hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_14839.1

Complex Portal: CPX-16947

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
TSEN54	tRNA-splicing endonuclease subunit Sen54 (SEN54 homolog) (HsSEN54) (tRNA-intron endonuclease Sen54)	5	UniProt NCBI
TSEN15	tRNA-splicing endonuclease subunit Sen15 (SEN15 homolog) (HsSEN15) (tRNA-intron endonuclease Sen15)	5	UniProt NCBI
PHLDA2	Pleckstrin homology-like domain family A member 2 (Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein) (Imprinted in placenta and liver protein) (Tumor-suppressing STF cDNA 3 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein) (p17-Beckwith-Wiedemann region 1 C) (p17-BWR1C)	5	UniProt NCBI
GREB1L	GREB1-like protein (Growth regulation by estrogen in breast cancer 1-like protein)	5	UniProt NCBI
AMMECR1	Nuclear protein AMMECR1 (AMME syndrome candidate gene 1 protein)	5	UniProt NCBI
CLP1	Polyribonucleotide 5'-hydroxyl-kinase Clp1 (EC 2.7.1.78) (Polyadenylation factor Clp1) (Polynucleotide kinase Clp1) (Pre-mRNA cleavage complex II protein Clp1)	5	UniProt NCBI
GADD45A	Growth arrest and DNA damage-inducible protein GADD45 alpha (DNA damage-inducible transcript 1 protein) (DDIT-1)	5	UniProt NCBI
THTPA	Thiamine-triphosphatase (ThTPase) (EC 3.6.1.28)	5	UniProt NCBI
BRCC3	Lys-63-specific deubiquitinase BRCC36 (EC 3.4.19.-) (BRCA1-A complex subunit BRCC36) (BRCA1/BRCA2-containing complex subunit 3) (BRCA1/BRCA2-containing complex subunit 36) (BRISC complex subunit BRCC36)	5	UniProt NCBI
TSEN2	tRNA-splicing endonuclease subunit Sen2 (EC 4.6.1.16) (tRNA-intron endonuclease Sen2) (HsSen2)	5	UniProt NCBI
TSEN34	tRNA-splicing endonuclease subunit Sen34 (EC 4.6.1.16) (Leukocyte receptor cluster member 5) (tRNA-intron endonuclease Sen34) (HsSen34)	5	UniProt NCBI
ARL4C	ADP-ribosylation factor-like protein 4C (ADP-ribosylation factor-like protein 7) (ADP-ribosylation factor-like protein LAK)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:5283	8.6757634689e-15	0.416666666667	TSEN54 TSEN2 TSEN15 TSEN34 CLP1	tRNA splicing endonuclease
HP:0012765	4.06667008229e-09	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Widened cerebellar subarachnoid space
HP:0006850	4.06667008229e-09	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Hypoplasia of the ventral pons
HP:0200049	1.89611702081e-08	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Upper limb hypertonia
CORUM:5284	2.5725558439e-08	0.25	TSEN54 TSEN2 CLP1	RNA endonuclease (SEN2deltaEx8, SEN54, CLP1)
HP:0003558	8.92709391965e-08	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Viral infection-induced rhabdomyolysis
REAC:R-HSA-6784531	1.32161351912e-07	0.416666666667	TSEN54 TSEN2 TSEN15 TSEN34 CLP1	tRNA processing in the nucleus
HP:0031162	1.33847738368e-07	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Impaired oropharyngeal swallow response
HP:0002268	6.42141970507e-07	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Paroxysmal dystonia
HP:0011171	1.61196916519e-06	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Simple febrile seizure
REAC:R-HSA-72306	2.66974315239e-06	0.416666666667	TSEN54 TSEN2 TSEN15 TSEN34 CLP1	tRNA processing
HP:0000253	4.18117621757e-06	0.416666666667	TSEN54 TSEN2 TSEN15 TSEN34 CLP1	Progressive microcephaly
GO:0006388	4.28500508143e-06	0.333333333333	TSEN54 TSEN2 TSEN34 CLP1	tRNA splicing, via endonucleolytic cleavage and ligation
GO:0000394	6.42469144165e-06	0.333333333333	TSEN54 TSEN2 TSEN34 CLP1	RNA splicing, via endonucleolytic cleavage and ligation
HP:0006895	1.09633409394e-05	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Lower limb hypertonia
GO:0000379	2.11464090368e-05	0.25	TSEN54 TSEN2 TSEN34	tRNA-type intron splice site recognition and cleavage
GO:0000214	2.11464090368e-05	0.25	TSEN54 TSEN2 CLP1	tRNA-intron endonuclease complex
HP:0200136	2.19788742004e-05	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Oral-pharyngeal dysphagia
HP:0012704	2.19788742004e-05	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Widened subarachnoid space
HP:0003201	2.19788742004e-05	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Rhabdomyolysis
HP:0025190	2.44102597958e-05	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Bilateral tonic-clonic seizure with generalized onset
HP:0006989	2.70373420057e-05	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Dysplastic corpus callosum
HP:0009062	2.98702695303e-05	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Infantile axial hypotonia
HP:0002509	6.30157659915e-05	0.416666666667	TSEN54 TSEN2 TSEN15 TSEN34 CLP1	Limb hypertonia
HP:0100704	6.52727045988e-05	0.416666666667	TSEN54 TSEN2 TSEN15 TSEN34 CLP1	Cerebral visual impairment
HP:0007598	9.04980614647e-05	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Bilateral single transverse palmar creases
HP:0005484	0.000195039967409	0.416666666667	TSEN54 TSEN2 TSEN15 TSEN34 CLP1	Secondary microcephaly
HP:0012703	0.000337308935009	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Abnormal subarachnoid space morphology
HP:0007362	0.000374694204528	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Aplasia/Hypoplasia of the brainstem
HP:0002365	0.000374694204528	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Hypoplasia of the brainstem
HP:0012110	0.000374694204528	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Hypoplasia of the pons
HP:0011471	0.000582391548217	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Gastrostomy tube feeding in infancy
HP:0007361	0.000940571126331	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Abnormal pons morphology
HP:0002363	0.000971927071709	0.416666666667	TSEN54 TSEN2 TSEN15 TSEN34 CLP1	Abnormal brainstem morphology
HP:0001266	0.00119411234863	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Choreoathetosis
HP:0002373	0.00178669616669	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Febrile seizure (within the age range of 3 months to 6 years)
HP:0032894	0.00178669616669	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Seizure precipitated by febrile infection
HP:0032892	0.00178669616669	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Infection-related seizure
HP:0008936	0.00193967472003	0.416666666667	TSEN54 TSEN2 TSEN15 TSEN34 CLP1	Axial hypotonia
HP:0002123	0.00226301354447	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Generalized myoclonic seizure
HP:0002033	0.00249365822872	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Poor suck
HP:0012469	0.00309941878508	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Infantile spasms
HP:0002305	0.00463066793055	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Athetosis
HP:0002536	0.00491154592884	0.416666666667	TSEN54 TSEN2 TSEN15 TSEN34 CLP1	Abnormal cortical gyration
HP:0002350	0.00502074818692	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Cerebellar cyst
HP:0032677	0.00770938822229	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Generalized-onset motor seizure
HP:0000340	0.00789509416941	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Sloping forehead
HP:0011097	0.0090797853206	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Epileptic spasm
HP:0007308	0.00963903005133	0.166666666667	TSEN54 TSEN2	Extrapyramidal dyskinesia
HP:0008947	0.0103912007807	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Infantile muscular hypotonia
HP:0033454	0.0110970502779	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Tube feeding
HP:0000954	0.0115869131251	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Single transverse palmar crease
HP:0002079	0.0123170320513	0.416666666667	TSEN54 TSEN2 TSEN15 TSEN34 CLP1	Hypoplasia of the corpus callosum
HP:0010576	0.0123514559183	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Intracranial cystic lesion
HP:0030724	0.0128814573983	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Central nervous system cyst
HP:0002269	0.0133641366119	0.416666666667	TSEN54 TSEN2 TSEN15 TSEN34 CLP1	Abnormality of neuronal migration
HP:0011344	0.0134280866901	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Severe global developmental delay
HP:0002020	0.0163797743271	0.416666666667	TSEN54 TSEN2 TSEN15 TSEN34 CLP1	Gastroesophageal reflux
HP:0002104	0.0180916943955	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Apnea
HP:0002072	0.0195148007901	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Chorea
HP:0032794	0.0214078732144	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Myoclonic seizure
HP:0010490	0.023433093799	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Abnormality of the palmar creases
HP:0001018	0.0255962049694	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Abnormal palmar dermatoglyphics
HP:0002438	0.0293586107272	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Cerebellar malformation
HP:0001446	0.0298559957703	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Abnormality of the musculature of the upper limbs
GO:0000213	0.0309012475255	0.166666666667	TSEN2 TSEN34	tRNA-intron endonuclease activity
REAC:R-HSA-8953854	0.0361764041169	0.416666666667	TSEN54 TSEN2 TSEN15 TSEN34 CLP1	Metabolism of RNA
HP:0001320	0.041166841228	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Cerebellar vermis hypoplasia
HP:0031828	0.0424491686172	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Abnormal superficial reflex
HP:0003487	0.0424491686172	0.333333333333	TSEN54 TSEN15 TSEN34 TSEN2	Babinski sign
HP:0001999	0.0493761037593	0.5	AMMECR1 TSEN2 BRCC3 TSEN54 TSEN15 TSEN34	Abnormal facial shape

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
TSEN15	TSEN34	1.0	0.22
TSEN15	TSEN2	0.999	0.084	structurally_consistent (dimer)
CLP1	TSEN2	0.999	0.166
TSEN2	TSEN34	0.999	0.108
TSEN2	TSEN54	0.999	0.116	structurally_consistent (dimer)
CLP1	TSEN54	0.999	0.124	structurally_consistent (dimer)
TSEN15	CLP1	0.998	0.07
CLP1	TSEN34	0.998	0.12
TSEN15	TSEN54	0.994	0.098	structurally_consistent (Q8NCE0)
ARL4C	GADD45A	0.982
CLP1	AMMECR1	0.981	0.11
TSEN34	TSEN54	0.971	0.156
ARL4C	TSEN54	0.969	0.104
BRCC3	CLP1	0.967	0.122
CLP1	THTPA	0.965	0.104
PHLDA2	CLP1	0.952	0.062
ARL4C	TSEN34	0.917	0.118
TSEN54	AMMECR1	0.907	0.104
PHLDA2	THTPA	0.837	0.054
CLP1	GREB1L	0.832
ARL4C	TSEN2	0.809	0.08
TSEN2	GREB1L	0.797
TSEN54	THTPA	0.782	0.068
ARL4C	CLP1	0.781	0.126
GADD45A	TSEN2	0.632
TSEN2	THTPA	0.593	0.102
GADD45A	TSEN54	0.489
TSEN34	THTPA	0.379	0.032
TSEN15	GREB1L	0.265
GADD45A	CLP1	0.239
ARL4C	THTPA	0.213	0.09
TSEN54	GREB1L	0.188
TSEN34	GREB1L	0.188
BRCC3	THTPA	0.186	0.09
GADD45A	TSEN34	0.17
GADD45A	THTPA	0.168
BRCC3	TSEN2	0.166	0.092
PHLDA2	TSEN2	0.122	0.062
TSEN15	PHLDA2	0.086	0.08
BRCC3	TSEN15	0.075	0.042
PHLDA2	TSEN54	0.069	0.08
BRCC3	TSEN54	0.069	0.094
BRCC3	GREB1L	0.065
PHLDA2	TSEN34	0.063	0.064
TSEN2	AMMECR1	0.061	0.152
PHLDA2	GREB1L	0.04
BRCC3	TSEN34	0.036	0.052
TSEN15	THTPA	0.023	0.1
ARL4C	PHLDA2	0.022	0.15
GADD45A	PHLDA2	0.019
BRCC3	AMMECR1	0.017	0.052
BRCC3	GADD45A	0.015
GREB1L	THTPA	0.013
BRCC3	PHLDA2	0.012	0.034

Related Complexes

Genename	Complexes
TSEN54	huMAP3_04582.1 huMAP3_06042.1 huMAP3_07243.1 huMAP3_10697.1 huMAP3_13483.1 huMAP3_13865.1 huMAP3_14586.1 huMAP3_14839.1
TSEN15	huMAP3_02940.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_13483.1 huMAP3_13865.1 huMAP3_14576.1 huMAP3_14586.1 huMAP3_14839.1 huMAP3_15245.1
PHLDA2	huMAP3_02940.1 huMAP3_04582.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_11956.1 huMAP3_13483.1 huMAP3_13693.1 huMAP3_14586.1 huMAP3_14839.1 huMAP3_14984.1
GREB1L	huMAP3_13483.1 huMAP3_14586.1 huMAP3_14839.1
AMMECR1	huMAP3_04582.1 huMAP3_08573.1 huMAP3_08812.1 huMAP3_10697.1 huMAP3_11762.1 huMAP3_13483.1 huMAP3_13511.1 huMAP3_14586.1 huMAP3_14839.1
CLP1	huMAP3_02940.1 huMAP3_04582.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_13483.1 huMAP3_14586.1 huMAP3_14839.1
GADD45A	huMAP3_01737.1 huMAP3_01965.1 huMAP3_05425.1 huMAP3_07243.1 huMAP3_07720.1 huMAP3_07918.1 huMAP3_10622.1 huMAP3_12847.1 huMAP3_13865.1 huMAP3_14298.1 huMAP3_14586.1 huMAP3_14839.1
THTPA	huMAP3_13483.1 huMAP3_14839.1 huMAP3_14984.1
BRCC3	huMAP3_01447.1 huMAP3_02592.1 huMAP3_08508.1 huMAP3_10482.1 huMAP3_14749.1 huMAP3_14839.1
TSEN2	huMAP3_02940.1 huMAP3_04582.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_13483.1 huMAP3_13865.1 huMAP3_14586.1 huMAP3_14839.1
TSEN34	huMAP3_02940.1 huMAP3_04582.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_13483.1 huMAP3_13865.1 huMAP3_14586.1 huMAP3_14839.1
ARL4C	huMAP3_01199.1 huMAP3_07243.1 huMAP3_13483.1 huMAP3_13865.1 huMAP3_14586.1 huMAP3_14839.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_14839.1

Complex Portal: CPX-16947