hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14824.1
Complex Portal: CPX-21873
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TMEM220 | Transmembrane protein 220 | 2 | UniProt NCBI |
| PPIAL4G | Peptidyl-prolyl cis-trans isomerase A-like 4G (PPIase A-like 4G) (EC 5.2.1.8) (Peptidylprolyl cis-trans isomerase A-like 4) | 3 | UniProt NCBI |
| DCHS1 | Protocadherin-16 (Cadherin-19) (Cadherin-25) (Fibroblast cadherin-1) (Protein dachsous homolog 1) | 5 | UniProt NCBI |
| FAT4 | Protocadherin Fat 4 (hFat4) (Cadherin family member 14) (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) | 5 | UniProt NCBI |
| FAT3 | Protocadherin Fat 3 (hFat3) (Cadherin family member 15) (FAT tumor suppressor homolog 3) | 5 | UniProt NCBI |
| DCDC2B | Doublecortin domain-containing protein 2B | 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0200138 | 0.000324079809263 | 0.333333333333 | FAT4 DCHS1 | Bilateral choanal atresia/stenosis |
| HP:0002825 | 0.000648041335154 | 0.333333333333 | FAT4 DCHS1 | Caudal appendage |
| HP:0040079 | 0.00161951205762 | 0.333333333333 | FAT4 DCHS1 | Irregular dentition |
| HP:0008519 | 0.00161951205762 | 0.333333333333 | FAT4 DCHS1 | Abnormal coccyx morphology |
| KEGG:04392 | 0.00235248417572 | 0.333333333333 | FAT4 DCHS1 | Hippo signaling pathway - multiple species |
| HP:0004502 | 0.00388470114881 | 0.333333333333 | FAT4 DCHS1 | Bilateral choanal atresia |
| HP:0032409 | 0.00485499013014 | 0.333333333333 | FAT4 DCHS1 | Subcortical band heterotopia |
| HP:0010044 | 0.00593279372985 | 0.333333333333 | FAT4 DCHS1 | Short 4th metacarpal |
| HP:0032391 | 0.00593279372985 | 0.333333333333 | FAT4 DCHS1 | Subcortical heterotopia |
| HP:0010042 | 0.00711805296098 | 0.333333333333 | FAT4 DCHS1 | Aplasia/Hypoplasia of the 4th metacarpal |
| HP:0004689 | 0.00841070885474 | 0.333333333333 | FAT4 DCHS1 | Short fourth metatarsal |
| HP:0040035 | 0.00841070885474 | 0.333333333333 | FAT4 DCHS1 | Abnormality of the fourth metatarsal bone |
| HP:0010012 | 0.0129324670968 | 0.333333333333 | FAT4 DCHS1 | Abnormal 4th metacarpal morphology |
| HP:0032388 | 0.0146541203169 | 0.333333333333 | FAT4 DCHS1 | Periventricular nodular heterotopia |
| HP:0008197 | 0.0297012565438 | 0.333333333333 | FAT4 DCHS1 | Absence of pubertal development |
| HP:0010537 | 0.0297012565438 | 0.333333333333 | FAT4 DCHS1 | Wide cranial sutures |
| HP:0000452 | 0.0322780794397 | 0.333333333333 | FAT4 DCHS1 | Choanal stenosis |
| HP:0002025 | 0.0406481036194 | 0.333333333333 | FAT4 DCHS1 | Anal stenosis |
| HP:0010554 | 0.0499762286031 | 0.333333333333 | FAT4 DCHS1 | Cutaneous finger syndactyly |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| FAT3 | DCDC2B | 0.969 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| FAT3 | PPIAL4G | 0.91 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| DCDC2B | FAT4 | 0.903 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| DCHS1 | PPIAL4G | 0.865 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| PPIAL4G | TMEM220 | 0.838 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| PPIAL4G | FAT4 | 0.837 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| FAT3 | FAT4 | 0.511 | 0.1 | bioplex_WMM bioplex3_WMM WMM_only | |
| DCHS1 | FAT4 | 0.461 | 0.11 | bioplex_WMM bioplex3_WMM WMM_only | |
| DCHS1 | FAT3 | 0.415 | 0.06 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes