hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14812.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LDHC | L-lactate dehydrogenase C chain (LDH-C) (EC 1.1.1.27) (Cancer/testis antigen 32) (CT32) (LDH testis subunit) (LDH-X) | 5 | UniProt NCBI |
| LDHA | L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59) | 5 | UniProt NCBI |
| LDHB | L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) | 5 | UniProt NCBI |
| LDHAL6A | L-lactate dehydrogenase A-like 6A (LDHA-like protein 6A) (EC 1.1.1.27) | 4 | UniProt NCBI |
| TMEM19 | Transmembrane protein 19 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0004457 | 6.57779757665e-10 | 0.8 | LDHC LDHAL6A LDHB LDHA | lactate dehydrogenase activity |
| GO:0004459 | 6.57779757665e-10 | 0.8 | LDHC LDHAL6A LDHB LDHA | L-lactate dehydrogenase activity |
| KEGG:00640 | 4.01312125562e-09 | 0.8 | LDHC LDHAL6A LDHB LDHA | Propanoate metabolism |
| REAC:R-HSA-70268 | 1.16894660556e-08 | 0.8 | LDHC LDHAL6A LDHB LDHA | Pyruvate metabolism |
| KEGG:00620 | 1.57296490579e-08 | 0.8 | LDHC LDHAL6A LDHB LDHA | Pyruvate metabolism |
| GO:0006089 | 1.65724193228e-08 | 0.8 | LDHC LDHAL6A LDHB LDHA | lactate metabolic process |
| KEGG:00270 | 2.07958856669e-08 | 0.8 | LDHC LDHAL6A LDHB LDHA | Cysteine and methionine metabolism |
| KEGG:00010 | 7.10279402923e-08 | 0.8 | LDHC LDHAL6A LDHB LDHA | Glycolysis / Gluconeogenesis |
| KEGG:05230 | 9.75657108053e-08 | 0.8 | LDHC LDHAL6A LDHB LDHA | Central carbon metabolism in cancer |
| REAC:R-HSA-71406 | 1.15337100464e-07 | 0.8 | LDHC LDHAL6A LDHB LDHA | Pyruvate metabolism and Citric Acid (TCA) cycle |
| WP:WP4236 | 3.45001487491e-07 | 0.6 | LDHC LDHB LDHA | Krebs cycle disorders |
| KEGG:04922 | 3.55181171997e-07 | 0.8 | LDHC LDHAL6A LDHB LDHA | Glucagon signaling pathway |
| KEGG:04066 | 4.78327275688e-07 | 0.8 | LDHC LDHAL6A LDHB LDHA | HIF-1 signaling pathway |
| WP:WP534 | 1.3807096837e-05 | 0.6 | LDHC LDHB LDHA | Glycolysis and gluconeogenesis |
| REAC:R-HSA-1428517 | 1.3881982562e-05 | 0.8 | LDHC LDHAL6A LDHB LDHA | The citric acid (TCA) cycle and respiratory electron transport |
| WP:WP4018 | 8.09375187038e-05 | 0.6 | LDHC LDHB LDHA | Clear cell renal cell carcinoma pathways |
| WP:WP5355 | 0.000122528877875 | 0.6 | LDHC LDHB LDHA | Metabolic Epileptic Disorders |
| GO:0006090 | 0.000305379790485 | 0.8 | LDHC LDHAL6A LDHB LDHA | pyruvate metabolic process |
| WP:WP5314 | 0.00032310719867 | 0.4 | LDHA LDHB | Lactate shuttle in glial cells |
| GO:0016616 | 0.000556087531591 | 0.8 | LDHC LDHAL6A LDHB LDHA | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| GO:0016614 | 0.000755130188848 | 0.8 | LDHC LDHAL6A LDHB LDHA | oxidoreductase activity, acting on CH-OH group of donors |
| KEGG:01100 | 0.0139298332568 | 0.8 | LDHC LDHAL6A LDHB LDHA | Metabolic pathways |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| LDHC | LDHA | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction | |
| LDHB | LDHC | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| LDHB | LDHA | 0.997 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM | |
| LDHC | LDHAL6A | 0.974 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TMEM19 | LDHA | 0.863 | bioplex3_WMM WMM_only | |
| LDHAL6A | LDHA | 0.825 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LDHB | LDHAL6A | 0.069 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LDHB | TMEM19 | 0.016 | 0.052 | bioplex3_WMM WMM_only |
Related Complexes