hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14841.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PALB2 | Partner and localizer of BRCA2 | 5 | UniProt NCBI |
| C14orf93 | Uncharacterized protein C14orf93 | 3 | UniProt NCBI |
| MORF4L2 | Mortality factor 4-like protein 2 (MORF-related gene X protein) (Protein MSL3-2) (Transcription factor-like protein MRGX) | 5 | UniProt NCBI |
| BRCA2 | Breast cancer type 2 susceptibility protein (Fanconi anemia group D1 protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0005249 | 0.00150383256857 | 0.5 | PALB2 BRCA2 | Functional intestinal obstruction |
| HP:0012334 | 0.00150383256857 | 0.5 | PALB2 BRCA2 | Extrahepatic cholestasis |
| HP:0100592 | 0.00183784982408 | 0.5 | PALB2 BRCA2 | Peritoneal abscess |
| KEGG:03440 | 0.00194963326435 | 0.5 | PALB2 BRCA2 | Homologous recombination |
| HP:0025318 | 0.00260592941411 | 0.5 | PALB2 BRCA2 | Ovarian carcinoma |
| REAC:R-HSA-9709603 | 0.00282403231951 | 0.5 | PALB2 BRCA2 | Impaired BRCA2 binding to PALB2 |
| KEGG:03460 | 0.0029370300722 | 0.5 | PALB2 BRCA2 | Fanconi anemia pathway |
| HP:0030406 | 0.00303997345979 | 0.5 | PALB2 BRCA2 | Primary peritoneal carcinoma |
| REAC:R-HSA-9701192 | 0.00306932002175 | 0.5 | PALB2 BRCA2 | Defective homologous recombination repair (HRR) due to BRCA1 loss of function |
| REAC:R-HSA-9701193 | 0.00306932002175 | 0.5 | PALB2 BRCA2 | Defective homologous recombination repair (HRR) due to PALB2 loss of function |
| REAC:R-HSA-9704646 | 0.00306932002175 | 0.5 | PALB2 BRCA2 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function |
| REAC:R-HSA-9704331 | 0.00306932002175 | 0.5 | PALB2 BRCA2 | Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function |
| HP:0003221 | 0.00350734148159 | 0.5 | PALB2 BRCA2 | Chromosomal breakage induced by crosslinking agents |
| REAC:R-HSA-5693554 | 0.00359044851421 | 0.5 | PALB2 BRCA2 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) |
| REAC:R-HSA-5693568 | 0.00539805716719 | 0.5 | PALB2 BRCA2 | Resolution of D-loop Structures through Holliday Junction Intermediates |
| HP:0002885 | 0.0057098705025 | 0.5 | PALB2 BRCA2 | Medulloblastoma |
| HP:0012432 | 0.0057098705025 | 0.5 | PALB2 BRCA2 | Chronic fatigue |
| REAC:R-HSA-5693537 | 0.00573491177379 | 0.5 | PALB2 BRCA2 | Resolution of D-Loop Structures |
| HP:0002254 | 0.00634372129255 | 0.5 | PALB2 BRCA2 | Intermittent diarrhea |
| WP:WP4016 | 0.00742144474402 | 0.5 | PALB2 BRCA2 | DNA IR damage and cellular response via ATR |
| HP:0005522 | 0.00771122114953 | 0.5 | PALB2 BRCA2 | Pyridoxine-responsive sideroblastic anemia |
| REAC:R-HSA-9675136 | 0.0079693038543 | 0.5 | PALB2 BRCA2 | Diseases of DNA Double-Strand Break Repair |
| REAC:R-HSA-9701190 | 0.0079693038543 | 0.5 | PALB2 BRCA2 | Defective homologous recombination repair (HRR) due to BRCA2 loss of function |
| HP:0010469 | 0.00844485194452 | 0.5 | PALB2 BRCA2 | Absent testis |
| REAC:R-HSA-5693579 | 0.008795277704 | 0.5 | PALB2 BRCA2 | Homologous DNA Pairing and Strand Exchange |
| HP:0011027 | 0.0108451581837 | 0.5 | PALB2 BRCA2 | Abnormal fallopian tube morphology |
| HPA:0250123 | 0.011326451641 | 0.75 | PALB2 C14orf93 MORF4L2 | hippocampus; glial cells[High] |
| HP:0012848 | 0.0117117011059 | 0.5 | PALB2 BRCA2 | Small intestinal stenosis |
| HP:0010293 | 0.0117117011059 | 0.5 | PALB2 BRCA2 | Aplasia/Hypoplasia of the uvula |
| HP:0100867 | 0.0117117011059 | 0.5 | PALB2 BRCA2 | Duodenal stenosis |
| REAC:R-HSA-9675135 | 0.0120053783973 | 0.5 | PALB2 BRCA2 | Diseases of DNA repair |
| HPA:0500653 | 0.0121011271968 | 0.75 | PALB2 C14orf93 MORF4L2 | soft tissue 1; fibroblasts[High] |
| HP:0100760 | 0.0126114492305 | 0.5 | PALB2 BRCA2 | Clubbing of toes |
| HP:0002245 | 0.0126114492305 | 0.5 | PALB2 BRCA2 | Meckel diverticulum |
| HP:0004389 | 0.0135443934278 | 0.5 | PALB2 BRCA2 | Intestinal pseudo-obstruction |
| HP:0100587 | 0.0145105245688 | 0.5 | PALB2 BRCA2 | Abnormal preputium morphology |
| WP:WP4946 | 0.0159973744593 | 0.5 | PALB2 BRCA2 | DNA repair pathways full network |
| HP:0001924 | 0.0165423111708 | 0.5 | PALB2 BRCA2 | Sideroblastic anemia |
| HP:0012125 | 0.0176079483787 | 0.5 | PALB2 BRCA2 | Prostate cancer |
| HP:0002667 | 0.0176079483787 | 0.5 | PALB2 BRCA2 | Nephroblastoma |
| HP:0100787 | 0.0176079483787 | 0.5 | PALB2 BRCA2 | Prostate neoplasm |
| HP:0006725 | 0.018706736024 | 0.5 | PALB2 BRCA2 | Pancreatic adenocarcinoma |
| HP:0011794 | 0.018706736024 | 0.5 | PALB2 BRCA2 | Embryonal renal neoplasm |
| REAC:R-HSA-5685942 | 0.0218635493976 | 0.5 | PALB2 BRCA2 | HDR through Homologous Recombination (HRR) |
| HP:0040012 | 0.0222019103471 | 0.5 | PALB2 BRCA2 | Chromosome breakage |
| HP:0001549 | 0.0222019103471 | 0.5 | PALB2 BRCA2 | Abnormal ileum morphology |
| HPA:0080123 | 0.022816947557 | 0.75 | PALB2 C14orf93 MORF4L2 | caudate; glial cells[High] |
| HP:0008775 | 0.0246976114972 | 0.5 | PALB2 BRCA2 | Abnormal prostate morphology |
| HP:0003003 | 0.0259951101914 | 0.5 | PALB2 BRCA2 | Colon cancer |
| HP:0004396 | 0.028689358225 | 0.5 | PALB2 BRCA2 | Poor appetite |
| HPA:0100123 | 0.0296286402726 | 0.75 | PALB2 C14orf93 MORF4L2 | cerebral cortex; glial cells[High] |
| HP:0000813 | 0.0329787201379 | 0.5 | PALB2 BRCA2 | Bicornuate uterus |
| HP:0025615 | 0.0375654511359 | 0.5 | PALB2 BRCA2 | Abscess |
| HP:0033019 | 0.0375654511359 | 0.5 | PALB2 BRCA2 | Male reproductive system neoplasm |
| HP:0007874 | 0.0375654511359 | 0.5 | PALB2 BRCA2 | Almond-shaped palpebral fissure |
| HP:0100026 | 0.0391604009626 | 0.5 | PALB2 BRCA2 | Arteriovenous malformation |
| HP:0003022 | 0.0424493051949 | 0.5 | PALB2 BRCA2 | Hypoplasia of the ulna |
| HPA:0130203 | 0.0429017544915 | 0.75 | PALB2 C14orf93 MORF4L2 | colon; endothelial cells[High] |
| HPA:0270353 | 0.0432340582692 | 0.75 | PALB2 C14orf93 MORF4L2 | kidney; cells in glomeruli[High] |
| HP:0003220 | 0.0441432413831 | 0.5 | PALB2 BRCA2 | Abnormality of chromosome stability |
| HPA:0050093 | 0.0447503600593 | 0.75 | PALB2 C14orf93 MORF4L2 | breast; myoepithelial cells[High] |
| HP:0200005 | 0.0458701548093 | 0.5 | PALB2 BRCA2 | Abnormal shape of the palpebral fissure |
| HP:0002585 | 0.0476300363671 | 0.5 | PALB2 BRCA2 | Abnormal peritoneum morphology |
| HP:0006495 | 0.049422876951 | 0.5 | PALB2 BRCA2 | Aplasia/Hypoplasia of the ulna |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| BRCA2 | PALB2 | 0.998 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only | |
| MORF4L2 | PALB2 | 0.991 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MORF4L2 | BRCA2 | 0.942 | 0.128 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| C14orf93 | MORF4L2 | 0.844 | hein_WMM bioplex3_WMM WMM_only |
Related Complexes