996	0.096	structurally_consistent (dimer)
BABAM2	ABRAXAS2	0.99	0.282	structurally_consistent (dimer)
C9orf85	ABRAXAS2	0.989	0.194	structurally_consistent (Q9NXR7)
SHMT2	BABAM2	0.985	0.136	structurally_consistent (Q15018) structurally_consistent (dimer)
ABRAXAS1	BRCC3	0.981	0.32
C9orf85	BABAM1	0.981	0.08	mutually_exclusive (Q9NXR7)
TNKS	BABAM1	0.975	0.124
TNKS2	BRCC3	0.967
PAGE4	TNKS2	0.966
BABAM2	UIMC1	0.965	0.154
TNKS	ABRAXAS2	0.965	0.254
C9orf85	BABAM2	0.959	0.116	structurally_consistent (dimer)
TNKS2	UIMC1	0.946
BRCC3	UIMC1	0.944	0.104
PAGE4	TNKS	0.942
TNKS2	ABRAXAS1	0.933
ABRAXAS1	SHMT2	0.929	0.16	structurally_consistent (Q9NXR7)
ABRAXAS1	UIMC1	0.916	0.228
TNKS2	BABAM2	0.883
ABRAXAS1	BABAM2	0.867	0.17	structurally_consistent (dimer)
TNKS2	ABRAXAS2	0.854
FCHSD2	BABAM2	0.846	0.046
FCHSD2	ABRAXAS2	0.846	0.038
FCHSD2	BRCC3	0.846	0.038
TNKS	UIMC1	0.825	0.07
SHMT2	UIMC1	0.824	0.078
TNKS	BABAM2	0.812	0.184
TNKS	ABRAXAS1	0.719	0.146
ABRAXAS2	UIMC1	0.714	0.058
TNKS2	SHMT2	0.554
GMDS	ABRAXAS2	0.49	0.044
ABRAXAS1	ABRAXAS2	0.4	0.096
TNKS	BRCC3	0.394	0.168
C9orf85	BRCC3	0.39	0.114
GMDS	BABAM2	0.321	0.03
TNKS	SHMT2	0.192	0.312
GMDS	BRCC3	0.057	0.046
GMDS	BABAM1	0.049	0.014
PAGE4	SHMT2	0.021
C9orf85	SHMT2	0.019	0.116	structurally_consistent (Q9NXR7)
FCHSD2	BABAM1	0.011	0.068
GMDS	UIMC1	0.006	0.052
GMDS	SHMT2	0.003	0.0854285714286

Related Complexes

Genename	Complexes
BABAM1	huMAP3_01447.1 huMAP3_02592.1 huMAP3_08508.1 huMAP3_10482.1 huMAP3_14749.1
ABRAXAS1	huMAP3_01447.1 huMAP3_02592.1 huMAP3_08508.1 huMAP3_10482.1 huMAP3_14749.1
SHMT2	huMAP3_01447.1 huMAP3_02592.1 huMAP3_08187.1 huMAP3_10482.1 huMAP3_14749.1
PAGE4	huMAP3_00704.1 huMAP3_09341.1 huMAP3_11038.1 huMAP3_14749.1
C9orf85	huMAP3_00889.1 huMAP3_01447.1 huMAP3_02592.1 huMAP3_07950.1 huMAP3_08508.1 huMAP3_10482.1 huMAP3_14749.1
TNKS	huMAP3_00704.1 huMAP3_09341.1 huMAP3_10123.1 huMAP3_11038.1 huMAP3_14749.1
GMDS	huMAP3_00704.1 huMAP3_01263.1 huMAP3_09173.1 huMAP3_10123.1 huMAP3_11038.1 huMAP3_14262.1 huMAP3_14749.1
BRCC3	huMAP3_01447.1 huMAP3_02592.1 huMAP3_08508.1 huMAP3_10482.1 huMAP3_14749.1 huMAP3_14839.1
BABAM2	huMAP3_01447.1 huMAP3_02592.1 huMAP3_08508.1 huMAP3_10482.1 huMAP3_14749.1
ABRAXAS2	huMAP3_01447.1 huMAP3_02592.1 huMAP3_08508.1 huMAP3_10482.1 huMAP3_14749.1
TNKS2	huMAP3_00704.1 huMAP3_01263.1 huMAP3_09341.1 huMAP3_10123.1 huMAP3_11038.1 huMAP3_14749.1
UIMC1	huMAP3_01447.1 huMAP3_03354.1 huMAP3_11912.1 huMAP3_14749.1
FCHSD2	huMAP3_00055.1 huMAP3_07087.1 huMAP3_07985.1 huMAP3_09325.1 huMAP3_10452.1 huMAP3_12750.1 huMAP3_12891.1 huMAP3_13078.1 huMAP3_13386.1 huMAP3_14749.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_14749.1

Complex Portal: CPX-15294