List of Gene Names or Uniprot ACCs (ex. OFD1 PCM1 Q1MSJ5):

Enrichment (ex. cilium):

Protein (ex. Centrosomal protein):

Complex: huMAP3_14776.1

Confidence: Medium   ?

Proteins

Genename	Protein Name	Uniprot Annotation Score	Links
MKNK2	MAP kinase-interacting serine/threonine-protein kinase 2 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 2) (MAPK signal-integrating kinase 2) (Mnk2)	5	UniProt   NCBI
MAPK14	Mitogen-activated protein kinase 14 (MAP kinase 14) (MAPK 14) (EC 2.7.11.24) (Cytokine suppressive anti-inflammatory drug-binding protein) (CSAID-binding protein) (CSBP) (MAP kinase MXI2) (MAX-interacting protein 2) (Mitogen-activated protein kinase p38 alpha) (MAP kinase p38 alpha) (Stress-activated protein kinase 2a) (SAPK2a)	5	UniProt   NCBI
CCL16	C-C motif chemokine 16 (Chemokine CC-4) (HCC-4) (Chemokine LEC) (IL-10-inducible chemokine) (LCC-1) (Liver-expressed chemokine) (Lymphocyte and monocyte chemoattractant) (LMC) (Monotactin-1) (MTN-1) (NCC-4) (Small-inducible cytokine A16)	5	UniProt   NCBI
CCDC8	Coiled-coil domain-containing protein 8	5	UniProt   NCBI
RPS6KA4	Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 4) (Nuclear mitogen- and stress-activated protein kinase 2) (Ribosomal protein kinase B) (RSKB)	5	UniProt   NCBI
MAPKAPK2	MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC 2.7.11.1)	5	UniProt   NCBI
MKNK1	MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1)	5	UniProt   NCBI
TTPAL	Alpha-tocopherol transfer protein-like	2	UniProt   NCBI
DUSP7	Dual specificity protein phosphatase 7 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST2)	5	UniProt   NCBI
DUSP9	Dual specificity protein phosphatase 9 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 4) (MAP kinase phosphatase 4) (MKP-4)	5	UniProt   NCBI
MAPKAPK3	MAP kinase-activated protein kinase 3 (MAPK-activated protein kinase 3) (MAPKAP kinase 3) (MAPKAP-K3) (MAPKAPK-3) (MK-3) (EC 2.7.11.1) (Chromosome 3p kinase) (3pK)	5	UniProt   NCBI
SLX4IP	Protein SLX4IP (SLX4-interacting protein)	3	UniProt   NCBI
MAPK11	Mitogen-activated protein kinase 11 (MAP kinase 11) (MAPK 11) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 beta) (MAP kinase p38 beta) (p38b) (Stress-activated protein kinase 2b) (SAPK2b) (p38-2)	5	UniProt   NCBI



Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP382	1.17192632788e-12	0.692307692308	MKNK1 MAPKAPK2 MAPK11 MAPKAPK3 DUSP9 RPS6KA4 DUSP7 MAPK14 MKNK2	MAPK signaling pathway
KEGG:04010	3.23423250152e-12	0.692307692308	MKNK1 MAPKAPK2 MAPK11 MAPKAPK3 DUSP9 RPS6KA4 DUSP7 MAPK14 MKNK2	MAPK signaling pathway
REAC:R-HSA-171007	2.15255382745e-08	0.307692307692	MAPK11 MAPK14 MAPKAPK3 MAPKAPK2	p38MAPK events
WP:WP2637	2.56150640364e-08	0.384615384615	MKNK1 MAPKAPK2 MKNK2 MAPK11 MAPK14	Interleukin 1 IL 1 structural pathway
REAC:R-HSA-167044	1.02402913305e-07	0.307692307692	MAPK11 MAPK14 MAPKAPK3 MAPKAPK2	Signalling to RAS
REAC:R-HSA-450294	2.36321703256e-07	0.384615384615	MAPK11 DUSP7 MAPK14 MAPKAPK3 MAPKAPK2	MAP kinase activation
REAC:R-HSA-448424	3.99245920467e-07	0.384615384615	MAPK11 DUSP7 MAPK14 MAPKAPK3 MAPKAPK2	Interleukin-17 signaling
REAC:R-HSA-450302	4.94182139826e-07	0.307692307692	MAPK11 MAPK14 MAPKAPK3 MAPKAPK2	activated TAK1 mediates p38 MAPK activation
GO:0009931	1.31435310045e-06	0.307692307692	MKNK1 MKNK2 MAPKAPK3 MAPKAPK2	calcium-dependent protein serine/threonine kinase activity
REAC:R-HSA-187687	1.52036969776e-06	0.307692307692	MAPK11 MAPK14 MAPKAPK3 MAPKAPK2	Signalling to ERKs
REAC:R-HSA-168176	1.66809915998e-06	0.384615384615	MAPK11 DUSP7 MAPK14 MAPKAPK3 MAPKAPK2	Toll Like Receptor 5 (TLR5) Cascade
REAC:R-HSA-975871	1.66809915998e-06	0.384615384615	MAPK11 DUSP7 MAPK14 MAPKAPK3 MAPKAPK2	MyD88 cascade initiated on plasma membrane
REAC:R-HSA-168142	1.66809915998e-06	0.384615384615	MAPK11 DUSP7 MAPK14 MAPKAPK3 MAPKAPK2	Toll Like Receptor 10 (TLR10) Cascade
REAC:R-HSA-975138	1.88564402368e-06	0.384615384615	MAPK11 DUSP7 MAPK14 MAPKAPK3 MAPKAPK2	TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REAC:R-HSA-168181	2.0025792625e-06	0.384615384615	MAPK11 DUSP7 MAPK14 MAPKAPK3 MAPKAPK2	Toll Like Receptor 7/8 (TLR7/8) Cascade
REAC:R-HSA-975155	2.0025792625e-06	0.384615384615	MAPK11 DUSP7 MAPK14 MAPKAPK3 MAPKAPK2	MyD88 dependent cascade initiated on endosome
GO:0010857	2.3646695756e-06	0.307692307692	MKNK1 MKNK2 MAPKAPK3 MAPKAPK2	calcium-dependent protein kinase activity
REAC:R-HSA-168138	2.52946121204e-06	0.384615384615	MAPK11 DUSP7 MAPK14 MAPKAPK3 MAPKAPK2	Toll Like Receptor 9 (TLR9) Cascade
REAC:R-HSA-450282	2.78151129819e-06	0.307692307692	DUSP7 MAPK14 MAPK11 MAPKAPK2	MAPK targets/ Nuclear events mediated by MAP kinases
REAC:R-HSA-168164	2.83136971719e-06	0.384615384615	MAPK11 DUSP7 MAPK14 MAPKAPK3 MAPKAPK2	Toll Like Receptor 3 (TLR3) Cascade
REAC:R-HSA-937061	3.16131252108e-06	0.384615384615	MAPK11 DUSP7 MAPK14 MAPKAPK3 MAPKAPK2	TRIF(TICAM1)-mediated TLR4 signaling
REAC:R-HSA-166166	3.16131252108e-06	0.384615384615	MAPK11 DUSP7 MAPK14 MAPKAPK3 MAPKAPK2	MyD88-independent TLR4 cascade
REAC:R-HSA-168188	3.52118088427e-06	0.384615384615	MAPK11 DUSP7 MAPK14 MAPKAPK3 MAPKAPK2	Toll Like Receptor TLR6:TLR2 Cascade
REAC:R-HSA-166058	3.52118088427e-06	0.384615384615	MAPK11 DUSP7 MAPK14 MAPKAPK3 MAPKAPK2	MyD88:MAL(TIRAP) cascade initiated on plasma membrane
REAC:R-HSA-187037	3.91294738344e-06	0.384615384615	MAPK11 DUSP7 MAPK14 MAPKAPK3 MAPKAPK2	Signaling by NTRK1 (TRKA)
REAC:R-HSA-168179	3.91294738344e-06	0.384615384615	MAPK11 DUSP7 MAPK14 MAPKAPK3 MAPKAPK2	Toll Like Receptor TLR1:TLR2 Cascade
REAC:R-HSA-181438	3.91294738344e-06	0.384615384615	MAPK11 DUSP7 MAPK14 MAPKAPK3 MAPKAPK2	Toll Like Receptor 2 (TLR2) Cascade
KEGG:04370	5.25600399175e-06	0.307692307692	MAPK11 MAPK14 MAPKAPK3 MAPKAPK2	VEGF signaling pathway
REAC:R-HSA-166520	8.84419909136e-06	0.384615384615	MAPK11 DUSP7 MAPK14 MAPKAPK3 MAPKAPK2	Signaling by NTRKs
REAC:R-HSA-166016	1.2963637311e-05	0.384615384615	MAPK11 DUSP7 MAPK14 MAPKAPK3 MAPKAPK2	Toll Like Receptor 4 (TLR4) Cascade
REAC:R-HSA-168898	2.66495401148e-05	0.384615384615	MAPK11 DUSP7 MAPK14 MAPKAPK3 MAPKAPK2	Toll-like Receptor Cascades
REAC:R-HSA-198725	3.17203787505e-05	0.307692307692	DUSP7 MAPK14 MAPK11 MAPKAPK2	Nuclear Events (kinase and transcription factor activation)
GO:0004683	0.000136405002658	0.307692307692	MKNK1 MKNK2 MAPKAPK3 MAPKAPK2	calmodulin-dependent protein kinase activity
WP:WP722	0.000165036530142	0.230769230769	MAPK14 MAPKAPK3 MAPKAPK2	Serotonin HTR1 group and FOS pathway
KEGG:04148	0.000190316417962	0.307692307692	DUSP7 MAPK14 MAPK11 MAPKAPK2	Efferocytosis
REAC:R-HSA-198753	0.000197954949394	0.230769230769	DUSP7 MAPK14 MAPK11	ERK/MAPK targets
GO:0004674	0.000219050983992	0.538461538462	MKNK1 MAPKAPK2 MAPKAPK3 RPS6KA4 MAPK11 MAPK14 MKNK2	protein serine/threonine kinase activity
REAC:R-HSA-4420097	0.000219649400377	0.307692307692	MAPK11 MAPK14 MAPKAPK3 MAPKAPK2	VEGFA-VEGFR2 Pathway
REAC:R-HSA-9006934	0.00025328489379	0.461538461538	MAPK11 MAPKAPK3 MAPKAPK2 DUSP7 MKNK1 MAPK14	Signaling by Receptor Tyrosine Kinases
WP:WP400	0.000257181924203	0.230769230769	MKNK1 MAPK14 MAPKAPK2	p38 MAPK signaling pathway
REAC:R-HSA-194138	0.000312909271517	0.307692307692	MAPK11 MAPK14 MAPKAPK3 MAPKAPK2	Signaling by VEGF
REAC:R-HSA-2559580	0.000504232320379	0.307692307692	MAPK11 MAPK14 MAPKAPK3 MAPKAPK2	Oxidative Stress Induced Senescence
GO:0004672	0.00156836004287	0.538461538462	MKNK1 MAPKAPK2 MAPKAPK3 RPS6KA4 MAPK11 MAPK14 MKNK2	protein kinase activity
KEGG:04625	0.00297848194823	0.230769230769	MAPK11 MAPK14 MAPKAPK2	C-type lectin receptor signaling pathway
REAC:R-HSA-2559583	0.00356657683455	0.307692307692	MAPK11 MAPK14 MAPKAPK3 MAPKAPK2	Cellular Senescence
KEGG:04668	0.00415259401034	0.230769230769	MAPK11 MAPK14 RPS6KA4	TNF signaling pathway
REAC:R-HSA-9652817	0.00418027557771	0.153846153846	DUSP7 DUSP9	Signaling by MAPK mutants
REAC:R-HSA-449147	0.00418476955002	0.384615384615	MAPK11 DUSP7 MAPK14 MAPKAPK3 MAPKAPK2	Signaling by Interleukins
KEGG:04722	0.00483870748794	0.230769230769	MAPK11 MAPK14 MAPKAPK2	Neurotrophin signaling pathway
REAC:R-HSA-376172	0.00557090384564	0.153846153846	MAPK11 MAPK14	DSCAM interactions
GO:0016773	0.00600116061073	0.538461538462	MKNK1 MAPKAPK2 MAPKAPK3 RPS6KA4 MAPK11 MAPK14 MKNK2	phosphotransferase activity, alcohol group as acceptor
REAC:R-HSA-2151209	0.00715899645867	0.153846153846	MAPK11 MAPK14	Activation of PPARGC1A (PGC-1alpha) by phosphorylation
GO:0035556	0.00814195745858	0.769230769231	CCL16 MKNK1 MAPKAPK2 MAPK11 MAPKAPK3 DUSP9 RPS6KA4 DUSP7 MAPK14 MKNK2	intracellular signal transduction
KEGG:04550	0.00831781661066	0.230769230769	DUSP9 MAPK14 MAPK11	Signaling pathways regulating pluripotency of stem cells
REAC:R-HSA-450341	0.00894425512963	0.153846153846	MAPK11 MAPK14	Activation of the AP-1 family of transcription factors
GO:0016301	0.00970582730969	0.538461538462	MKNK1 MAPKAPK2 MAPKAPK3 RPS6KA4 MAPK11 MAPK14 MKNK2	kinase activity
KEGG:04218	0.0131204980655	0.230769230769	MAPK11 MAPK14 MAPKAPK2	Cellular senescence
REAC:R-HSA-450531	0.013246545693	0.230769230769	MAPK11 MAPK14 MAPKAPK2	Regulation of mRNA stability by proteins that bind AU-rich elements
WP:WP4767	0.0144668298298	0.153846153846	MAPK11 MAPK14	FGFR3 signaling in chondrocyte proliferation and terminal differentiation
WP:WP5272	0.0144668298298	0.153846153846	MAPK11 MAPK14	LDL influence on CD14 and TLR4
WP:WP3915	0.0145884443755	0.230769230769	MAPK11 MAPK14 RPS6KA4	Angiopoietin like protein 8 regulatory pathway
WP:WP4864	0.0160661903095	0.153846153846	MAPK11 MAPK14	Host pathogen interaction of human coronaviruses apoptosis
WP:WP3879	0.0177484588035	0.153846153846	MKNK1 MKNK2	4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression
WP:WP1528	0.0177484588035	0.153846153846	MAPK11 MAPK14	Physiological and pathological hypertrophy of the heart
WP:WP3612	0.0195135093394	0.153846153846	MAPK11 MAPK14	Photodynamic therapy induced NFE2L2 NRF2 survival signaling
KEGG:05167	0.0224285036461	0.230769230769	MAPK11 MAPK14 MAPKAPK2	Kaposi sarcoma-associated herpesvirus infection
REAC:R-HSA-162582	0.0244930985656	0.615384615385	CCL16 DUSP7 MAPKAPK2 MAPK11 MAPKAPK3 DUSP9 MKNK1 MAPK14	Signal Transduction
WP:WP3869	0.025304095421	0.153846153846	MAPK11 MAPK14	Cannabinoid receptor signaling
REAC:R-HSA-450604	0.0269367236592	0.153846153846	MAPK11 MAPK14	KSRP (KHSRP) binds and destabilizes mRNA
WP:WP481	0.0285212659169	0.230769230769	MAPK11 MAPK14 RPS6KA4	Insulin signaling
WP:WP5087	0.0287514677441	0.307692307692	MKNK1 MAPKAPK2 MKNK2 MAPK14	Pleural mesothelioma
WP:WP2643	0.0295760926946	0.153846153846	MAPK11 MAPK14	Nanoparticle mediated activation of receptor signaling
GO:0005516	0.0316631841092	0.307692307692	MKNK1 MKNK2 MAPKAPK3 MAPKAPK2	calmodulin binding
REAC:R-HSA-1280215	0.0328817707436	0.384615384615	MAPK11 DUSP7 MAPK14 MAPKAPK3 MAPKAPK2	Cytokine Signaling in Immune system
REAC:R-HSA-112409	0.0338349899843	0.153846153846	DUSP7 DUSP9	RAF-independent MAPK1/3 activation
GO:0016772	0.0356259003752	0.538461538462	MKNK1 MAPKAPK2 MAPKAPK3 RPS6KA4 MAPK11 MAPK14 MKNK2	transferase activity, transferring phosphorus-containing groups
GO:0051019	0.0362257557392	0.230769230769	MAPK14 MAPKAPK3 MAPKAPK2	mitogen-activated protein kinase binding
WP:WP4877	0.0365989932385	0.153846153846	MAPK11 MAPK14	Host pathogen interaction of human coronaviruses MAPK signaling
REAC:R-HSA-5668599	0.0415100566553	0.153846153846	MAPK11 MAPK14	RHO GTPases Activate NADPH Oxidases
WP:WP2371	0.0471054379723	0.153846153846	MAPK11 MAPK14	Parkinson 39 s disease pathway



Edges

Protein 1	Protein 2	Score ?	ProteomeHD?
MAPKAPK2	MAPK14	1.0	0.58
MAPKAPK3	MAPK14	1.0	0.286
MAPKAPK2	MAPK11	0.999
MAPK14	MKNK1	0.999	0.154
MAPKAPK3	MAPK11	0.998
MAPKAPK2	MAPKAPK3	0.997	0.226
DUSP9	DUSP7	0.993	0.054
MAPK14	RPS6KA4	0.985	0.08
MKNK2	MAPK14	0.975
MAPK14	DUSP9	0.975	0.146
MAPK11	MAPK14	0.964
MAPKAPK2	MKNK1	0.932	0.086
MAPK14	DUSP7	0.931	0.166
MAPKAPK2	TTPAL	0.923	0.032
MAPK14	SLX4IP	0.905	0.052
MAPK11	RPS6KA4	0.903
MKNK1	CCL16	0.892
MAPKAPK3	MKNK1	0.884	0.224
CCDC8	MAPK14	0.874	0.116
MKNK2	DUSP7	0.798
MKNK2	MKNK1	0.551
MAPKAPK3	DUSP7	0.513	0.126
MKNK2	MAPKAPK3	0.513
MKNK2	DUSP9	0.466
MKNK2	MAPKAPK2	0.382
MAPKAPK2	DUSP7	0.378	0.21
MKNK1	DUSP7	0.357	0.084
MKNK1	DUSP9	0.357	0.13
RPS6KA4	DUSP9	0.258	0.058
MAPKAPK2	SLX4IP	0.251	0.062
RPS6KA4	DUSP7	0.248	0.088
MAPKAPK3	RPS6KA4	0.248	0.076
MKNK2	CCDC8	0.236
MKNK2	SLX4IP	0.224
MAPKAPK3	DUSP9	0.224	0.132
MAPKAPK2	DUSP9	0.224	0.112
MKNK1	SLX4IP	0.215	0.182
MKNK2	RPS6KA4	0.215
MKNK1	RPS6KA4	0.199	0.082
MAPKAPK2	RPS6KA4	0.199	0.034
MAPKAPK3	CCDC8	0.189	0.092
CCDC8	DUSP7	0.189	0.13
RPS6KA4	SLX4IP	0.181	0.058
DUSP7	SLX4IP	0.178	0.086
MAPKAPK3	SLX4IP	0.178	0.08
DUSP9	SLX4IP	0.17	0.086
CCDC8	MKNK1	0.099	0.09
MAPKAPK2	CCDC8	0.099	0.128
CCDC8	SLX4IP	0.081	0.124
CCDC8	DUSP9	0.08	0.146
CCDC8	RPS6KA4	0.034	0.128





Related Complexes

Genename	Complexes
MKNK2	huMAP3_01311.1 huMAP3_01628.1 huMAP3_03995.1 huMAP3_05402.1 huMAP3_06585.1 huMAP3_07439.1 huMAP3_07582.1 huMAP3_07936.1 huMAP3_08665.1 huMAP3_10997.1 huMAP3_13413.1 huMAP3_14776.1
MAPK14	huMAP3_01628.1 huMAP3_03995.1 huMAP3_05402.1 huMAP3_06585.1 huMAP3_07439.1 huMAP3_07936.1 huMAP3_08665.1 huMAP3_10997.1 huMAP3_14776.1
CCL16	huMAP3_13620.1 huMAP3_14458.1 huMAP3_14487.1 huMAP3_14776.1
CCDC8	huMAP3_01555.1 huMAP3_05980.1 huMAP3_07874.1 huMAP3_11705.1 huMAP3_12997.1 huMAP3_14114.1 huMAP3_14776.1
RPS6KA4	huMAP3_01966.1 huMAP3_06300.1 huMAP3_09590.1 huMAP3_14776.1
MAPKAPK2	huMAP3_01525.1 huMAP3_04030.1 huMAP3_05536.1 huMAP3_07206.1 huMAP3_07964.1 huMAP3_08407.1 huMAP3_10074.1 huMAP3_10583.1 huMAP3_11114.1 huMAP3_11371.1 huMAP3_11575.1 huMAP3_14776.1 huMAP3_15022.1
MKNK1	huMAP3_01628.1 huMAP3_03995.1 huMAP3_05402.1 huMAP3_06585.1 huMAP3_07439.1 huMAP3_07936.1 huMAP3_08665.1 huMAP3_10997.1 huMAP3_13620.1 huMAP3_14776.1
TTPAL	huMAP3_11371.1 huMAP3_11575.1 huMAP3_14776.1
DUSP7	huMAP3_04437.1 huMAP3_14776.1
DUSP9	huMAP3_04437.1 huMAP3_06585.1 huMAP3_07439.1 huMAP3_14776.1
MAPKAPK3	huMAP3_01525.1 huMAP3_04030.1 huMAP3_05402.1 huMAP3_06585.1 huMAP3_07936.1 huMAP3_08407.1 huMAP3_10997.1 huMAP3_12751.1 huMAP3_14776.1
SLX4IP	huMAP3_11548.1 huMAP3_12248.1 huMAP3_14356.1 huMAP3_14760.1 huMAP3_14776.1
MAPK11	huMAP3_01525.1 huMAP3_04030.1 huMAP3_05402.1 huMAP3_06585.1 huMAP3_07206.1 huMAP3_07936.1 huMAP3_08407.1 huMAP3_10997.1 huMAP3_12751.1 huMAP3_14776.1