hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_14834.1

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
MAX	Protein max (Class D basic helix-loop-helix protein 4) (bHLHd4) (Myc-associated factor X)	5	UniProt NCBI
WBP2NL	Postacrosomal sheath WW domain-binding protein (WW domain-binding protein 2-like)	5	UniProt NCBI
MXI1	Max-interacting protein 1 (Max interactor 1) (Class C basic helix-loop-helix protein 11) (bHLHc11)	5	UniProt NCBI
MXD3	Max dimerization protein 3 (Max dimerizer 3) (Class C basic helix-loop-helix protein 13) (bHLHc13) (Max-associated protein 3) (Max-interacting transcriptional repressor MAD3) (Myx)	5	UniProt NCBI
MXD4	Max dimerization protein 4 (Max dimerizer 4) (Class C basic helix-loop-helix protein 12) (bHLHc12) (Max-associated protein 4) (Max-interacting transcriptional repressor MAD4)	3	UniProt NCBI
DNAH6	Dynein axonemal heavy chain 6 (Axonemal beta dynein heavy chain 6) (Ciliary dynein heavy chain 6)	5	UniProt NCBI
MNT	Max-binding protein MNT (Class D basic helix-loop-helix protein 3) (bHLHd3) (Myc antagonist MNT) (Protein ROX)	5	UniProt NCBI
MXD1	Max dimerization protein 1 (Max dimerizer 1) (Protein MAD)	5	UniProt NCBI
MYC	Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:3052	2.73623797451e-05	0.222222222222	MYC MAX	MYC-MAX complex
CORUM:3051	2.73623797451e-05	0.222222222222	MXD1 MAX	MAD-MAX complex
CORUM:2655	2.73623797451e-05	0.222222222222	MYC MAX	MYC-MAX complex
CORUM:2653	0.000164069436391	0.222222222222	MYC MAX	MYC-MAX-KAT2A-TRRAP complex
GO:0090571	0.000676970649307	0.333333333333	MXD1 MAX MYC	RNA polymerase II transcription repressor complex
GO:0000978	0.00170488754112	0.777777777778	MXD1 MXD3 MNT MYC MXI1 MXD4 MAX	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000987	0.00196824408549	0.777777777778	MXD1 MXD3 MNT MYC MXI1 MXD4 MAX	cis-regulatory region sequence-specific DNA binding
WP:WP5380	0.0020456158253	0.333333333333	MXD3 MAX MYC	5q35 copy number variation
GO:0140110	0.00205034568638	0.888888888889	WBP2NL MXD1 MXD3 MNT MYC MXI1 MXD4 MAX	transcription regulator activity
GO:0001227	0.00218459192991	0.555555555556	MXI1 MXD1 MAX MYC MNT	DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001217	0.00275100807786	0.555555555556	MXI1 MXD1 MAX MYC MNT	DNA-binding transcription repressor activity
GO:0000981	0.0043263538375	0.777777777778	MXD1 MXD3 MNT MYC MXI1 MXD4 MAX	DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003677	0.00497987143669	0.888888888889	WBP2NL MXD1 MXD3 MNT MYC MXI1 MXD4 MAX	DNA binding
GO:0000977	0.00525750482744	0.777777777778	MXD1 MXD3 MNT MYC MXI1 MXD4 MAX	RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0003700	0.00664474443886	0.777777777778	MXD1 MXD3 MNT MYC MXI1 MXD4 MAX	DNA-binding transcription factor activity
GO:0000785	0.00901308220575	0.777777777778	MXD1 MXD3 MNT MYC MXI1 MXD4 MAX	chromatin
GO:0000976	0.00947042519516	0.777777777778	MXD1 MXD3 MNT MYC MXI1 MXD4 MAX	transcription cis-regulatory region binding
GO:0001067	0.00953734567893	0.777777777778	MXD1 MXD3 MNT MYC MXI1 MXD4 MAX	transcription regulatory region nucleic acid binding
REAC:R-HSA-1362277	0.0121597301349	0.222222222222	MYC MAX	Transcription of E2F targets under negative control by DREAM complex
GO:1990837	0.0130843791721	0.777777777778	MXD1 MXD3 MNT MYC MXI1 MXD4 MAX	sequence-specific double-stranded DNA binding
WP:WP400	0.0132604628613	0.222222222222	MYC MAX	p38 MAPK signaling pathway
GO:0032993	0.0135300296914	0.777777777778	MXD1 MXD3 MNT MYC MXI1 MXD4 MAX	protein-DNA complex
GO:0070443	0.016855225923	0.222222222222	MXD1 MAX	Mad-Max complex
GO:0071943	0.016855225923	0.222222222222	MYC MAX	Myc-Max complex
GO:0000122	0.0206219094099	0.666666666667	MXD1 MXD4 MNT MYC MXI1 MAX	negative regulation of transcription by RNA polymerase II
GO:0043565	0.021398910247	0.777777777778	MXD1 MXD3 MNT MYC MXI1 MXD4 MAX	sequence-specific DNA binding
GO:0003690	0.0218027933968	0.777777777778	MXD1 MXD3 MNT MYC MXI1 MXD4 MAX	double-stranded DNA binding
REAC:R-HSA-1538133	0.0257635620293	0.222222222222	MYC MAX	G0 and Early G1
WP:WP3651	0.0499409119424	0.222222222222	MYC MAX	Pathways affected in adenoid cystic carcinoma

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
MAX	MXD3	0.999		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
MAX	MXI1	0.998		bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
MAX	MYC	0.997	0.472	bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
MXD3	MNT	0.995		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
MAX	MXD4	0.995		bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only
MAX	MXD1	0.992		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
MXI1	MXD3	0.992		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
MAX	MNT	0.986	0.092624	bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction
MAX	DNAH6	0.97	0.046	bioplex3_WMM bioplex3_HCT116 WMM_only
MAX	WBP2NL	0.963		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
MXD4	MYC	0.946		bioplex3_WMM WMM_only
MXI1	MXD4	0.946		bioplex3_WMM WMM_only
MXD4	MNT	0.946		bioplex3_WMM WMM_only
MNT	MYC	0.795	0.350989295272	bioplex3_WMM WMM_only
MXI1	MNT	0.786		bioplex_WMM bioplex3_WMM WMM_only
MXI1	MYC	0.757		bioplex3_WMM WMM_only
MXI1	MXD1	0.415		bioplex3_WMM WMM_only
MXD4	MXD1	0.415		bioplex3_WMM WMM_only
MNT	MXD1	0.415		bioplex3_WMM WMM_only
MXD1	MYC	0.21		bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
MAX	huMAP3_00748.1 huMAP3_12522.1 huMAP3_14051.1 huMAP3_14834.1
WBP2NL	huMAP3_12059.1 huMAP3_14051.1 huMAP3_14834.1
MXI1	huMAP3_00748.1 huMAP3_05321.1 huMAP3_09645.1 huMAP3_11611.1 huMAP3_12522.1 huMAP3_13077.1 huMAP3_14834.1
MXD3	huMAP3_00748.1 huMAP3_05321.1 huMAP3_09645.1 huMAP3_12522.1 huMAP3_13077.1 huMAP3_14834.1
MXD4	huMAP3_00748.1 huMAP3_11611.1 huMAP3_12522.1 huMAP3_13077.1 huMAP3_14061.1 huMAP3_14313.1 huMAP3_14834.1
DNAH6	huMAP3_00748.1 huMAP3_12522.1 huMAP3_14834.1
MNT	huMAP3_00748.1 huMAP3_04414.1 huMAP3_08137.1 huMAP3_09645.1 huMAP3_13077.1 huMAP3_13287.1 huMAP3_14313.1 huMAP3_14834.1
MXD1	huMAP3_00748.1 huMAP3_13482.1 huMAP3_14834.1 huMAP3_15128.1
MYC	huMAP3_00748.1 huMAP3_01383.1 huMAP3_04533.1 huMAP3_08160.1 huMAP3_10481.1 huMAP3_11280.1 huMAP3_11590.1 huMAP3_12522.1 huMAP3_13063.1 huMAP3_14061.1 huMAP3_14306.1 huMAP3_14834.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_14834.1