hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_14783.1

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
LRRC58	Leucine-rich repeat-containing protein 58	2	UniProt NCBI
ATG14	Beclin 1-associated autophagy-related key regulator (Barkor) (Autophagy-related protein 14-like protein) (Atg14L)	5	UniProt NCBI
BECN1	Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197) [Cleaved into: Beclin-1-C 35 kDa; Beclin-1-C 37 kDa]	5	UniProt NCBI
UVRAG	UV radiation resistance-associated gene protein (p63)	5	UniProt NCBI
NRBF2	Nuclear receptor-binding factor 2 (NRBF-2) (Comodulator of PPAR and RXR)	5	UniProt NCBI
RUBCN	Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (Rubicon) (Beclin-1 associated RUN domain containing protein) (Baron)	5	UniProt NCBI
PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3-kinase type 3) (PI3K type 3) (PtdIns-3-kinase type 3) (EC 2.7.1.137) (Phosphatidylinositol 3-kinase p100 subunit) (Phosphoinositide-3-kinase class 3) (hVps34)	5	UniProt NCBI
PIK3R4	Phosphoinositide 3-kinase regulatory subunit 4 (PI3-kinase regulatory subunit 4) (EC 2.7.11.1) (PI3-kinase p150 subunit) (Phosphoinositide 3-kinase adaptor protein)	5	UniProt NCBI
RUBCNL	Protein associated with UVRAG as autophagy enhancer (Pacer) (Protein Rubicon-like)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0035032	2.17398353113e-15	0.666666666667	BECN1 NRBF2 UVRAG PIK3C3 PIK3R4 ATG14	phosphatidylinositol 3-kinase complex, class III
CORUM:6472	5.38212907005e-12	0.444444444444	PIK3R4 BECN1 PIK3C3 UVRAG	Bcl-2-Beclin1-UVRAG-PI(3)KC3 complex
GO:0097352	5.45184647421e-12	0.777777777778	BECN1 UVRAG PIK3C3 RUBCN RUBCNL PIK3R4 ATG14	autophagosome maturation
KEGG:04140	2.46548456096e-11	0.777777777778	BECN1 NRBF2 PIK3R4 PIK3C3 RUBCN UVRAG ATG14	Autophagy - animal
GO:0005942	5.48276887252e-11	0.666666666667	BECN1 NRBF2 UVRAG PIK3C3 PIK3R4 ATG14	phosphatidylinositol 3-kinase complex
WP:WP4923	2.02408582855e-10	0.555555555556	PIK3R4 BECN1 PIK3C3 ATG14 UVRAG	Autophagy
GO:0036092	2.85581378866e-10	0.555555555556	PIK3R4 BECN1 PIK3C3 ATG14 UVRAG	phosphatidylinositol-3-phosphate biosynthetic process
REAC:R-HSA-9679504	5.17527951477e-09	0.444444444444	PIK3R4 BECN1 PIK3C3 UVRAG	Translation of Replicase and Assembly of the Replication Transcription Complex
REAC:R-HSA-9694676	7.76079336729e-09	0.444444444444	PIK3R4 BECN1 PIK3C3 UVRAG	Translation of Replicase and Assembly of the Replication Transcription Complex
GO:0032984	1.23354261827e-07	0.777777777778	BECN1 UVRAG PIK3C3 RUBCN RUBCNL PIK3R4 ATG14	protein-containing complex disassembly
KEGG:05017	2.61758402204e-07	0.555555555556	PIK3R4 BECN1 PIK3C3 ATG14 NRBF2	Spinocerebellar ataxia
REAC:R-HSA-983170	2.74026869006e-07	0.444444444444	PIK3R4 BECN1 ATG14 PIK3C3	Antigen Presentation: Folding, assembly and peptide loading of class I MHC
GO:0006914	3.15498215751e-07	0.888888888889	BECN1 NRBF2 PIK3R4 PIK3C3 RUBCN RUBCNL UVRAG ATG14	autophagy
GO:0061919	3.15498215751e-07	0.888888888889	BECN1 NRBF2 PIK3R4 PIK3C3 RUBCN RUBCNL UVRAG ATG14	process utilizing autophagic mechanism
WP:WP4577	5.47480563025e-07	0.444444444444	PIK3R4 BECN1 ATG14 PIK3C3	Neurodegeneration with brain iron accumulation NBIA subtypes pathway
REAC:R-HSA-9772572	6.37877602254e-07	0.444444444444	PIK3R4 BECN1 PIK3C3 UVRAG	Early SARS-CoV-2 Infection Events
REAC:R-HSA-1632852	1.27732061414e-06	0.555555555556	PIK3R4 BECN1 PIK3C3 ATG14 UVRAG	Macroautophagy
GO:0016236	1.28179479185e-06	0.777777777778	BECN1 UVRAG PIK3C3 RUBCN RUBCNL PIK3R4 ATG14	macroautophagy
GO:0046854	1.72371883104e-06	0.555555555556	PIK3R4 BECN1 PIK3C3 ATG14 UVRAG	phosphatidylinositol phosphate biosynthetic process
GO:0016241	2.17979781874e-06	0.666666666667	BECN1 UVRAG PIK3C3 RUBCN PIK3R4 ATG14	regulation of macroautophagy
REAC:R-HSA-9612973	2.25319041775e-06	0.555555555556	PIK3R4 BECN1 PIK3C3 ATG14 UVRAG	Autophagy
GO:0019898	2.97195943126e-06	0.666666666667	BECN1 NRBF2 UVRAG PIK3C3 PIK3R4 ATG14	extrinsic component of membrane
GO:0034272	8.07408345042e-06	0.333333333333	PIK3R4 BECN1 PIK3C3	phosphatidylinositol 3-kinase complex, class III, type II
GO:0034271	8.07408345042e-06	0.333333333333	PIK3R4 BECN1 PIK3C3	phosphatidylinositol 3-kinase complex, class III, type I
REAC:R-HSA-9705683	9.56404832881e-06	0.555555555556	PIK3R4 BECN1 PIK3C3 ATG14 UVRAG	SARS-CoV-2-host interactions
WP:WP5124	1.03150363211e-05	0.555555555556	PIK3R4 BECN1 PIK3C3 ATG14 NRBF2	Alzheimer 39 s disease
WP:WP2059	1.03150363211e-05	0.555555555556	PIK3R4 BECN1 PIK3C3 ATG14 NRBF2	Alzheimer 39 s disease and miRNA effects
WP:WP4863	1.19672902719e-05	0.333333333333	PIK3R4 BECN1 PIK3C3	Host pathogen interaction of human coronaviruses autophagy
KEGG:05016	1.26658749881e-05	0.555555555556	PIK3R4 BECN1 PIK3C3 ATG14 NRBF2	Huntington disease
GO:0005776	2.06232346045e-05	0.555555555556	BECN1 PIK3C3 RUBCNL ATG14 UVRAG	autophagosome
GO:0022411	2.0815903456e-05	0.777777777778	BECN1 UVRAG PIK3C3 RUBCN RUBCNL PIK3R4 ATG14	cellular component disassembly
WP:WP2509	2.25575023346e-05	0.333333333333	BECN1 ATG14 UVRAG	Nanoparticle triggered autophagic cell death
CORUM:429	2.73623797451e-05	0.222222222222	PIK3C3 PIK3R4	Phosphatidylinositol 3-kinase complex (PIK3C3, PIK3R4)
KEGG:05014	3.07488589139e-05	0.555555555556	PIK3R4 BECN1 PIK3C3 ATG14 NRBF2	Amyotrophic lateral sclerosis
KEGG:04136	3.28707503917e-05	0.333333333333	PIK3R4 BECN1 PIK3C3	Autophagy - other
GO:0006622	3.50368755955e-05	0.444444444444	PIK3R4 BECN1 ATG14 PIK3C3	protein targeting to lysosome
KEGG:05010	3.90411068124e-05	0.555555555556	PIK3R4 BECN1 PIK3C3 ATG14 NRBF2	Alzheimer disease
REAC:R-HSA-9694516	6.15791296216e-05	0.555555555556	PIK3R4 BECN1 PIK3C3 ATG14 UVRAG	SARS-CoV-2 Infection
REAC:R-HSA-9705671	9.47387065173e-05	0.444444444444	PIK3R4 BECN1 ATG14 PIK3C3	SARS-CoV-2 activates/modulates innate and adaptive immune responses
KEGG:05022	0.000103265011515	0.555555555556	PIK3R4 BECN1 PIK3C3 ATG14 NRBF2	Pathways of neurodegeneration - multiple diseases
GO:0006661	0.000117830712316	0.555555555556	PIK3R4 BECN1 PIK3C3 ATG14 UVRAG	phosphatidylinositol biosynthetic process
CORUM:6816	0.000164069436391	0.222222222222	PIK3C3 ATG14	ULK1-ATG13-ATG14-PIK3C3 complex
GO:0061695	0.000172106100962	0.666666666667	BECN1 NRBF2 UVRAG PIK3C3 PIK3R4 ATG14	transferase complex, transferring phosphorus-containing groups
REAC:R-HSA-9678108	0.000183296651542	0.444444444444	PIK3R4 BECN1 PIK3C3 UVRAG	SARS-CoV-1 Infection
GO:0006623	0.000216994046867	0.444444444444	PIK3R4 BECN1 ATG14 PIK3C3	protein targeting to vacuole
GO:0045022	0.000242456263636	0.444444444444	PIK3R4 BECN1 ATG14 PIK3C3	early endosome to late endosome transport
GO:0010506	0.000246385193459	0.666666666667	BECN1 UVRAG PIK3C3 RUBCN PIK3R4 ATG14	regulation of autophagy
GO:0046488	0.000258879059779	0.555555555556	PIK3R4 BECN1 PIK3C3 ATG14 UVRAG	phosphatidylinositol metabolic process
GO:0042149	0.000300019348538	0.444444444444	PIK3R4 BECN1 ATG14 PIK3C3	cellular response to glucose starvation
REAC:R-HSA-9679506	0.000301009219874	0.555555555556	PIK3R4 BECN1 PIK3C3 ATG14 UVRAG	SARS-CoV Infections
KEGG:05131	0.000339656530832	0.444444444444	PIK3R4 BECN1 ATG14 PIK3C3	Shigellosis
GO:0098927	0.000367247519095	0.444444444444	PIK3R4 BECN1 ATG14 PIK3C3	vesicle-mediated transport between endosomal compartments
GO:0044248	0.000748330125733	0.888888888889	BECN1 NRBF2 PIK3R4 PIK3C3 RUBCN RUBCNL UVRAG ATG14	cellular catabolic process
GO:0061462	0.000753968512946	0.444444444444	PIK3R4 BECN1 ATG14 PIK3C3	protein localization to lysosome
GO:0072666	0.000957877391318	0.444444444444	PIK3R4 BECN1 ATG14 PIK3C3	establishment of protein localization to vacuole
WP:WP5420	0.00106496837821	0.444444444444	PIK3R4 BECN1 ATG14 PIK3C3	ADHD and autism ASD linked metabolic pathways and SNP
GO:0046474	0.00111394072498	0.555555555556	PIK3R4 BECN1 PIK3C3 ATG14 UVRAG	glycerophospholipid biosynthetic process
KEGG:04371	0.00175151727893	0.333333333333	PIK3R4 BECN1 PIK3C3	Apelin signaling pathway
GO:0008654	0.00212789387055	0.555555555556	PIK3R4 BECN1 PIK3C3 ATG14 UVRAG	phospholipid biosynthetic process
GO:0045017	0.00255057186418	0.555555555556	PIK3R4 BECN1 PIK3C3 ATG14 UVRAG	glycerolipid biosynthetic process
GO:0032465	0.00354093280479	0.444444444444	PIK3R4 BECN1 PIK3C3 UVRAG	regulation of cytokinesis
GO:0072665	0.00395198876289	0.444444444444	PIK3R4 BECN1 ATG14 PIK3C3	protein localization to vacuole
REAC:R-HSA-1660517	0.00438093013445	0.222222222222	PIK3C3 PIK3R4	Synthesis of PIPs at the late endosome membrane
KEGG:05167	0.00602207106452	0.333333333333	BECN1 ATG14 PIK3C3	Kaposi sarcoma-associated herpesvirus infection
GO:0006650	0.00615819988753	0.555555555556	PIK3R4 BECN1 PIK3C3 ATG14 UVRAG	glycerophospholipid metabolic process
REAC:R-HSA-9824446	0.00644900522555	0.555555555556	PIK3R4 BECN1 PIK3C3 ATG14 UVRAG	Viral Infection Pathways
REAC:R-HSA-1660516	0.00835291407054	0.222222222222	PIK3C3 PIK3R4	Synthesis of PIPs at the early endosome membrane
REAC:R-HSA-983169	0.00839078635289	0.444444444444	PIK3R4 BECN1 ATG14 PIK3C3	Class I MHC mediated antigen processing & presentation
GO:0031329	0.00935272795605	0.666666666667	BECN1 UVRAG PIK3C3 RUBCN PIK3R4 ATG14	regulation of cellular catabolic process
REAC:R-HSA-1660514	0.00954313848115	0.222222222222	PIK3C3 PIK3R4	Synthesis of PIPs at the Golgi membrane
GO:0032801	0.0123615112794	0.333333333333	PIK3R4 BECN1 UVRAG	receptor catabolic process
GO:0007041	0.0160151987026	0.444444444444	PIK3R4 BECN1 ATG14 PIK3C3	lysosomal transport
GO:0006644	0.0166605450833	0.555555555556	PIK3R4 BECN1 PIK3C3 ATG14 UVRAG	phospholipid metabolic process
REAC:R-HSA-5668599	0.0166738379974	0.222222222222	PIK3C3 PIK3R4	RHO GTPases Activate NADPH Oxidases
REAC:R-HSA-5663205	0.0174507834687	0.555555555556	PIK3R4 BECN1 PIK3C3 ATG14 UVRAG	Infectious disease
GO:0046486	0.0178464783057	0.555555555556	PIK3R4 BECN1 PIK3C3 ATG14 UVRAG	glycerolipid metabolic process
GO:0051302	0.0179204158456	0.444444444444	PIK3R4 BECN1 PIK3C3 UVRAG	regulation of cell division
GO:0016192	0.0208703166512	0.777777777778	BECN1 UVRAG PIK3C3 RUBCN RUBCNL PIK3R4 ATG14	vesicle-mediated transport
GO:0009267	0.0255085593346	0.444444444444	PIK3R4 BECN1 ATG14 PIK3C3	cellular response to starvation
WP:WP4971	0.0261461277128	0.222222222222	PIK3C3 PIK3R4	Phosphoinositides metabolism
REAC:R-HSA-109704	0.0278157587689	0.222222222222	PIK3C3 PIK3R4	PI3K Cascade
GO:0009056	0.0286508781964	0.888888888889	BECN1 NRBF2 PIK3R4 PIK3C3 RUBCN RUBCNL UVRAG ATG14	catabolic process
REAC:R-HSA-112399	0.0344394959621	0.222222222222	PIK3C3 PIK3R4	IRS-mediated signalling
GO:0007034	0.0386755934753	0.444444444444	PIK3R4 BECN1 ATG14 PIK3C3	vacuolar transport
GO:0000407	0.0396911574974	0.333333333333	BECN1 ATG14 PIK3C3	phagophore assembly site
REAC:R-HSA-2428928	0.0417623735111	0.222222222222	PIK3C3 PIK3R4	IRS-related events triggered by IGF1R
REAC:R-HSA-2428924	0.0417623735111	0.222222222222	PIK3C3 PIK3R4	IGF1R signaling cascade
REAC:R-HSA-2404192	0.0417623735111	0.222222222222	PIK3C3 PIK3R4	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
GO:0042594	0.0435922560843	0.444444444444	PIK3R4 BECN1 ATG14 PIK3C3	response to starvation
REAC:R-HSA-74751	0.0497823629923	0.222222222222	PIK3C3 PIK3R4	Insulin receptor signalling cascade

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
PIK3C3	PIK3R4	0.999	0.316	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM Malo fraction
BECN1	PIK3C3	0.999	0.138	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein ()
ATG14	BECN1	0.997	0.174	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116
BECN1	UVRAG	0.997	0.246	hein_WMM bioplex_WMM bioplex3_WMM hein ()
PIK3C3	RUBCNL	0.997		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
BECN1	PIK3R4	0.997	0.274	hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein ()
UVRAG	RUBCNL	0.997		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
RUBCN	PIK3R4	0.996	0.182	hein_WMM bioplex3_HEK293 bioplex3_WMM WMM_only
ATG14	PIK3C3	0.996	0.156	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
UVRAG	RUBCN	0.995	0.176	hein_WMM bioplex3_HEK293 bioplex3_WMM WMM_only
NRBF2	PIK3C3	0.995	0.152	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
NRBF2	PIK3R4	0.995	0.134	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116
BECN1	RUBCN	0.994	0.154	hein_WMM bioplex3_HEK293 bioplex3_WMM hein ()
BECN1	RUBCNL	0.993		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
ATG14	NRBF2	0.993	0.124	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
ATG14	PIK3R4	0.992	0.24	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
RUBCN	PIK3C3	0.992	0.076	hein_WMM bioplex3_HEK293 bioplex3_WMM WMM_only
BECN1	NRBF2	0.992	0.24225	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () bioplex3_HCT116
PIK3R4	RUBCNL	0.983		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
UVRAG	PIK3C3	0.979	0.152	hein_WMM bioplex_WMM bioplex3_WMM WMM_only
ATG14	LRRC58	0.969	0.134	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
UVRAG	PIK3R4	0.871	0.184	hein_WMM bioplex_WMM bioplex3_WMM WMM_only
ATG14	UVRAG	0.423	0.096	hein_WMM WMM_only
UVRAG	NRBF2	0.423	0.218	hein_WMM WMM_only
ATG14	RUBCN	0.315	0.134	hein_WMM WMM_only
NRBF2	RUBCN	0.315	0.122	hein_WMM WMM_only
BECN1	LRRC58	0.164	0.234	bioplex_WMM bioplex3_WMM WMM_only
NRBF2	LRRC58	0.15	0.034	bioplex_WMM bioplex3_WMM WMM_only
PIK3C3	LRRC58	0.143	0.096	bioplex_WMM bioplex3_WMM WMM_only
PIK3R4	LRRC58	0.136	0.08	bioplex_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
LRRC58	huMAP3_02434.1 huMAP3_10055.1 huMAP3_12120.1 huMAP3_12553.1 huMAP3_14783.1
ATG14	huMAP3_00300.1 huMAP3_01249.1 huMAP3_10358.1 huMAP3_12120.1 huMAP3_14783.1
BECN1	huMAP3_00300.1 huMAP3_01249.1 huMAP3_11445.1 huMAP3_14783.1
UVRAG	huMAP3_00300.1 huMAP3_11445.1 huMAP3_14783.1
NRBF2	huMAP3_00300.1 huMAP3_01249.1 huMAP3_13627.1 huMAP3_14783.1
RUBCN	huMAP3_00300.1 huMAP3_01249.1 huMAP3_11445.1 huMAP3_14783.1
PIK3C3	huMAP3_00300.1 huMAP3_01249.1 huMAP3_11445.1 huMAP3_14783.1
PIK3R4	huMAP3_00300.1 huMAP3_01249.1 huMAP3_08728.1 huMAP3_14783.1
RUBCNL	huMAP3_00300.1 huMAP3_01249.1 huMAP3_11237.1 huMAP3_11445.1 huMAP3_13535.1 huMAP3_14783.1

hu.MAP 3.0: Complex View

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Complex: huMAP3_14783.1