hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14792.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TGM2 | Protein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) (Erythrocyte transglutaminase) (Heart G alpha(h)) (hhG alpha(h)) (Isopeptidase TGM2) (EC 3.4.-.-) (Protein G alpha(h)) (G(h)) (Protein-glutamine deamidase TGM2) (EC 3.5.1.44) (Protein-glutamine dopaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine histaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine noradrenalinyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine serotonyltransferase TGM2) (EC 2.3.1.-) (Tissue transglutaminase) (tTG) (tTgase) (Transglutaminase C) (TG(C)) (TGC) (TGase C) (Transglutaminase H) (TGase H) (Transglutaminase II) (TGase II) (Transglutaminase-2) (TG2) (TGase-2) (hTG2) | 5 | UniProt NCBI |
| EFCAB14 | EF-hand calcium-binding domain-containing protein 14 | 2 | UniProt NCBI |
| CR2 | Complement receptor type 2 (Cr2) (Complement C3d receptor) (Epstein-Barr virus receptor) (EBV receptor) (CD antigen CD21) | 5 | UniProt NCBI |
| PLA2G2E | Group IIE secretory phospholipase A2 (GIIE sPLA2) (sPLA2-IIE) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase 2E) | 5 | UniProt NCBI |
| NAGPA | N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (EC 3.1.4.45) (Mannose 6-phosphate-uncovering enzyme) (Phosphodiester alpha-GlcNAcase) | 5 | UniProt NCBI |
| NUDT18 | 8-oxo-dGDP phosphatase NUDT18 (EC 3.6.1.58) (2-hydroxy-dADP phosphatase) (7,8-dihydro-8-oxoguanine phosphatase) (MutT homolog 3) (Nucleoside diphosphate-linked moiety X motif 18) (Nudix motif 18) | 5 | UniProt NCBI |
| ACE | Angiotensin-converting enzyme (ACE) (EC 3.4.15.1) (Dipeptidyl carboxypeptidase I) (Kininase II) (CD antigen CD143) [Cleaved into: Angiotensin-converting enzyme, soluble form] | 5 | UniProt NCBI |
| ITGA5 | Integrin alpha-5 (CD49 antigen-like family member E) (Fibronectin receptor subunit alpha) (Integrin alpha-F) (VLA-5) (CD antigen CD49e) [Cleaved into: Integrin alpha-5 heavy chain; Integrin alpha-5 light chain] | 5 | UniProt NCBI |
| MERTK | Tyrosine-protein kinase Mer (EC 2.7.10.1) (Proto-oncogene c-Mer) (Receptor tyrosine kinase MerTK) | 5 | UniProt NCBI |
| PTPRG | Receptor-type tyrosine-protein phosphatase gamma (Protein-tyrosine phosphatase gamma) (R-PTP-gamma) (EC 3.1.3.48) | 5 | UniProt NCBI |
| HEG1 | Protein HEG homolog 1 | 5 | UniProt NCBI |
| NECTIN1 | Nectin-1 (Herpes virus entry mediator C) (Herpesvirus entry mediator C) (HveC) (Herpesvirus Ig-like receptor) (HIgR) (Nectin cell adhesion molecule 1) (Poliovirus receptor-related protein 1) (CD antigen CD111) | 5 | UniProt NCBI |
| FCN2 | Ficolin-2 (37 kDa elastin-binding protein) (Collagen/fibrinogen domain-containing protein 2) (EBP-37) (Ficolin-B) (Ficolin-beta) (Hucolin) (L-ficolin) (Serum lectin p35) | 5 | UniProt NCBI |
| SDK1 | Protein sidekick-1 | 5 | UniProt NCBI |
| LGALS1 | Galectin-1 (Gal-1) (14 kDa laminin-binding protein) (HLBP14) (14 kDa lectin) (Beta-galactoside-binding lectin L-14-I) (Galaptin) (HBL) (HPL) (Lactose-binding lectin 1) (Lectin galactoside-binding soluble 1) (Putative MAPK-activating protein PM12) (S-Lac lectin 1) | 5 | UniProt NCBI |
| GRAMD2A | GRAM domain-containing protein 2A | 5 | UniProt NCBI |
| ITGA1 | Integrin alpha-1 (CD49 antigen-like family member A) (Laminin and collagen receptor) (VLA-1) (CD antigen CD49a) | 5 | UniProt NCBI |
| JAG1 | Protein jagged-1 (Jagged1) (hJ1) (CD antigen CD339) | 5 | UniProt NCBI |
| MEGF9 | Multiple epidermal growth factor-like domains protein 9 (Multiple EGF-like domains protein 9) (Epidermal growth factor-like protein 5) (EGF-like protein 5) | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2383 | 0.000306067313039 | 0.125 | TGM2 ITGA5 | ITGA5-ITGB1-FN1-TGM2 complex |
| KEGG:03266 | 0.00139513989803 | 0.125 | NECTIN1 ITGA5 | Virion - Herpesvirus |
| WP:WP3413 | 0.013030160209 | 0.125 | JAG1 ITGA1 | NOTCH1 regulation of endothelial cell calcification |
| WP:WP4217 | 0.0281767092608 | 0.1875 | MERTK ITGA5 ITGA1 | Ebola virus infection in host |
| GO:0098609 | 0.045418693831 | 0.4375 | ITGA1 NECTIN1 PLA2G2E LGALS1 JAG1 SDK1 ITGA5 | cell-cell adhesion |
| CORUM:2882 | 0.0497620750785 | 0.0625 | ITGA5 | ITGA5-ITGB3-COL6A3 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| LGALS1 | MEGF9 | 0.993 | 0.064 |
| LGALS1 | NAGPA | 0.992 | 0.106 |
| ITGA5 | TGM2 | 0.982 | 0.154 |
| LGALS1 | ACE | 0.982 | 0.282 |
| LGALS1 | ITGA1 | 0.981 | 0.18 |
| LGALS1 | EFCAB14 | 0.98 | 0.07 |
| CR2 | LGALS1 | 0.975 | 0.0961818181818 |
| HEG1 | ITGA1 | 0.967 | 0.074 |
| ITGA1 | ITGA5 | 0.966 | 0.144 |
| ITGA5 | PLA2G2E | 0.957 | |
| LGALS1 | ITGA5 | 0.955 | 0.17 |
| NECTIN1 | ITGA1 | 0.955 | 0.056 |
| HEG1 | NECTIN1 | 0.954 | 0.052 |
| LGALS1 | NECTIN1 | 0.953 | 0.126 |
| NECTIN1 | ITGA5 | 0.947 | 0.11 |
| ACE | MEGF9 | 0.946 | 0.078 |
| MEGF9 | EFCAB14 | 0.946 | 0.064 |
| ACE | EFCAB14 | 0.946 | 0.07 |
| LGALS1 | MERTK | 0.941 | 0.088 |
| NECTIN1 | PTPRG | 0.932 | 0.088 |
| ACE | HEG1 | 0.931 | 0.059 |
| LGALS1 | PTPRG | 0.931 | 0.156 |
| LGALS1 | SDK1 | 0.929 | |
| ACE | ITGA1 | 0.923 | 0.14 |
| EFCAB14 | ITGA1 | 0.923 | 0.106583333333 |
| HEG1 | ITGA5 | 0.906 | 0.11 |
| NUDT18 | HEG1 | 0.904 | 0.072 |
| LGALS1 | JAG1 | 0.902 | 0.246785714286 |
| CR2 | MEGF9 | 0.902 | |
| CR2 | ACE | 0.902 | 0.106 |
| CR2 | NECTIN1 | 0.902 | |
| CR2 | ITGA1 | 0.902 | 0.141583333333 |
| MEGF9 | NECTIN1 | 0.902 | 0.064 |
| ACE | NECTIN1 | 0.902 | 0.13 |
| NUDT18 | FCN2 | 0.902 | |
| EFCAB14 | GRAMD2A | 0.902 | |
| CR2 | EFCAB14 | 0.902 | |
| FCN2 | HEG1 | 0.902 | |
| EFCAB14 | NECTIN1 | 0.902 | 0.054 |
| CR2 | JAG1 | 0.902 | |
| ACE | JAG1 | 0.902 | 0.198 |
| CR2 | HEG1 | 0.902 | |
| MEGF9 | JAG1 | 0.902 | 0.146 |
| NECTIN1 | JAG1 | 0.902 | 0.092 |
| ITGA1 | PTPRG | 0.899 | 0.156 |
| HEG1 | PTPRG | 0.895 | 0.108 |
| CR2 | NAGPA | 0.892 | |
| CR2 | ITGA5 | 0.881 | 0.13 |
| PTPRG | ITGA5 | 0.88 | 0.088 |
| LGALS1 | HEG1 | 0.878 | 0.116 |
| ACE | ITGA5 | 0.874 | 0.31 |
| ITGA1 | SDK1 | 0.832 | |
| MEGF9 | ITGA1 | 0.827 | 0.118 |
| NAGPA | ACE | 0.826 | 0.05 |
| MEGF9 | HEG1 | 0.826 | 0.112 |
| ACE | PTPRG | 0.787 | 0.118 |
| NAGPA | ITGA1 | 0.78 | 0.074 |
| EFCAB14 | HEG1 | 0.776 | 0.052 |
| NAGPA | MEGF9 | 0.757 | 0.058 |
| MEGF9 | ITGA5 | 0.74 | 0.07 |
| PTPRG | JAG1 | 0.739 | 0.27 |
| EFCAB14 | JAG1 | 0.717 | 0.14 |
| NAGPA | NECTIN1 | 0.715 | 0.094 |
| EFCAB14 | ITGA5 | 0.661 | 0.112 |
| MEGF9 | PTPRG | 0.658 | 0.12 |
| ITGA1 | JAG1 | 0.656 | 0.246 |
| CR2 | PTPRG | 0.654 | |
| HEG1 | SDK1 | 0.619 | |
| NAGPA | EFCAB14 | 0.541 | 0.088 |
| EFCAB14 | PTPRG | 0.5 | 0.06 |
| ITGA5 | SDK1 | 0.478 | |
| HEG1 | JAG1 | 0.468 | 0.208 |
| NAGPA | ITGA5 | 0.441 | 0.074 |
| EFCAB14 | MERTK | 0.415 | 0.092 |
| ACE | MERTK | 0.415 | 0.102 |
| NECTIN1 | SDK1 | 0.401 | |
| NAGPA | JAG1 | 0.401 | 0.132 |
| ITGA5 | JAG1 | 0.391 | 0.288 |
| NAGPA | HEG1 | 0.367 | 0.17 |
| MEGF9 | MERTK | 0.274 | 0.12 |
| EFCAB14 | SDK1 | 0.25 | |
| ACE | SDK1 | 0.25 | |
| SDK1 | MERTK | 0.247 | |
| FCN2 | PTPRG | 0.242 | |
| NAGPA | PTPRG | 0.215 | 0.084 |
| CR2 | MERTK | 0.214 | |
| CR2 | SDK1 | 0.214 | |
| PTPRG | SDK1 | 0.198 | |
| NECTIN1 | MERTK | 0.146 | 0.128 |
| MEGF9 | SDK1 | 0.113 | |
| HEG1 | MERTK | 0.095 | 0.104 |
| ITGA5 | MERTK | 0.091 | 0.086 |
| PTPRG | MERTK | 0.082 | 0.124 |
| ITGA1 | MERTK | 0.079 | 0.064 |
| NAGPA | SDK1 | 0.079 | |
| NAGPA | MERTK | 0.076 | 0.118 |
| SDK1 | JAG1 | 0.055 | |
| NUDT18 | PTPRG | 0.046 | 0.08 |
| MERTK | JAG1 | 0.046 | 0.212 |
| LGALS1 | TGM2 | 0.034 | 0.39 |
Related Complexes