hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14796.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| AP5S1 | AP-5 complex subunit sigma-1 (Adaptor-related protein complex 5 sigma subunit) (Sigma5) | 5 | UniProt NCBI |
| ZFYVE26 | Zinc finger FYVE domain-containing protein 26 (FYVE domain-containing centrosomal protein) (FYVE-CENT) (Spastizin) | 5 | UniProt NCBI |
| AP5Z1 | AP-5 complex subunit zeta-1 (Adaptor-related protein complex 5 zeta subunit) (Zeta5) | 5 | UniProt NCBI |
| SPG11 | Spatacsin (Colorectal carcinoma-associated protein) (Spastic paraplegia 11 protein) | 5 | UniProt NCBI |
| AP5B1 | AP-5 complex subunit beta-1 (Adaptor-related protein complex 5 beta subunit) (Beta5) | 4 | UniProt NCBI |
| AP5M1 | AP-5 complex subunit mu-1 (Adaptor-related protein complex 5 subunit mu-1) (Mu5) (Mu-2-related death-inducing protein) (MuD) (Putative HIV-1 infection-related protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6602 | 8.99732797057e-21 | 1.0 | AP5Z1 SPG11 AP5S1 ZFYVE26 AP5B1 AP5M1 | AP5-SPG11-SPG15 complex |
| CORUM:6626 | 9.60315000334e-13 | 0.666666666667 | AP5B1 AP5M1 AP5S1 AP5Z1 | AP5 adaptor complex |
| GO:0044599 | 3.94689465137e-10 | 0.666666666667 | AP5B1 AP5M1 AP5S1 AP5Z1 | AP-5 adaptor complex |
| GO:0030119 | 2.05958456954e-05 | 0.666666666667 | AP5B1 AP5M1 AP5S1 AP5Z1 | AP-type membrane coat adaptor complex |
| HP:0002839 | 6.77932406197e-05 | 0.5 | SPG11 ZFYVE26 AP5Z1 | Urinary bladder sphincter dysfunction |
| GO:0005770 | 0.000138916017944 | 0.833333333333 | AP5M1 AP5B1 AP5Z1 AP5S1 ZFYVE26 | late endosome |
| GO:0030117 | 0.000870570917794 | 0.666666666667 | AP5B1 AP5M1 AP5S1 AP5Z1 | membrane coat |
| GO:0048475 | 0.000870570917794 | 0.666666666667 | AP5B1 AP5M1 AP5S1 AP5Z1 | coated membrane |
| HP:0002064 | 0.00134028574518 | 0.5 | SPG11 ZFYVE26 AP5Z1 | Spastic gait |
| HP:0030890 | 0.00153388121466 | 0.5 | SPG11 ZFYVE26 AP5Z1 | Hyperintensity of cerebral white matter on MRI |
| HP:0001258 | 0.00500109820736 | 0.5 | SPG11 ZFYVE26 AP5Z1 | Spastic paraplegia |
| HP:0000020 | 0.00900226782501 | 0.5 | SPG11 ZFYVE26 AP5Z1 | Urinary incontinence |
| HP:0010550 | 0.00990331418434 | 0.5 | SPG11 ZFYVE26 AP5Z1 | Paraplegia |
| HP:0031064 | 0.0153102613551 | 0.5 | SPG11 ZFYVE26 AP5Z1 | Impaired continence |
| HP:0001152 | 0.0184186741717 | 0.333333333333 | SPG11 ZFYVE26 | Saccadic smooth pursuit |
| HP:0031058 | 0.0186233915395 | 0.5 | SPG11 ZFYVE26 AP5Z1 | Impairment of activities of daily living |
| GO:0005764 | 0.026442044167 | 0.833333333333 | SPG11 AP5B1 AP5M1 AP5S1 ZFYVE26 | lysosome |
| GO:0000323 | 0.026442044167 | 0.833333333333 | SPG11 AP5B1 AP5M1 AP5S1 ZFYVE26 | lytic vacuole |
| HP:0006986 | 0.0272311241025 | 0.333333333333 | SPG11 ZFYVE26 | Upper limb spasticity |
| HP:0010551 | 0.0333560250352 | 0.5 | SPG11 ZFYVE26 AP5Z1 | Paraplegia/paraparesis |
| HP:0007340 | 0.038243542052 | 0.5 | SPG11 ZFYVE26 AP5Z1 | Lower limb muscle weakness |
| HP:0002061 | 0.0388140472191 | 0.5 | SPG11 ZFYVE26 AP5Z1 | Lower limb spasticity |
| GO:0005773 | 0.0427446223865 | 0.833333333333 | SPG11 AP5B1 AP5M1 AP5S1 ZFYVE26 | vacuole |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| AP5S1 | ZFYVE26 | 0.999 | 0.148 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| AP5Z1 | SPG11 | 0.999 | 0.15 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| AP5M1 | AP5B1 | 0.999 | 0.18 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| AP5S1 | AP5Z1 | 0.998 | 0.334 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| AP5S1 | SPG11 | 0.998 | 0.112 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| SPG11 | AP5M1 | 0.998 | 0.202 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| AP5S1 | AP5M1 | 0.998 | 0.232 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| SPG11 | AP5B1 | 0.998 | 0.268 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| AP5S1 | AP5B1 | 0.998 | 0.444 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| ZFYVE26 | AP5M1 | 0.811 | 0.174 | bioplex3_WMM WMM_only |
| AP5Z1 | AP5M1 | 0.804 | 0.102 | bioplex3_WMM WMM_only |
| AP5Z1 | AP5B1 | 0.76 | 0.554 | bioplex3_WMM WMM_only |
| ZFYVE26 | AP5Z1 | 0.727 | 0.214 | bioplex3_WMM WMM_only |
| ZFYVE26 | SPG11 | 0.722 | 0.198 | bioplex3_WMM WMM_only |
| ZFYVE26 | AP5B1 | 0.431 | 0.188 | bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| AP5S1 | huMAP3_01297.1 huMAP3_09124.1 huMAP3_14796.1 |
| ZFYVE26 | huMAP3_01297.1 huMAP3_09124.1 huMAP3_14796.1 |
| AP5Z1 | huMAP3_01297.1 huMAP3_09124.1 huMAP3_14796.1 |
| SPG11 | huMAP3_01297.1 huMAP3_09124.1 huMAP3_14796.1 |
| AP5B1 | huMAP3_01420.1 huMAP3_09124.1 huMAP3_14796.1 |
| AP5M1 | huMAP3_01297.1 huMAP3_09124.1 huMAP3_12854.1 huMAP3_14796.1 |