hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14772.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PFN3 | Profilin-3 (Profilin III) | 3 | UniProt NCBI |
| POTEI | POTE ankyrin domain family member I | 4 | UniProt NCBI |
| NDUFA4L2 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 (NADH-ubiquinone oxidoreductase MLRQ subunit homolog) (NUOMS) | 2 | UniProt NCBI |
| LRRC20 | Leucine-rich repeat-containing protein 20 | 2 | UniProt NCBI |
| ABRA | Actin-binding Rho-activating protein (Striated muscle activator of Rho-dependent signaling) (STARS) | 3 | UniProt NCBI |
| ACTC1 | Actin, alpha cardiac muscle 1 (EC 3.6.4.-) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form] | 5 | UniProt NCBI |
| ACTBL2 | Beta-actin-like protein 2 (Kappa-actin) | 4 | UniProt NCBI |
| ACTA2 | Actin, aortic smooth muscle (EC 3.6.4.-) (Alpha-actin-2) (Cell growth-inhibiting gene 46 protein) [Cleaved into: Actin, aortic smooth muscle, intermediate form] | 5 | UniProt NCBI |
| PHACTR2 | Phosphatase and actin regulator 2 | 5 | UniProt NCBI |
| ANXA11 | Annexin A11 (56 kDa autoantigen) (Annexin XI) (Annexin-11) (Calcyclin-associated annexin 50) (CAP-50) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP383 | 0.0243817991122 | 0.2 | ACTC1 ACTA2 | Striated muscle contraction pathway |
| WP:WP4534 | 0.0319043985122 | 0.2 | ACTC1 ACTA2 | Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| LRRC20 | ACTBL2 | 0.992 | 0.094 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ACTBL2 | PHACTR2 | 0.983 | 0.311333333333 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ACTA2 | ACTBL2 | 0.98 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM | |
| ACTA2 | PHACTR2 | 0.959 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| LRRC20 | ACTA2 | 0.958 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PHACTR2 | POTEI | 0.949 | 0.124 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| ACTC1 | PFN3 | 0.934 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ACTC1 | ACTBL2 | 0.93 | bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM WMM_only | |
| ACTA2 | ABRA | 0.911 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only | |
| ABRA | POTEI | 0.88 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ACTBL2 | PFN3 | 0.879 | 0.12 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| POTEI | NDUFA4L2 | 0.878 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ACTA2 | ANXA11 | 0.859 | hein_WMM bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ACTC1 | PHACTR2 | 0.851 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ACTA2 | PFN3 | 0.843 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LRRC20 | POTEI | 0.822 | 0.062 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| LRRC20 | ACTC1 | 0.735 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ACTC1 | ABRA | 0.621 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| ACTA2 | ACTC1 | 0.449 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only boldt_WMM | |
| ACTC1 | POTEI | 0.449 | bioplex_WMM bioplex3_WMM WMM_only | |
| ACTC1 | NDUFA4L2 | 0.416 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ACTA2 | POTEI | 0.338 | bioplex_WMM bioplex3_WMM WMM_only | |
| ACTBL2 | POTEI | 0.337 | 0.086 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
| ACTBL2 | ABRA | 0.293 | bioplex3_HEK293 bioplex3_WMM gupta_WMM WMM_only | |
| ACTBL2 | NDUFA4L2 | 0.153 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| POTEI | ANXA11 | 0.032 | 0.054 | bioplex_WMM bioplex3_WMM WMM_only |
| ACTC1 | ANXA11 | 0.024 | bioplex_WMM bioplex3_WMM WMM_only | |
| ANXA11 | NDUFA4L2 | 0.018 | bioplex3_HEK293 bioplex () | |
| ACTBL2 | ANXA11 | 0.01 | 0.182 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only treiber_WMM |
| LRRC20 | ANXA11 | 0.007 | 0.022 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| ABRA | ANXA11 | 0.004 | bioplex3_HCT116 WMM_only |
Related Complexes