hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_14808.1

Complex Portal: CPX-17893

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
CHP2	Calcineurin B homologous protein 2 (Hepatocellular carcinoma-associated antigen 520)	5	UniProt NCBI
CENPI	Centromere protein I (CENP-I) (FSH primary response protein 1) (Follicle-stimulating hormone primary response protein) (Interphase centromere complex protein 19) (Leucine-rich primary response protein 1)	5	UniProt NCBI
CENPO	Centromere protein O (CENP-O) (Interphase centromere complex protein 36)	5	UniProt NCBI
ITGB3BP	Centromere protein R (CENP-R) (Beta-3-endonexin) (Integrin beta-3-binding protein) (Nuclear receptor-interacting factor 3)	5	UniProt NCBI
CENPK	Centromere protein K (CENP-K) (Interphase centromere complex protein 37) (Protein AF-5alpha) (p33)	5	UniProt NCBI
CENPM	Centromere protein M (CENP-M) (Interphase centromere complex protein 39) (Proliferation-associated nuclear element protein 1)	5	UniProt NCBI
CENPT	Centromere protein T (CENP-T) (Interphase centromere complex protein 22)	5	UniProt NCBI
CENPQ	Centromere protein Q (CENP-Q)	5	UniProt NCBI
ZFX	Zinc finger X-chromosomal protein	5	UniProt NCBI
CENPH	Centromere protein H (CENP-H) (Interphase centromere complex protein 35)	5	UniProt NCBI
CENPP	Centromere protein P (CENP-P)	5	UniProt NCBI
TBC1D13	TBC1 domain family member 13	4	UniProt NCBI
CENPW	Centromere protein W (CENP-W) (Cancer-up-regulated gene 2 protein)	5	UniProt NCBI
CENPN	Centromere protein N (CENP-N) (Interphase centromere complex protein 32)	5	UniProt NCBI
CENPU	Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1)	5	UniProt NCBI
CENPX	Centromere protein X (CENP-X) (FANCM-associated histone fold protein 2) (FANCM-interacting histone fold protein 2) (Fanconi anemia-associated polypeptide of 10 kDa) (Retinoic acid-inducible gene D9 protein homolog) (Stimulated by retinoic acid gene 13 protein homolog)	5	UniProt NCBI
CENPL	Centromere protein L (CENP-L) (Interphase centromere complex protein 33)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0000939	3.11280041744e-39	0.875	CENPW CENPP ITGB3BP CENPQ CENPT CENPK CENPM CENPN CENPH CENPU CENPI CENPO CENPL CENPX	inner kinetochore
CORUM:7394	1.22423108745e-33	0.6875	CENPU CENPP ITGB3BP CENPQ CENPK CENPM CENPN CENPH CENPI CENPO CENPL	CENP-H-I complex
CORUM:1179	9.54300950367e-32	0.6875	CENPU CENPP ITGB3BP CENPQ CENPT CENPK CENPM CENPN CENPH CENPO CENPL	CENP-A NAC-CAD complex
REAC:R-HSA-774815	3.39547242668e-30	0.875	CENPW CENPP ITGB3BP CENPQ CENPT CENPK CENPM CENPN CENPH CENPU CENPI CENPO CENPL CENPX	Nucleosome assembly
REAC:R-HSA-606279	3.39547242668e-30	0.875	CENPW CENPP ITGB3BP CENPQ CENPT CENPK CENPM CENPN CENPH CENPU CENPI CENPO CENPL CENPX	Deposition of new CENPA-containing nucleosomes at the centromere
REAC:R-HSA-73886	2.31628904381e-25	0.875	CENPW CENPP ITGB3BP CENPQ CENPT CENPK CENPM CENPN CENPH CENPU CENPI CENPO CENPL CENPX	Chromosome Maintenance
GO:0000776	1.20909463148e-22	0.875	CENPW CENPP ITGB3BP CENPQ CENPT CENPK CENPM CENPN CENPH CENPU CENPI CENPO CENPL CENPX	kinetochore
GO:0000779	1.84489428651e-22	0.875	CENPW CENPP ITGB3BP CENPQ CENPT CENPK CENPM CENPN CENPH CENPU CENPI CENPO CENPL CENPX	condensed chromosome, centromeric region
REAC:R-HSA-141424	9.5862994136e-22	0.75	CENPU CENPP ITGB3BP CENPQ CENPT CENPK CENPM CENPN CENPH CENPI CENPO CENPL	Amplification of signal from the kinetochores
REAC:R-HSA-141444	9.5862994136e-22	0.75	CENPU CENPP ITGB3BP CENPQ CENPT CENPK CENPM CENPN CENPH CENPI CENPO CENPL	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
REAC:R-HSA-69618	7.33794988328e-21	0.75	CENPU CENPP ITGB3BP CENPQ CENPT CENPK CENPM CENPN CENPH CENPI CENPO CENPL	Mitotic Spindle Checkpoint
REAC:R-HSA-9648025	1.29869303848e-20	0.75	CENPU CENPP ITGB3BP CENPQ CENPT CENPK CENPM CENPN CENPH CENPI CENPO CENPL	EML4 and NUDC in mitotic spindle formation
GO:0000775	2.23183001835e-20	0.875	CENPW CENPP ITGB3BP CENPQ CENPT CENPK CENPM CENPN CENPH CENPU CENPI CENPO CENPL CENPX	chromosome, centromeric region
REAC:R-HSA-2500257	3.06947700745e-20	0.75	CENPU CENPP ITGB3BP CENPQ CENPT CENPK CENPM CENPN CENPH CENPI CENPO CENPL	Resolution of Sister Chromatid Cohesion
GO:0000793	3.97860912846e-20	0.875	CENPW CENPP ITGB3BP CENPQ CENPT CENPK CENPM CENPN CENPH CENPU CENPI CENPO CENPL CENPX	condensed chromosome
REAC:R-HSA-5663220	9.12720897515e-20	0.75	CENPU CENPP ITGB3BP CENPQ CENPT CENPK CENPM CENPN CENPH CENPI CENPO CENPL	RHO GTPases Activate Formins
REAC:R-HSA-2467813	5.62489385279e-18	0.75	CENPU CENPP ITGB3BP CENPQ CENPT CENPK CENPM CENPN CENPH CENPI CENPO CENPL	Separation of Sister Chromatids
REAC:R-HSA-68877	1.14988579064e-17	0.75	CENPU CENPP ITGB3BP CENPQ CENPT CENPK CENPM CENPN CENPH CENPI CENPO CENPL	Mitotic Prometaphase
GO:0098687	2.42083789917e-17	0.875	CENPW CENPP ITGB3BP CENPQ CENPT CENPK CENPM CENPN CENPH CENPU CENPI CENPO CENPL CENPX	chromosomal region
GO:0007059	2.89123634457e-17	0.875	CENPW CENPP ITGB3BP CENPQ CENPT CENPK CENPM CENPN CENPH CENPU CENPI CENPO CENPL CENPX	chromosome segregation
REAC:R-HSA-68882	5.969674614e-17	0.75	CENPU CENPP ITGB3BP CENPQ CENPT CENPK CENPM CENPN CENPH CENPI CENPO CENPL	Mitotic Anaphase
REAC:R-HSA-2555396	6.30596471626e-17	0.75	CENPU CENPP ITGB3BP CENPQ CENPT CENPK CENPM CENPN CENPH CENPI CENPO CENPL	Mitotic Metaphase and Anaphase
REAC:R-HSA-69620	9.20293454996e-16	0.75	CENPU CENPP ITGB3BP CENPQ CENPT CENPK CENPM CENPN CENPH CENPI CENPO CENPL	Cell Cycle Checkpoints
REAC:R-HSA-195258	1.88946897145e-15	0.75	CENPU CENPP ITGB3BP CENPQ CENPT CENPK CENPM CENPN CENPH CENPI CENPO CENPL	RHO GTPase Effectors
REAC:R-HSA-1640170	3.13292371074e-15	0.875	CENPW CENPP ITGB3BP CENPQ CENPT CENPK CENPM CENPN CENPH CENPU CENPI CENPO CENPL CENPX	Cell Cycle
REAC:R-HSA-68886	4.85817317921e-14	0.75	CENPU CENPP ITGB3BP CENPQ CENPT CENPK CENPM CENPN CENPH CENPI CENPO CENPL	M Phase
CORUM:929	9.76990211627e-14	0.4375	CENPH CENPM CENPO CENPK CENPI CENPU CENPL	CEN complex
CORUM:927	2.14399101829e-13	0.3125	CENPU CENPH CENPN CENPM CENPT	CENP-A NAC complex
REAC:R-HSA-69278	1.94979065754e-12	0.75	CENPU CENPP ITGB3BP CENPQ CENPT CENPK CENPM CENPN CENPH CENPI CENPO CENPL	Cell Cycle, Mitotic
REAC:R-HSA-194315	1.68859896296e-11	0.75	CENPU CENPP ITGB3BP CENPQ CENPT CENPK CENPM CENPN CENPH CENPI CENPO CENPL	Signaling by Rho GTPases
REAC:R-HSA-9716542	2.19518933063e-11	0.75	CENPU CENPP ITGB3BP CENPQ CENPT CENPK CENPM CENPN CENPH CENPI CENPO CENPL	Signaling by Rho GTPases, Miro GTPases and RHOBTB3
CORUM:7388	2.81942940922e-11	0.3125	CENPI CENPN CENPT CENPL CENPH	CENP-A nucleosomal complex
GO:0099080	3.51848959527e-11	0.875	CENPW CENPP ITGB3BP CENPQ CENPT CENPK CENPM CENPN CENPH CENPU CENPI CENPO CENPL CENPX	supramolecular complex
GO:0022402	1.79874023641e-10	0.875	CENPW CENPP ITGB3BP CENPQ CENPT CENPK CENPM CENPN CENPH CENPU CENPI CENPO CENPL CENPX	cell cycle process
GO:0007049	5.70309259824e-09	0.875	CENPW CENPP ITGB3BP CENPQ CENPT CENPK CENPM CENPN CENPH CENPU CENPI CENPO CENPL CENPX	cell cycle
GO:0005694	2.49839209217e-08	0.875	CENPW CENPP ITGB3BP CENPQ CENPT CENPK CENPM CENPN CENPH CENPU CENPI CENPO CENPL CENPX	chromosome
CORUM:6146	1.95604750042e-07	0.1875	CENPW CENPT CENPX	CENP-T-W-S-X heterotetramer complex
REAC:R-HSA-162582	1.49542236193e-05	0.75	CENPU CENPP ITGB3BP CENPQ CENPT CENPK CENPM CENPN CENPH CENPI CENPO CENPL	Signal Transduction
CORUM:6144	5.10764421909e-05	0.125	CENPW CENPT	CENP-T-W complex
GO:0005654	0.000481496546311	0.9375	CENPW CENPP ITGB3BP CENPQ CENPM CENPO CENPK CENPN CENPL CENPI CENPU CHP2 CENPT CENPH CENPX	nucleoplasm
GO:0043228	0.000713692955411	0.9375	CENPW CENPP ITGB3BP CENPQ CENPM CENPO CENPK CENPN CENPL CENPI CENPU CHP2 CENPT CENPH CENPX	non-membrane-bounded organelle
GO:0043232	0.000713692955411	0.9375	CENPW CENPP ITGB3BP CENPQ CENPM CENPO CENPK CENPN CENPL CENPI CENPU CHP2 CENPT CENPH CENPX	intracellular non-membrane-bounded organelle
GO:0031981	0.00124381652533	0.9375	CENPW CENPP ITGB3BP CENPQ CENPM CENPO CENPK CENPN CENPL CENPI CENPU CHP2 CENPT CENPH CENPX	nuclear lumen
GO:0070013	0.0289366042636	0.9375	CENPW CENPP ITGB3BP CENPQ CENPM CENPO CENPK CENPN CENPL CENPI CENPU CHP2 CENPT CENPH CENPX	intracellular organelle lumen
GO:0031974	0.0289366042636	0.9375	CENPW CENPP ITGB3BP CENPQ CENPM CENPO CENPK CENPN CENPL CENPI CENPU CHP2 CENPT CENPH CENPX	membrane-enclosed lumen
GO:0043233	0.0289366042636	0.9375	CENPW CENPP ITGB3BP CENPQ CENPM CENPO CENPK CENPN CENPL CENPI CENPU CHP2 CENPT CENPH CENPX	organelle lumen
GO:0051383	0.0298827994283	0.1875	CENPH CENPT CENPW	kinetochore organization

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
CENPO	CENPP	1.0	0.376	structurally_consistent (Q96H22)
CENPK	CENPH	1.0	0.43
ITGB3BP	CENPP	1.0	0.298
CENPU	ITGB3BP	1.0	0.25
CENPH	CENPI	1.0	0.328
CENPU	CENPQ	1.0	0.524
CENPQ	CENPP	1.0	0.302
CENPO	ITGB3BP	0.999	0.218
CENPU	CENPO	0.999	0.364
CENPU	CENPP	0.999	0.212	structurally_consistent (dimer)
CENPO	CENPQ	0.999	0.462
ITGB3BP	CENPQ	0.999	0.302
CENPK	CENPI	0.999	0.206
CENPU	CENPI	0.999	0.268
ITGB3BP	CENPT	0.998	0.156
CENPU	CENPT	0.998	0.19
CENPP	CENPH	0.998	0.284
CENPH	CENPM	0.998	0.26
CENPN	ITGB3BP	0.998	0.21
CENPQ	CENPI	0.998	0.316	structurally_consistent (Q8N0S6)
CENPN	CENPQ	0.998	0.286
CENPN	CENPI	0.998	0.238
CENPO	CENPT	0.997	0.36
CENPO	CENPI	0.996	0.256
CENPT	CENPQ	0.996	0.172
CENPI	CENPM	0.996	0.138
CENPN	CENPU	0.996	0.322
CENPN	CENPO	0.996	0.38	structurally_consistent (dimer)
CENPU	CENPH	0.996	0.194
CENPT	CENPH	0.995	0.26
CENPU	CENPX	0.995	0.168
ITGB3BP	CENPH	0.995	0.196
CENPQ	CENPX	0.994	0.124
CENPO	CENPX	0.994	0.156
CENPN	CENPT	0.993	0.218
ITGB3BP	CENPX	0.993	0.106
CENPK	CENPM	0.993	0.22	structurally_consistent (dimer)
CENPO	CENPH	0.993	0.172
ITGB3BP	CENPI	0.993	0.206
CENPQ	CENPH	0.992	0.424
CENPP	CENPX	0.991	0.152
CENPT	CENPI	0.99	0.168
CENPP	CENPI	0.99	0.156
CENPN	CENPH	0.989	0.228
CENPL	CENPQ	0.988	0.176	structurally_consistent (dimer)
CENPN	CENPP	0.985	0.258	structurally_consistent (dimer)
TBC1D13	CENPM	0.984	0.054
CENPT	CENPP	0.984	0.138
ZFX	CENPU	0.983	0.138
ZFX	CENPI	0.973	0.108
CENPL	CENPI	0.966	0.218	structurally_consistent (dimer)
ITGB3BP	CENPK	0.965	0.194
CENPO	CENPK	0.962	0.264
CENPU	CENPK	0.962	0.228
CENPN	CENPL	0.961	0.276	structurally_consistent (dimer)
CENPQ	CENPK	0.96	0.352
CENPQ	CENPM	0.959	0.17
CENPU	CENPL	0.956	0.216	structurally_consistent (Q6IPU0)
CENPO	CENPM	0.953	0.184	structurally_consistent (Q96H22)
CENPL	CENPO	0.938	0.308	structurally_consistent (Q96H22)
CENPL	ITGB3BP	0.931	0.22
ZFX	CENPO	0.925	0.118
CENPX	CHP2	0.915
CENPU	CENPM	0.915	0.266
ZFX	CENPN	0.898	0.1
CENPX	CENPH	0.886	0.212
ZFX	ITGB3BP	0.852	0.118
CENPH	CENPW	0.848
ZFX	CENPQ	0.845	0.098
CENPT	CENPW	0.794
CENPN	CENPM	0.785	0.136	structurally_consistent (dimer)
CENPP	CENPM	0.785	0.172
CENPT	CENPK	0.785	0.166
CENPP	CENPK	0.785	0.22
CENPN	CENPK	0.785	0.224	structurally_consistent (Q9NSP4)
ITGB3BP	CENPM	0.785	0.226
CENPT	CENPM	0.785	0.136
CENPL	CENPH	0.765	0.252
CENPX	CENPM	0.764	0.148
CENPX	CENPK	0.764	0.226
CENPN	CENPX	0.764	0.134
CENPT	CENPX	0.764	0.166
CENPX	CENPI	0.764	0.124
CENPQ	CENPW	0.423
CENPL	CENPW	0.315
ZFX	CENPM	0.232	0.062
ZFX	CENPT	0.232	0.104
ZFX	CENPX	0.232	0.062
ZFX	CENPP	0.232	0.112
ZFX	CENPH	0.232	0.112
ZFX	CENPK	0.232	0.118
CENPL	CENPT	0.192	0.16
CENPX	CENPW	0.192
CENPN	CENPW	0.192
ITGB3BP	CENPW	0.192
CENPL	CENPM	0.192	0.148
CENPL	CENPX	0.192	0.134
CENPK	CENPW	0.192
CENPM	CENPW	0.192
CENPO	CENPW	0.192
CENPI	CENPW	0.192
CENPU	CENPW	0.192
CENPL	CENPK	0.192	0.182
CENPP	CENPW	0.192
CENPL	CENPP	0.192	0.294	structurally_consistent (dimer)
ZFX	CENPL	0.135	0.09

Related Complexes

Genename	Complexes
CHP2	huMAP3_11582.1 huMAP3_11696.1 huMAP3_11899.1 huMAP3_11995.1 huMAP3_12695.1 huMAP3_13031.1 huMAP3_13592.1 huMAP3_14509.1 huMAP3_14808.1 huMAP3_15172.1
CENPI	huMAP3_04427.1 huMAP3_06427.1 huMAP3_09807.1 huMAP3_11265.1 huMAP3_11899.1 huMAP3_14808.1
CENPO	huMAP3_04053.1 huMAP3_06427.1 huMAP3_09807.1 huMAP3_11899.1 huMAP3_14808.1
ITGB3BP	huMAP3_04053.1 huMAP3_06427.1 huMAP3_09807.1 huMAP3_11899.1 huMAP3_14808.1
CENPK	huMAP3_04427.1 huMAP3_06427.1 huMAP3_09807.1 huMAP3_11899.1 huMAP3_14808.1
CENPM	huMAP3_09807.1 huMAP3_11899.1 huMAP3_12305.1 huMAP3_13642.1 huMAP3_14808.1
CENPT	huMAP3_04053.1 huMAP3_06427.1 huMAP3_09807.1 huMAP3_11899.1 huMAP3_14808.1
CENPQ	huMAP3_04053.1 huMAP3_06427.1 huMAP3_09807.1 huMAP3_11899.1 huMAP3_14808.1
ZFX	huMAP3_01056.1 huMAP3_02155.1 huMAP3_04594.1 huMAP3_06427.1 huMAP3_09807.1 huMAP3_11265.1 huMAP3_11899.1 huMAP3_14808.1
CENPH	huMAP3_04427.1 huMAP3_06427.1 huMAP3_09807.1 huMAP3_11899.1 huMAP3_13975.1 huMAP3_14808.1
CENPP	huMAP3_04053.1 huMAP3_06427.1 huMAP3_09807.1 huMAP3_11899.1 huMAP3_14808.1
TBC1D13	huMAP3_04880.1 huMAP3_11899.1 huMAP3_12305.1 huMAP3_13642.1 huMAP3_14808.1 huMAP3_14813.1
CENPW	huMAP3_11899.1 huMAP3_13975.1 huMAP3_14808.1
CENPN	huMAP3_01056.1 huMAP3_06427.1 huMAP3_09807.1 huMAP3_11899.1 huMAP3_14808.1
CENPU	huMAP3_01056.1 huMAP3_06427.1 huMAP3_09807.1 huMAP3_11899.1 huMAP3_14808.1
CENPX	huMAP3_04053.1 huMAP3_06427.1 huMAP3_09167.1 huMAP3_09780.1 huMAP3_09807.1 huMAP3_09816.1 huMAP3_11696.1 huMAP3_11899.1 huMAP3_12695.1 huMAP3_13031.1 huMAP3_14509.1 huMAP3_14808.1
CENPL	huMAP3_01056.1 huMAP3_06427.1 huMAP3_09807.1 huMAP3_11899.1 huMAP3_14808.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_14808.1

Complex Portal: CPX-17893