hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14834.1
Complex Portal: CPX-13073
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MAX | Protein max (Class D basic helix-loop-helix protein 4) (bHLHd4) (Myc-associated factor X) | 5 | UniProt NCBI |
| WBP2NL | Postacrosomal sheath WW domain-binding protein (WW domain-binding protein 2-like) | 5 | UniProt NCBI |
| MXI1 | Max-interacting protein 1 (Max interactor 1) (Class C basic helix-loop-helix protein 11) (bHLHc11) | 5 | UniProt NCBI |
| MXD3 | Max dimerization protein 3 (Max dimerizer 3) (Class C basic helix-loop-helix protein 13) (bHLHc13) (Max-associated protein 3) (Max-interacting transcriptional repressor MAD3) (Myx) | 5 | UniProt NCBI |
| MXD4 | Max dimerization protein 4 (Max dimerizer 4) (Class C basic helix-loop-helix protein 12) (bHLHc12) (Max-associated protein 4) (Max-interacting transcriptional repressor MAD4) | 3 | UniProt NCBI |
| DNAH6 | Dynein axonemal heavy chain 6 (Axonemal beta dynein heavy chain 6) (Ciliary dynein heavy chain 6) | 5 | UniProt NCBI |
| MNT | Max-binding protein MNT (Class D basic helix-loop-helix protein 3) (bHLHd3) (Myc antagonist MNT) (Protein ROX) | 5 | UniProt NCBI |
| MXD1 | Max dimerization protein 1 (Max dimerizer 1) (Protein MAD) | 5 | UniProt NCBI |
| MYC | Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:3052 | 2.73623797451e-05 | 0.222222222222 | MAX MYC | MYC-MAX complex |
| CORUM:3051 | 2.73623797451e-05 | 0.222222222222 | MAX MXD1 | MAD-MAX complex |
| CORUM:2655 | 2.73623797451e-05 | 0.222222222222 | MAX MYC | MYC-MAX complex |
| CORUM:2653 | 0.000164069436391 | 0.222222222222 | MAX MYC | MYC-MAX-KAT2A-TRRAP complex |
| GO:0090571 | 0.000676970649307 | 0.333333333333 | MYC MAX MXD1 | RNA polymerase II transcription repressor complex |
| GO:0000978 | 0.00170488754112 | 0.777777777778 | MNT MAX MYC MXD3 MXD1 MXI1 MXD4 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0000987 | 0.00196824408549 | 0.777777777778 | MNT MAX MYC MXD3 MXD1 MXI1 MXD4 | cis-regulatory region sequence-specific DNA binding |
| WP:WP5380 | 0.0020456158253 | 0.333333333333 | MXD3 MAX MYC | 5q35 copy number variation |
| GO:0140110 | 0.00205034568638 | 0.888888888889 | MNT MAX WBP2NL MXD3 MYC MXD1 MXI1 MXD4 | transcription regulator activity |
| GO:0001227 | 0.00218459192991 | 0.555555555556 | MYC MXI1 MXD1 MAX MNT | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| GO:0001217 | 0.00275100807786 | 0.555555555556 | MYC MXI1 MXD1 MAX MNT | DNA-binding transcription repressor activity |
| GO:0000981 | 0.0043263538375 | 0.777777777778 | MNT MAX MYC MXD3 MXD1 MXI1 MXD4 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0003677 | 0.00497987143669 | 0.888888888889 | MNT MAX WBP2NL MXD3 MYC MXD1 MXI1 MXD4 | DNA binding |
| GO:0000977 | 0.00525750482744 | 0.777777777778 | MNT MAX MYC MXD3 MXD1 MXI1 MXD4 | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| GO:0003700 | 0.00664474443886 | 0.777777777778 | MNT MAX MYC MXD3 MXD1 MXI1 MXD4 | DNA-binding transcription factor activity |
| GO:0000785 | 0.00901308220575 | 0.777777777778 | MNT MAX MYC MXD3 MXD1 MXI1 MXD4 | chromatin |
| GO:0000976 | 0.00947042519516 | 0.777777777778 | MNT MAX MYC MXD3 MXD1 MXI1 MXD4 | transcription cis-regulatory region binding |
| GO:0001067 | 0.00953734567893 | 0.777777777778 | MNT MAX MYC MXD3 MXD1 MXI1 MXD4 | transcription regulatory region nucleic acid binding |
| REAC:R-HSA-1362277 | 0.0121597301349 | 0.222222222222 | MAX MYC | Transcription of E2F targets under negative control by DREAM complex |
| GO:1990837 | 0.0130843791721 | 0.777777777778 | MNT MAX MYC MXD3 MXD1 MXI1 MXD4 | sequence-specific double-stranded DNA binding |
| WP:WP400 | 0.0132604628613 | 0.222222222222 | MAX MYC | p38 MAPK signaling pathway |
| GO:0032993 | 0.0135300296914 | 0.777777777778 | MNT MAX MYC MXD3 MXD1 MXI1 MXD4 | protein-DNA complex |
| GO:0070443 | 0.016855225923 | 0.222222222222 | MAX MXD1 | Mad-Max complex |
| GO:0071943 | 0.016855225923 | 0.222222222222 | MAX MYC | Myc-Max complex |
| GO:0000122 | 0.0206219094099 | 0.666666666667 | MNT MYC MAX MXD1 MXI1 MXD4 | negative regulation of transcription by RNA polymerase II |
| GO:0043565 | 0.021398910247 | 0.777777777778 | MNT MAX MYC MXD3 MXD1 MXI1 MXD4 | sequence-specific DNA binding |
| GO:0003690 | 0.0218027933968 | 0.777777777778 | MNT MAX MYC MXD3 MXD1 MXI1 MXD4 | double-stranded DNA binding |
| REAC:R-HSA-1538133 | 0.0257635620293 | 0.222222222222 | MAX MYC | G0 and Early G1 |
| WP:WP3651 | 0.0499409119424 | 0.222222222222 | MAX MYC | Pathways affected in adenoid cystic carcinoma |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MAX | MXD3 | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MAX | MXI1 | 0.998 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MAX | MYC | 0.997 | 0.472 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| MXD3 | MNT | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| MAX | MXD4 | 0.995 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MAX | MXD1 | 0.992 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MXI1 | MXD3 | 0.992 |
mutually_exclusive (P61244)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MAX | MNT | 0.986 | 0.092624 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| MAX | DNAH6 | 0.97 | 0.046 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MAX | WBP2NL | 0.963 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| MXD4 | MYC | 0.946 |
mutually_exclusive (P61244)
|
bioplex3_WMM WMM_only | |
| MXI1 | MXD4 | 0.946 |
mutually_exclusive (P61244)
|
bioplex3_WMM WMM_only | |
| MXD4 | MNT | 0.946 | bioplex3_WMM WMM_only | ||
| MNT | MYC | 0.795 | 0.350989295272 |
mutually_exclusive (P61244)
|
bioplex3_WMM WMM_only |
| MXI1 | MNT | 0.786 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MXI1 | MYC | 0.757 |
mutually_exclusive (P61244)
|
bioplex3_WMM WMM_only | |
| MNT | MXD1 | 0.415 | bioplex3_WMM WMM_only | ||
| MXD4 | MXD1 | 0.415 |
mutually_exclusive (P61244)
|
bioplex3_WMM WMM_only | |
| MXI1 | MXD1 | 0.415 | bioplex3_WMM WMM_only | ||
| MXD1 | MYC | 0.21 | bioplex3_WMM WMM_only |
Related Complexes