hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14790.1
Complex Portal: CPX-18815
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DGKZ | Diacylglycerol kinase zeta (DAG kinase zeta) (EC 2.7.1.107) (EC 2.7.1.93) (Diglyceride kinase zeta) (DGK-zeta) | 5 | UniProt NCBI |
| FNTA | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (EC 2.5.1.58) (EC 2.5.1.59) (CAAX farnesyltransferase subunit alpha) (FTase-alpha) (Ras proteins prenyltransferase subunit alpha) (Type I protein geranyl-geranyltransferase subunit alpha) (GGTase-I-alpha) | 5 | UniProt NCBI |
| FNTB | Protein farnesyltransferase subunit beta (FTase-beta) (EC 2.5.1.58) (CAAX farnesyltransferase subunit beta) (Ras proteins prenyltransferase subunit beta) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:419 | 3.41752350426e-06 | 0.666666666667 | FNTB FNTA | Farnesyltransferase |
| KEGG:00900 | 0.00017617774418 | 0.666666666667 | FNTB FNTA | Terpenoid backbone biosynthesis |
| GO:0004660 | 0.00140460216025 | 0.666666666667 | FNTB FNTA | protein farnesyltransferase activity |
| GO:0005965 | 0.00140460216025 | 0.666666666667 | FNTB FNTA | protein farnesyltransferase complex |
| REAC:R-HSA-9648002 | 0.00157362645287 | 0.666666666667 | FNTB FNTA | RAS processing |
| REAC:R-HSA-2514859 | 0.00172341693863 | 0.666666666667 | FNTB FNTA | Inactivation, recovery and regulation of the phototransduction cascade |
| REAC:R-HSA-2514856 | 0.00172341693863 | 0.666666666667 | FNTB FNTA | The phototransduction cascade |
| GO:0018343 | 0.00421361424067 | 0.666666666667 | FNTB FNTA | protein farnesylation |
| REAC:R-HSA-2187338 | 0.0204048321881 | 0.666666666667 | FNTB FNTA | Visual phototransduction |
| GO:0008318 | 0.0210651876021 | 0.666666666667 | FNTB FNTA | protein prenyltransferase activity |
| REAC:R-HSA-9679191 | 0.0242497192193 | 0.666666666667 | FNTB FNTA | Potential therapeutics for SARS |
| CORUM:6219 | 0.0499402709677 | 0.333333333333 | DGKZ | DGKZ-RASGRP1-HRAS complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| FNTA | FNTB | 1.0 | 0.33 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM |
| DGKZ | FNTB | 0.992 | 0.156 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FNTA | DGKZ | 0.982 | 0.088 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes