hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14794.1
Complex Portal: CPX-14825
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CARMIL1 | F-actin-uncapping protein LRRC16A (CARMIL homolog) (Capping protein regulator and myosin 1 linker protein 1) (Capping protein, Arp2/3 and myosin-I linker homolog 1) (Capping protein, Arp2/3 and myosin-I linker protein 1) (Leucine-rich repeat-containing protein 16A) | 5 | UniProt NCBI |
| PAK5 | Serine/threonine-protein kinase PAK 5 (EC 2.7.11.1) (p21-activated kinase 5) (PAK-5) (p21-activated kinase 7) (PAK-7) | 5 | UniProt NCBI |
| ARHGEF11 | Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF) | 5 | UniProt NCBI |
| GMPPA | Mannose-1-phosphate guanyltransferase alpha (GDP-mannose pyrophosphorylase A) (GMPP-alpha) (GTP-mannose-1-phosphate guanylyltransferase alpha) | 5 | UniProt NCBI |
| PARM1 | Prostate androgen-regulated mucin-like protein 1 (PARM-1) | 5 | UniProt NCBI |
| FAM124B | Protein FAM124B | 5 | UniProt NCBI |
| PAK4 | Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-428540 | 0.00296507918884 | 0.285714285714 | PAK5 PAK4 | Activation of RAC1 |
| REAC:R-HSA-9013148 | 0.00413825544794 | 0.428571428571 | PAK5 PAK4 ARHGEF11 | CDC42 GTPase cycle |
| REAC:R-HSA-9013149 | 0.00814566466165 | 0.428571428571 | PAK5 PAK4 ARHGEF11 | RAC1 GTPase cycle |
| WP:WP4564 | 0.00991981492579 | 0.285714285714 | PAK5 PAK4 | Neural crest cell migration during development |
| WP:WP4565 | 0.0111348137492 | 0.285714285714 | PAK5 PAK4 | Neural crest cell migration in cancer |
| WP:WP4534 | 0.0137733753117 | 0.285714285714 | PAK5 PAK4 | Mechanoregulation and pathology of YAP TAZ via Hippo and non Hippo mechanisms |
| KEGG:05211 | 0.0210427715268 | 0.285714285714 | PAK5 PAK4 | Renal cell carcinoma |
| REAC:R-HSA-9013407 | 0.0212237900738 | 0.285714285714 | PAK5 PAK4 | RHOH GTPase cycle |
| WP:WP4205 | 0.028073243565 | 0.285714285714 | PAK5 PAK4 | MET in type 1 papillary renal cell carcinoma |
| KEGG:04012 | 0.0287602683365 | 0.285714285714 | PAK5 PAK4 | ErbB signaling pathway |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PAK4 | PAK5 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| ARHGEF11 | PAK5 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| CARMIL1 | PARM1 | 0.992 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| CARMIL1 | PAK5 | 0.985 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| GMPPA | PAK5 | 0.981 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| ARHGEF11 | FAM124B | 0.934 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| ARHGEF11 | CARMIL1 | 0.886 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| ARHGEF11 | PAK4 | 0.848 | bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | ||
| PAK4 | CARMIL1 | 0.685 | 0.026 | bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| ARHGEF11 | GMPPA | 0.133 | bioplex_WMM bioplex3_WMM WMM_only | ||
| GMPPA | CARMIL1 | 0.052 | 0.024 | bioplex_WMM bioplex3_WMM WMM_only | |
| PAK4 | GMPPA | 0.028 | 0.03 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM |
Related Complexes