hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_14765.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PDE4D | 3',5'-cyclic-AMP phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43) (cAMP-specific phosphodiesterase 4D) | 5 | UniProt NCBI |
| ITPKB | Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B) | 5 | UniProt NCBI |
| PDE4B | 3',5'-cyclic-AMP phosphodiesterase 4B (EC 3.1.4.53) (DPDE4) (PDE32) (cAMP-specific phosphodiesterase 4B) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5294 | 0.000193548942551 | 0.666666666667 | PDE4D PDE4B | Sildenafil treatment |
| WP:WP4222 | 0.00079501095268 | 0.666666666667 | PDE4D PDE4B | Phosphodiesterases in neuronal function |
| GO:1901898 | 0.00140460216025 | 0.666666666667 | PDE4D PDE4B | negative regulation of relaxation of cardiac muscle |
| KEGG:05032 | 0.00173372250929 | 0.666666666667 | PDE4D PDE4B | Morphine addiction |
| KEGG:04928 | 0.00258815105453 | 0.666666666667 | PDE4D PDE4B | Parathyroid hormone synthesis, secretion and action |
| WP:WP35 | 0.00338983502479 | 0.666666666667 | PDE4D PDE4B | G protein signaling pathways |
| KEGG:00230 | 0.00361241039138 | 0.666666666667 | PDE4D PDE4B | Purine metabolism |
| KEGG:04024 | 0.00940070336911 | 0.666666666667 | PDE4D PDE4B | cAMP signaling pathway |
| WP:WP289 | 0.00958854810456 | 0.666666666667 | PDE4D PDE4B | Myometrial relaxation and contraction pathways |
| GO:1901078 | 0.0140440992017 | 0.666666666667 | PDE4D PDE4B | negative regulation of relaxation of muscle |
| GO:1901897 | 0.0140440992017 | 0.666666666667 | PDE4D PDE4B | regulation of relaxation of cardiac muscle |
| KEGG:01100 | 0.0189521995452 | 1.0 | ITPKB PDE4D PDE4B | Metabolic pathways |
| GO:0071871 | 0.0393180950424 | 0.666666666667 | PDE4D PDE4B | response to epinephrine |
| GO:0071872 | 0.0393180950424 | 0.666666666667 | PDE4D PDE4B | cellular response to epinephrine stimulus |
| CORUM:518 | 0.0499402709677 | 0.333333333333 | PDE4D | AKAP250-PKA-PDE4D complex |
| CORUM:6046 | 0.0499402709677 | 0.333333333333 | PDE4B | PDE4B-DISC1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PDE4D | PDE4B | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PDE4D | ITPKB | 0.894 | hein_WMM hein () |
Related Complexes