hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14846.1
Confidence: Medium  
ProteinsGenename | Protein Name | Uniprot Annotation Score | Links |
---|---|---|---|
SSBP1 | Single-stranded DNA-binding protein, mitochondrial (Mt-SSB) (MtSSB) (PWP1-interacting protein 17) | 5 | UniProt   NCBI |
XPC | DNA repair protein complementing XP-C cells (Xeroderma pigmentosum group C-complementing protein) (p125) | 5 | UniProt   NCBI |
HLTF | Helicase-like transcription factor (EC 2.3.2.27) (EC 3.6.4.-) (DNA-binding protein/plasminogen activator inhibitor 1 regulator) (HIP116) (RING finger protein 80) (RING-type E3 ubiquitin transferase HLTF) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3) (Sucrose nonfermenting protein 2-like 3) | 5 | UniProt   NCBI |
CLEC1B | C-type lectin domain family 1 member B (C-type lectin-like receptor 2) (CLEC-2) | 5 | UniProt   NCBI |
RPA3 | Replication protein A 14 kDa subunit (RP-A p14) (Replication factor A protein 3) (RF-A protein 3) | 5 | UniProt   NCBI |
APLF | Aprataxin and PNK-like factor (EC 3.1.-.-) (Apurinic-apyrimidinic endonuclease APLF) (PNK and APTX-like FHA domain-containing protein) (XRCC1-interacting protein 1) | 5 | UniProt   NCBI |
PNKP | Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)] | 5 | UniProt   NCBI |
RPA4 | Replication protein A 30 kDa subunit (RP-A p30) (Replication factor A protein 4) (RF-A protein 4) | 5 | UniProt   NCBI |
SSRP1 | FACT complex subunit SSRP1 (Chromatin-specific transcription elongation factor 80 kDa subunit) (Facilitates chromatin transcription complex 80 kDa subunit) (FACT 80 kDa subunit) (FACTp80) (Facilitates chromatin transcription complex subunit SSRP1) (Recombination signal sequence recognition protein 1) (Structure-specific recognition protein 1) (hSSRP1) (T160) | 5 | UniProt   NCBI |
RPA2 | Replication protein A 32 kDa subunit (RP-A p32) (Replication factor A protein 2) (RF-A protein 2) (Replication protein A 34 kDa subunit) (RP-A p34) | 5 | UniProt   NCBI |
WRN | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)] | 5 | UniProt   NCBI |
RNF146 | E3 ubiquitin-protein ligase RNF146 (EC 2.3.2.27) (Dactylidin) (Iduna) (RING finger protein 146) (RING-type E3 ubiquitin transferase RNF146) | 5 | UniProt   NCBI |
RPA1 | Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed] | 5 | UniProt   NCBI |
TDP1 | Tyrosyl-DNA phosphodiesterase 1 (Tyr-DNA phosphodiesterase 1) (EC 3.1.4.-) | 5 | UniProt   NCBI |
PARP1 | Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)] | 5 | UniProt   NCBI |
CHD1L | Chromodomain-helicase-DNA-binding protein 1-like (EC 3.6.4.-) (Amplified in liver cancer protein 1) | 5 | UniProt   NCBI |
CETN2 | Centrin-2 (Caltractin isoform 1) | 5 | UniProt   NCBI |
XRCC5 | X-ray repair cross-complementing protein 5 (EC 3.6.4.-) (86 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 2) (ATP-dependent DNA helicase II 80 kDa subunit) (CTC box-binding factor 85 kDa subunit) (CTC85) (CTCBF) (DNA repair protein XRCC5) (Ku80) (Ku86) (Lupus Ku autoantigen protein p86) (Nuclear factor IV) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)) | 5 | UniProt   NCBI |
PARP2 | Poly [ADP-ribose] polymerase 2 (PARP-2) (hPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (DNA ADP-ribosyltransferase PARP2) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2) (Protein poly-ADP-ribosyltransferase PARP2) (EC 2.4.2.-) | 5 | UniProt   NCBI |
MACROD1 | ADP-ribose glycohydrolase MACROD1 (MACRO domain-containing protein 1) (O-acetyl-ADP-ribose deacetylase MACROD1) (EC 3.1.1.106) (Protein LRP16) ([Protein ADP-ribosylaspartate] hydrolase MACROD1) (EC 3.2.2.-) ([Protein ADP-ribosylglutamate] hydrolase MACROD1) (EC 3.2.2.-) | 5 | UniProt   NCBI |
XRCC6 | X-ray repair cross-complementing protein 6 (EC 3.6.4.-) (EC 4.2.99.-) (5'-deoxyribose-5-phosphate lyase Ku70) (5'-dRP lyase Ku70) (70 kDa subunit of Ku antigen) (ATP-dependent DNA helicase 2 subunit 1) (ATP-dependent DNA helicase II 70 kDa subunit) (CTC box-binding factor 75 kDa subunit) (CTC75) (CTCBF) (DNA repair protein XRCC6) (Lupus Ku autoantigen protein p70) (Ku70) (Thyroid-lupus autoantigen) (TLAA) (X-ray repair complementing defective repair in Chinese hamster cells 6) | 5 | UniProt   NCBI |
RPAIN | RPA-interacting protein (hRIP) | 5 | UniProt   NCBI |
POLB | DNA polymerase beta (EC 2.7.7.7) (5'-deoxyribose-phosphate lyase) (5'-dRP lyase) (EC 4.2.99.-) (AP lyase) (EC 4.2.99.18) | 5 | UniProt   NCBI |
XRCC1 | DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) | 5 | UniProt   NCBI |
XPA | DNA repair protein complementing XP-A cells (Xeroderma pigmentosum group A-complementing protein) | 5 | UniProt   NCBI |
PRIMPOL | DNA-directed primase/polymerase protein (hPrimpol1) (EC 2.7.7.-) (Coiled-coil domain-containing protein 111) | 5 | UniProt   NCBI |
LIG3 | DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3) | 5 | UniProt   NCBI |
Enrichments
Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
---|---|---|---|---|
  GO:0006281 | 2.21063478512e-16 | 0.739130434783 | HLTF RPA4 PARP1 PNKP POLB TDP1 CETN2 PRIMPOL PARP2 XPA LIG3 CHD1L APLF WRN RPA3 XPC RPA1 | DNA repair |
  WP:WP4946 | 5.62317763157e-16 | 0.478260869565 | RPA1 WRN POLB XPA LIG3 CETN2 RPA3 PNKP PARP1 XPC PARP2 | DNA repair pathways full network |
  GO:0006974 | 3.02062165199e-15 | 0.782608695652 | HLTF PRIMPOL RPA4 PARP1 PNKP POLB TDP1 CETN2 MACROD1 PARP2 XPA LIG3 CHD1L APLF WRN RPA3 XPC RPA1 | DNA damage response |
  GO:0006259 | 9.2129603244e-15 | 0.782608695652 | HLTF RPA4 XPA PARP1 PNKP POLB TDP1 CETN2 PRIMPOL PARP2 SSBP1 LIG3 CHD1L APLF RPA3 WRN XPC RPA1 | DNA metabolic process |
  REAC:R-HSA-73894 | 3.52768534362e-14 | 0.565217391304 | RPA1 WRN POLB TDP1 PARP2 XPA LIG3 CHD1L RPA3 PNKP PARP1 XPC CETN2 | DNA Repair |
  REAC:R-HSA-5696395 | 3.51214163428e-13 | 0.347826086957 | RPA1 RPA3 XPA CETN2 CHD1L PARP1 XPC PARP2 | Formation of Incision Complex in GG-NER |
  REAC:R-HSA-5696399 | 9.71865018567e-13 | 0.391304347826 | RPA1 RPA3 XPA LIG3 CETN2 CHD1L PARP1 XPC PARP2 | Global Genome Nucleotide Excision Repair (GG-NER) |
  REAC:R-HSA-5696398 | 1.1317044235e-11 | 0.391304347826 | RPA1 RPA3 XPA LIG3 CETN2 CHD1L PARP1 XPC PARP2 | Nucleotide Excision Repair |
  WP:WP5114 | 1.51036043751e-11 | 0.347826086957 | RPA1 RPA3 XPA CETN2 CHD1L PARP1 XPC LIG3 | Nucleotide excision repair in xeroderma pigmentosum |
  REAC:R-HSA-73933 | 1.83459378726e-11 | 0.304347826087 | RPA1 RPA3 PARP2 POLB PNKP PARP1 LIG3 | Resolution of Abasic Sites (AP sites) |
  GO:0006284 | 3.55351324569e-11 | 0.347826086957 | RPA1 WRN POLB XPA RPA3 PNKP PARP1 LIG3 | base-excision repair |
  GO:0033554 | 1.03742443965e-10 | 0.782608695652 | HLTF PRIMPOL RPA4 PARP1 PNKP POLB TDP1 CETN2 MACROD1 PARP2 XPA LIG3 CHD1L APLF WRN RPA3 XPC RPA1 | cellular response to stress |
  GO:0003684 | 5.54928479526e-10 | 0.347826086957 | RPA1 WRN XPA PARP2 RPA3 PNKP PARP1 XPC | damaged DNA binding |
  KEGG:03410 | 2.70099149654e-09 | 0.260869565217 | LIG3 PNKP TDP1 PARP2 POLB PARP1 | Base excision repair |
  GO:0006302 | 3.87962074861e-09 | 0.478260869565 | RPA1 PARP1 PNKP POLB TDP1 LIG3 PARP2 APLF RPA3 WRN RPA4 | double-strand break repair |
  REAC:R-HSA-73884 | 5.73397588662e-09 | 0.304347826087 | RPA1 RPA3 PARP2 POLB PNKP PARP1 LIG3 | Base Excision Repair |
  REAC:R-HSA-5696400 | 1.04568773938e-08 | 0.260869565217 | RPA1 RPA3 XPA PARP2 PARP1 CHD1L | Dual Incision in GG-NER |
  KEGG:03420 | 1.76654433824e-08 | 0.260869565217 | RPA1 RPA3 XPA CETN2 XPC RPA4 | Nucleotide excision repair |
  GO:0006260 | 1.86380833392e-08 | 0.434782608696 | RPA1 PNKP POLB SSBP1 LIG3 WRN PARP1 RPA3 PRIMPOL RPA4 | DNA replication |
  GO:0006261 | 2.03852217629e-08 | 0.391304347826 | RPA1 WRN POLB SSBP1 LIG3 PNKP PARP1 PRIMPOL RPA4 | DNA-templated DNA replication |
  GO:0090734 | 9.57341960823e-08 | 0.347826086957 | RPA1 PNKP PARP2 CHD1L APLF RPA3 PARP1 RPA4 | site of DNA damage |
  REAC:R-HSA-110373 | 1.0174423399e-07 | 0.217391304348 | PARP2 RPA3 POLB RPA1 PARP1 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
  WP:WP4752 | 1.05470237948e-07 | 0.217391304348 | PNKP POLB LIG3 PARP2 PARP1 | Base excision repair |
  CORUM:5243 | 1.07739615662e-07 | 0.130434782609 | PNKP TDP1 LIG3 | XRCC1-LIG3-PNK-TDP1 complex |
  CORUM:362 | 1.07739615662e-07 | 0.130434782609 | PNKP LIG3 POLB | DNA ligase III-XRCC1-PNK-DNA-pol III multiprotein complex |
  WP:WP4016 | 2.06625093263e-07 | 0.260869565217 | RPA1 WRN TDP1 XPA POLB PARP1 | DNA IR damage and cellular response via ATR |
  GO:0005657 | 2.86036646421e-07 | 0.304347826087 | RPA1 RPA3 XPA WRN PARP1 PRIMPOL RPA4 | replication fork |
  GO:0006950 | 4.83937124012e-07 | 0.826086956522 | MACROD1 HLTF PRIMPOL RPA4 PARP1 PNKP POLB TDP1 CETN2 CLEC1B PARP2 XPA LIG3 CHD1L APLF RPA3 WRN XPC RPA1 | response to stress |
  WP:WP4753 | 7.02970284826e-07 | 0.217391304348 | RPA3 XPA XPC CETN2 RPA1 | Nucleotide excision repair |
  REAC:R-HSA-5693532 | 1.03297399911e-06 | 0.304347826087 | RPA1 RPA3 TDP1 PARP2 WRN PARP1 LIG3 | DNA Double-Strand Break Repair |
  GO:0006289 | 1.07196602592e-06 | 0.304347826087 | RPA4 RPA3 XPA CETN2 PNKP XPC RPA1 | nucleotide-excision repair |
  KEGG:03430 | 2.49112561543e-06 | 0.173913043478 | SSBP1 RPA1 RPA4 RPA3 | Mismatch repair |
  CORUM:1004 | 8.99452984903e-06 | 0.130434782609 | RPA3 RPA1 PARP1 | RC complex during S-phase of cell cycle |
  REAC:R-HSA-5693538 | 1.21131215953e-05 | 0.260869565217 | LIG3 RPA3 PARP2 WRN PARP1 RPA1 | Homology Directed Repair |
  CORUM:1005 | 1.28361389281e-05 | 0.130434782609 | RPA3 RPA1 PARP1 | RC complex during G2/M-phase of cell cycle |
  GO:0070013 | 1.6290692267e-05 | 0.95652173913 | SSRP1 PNKP PARP2 RPA1 WRN MACROD1 POLB PARP1 XPC HLTF RPA4 RPAIN XPA CETN2 APLF CHD1L PRIMPOL LIG3 SSBP1 RPA3 TDP1 RNF146 | intracellular organelle lumen |
  GO:0031974 | 1.6290692267e-05 | 0.95652173913 | SSRP1 PNKP PARP2 RPA1 WRN MACROD1 POLB PARP1 XPC HLTF RPA4 RPAIN XPA CETN2 APLF CHD1L PRIMPOL LIG3 SSBP1 RPA3 TDP1 RNF146 | membrane-enclosed lumen |
  GO:0043233 | 1.6290692267e-05 | 0.95652173913 | SSRP1 PNKP PARP2 RPA1 WRN MACROD1 POLB PARP1 XPC HLTF RPA4 RPAIN XPA CETN2 APLF CHD1L PRIMPOL LIG3 SSBP1 RPA3 TDP1 RNF146 | organelle lumen |
  KEGG:03030 | 1.63486074628e-05 | 0.173913043478 | SSBP1 RPA1 RPA4 RPA3 | DNA replication |
  GO:0140097 | 1.6549829348e-05 | 0.347826086957 | HLTF LIG3 WRN TDP1 APLF POLB CHD1L PRIMPOL | catalytic activity, acting on DNA |
  REAC:R-HSA-3108214 | 2.37810580949e-05 | 0.217391304348 | PARP1 WRN XPC CETN2 RPA1 | SUMOylation of DNA damage response and repair proteins |
  KEGG:03440 | 2.5259126325e-05 | 0.173913043478 | SSBP1 RPA1 RPA4 RPA3 | Homologous recombination |
  GO:0005654 | 2.83592923666e-05 | 0.869565217391 | MACROD1 HLTF TDP1 RPA4 RPAIN PARP1 PNKP POLB RPA1 CETN2 RNF146 PARP2 XPA LIG3 CHD1L APLF WRN RPA3 XPC SSRP1 | nucleoplasm |
  REAC:R-HSA-5649702 | 3.82811230328e-05 | 0.130434782609 | PNKP LIG3 POLB | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway |
  REAC:R-HSA-110362 | 6.11869241326e-05 | 0.130434782609 | PARP1 PARP2 POLB | POLB-Dependent Long Patch Base Excision Repair |
  CORUM:5229 | 7.49713811273e-05 | 0.0869565217391 | RPA3 RPA1 | RPA complex |
  CORUM:5235 | 7.49713811273e-05 | 0.0869565217391 | WRN PARP1 | WRN-Ku70-Ku80-PARP1 complex |
  CORUM:7352 | 7.49713811273e-05 | 0.0869565217391 | PARP1 LIG3 | PARP1-LIG3 complex |
  GO:0035861 | 7.60953569476e-05 | 0.260869565217 | RPA4 PARP1 PNKP APLF RPA3 CHD1L | site of double-strand break |
  GO:0031981 | 9.7139886495e-05 | 0.869565217391 | MACROD1 HLTF TDP1 RPA4 RPAIN PARP1 PNKP POLB RPA1 CETN2 RNF146 PARP2 XPA LIG3 CHD1L APLF WRN RPA3 XPC SSRP1 | nuclear lumen |
  REAC:R-HSA-5696394 | 0.000107100893456 | 0.173913043478 | PARP2 PARP1 XPC CETN2 | DNA Damage Recognition in GG-NER |
  GO:0005662 | 0.000165040423252 | 0.173913043478 | RPA3 XPA RPA4 RPA1 | DNA replication factor A complex |
  GO:0043596 | 0.000168457538004 | 0.217391304348 | PARP1 RPA3 XPA RPA4 RPA1 | nuclear replication fork |
  REAC:R-HSA-5685939 | 0.000179728307106 | 0.130434782609 | PARP1 PARP2 LIG3 | HDR through MMEJ (alt-NHEJ) |
  CORUM:7295 | 0.00022469866415 | 0.0869565217391 | XPA RPA1 | ERCC1-RPA1-XPA complex |
  GO:0032042 | 0.000314421871079 | 0.173913043478 | SSBP1 LIG3 PRIMPOL PARP1 | mitochondrial DNA metabolic process |
  CORUM:1086 | 0.00044896681224 | 0.0869565217391 | POLB LIG3 | DNA repair complex NEIL1-PNK-Pol(beta)-LigIII(alpha)-XRCC1 |
  CORUM:1085 | 0.00044896681224 | 0.0869565217391 | POLB LIG3 | DNA repair complex NEIL2-PNK-Pol(beta)-LigIII(alpha)-XRCC1 |
  GO:0003697 | 0.000456654731149 | 0.260869565217 | RPA4 RPA3 TDP1 SSBP1 XPC RPA1 | single-stranded DNA binding |
  GO:0005634 | 0.000460476294842 | 0.95652173913 | SSRP1 PNKP PARP2 RPA1 WRN MACROD1 POLB PARP1 XPC HLTF RPA4 RPAIN XPA CETN2 APLF CHD1L PRIMPOL LIG3 SSBP1 RPA3 TDP1 RNF146 | nucleus |
  HPA:0330222 | 0.000584987599948 | 0.739130434783 | RPA4 RPAIN XPA PARP1 PNKP POLB RPA1 CETN2 TDP1 PARP2 SSBP1 LIG3 CHD1L RPA3 WRN XPC SSRP1 | oral mucosa; squamous epithelial cells[>=Medium] |
  REAC:R-HSA-174437 | 0.00073614863329 | 0.130434782609 | RPA3 RPA1 WRN | Removal of the Flap Intermediate from the C-strand |
  CORUM:2222 | 0.000747561230202 | 0.0869565217391 | RPA3 RPA1 | BLM complex II |
  CORUM:2738 | 0.000747561230202 | 0.0869565217391 | RPA3 RPA1 | BLM complex II |
  REAC:R-HSA-174414 | 0.00104685961 | 0.130434782609 | RPA3 RPA1 WRN | Processive synthesis on the C-strand of the telomere |
  GO:0009411 | 0.00115694148803 | 0.260869565217 | WRN XPC XPA RPAIN PARP1 PRIMPOL | response to UV |
  GO:0005694 | 0.00120593486185 | 0.565217391304 | RPA4 PARP1 PNKP RPA1 PRIMPOL PARP2 XPA CHD1L APLF RPA3 WRN XPC SSRP1 | chromosome |
  REAC:R-HSA-3108232 | 0.0012854097409 | 0.217391304348 | PARP1 WRN XPC CETN2 RPA1 | SUMO E3 ligases SUMOylate target proteins |
  REAC:R-HSA-5651801 | 0.00143391828595 | 0.130434782609 | RPA3 RPA1 POLB | PCNA-Dependent Long Patch Base Excision Repair |
  REAC:R-HSA-2990846 | 0.00149731418049 | 0.217391304348 | PARP1 WRN XPC CETN2 RPA1 | SUMOylation |
  HPA:0620222 | 0.00151676629366 | 0.695652173913 | RPA4 RPAIN XPA PNKP TDP1 CETN2 RNF146 PARP2 SSBP1 LIG3 CHD1L WRN PARP1 RPA3 XPC RPA1 | vagina; squamous epithelial cells[>=Medium] |
  GO:0000002 | 0.00167274433788 | 0.173913043478 | SSBP1 LIG3 PRIMPOL PARP1 | mitochondrial genome maintenance |
  GO:0043601 | 0.00167274433788 | 0.173913043478 | RPA3 XPA RPA4 RPA1 | nuclear replisome |
  GO:0043504 | 0.00169879277018 | 0.130434782609 | PARP1 PRIMPOL LIG3 | mitochondrial DNA repair |
  REAC:R-HSA-6781827 | 0.00188535330492 | 0.173913043478 | RPA3 LIG3 RPA1 XPA | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
  GO:0051716 | 0.00218419298103 | 0.869565217391 | MACROD1 HLTF PRIMPOL RPA4 PARP1 PNKP POLB RNF146 TDP1 CETN2 CLEC1B PARP2 XPA LIG3 CHD1L APLF RPA3 WRN XPC RPA1 | cellular response to stimulus |
  GO:0030894 | 0.00242482694796 | 0.173913043478 | RPA3 XPA RPA4 RPA1 | replisome |
  REAC:R-HSA-5696397 | 0.0024695445471 | 0.130434782609 | RPA3 RPA1 LIG3 | Gap-filling DNA repair synthesis and ligation in GG-NER |
  CORUM:248 | 0.00268092511124 | 0.0869565217391 | RPA3 RPA1 | BRAFT complex |
  GO:0003677 | 0.00286391226727 | 0.565217391304 | HLTF RPA4 XPA PARP1 PNKP RPA1 TDP1 SSBP1 PARP2 RPA3 WRN XPC SSRP1 | DNA binding |
  HPA:0460672 | 0.00286658880338 | 0.652173913043 | TDP1 RPA4 RPAIN XPA PNKP POLB RPA1 RNF146 SSBP1 LIG3 CHD1L RPA3 PARP1 XPC SSRP1 | skin 1; melanocytes[>=Medium] |
  GO:0050896 | 0.00315225595199 | 0.913043478261 | MACROD1 HLTF PRIMPOL RPA4 RPAIN PARP1 PNKP POLB RNF146 TDP1 CETN2 CLEC1B PARP2 XPA LIG3 CHD1L APLF RPA3 WRN XPC RPA1 | response to stimulus |
  REAC:R-HSA-6804756 | 0.00335935454073 | 0.173913043478 | RPA3 RPA1 SSRP1 WRN | Regulation of TP53 Activity through Phosphorylation |
  GO:0072572 | 0.00339409783315 | 0.130434782609 | APLF RNF146 PARP2 | poly-ADP-D-ribose binding |
  GO:0160002 | 0.00339409783315 | 0.130434782609 | APLF PARP2 CHD1L | ADP-D-ribose modification-dependent protein binding |
  GO:0006139 | 0.00346749513976 | 0.826086956522 | HLTF PRIMPOL RPA4 XPA PARP1 PNKP POLB TDP1 CETN2 MACROD1 PARP2 SSBP1 LIG3 CHD1L APLF RPA3 WRN XPC RPA1 | nucleobase-containing compound metabolic process |
  KEGG:03460 | 0.00368424416283 | 0.130434782609 | RPA3 RPA4 RPA1 | Fanconi anemia pathway |
  CORUM:244 | 0.00408801752763 | 0.0869565217391 | RPA3 RPA1 | BRAFT complex |
  REAC:R-HSA-110381 | 0.00457656492477 | 0.0869565217391 | POLB LIG3 | Resolution of AP sites via the single-nucleotide replacement pathway |
  GO:0009314 | 0.00461841022237 | 0.304347826087 | WRN PNKP PRIMPOL XPA RPAIN PARP1 XPC | response to radiation |
  WP:WP466 | 0.00470554581227 | 0.130434782609 | RPA3 RPA4 RPA1 | DNA replication |
  HPA:0190222 | 0.00523093426717 | 0.739130434783 | RPA4 RPAIN XPA PNKP POLB TDP1 CETN2 RNF146 PARP2 SSBP1 LIG3 CHD1L WRN PARP1 RPA3 XPC RPA1 | esophagus; squamous epithelial cells[>=Medium] |
  GO:0046483 | 0.00578465270442 | 0.826086956522 | HLTF PRIMPOL RPA4 XPA PARP1 PNKP POLB TDP1 CETN2 MACROD1 PARP2 SSBP1 LIG3 CHD1L APLF RPA3 WRN XPC RPA1 | heterocycle metabolic process |
  REAC:R-HSA-68962 | 0.00581026889635 | 0.130434782609 | RPA3 RPA4 RPA1 | Activation of the pre-replicative complex |
  GO:0006725 | 0.00610839874469 | 0.826086956522 | HLTF PRIMPOL RPA4 XPA PARP1 PNKP POLB TDP1 CETN2 MACROD1 PARP2 SSBP1 LIG3 CHD1L APLF RPA3 WRN XPC RPA1 | cellular aromatic compound metabolic process |
  GO:0090304 | 0.0062838493694 | 0.782608695652 | HLTF RPA4 XPA PARP1 PNKP POLB TDP1 CETN2 PRIMPOL PARP2 SSBP1 LIG3 CHD1L APLF RPA3 WRN XPC RPA1 | nucleic acid metabolic process |
  GO:0000724 | 0.00629320614948 | 0.260869565217 | RPA4 LIG3 RPA3 WRN PARP1 RPA1 | double-strand break repair via homologous recombination |
  REAC:R-HSA-9709570 | 0.00636601399978 | 0.130434782609 | RPA3 RPA1 WRN | Impaired BRCA2 binding to RAD51 |
  REAC:R-HSA-174417 | 0.00636601399978 | 0.130434782609 | RPA3 RPA1 WRN | Telomere C-strand (Lagging Strand) Synthesis |
  REAC:R-HSA-5685938 | 0.00695568324258 | 0.130434782609 | RPA3 RPA1 WRN | HDR through Single Strand Annealing (SSA) |
  GO:0000725 | 0.00729991150006 | 0.260869565217 | RPA4 LIG3 RPA3 WRN PARP1 RPA1 | recombinational repair |
  HPA:0630052 | 0.00838179133043 | 0.652173913043 | RPA4 RPAIN XPA PNKP POLB TDP1 CETN2 RNF146 SSBP1 LIG3 CHD1L RPA3 PARP1 XPC RPA1 | cervix; glandular cells[>=Medium] |
  HPA:0460671 | 0.00957837569837 | 0.739130434783 | TDP1 RPA4 RPAIN XPA PARP1 PNKP POLB RPA1 CETN2 RNF146 SSBP1 LIG3 CHD1L RPA3 WRN XPC SSRP1 | skin 1; melanocytes[>=Low] |
  REAC:R-HSA-5693616 | 0.00967264952063 | 0.130434782609 | RPA3 RPA1 WRN | Presynaptic phase of homologous DNA pairing and strand exchange |
  HP:0003621 | 0.0101378327784 | 0.304347826087 | RPA1 XPA WRN TDP1 SSBP1 PNKP LIG3 | Juvenile onset |
  HPA:0620000 | 0.0103621335931 | 0.782608695652 | TDP1 RPA4 RPAIN XPA PARP1 PNKP POLB RPA1 CETN2 RNF146 PARP2 SSBP1 LIG3 CHD1L RPA3 WRN XPC SSRP1 | vagina |
  HPA:0620221 | 0.0103621335931 | 0.782608695652 | TDP1 RPA4 RPAIN XPA PARP1 PNKP POLB RPA1 CETN2 RNF146 PARP2 SSBP1 LIG3 CHD1L RPA3 WRN XPC SSRP1 | vagina; squamous epithelial cells[>=Low] |
  REAC:R-HSA-9675136 | 0.010446189328 | 0.130434782609 | RPA3 RPA1 WRN | Diseases of DNA Double-Strand Break Repair |
  REAC:R-HSA-9701190 | 0.010446189328 | 0.130434782609 | RPA3 RPA1 WRN | Defective homologous recombination repair (HRR) due to BRCA2 loss of function |
  GO:1901360 | 0.0114813707769 | 0.826086956522 | HLTF PRIMPOL RPA4 XPA PARP1 PNKP POLB TDP1 CETN2 MACROD1 PARP2 SSBP1 LIG3 CHD1L APLF RPA3 WRN XPC RPA1 | organic cyclic compound metabolic process |
  HPA:0380512 | 0.0118527820237 | 0.608695652174 | RPA4 RPAIN WRN TDP1 CETN2 RNF146 XPA LIG3 CHD1L RPA3 PNKP PARP1 XPC RPA1 | placenta; decidual cells[>=Medium] |
  REAC:R-HSA-5693579 | 0.0121129856716 | 0.130434782609 | RPA3 RPA1 WRN | Homologous DNA Pairing and Strand Exchange |
  HPA:0380511 | 0.0152509680484 | 0.695652173913 | RPA4 RPAIN WRN POLB TDP1 CETN2 RNF146 PARP2 XPA LIG3 CHD1L RPA3 PNKP PARP1 XPC RPA1 | placenta; decidual cells[>=Low] |
  GO:0009416 | 0.0160078601911 | 0.260869565217 | WRN XPC XPA RPAIN PARP1 PRIMPOL | response to light stimulus |
  REAC:R-HSA-9675135 | 0.0193006855498 | 0.130434782609 | RPA3 RPA1 WRN | Diseases of DNA repair |
  HPA:0330221 | 0.0193024640344 | 0.782608695652 | TDP1 RPA4 RPAIN XPA PARP1 PNKP POLB RPA1 CETN2 RNF146 PARP2 SSBP1 LIG3 CHD1L RPA3 WRN XPC SSRP1 | oral mucosa; squamous epithelial cells[>=Low] |
  HPA:0330000 | 0.0193024640344 | 0.782608695652 | TDP1 RPA4 RPAIN XPA PARP1 PNKP POLB RPA1 CETN2 RNF146 PARP2 SSBP1 LIG3 CHD1L RPA3 WRN XPC SSRP1 | oral mucosa |
  GO:0000012 | 0.0202810995064 | 0.130434782609 | APLF TDP1 PARP1 | single strand break repair |
  REAC:R-HSA-180786 | 0.0217711970027 | 0.130434782609 | RPA3 RPA1 WRN | Extension of Telomeres |
  HPA:0630051 | 0.0246071062192 | 0.739130434783 | RPA4 RPAIN XPA PNKP POLB TDP1 CETN2 RNF146 PARP2 SSBP1 LIG3 CHD1L WRN PARP1 RPA3 XPC RPA1 | cervix; glandular cells[>=Low] |
  GO:0034641 | 0.0246451741372 | 0.826086956522 | HLTF PRIMPOL RPA4 XPA PARP1 PNKP POLB TDP1 CETN2 MACROD1 PARP2 SSBP1 LIG3 CHD1L APLF RPA3 WRN XPC RPA1 | cellular nitrogen compound metabolic process |
  GO:0140640 | 0.0252259069443 | 0.347826086957 | HLTF LIG3 WRN TDP1 APLF POLB CHD1L PRIMPOL | catalytic activity, acting on a nucleic acid |
  REAC:R-HSA-5633007 | 0.0275386892805 | 0.173913043478 | RPA3 RPA1 SSRP1 WRN | Regulation of TP53 Activity |
  GO:0000109 | 0.0278578876014 | 0.130434782609 | XPA XPC CETN2 | nucleotide-excision repair complex |
  GO:0006264 | 0.0278578876014 | 0.130434782609 | SSBP1 PRIMPOL LIG3 | mitochondrial DNA replication |
  HPA:0040000 | 0.0280707551987 | 0.782608695652 | RPA4 RPAIN XPA PARP1 PNKP POLB TDP1 CETN2 CLEC1B PARP2 SSBP1 LIG3 CHD1L RNF146 RPA3 WRN XPC RPA1 | bone marrow |
  HPA:0040081 | 0.0280707551987 | 0.782608695652 | RPA4 RPAIN XPA PARP1 PNKP POLB TDP1 CETN2 CLEC1B PARP2 SSBP1 LIG3 CHD1L RNF146 RPA3 WRN XPC RPA1 | bone marrow; hematopoietic cells[>=Low] |
  HPA:0090191 | 0.029013888338 | 0.652173913043 | SSRP1 RPAIN RPA3 RPA1 CETN2 RNF146 PARP2 XPA LIG3 CHD1L WRN PNKP PARP1 XPC RPA4 | cerebellum; cells in molecular layer[>=Low] |
  HPA:0301371 | 0.0324391274778 | 0.391304347826 | RPA1 XPA PNKP SSBP1 PARP2 CHD1L PARP1 XPC LIG3 | lung; alveolar cells type II[>=Low] |
  HPA:0380513 | 0.0348495607474 | 0.347826086957 | RPA1 RPAIN RPA3 XPA CHD1L PNKP PARP1 LIG3 | placenta; decidual cells[High] |
  WP:WP2446 | 0.0400963184579 | 0.130434782609 | HLTF RPA1 RPA3 | Retinoblastoma gene in cancer |
  REAC:R-HSA-6782210 | 0.0410071526782 | 0.130434782609 | RPA3 RPA1 LIG3 | Gap-filling DNA repair synthesis and ligation in TC-NER |
  HPA:0610833 | 0.0420474822818 | 0.434782608696 | RPA4 RPAIN RPA3 POLB XPA LIG3 PNKP CHD1L XPC RPA1 | urinary bladder; urothelial cells[High] |
  REAC:R-HSA-6782135 | 0.0429797702741 | 0.130434782609 | RPA3 RPA1 XPA | Dual incision in TC-NER |
  HPA:0340461 | 0.0430726814647 | 0.608695652174 | SSRP1 RPAIN RPA3 POLB RPA1 CETN2 RNF146 XPA LIG3 CHD1L PNKP PARP1 XPC RPA4 | ovary; ovarian stroma cells[>=Low] |
  WP:WP3645 | 0.044731571894 | 0.0869565217391 | PARP1 PARP2 | NAD biosynthetic pathways |
  REAC:R-HSA-5685942 | 0.0471083437265 | 0.130434782609 | RPA3 RPA1 WRN | HDR through Homologous Recombination (HRR) |
  GO:0006287 | 0.0481879293545 | 0.130434782609 | PNKP LIG3 POLB | base-excision repair, gap-filling |
  GO:0006266 | 0.0481879293545 | 0.130434782609 | APLF LIG3 PNKP | DNA ligation |
  HPA:0190000 | 0.0487715282554 | 0.782608695652 | TDP1 RPA4 RPAIN XPA PARP1 PNKP POLB RPA1 CETN2 RNF146 PARP2 SSBP1 LIG3 CHD1L RPA3 WRN XPC SSRP1 | esophagus |
  HPA:0190221 | 0.0487715282554 | 0.782608695652 | TDP1 RPA4 RPAIN XPA PARP1 PNKP POLB RPA1 CETN2 RNF146 PARP2 SSBP1 LIG3 CHD1L RPA3 WRN XPC SSRP1 | esophagus; squamous epithelial cells[>=Low] |
  CORUM:365 | 0.0498014438088 | 0.0434782608696 | LIG3 | DNA ligase III-XRCC1 complex |
  CORUM:363 | 0.0498014438088 | 0.0434782608696 | LIG3 | DNA ligase III-XRCC1 complex |
  CORUM:212 | 0.0498014438088 | 0.0434782608696 | LIG3 | DNA ligase III-XRCC1 complex |
  CORUM:4082 | 0.0498014438088 | 0.0434782608696 | WRN | XRCC6-XRCC5-WRN complex |
  WP:WP5103 | 0.0499462656714 | 0.0869565217391 | WRN PARP1 | Progeria associated lipodystrophy |
  REAC:R-HSA-3371511 | 0.0499578070164 | 0.0869565217391 | RPA3 RPA1 | HSF1 activation |
Edges
Protein 1 | Protein 2 | Score | ProteomeHD |
---|---|---|---|
 RPA3 |  RPA2 | 1.0 | 0.958           |
 RPA1 |  RPA2 | 1.0 | 0.802           |
 RPA3 |  RPA1 | 1.0 | 0.658           |
 XRCC6 |  XRCC5 | 1.0 | 0.96           |
 LIG3 |  XRCC1 | 1.0 | 0.55           |
 POLB |  XRCC1 | 0.999 | 0.084           |
 POLB |  PARP2 | 0.999 | 0.04           |
 LIG3 |  POLB | 0.999 | 0.1           |
 RPA1 |  RPAIN | 0.999 | 0.196           |
 RPA2 |  RPAIN | 0.999 | 0.208           |
 WRN |  XRCC6 | 0.999 | 0.32           |
 XPC |  CETN2 | 0.999 | 0.08           |
 RNF146 |  PARP2 | 0.999 | 0.088           |
 RPA1 |  RPA4 | 0.998 |            |
 XRCC5 |  APLF | 0.998 |            |
 LIG3 |  PNKP | 0.998 | 0.18           |
 XRCC6 |  APLF | 0.998 |            |
 XRCC6 |  RPA2 | 0.997 | 0.456           |
 APLF |  XPC | 0.997 |            |
 APLF |  PARP1 | 0.997 |            |
 APLF |  PARP2 | 0.997 |            |
 RPAIN |  RPA4 | 0.997 |            |
 XPA |  RPA3 | 0.996 | 0.106           |
 APLF |  LIG3 | 0.996 |            |
 LIG3 |  TDP1 | 0.996 | 0.0660385964912           |
 XPC |  RPA2 | 0.995 | 0.14           |
 XRCC6 |  PARP1 | 0.995 | 0.55           |
 APLF |  RPA2 | 0.995 |            |
 APLF |  RPA1 | 0.995 |            |
 RPA3 |  RPA4 | 0.995 |            |
 XPC |  RPA1 | 0.994 | 0.218           |
 APLF |  HLTF | 0.994 |            |
 PNKP |  POLB | 0.994 | 0.108           |
 SSRP1 |  PARP1 | 0.994 | 0.562           |
 XPC |  PARP2 | 0.993 | 0.032           |
 PNKP |  XRCC1 | 0.993 | 0.13           |
 XPC |  RPA3 | 0.993 | 0.156           |
 SSBP1 |  RPA2 | 0.993 | 0.24           |
 APLF |  POLB | 0.993 |            |
 HLTF |  CHD1L | 0.993 | 0.09           |
 XPC |  PARP1 | 0.992 | 0.363073394495           |
 SSBP1 |  RPA4 | 0.992 |            |
 LIG3 |  PARP2 | 0.991 | 0.076           |
 MACROD1 |  PARP1 | 0.991 | 0.166           |
 APLF |  XRCC1 | 0.99 |            |
 XPC |  RPA4 | 0.99 |            |
 XRCC5 |  RPA2 | 0.99 | 0.424           |
 RPA3 |  RPAIN | 0.989 | 0.288           |
 XPA |  RPA2 | 0.989 | 0.196           |
 LIG3 |  RPA2 | 0.989 | 0.106           |
 SSRP1 |  APLF | 0.989 |            |
 RNF146 |  CHD1L | 0.988 | 0.06           |
 XPC |  CHD1L | 0.988 | 0.024           |
 POLB |  TDP1 | 0.986 | 0.13           |
 LIG3 |  RPA4 | 0.986 |            |
 RPA2 |  PARP1 | 0.985 | 0.424           |
 XPC |  RNF146 | 0.984 | 0.182           |
 HLTF |  XPC | 0.984 | 0.032           |
 RPA2 |  PARP2 | 0.983 | 0.048           |
 APLF |  RPA3 | 0.983 |            |
 RPAIN |  PARP1 | 0.983 | 0.226           |
 LIG3 |  PARP1 | 0.982 | 0.53           |
 LIG3 |  XPC | 0.981 | 0.164           |
 MACROD1 |  RPA2 | 0.978 | 0.026           |
 HLTF |  RPA2 | 0.977 | 0.07           |
 XPC |  POLB | 0.976 | 0.19           |
 POLB |  PARP1 | 0.974 | 0.313555555556           |
 RPA1 |  SSBP1 | 0.974 | 0.244           |
 LIG3 |  HLTF | 0.973 | 0.1           |
 HLTF |  RPA1 | 0.972 | 0.204166666667           |
 RNF146 |  PARP1 | 0.972 | 0.216           |
 RPA4 |  PARP1 | 0.97 |            |
 XRCC6 |  PARP2 | 0.97 | 0.206           |
 SSRP1 |  POLB | 0.97 | 0.154           |
 PARP2 |  CHD1L | 0.966 | 0.054           |
 XRCC6 |  CHD1L | 0.966 | 0.198           |
 XRCC5 |  CHD1L | 0.965 | 0.264           |
 MACROD1 |  XPC | 0.964 | 0.022           |
 HLTF |  PARP1 | 0.963 | 0.482857142857           |
 RPA1 |  CHD1L | 0.962 | 0.204           |
 LIG3 |  RPA3 | 0.962 | 0.12           |
 WRN |  XRCC5 | 0.96 | 0.48           |
 SSBP1 |  CLEC1B | 0.96 |            |
 XRCC6 |  LIG3 | 0.96 | 0.338           |
 CHD1L |  PARP1 | 0.958 | 0.470310125952           |
 HLTF |  RPA3 | 0.957 | 0.048           |
 XRCC5 |  LIG3 | 0.955 | 0.306           |
 PRIMPOL |  RPA2 | 0.951 |            |
 LIG3 |  RPA1 | 0.951 | 0.202           |
 MACROD1 |  PARP2 | 0.95 | 0.034           |
 APLF |  CETN2 | 0.949 |            |
 XPA |  SSBP1 | 0.948 | 0.062           |
 SSRP1 |  MACROD1 | 0.947 | 0.04           |
 XRCC1 |  CHD1L | 0.943 | 0.102           |
 XRCC1 |  RPA2 | 0.943 | 0.232           |
 SSRP1 |  CHD1L | 0.94 | 0.144           |
 XRCC6 |  RPA4 | 0.937 |            |
 XRCC6 |  XPC | 0.932 | 0.314           |
 RPA2 |  RPA4 | 0.931 |            |
 PRIMPOL |  SSBP1 | 0.926 |            |
 CETN2 |  RPA2 | 0.923 | 0.088           |
 RPA3 |  RNF146 | 0.92 | 0.148           |
 LIG3 |  CHD1L | 0.92 | 0.094           |
 XRCC6 |  SSRP1 | 0.92 | 0.588           |
 XRCC1 |  TDP1 | 0.918 | 0.172           |
 RPA3 |  CETN2 | 0.915 | 0.082           |
 SSRP1 |  RNF146 | 0.915 | 0.106           |
 SSRP1 |  XPC | 0.914 | 0.184           |
 RNF146 |  RPA2 | 0.91 | 0.112           |
 XRCC1 |  PARP2 | 0.908 | 0.07           |
 XRCC5 |  PARP1 | 0.905 | 0.672           |
 APLF |  TDP1 | 0.904 |            |
 SSRP1 |  RPA2 | 0.904 | 0.323           |
 HLTF |  RNF146 | 0.903 | 0.094           |
 RPA2 |  CHD1L | 0.9 | 0.082           |
 SSRP1 |  LIG3 | 0.896 | 0.108           |
 LIG3 |  CETN2 | 0.893 | 0.086           |
 CETN2 |  PARP2 | 0.889 | 0.018           |
 SSRP1 |  CETN2 | 0.884 | 0.062           |
 RPA3 |  PARP2 | 0.883 | 0.078           |
 XPA |  RPA1 | 0.88 | 0.122           |
 HLTF |  POLB | 0.878 | 0.036           |
 RPA3 |  SSBP1 | 0.875 | 0.348           |
 PNKP |  TDP1 | 0.862 | 0.12           |
 XRCC6 |  RNF146 | 0.862 | 0.136           |
 XRCC5 |  RNF146 | 0.861 | 0.136           |
 XPC |  SSBP1 | 0.859 | 0.136           |
 XRCC6 |  CETN2 | 0.858 | 0.154           |
 PRIMPOL |  RPA1 | 0.857 |            |
 SSRP1 |  RPA1 | 0.855 | 0.398           |
 XRCC5 |  XPC | 0.853 | 0.292           |
 XRCC5 |  RPA4 | 0.852 |            |
 MACROD1 |  RPA1 | 0.841 | 0.052           |
 HLTF |  CETN2 | 0.838 | 0.038           |
 RPA3 |  CHD1L | 0.836 | 0.102           |
 RPA1 |  RNF146 | 0.834 | 0.112           |
 XRCC5 |  SSRP1 | 0.831 | 0.408           |
 POLB |  RPA1 | 0.825 | 0.112           |
 XRCC5 |  HLTF | 0.823 | 0.114           |
 POLB |  RPA2 | 0.823 | 0.1           |
 APLF |  CHD1L | 0.818 |            |
 XRCC6 |  RPA3 | 0.808 | 0.612           |
 XRCC6 |  XRCC1 | 0.807 | 0.336           |
 TDP1 |  CETN2 | 0.804 | 0.05           |
 SSRP1 |  HLTF | 0.795 | 0.186           |
 XRCC6 |  POLB | 0.794 | 0.302           |
 HLTF |  XRCC1 | 0.791 | 0.07           |
 XPC |  TDP1 | 0.787 | 0.05           |
 PARP2 |  RPA4 | 0.786 |            |
 TDP1 |  PARP2 | 0.785 | 0.092           |
 XRCC5 |  MACROD1 | 0.779 | 0.186           |
 SSRP1 |  PARP2 | 0.777 | 0.266           |
 POLB |  RPA3 | 0.737 | 0.106           |
 MACROD1 |  RPA3 | 0.734 | 0.052           |
 WRN |  LIG3 | 0.719 | 0.146           |
 XRCC5 |  POLB | 0.71 | 0.306           |
 XRCC5 |  CETN2 | 0.704 | 0.104           |
 WRN |  XPC | 0.687 | 0.126           |
 SSRP1 |  RPA4 | 0.681 |            |
 PNKP |  PARP2 | 0.661 | 0.046           |
 HLTF |  PARP2 | 0.654 | 0.086           |
 WRN |  CHD1L | 0.651 | 0.162           |
 MACROD1 |  CETN2 | 0.642 | 0.032           |
 XRCC6 |  MACROD1 | 0.63 | 0.2           |
 POLB |  CETN2 | 0.628 | 0.14           |
 PNKP |  RPA2 | 0.624 | 0.1           |
 XRCC6 |  RPA1 | 0.614 | 0.654           |
 RPA1 |  PARP1 | 0.605 | 0.63           |
 XRCC6 |  HLTF | 0.561 | 0.106           |
 RPA1 |  PARP2 | 0.555 | 0.11           |
 XRCC5 |  PARP2 | 0.538 | 0.198           |
 XRCC5 |  PNKP | 0.532 | 0.336193548387           |
 SSRP1 |  RPA3 | 0.516 | 0.368           |
 XRCC5 |  RPA1 | 0.516 | 0.632           |
 XPC |  XRCC1 | 0.515 | 0.126           |
 LIG3 |  RPAIN | 0.512 | 0.1           |
 PRIMPOL |  RPA3 | 0.505 |            |
 WRN |  PARP2 | 0.488 | 0.17           |
 XPC |  RPAIN | 0.469 | 0.062           |
 TDP1 |  RPA1 | 0.465 | 0.11           |
 RNF146 |  CETN2 | 0.458 | 0.052           |
 TDP1 |  RPA3 | 0.457 | 0.034           |
 XRCC1 |  RPA1 | 0.429 | 0.22           |
 PARP2 |  PARP1 | 0.423 | 0.307277777778           |
 CETN2 |  PARP1 | 0.422 | 0.1227           |
 RPA1 |  CETN2 | 0.401 | 0.054           |
 SSRP1 |  XRCC1 | 0.399 | 0.196           |
 TDP1 |  RPA2 | 0.379 | 0.042           |
 XRCC6 |  PNKP | 0.375 | 0.308           |
 XRCC1 |  CETN2 | 0.364 | 0.026           |
 LIG3 |  RNF146 | 0.345 | 0.064           |
 CETN2 |  RPA4 | 0.335 |            |
 CETN2 |  CHD1L | 0.335 | 0.032           |
 XRCC5 |  RPA3 | 0.32 | 0.578           |
 TDP1 |  PARP1 | 0.314 | 0.214           |
 LIG3 |  MACROD1 | 0.304 | 0.036           |
 APLF |  PNKP | 0.297 |            |
 PNKP |  PARP1 | 0.292 | 0.338764705882           |
 WRN |  PARP1 | 0.287 | 0.543322033898           |
 CETN2 |  SSBP1 | 0.286 | 0.102           |
 SSRP1 |  TDP1 | 0.284 | 0.187333333333           |
 HLTF |  RPAIN | 0.283 | 0.078           |
 SSBP1 |  PARP1 | 0.264 | 0.462           |
 XRCC1 |  RPA3 | 0.253 | 0.098           |
 RPA3 |  PARP1 | 0.242 | 0.42           |
 XRCC5 |  XRCC1 | 0.234 | 0.286           |
 WRN |  SSRP1 | 0.234 | 0.45           |
 XRCC1 |  PARP1 | 0.23 | 0.434955555556           |
 PARP2 |  RPAIN | 0.204 | 0.088           |
 SSRP1 |  RPAIN | 0.195 | 0.094           |
 SSBP1 |  PARP2 | 0.17 | 0.09           |
 WRN |  RPA2 | 0.169 | 0.198           |
 CETN2 |  RPAIN | 0.167 | 0.214           |
 XRCC1 |  RNF146 | 0.164 | 0.14           |
 WRN |  APLF | 0.164 |            |
 WRN |  RPA1 | 0.16 | 0.296           |
 WRN |  XRCC1 | 0.157 | 0.13           |
 WRN |  HLTF | 0.13 | 0.318           |
 POLB |  CHD1L | 0.115 | 0.064           |
 XRCC6 |  TDP1 | 0.114 | 0.365333333333           |
 XPC |  PNKP | 0.111 | 0.108           |
 WRN |  RPA3 | 0.107 | 0.136           |
 HLTF |  TDP1 | 0.095 | 0.06           |
 TDP1 |  CHD1L | 0.094 | 0.17           |
 SSBP1 |  RPAIN | 0.091 | 0.076           |
 XRCC5 |  TDP1 | 0.078 | 0.278           |
 XPC |  XPA | 0.076 | 0.094           |
 XRCC5 |  RPAIN | 0.073 | 0.136           |
 WRN |  CETN2 | 0.071 | 0.092           |
 PNKP |  RPA1 | 0.071 | 0.106           |
 HLTF |  MACROD1 | 0.067 | 0.036           |
 XRCC6 |  RPAIN | 0.067 | 0.232           |
 XPA |  PARP1 | 0.059 | 0.212275862069           |
 APLF |  SSBP1 | 0.058 |            |
 HLTF |  PNKP | 0.053 | 0.042           |
 LIG3 |  SSBP1 | 0.042 | 0.094           |
 SSRP1 |  PNKP | 0.04 | 0.104           |
 PNKP |  CETN2 | 0.034 | 0.052           |
 HLTF |  SSBP1 | 0.031 | 0.05           |
 XRCC5 |  SSBP1 | 0.031 | 0.332           |
 XPA |  CETN2 | 0.027 | 0.078           |
 HLTF |  RPA4 | 0.024 |            |
 HLTF |  XPA | 0.021 | 0.078           |
 XRCC1 |  SSBP1 | 0.016 | 0.156           |
 SSRP1 |  XPA | 0.016 | 0.096           |
 PNKP |  RPA3 | 0.015 | 0.056           |
 XRCC6 |  XPA | 0.014 | 0.256           |
 WRN |  TDP1 | 0.014 | 0.246           |
 RNF146 |  SSBP1 | 0.013 | 0.14           |
 WRN |  PNKP | 0.008 | 0.08           |
 XRCC6 |  SSBP1 | 0.008 | 0.374           |
 CLEC1B |  PARP1 | 0.006 |            |
 XRCC5 |  XPA | 0.004 | 0.192           |
 MACROD1 |  SSBP1 | 0.004 | 0.104           |
 PRIMPOL |  XRCC5 | 0.004 |            |
 POLB |  SSBP1 | 0.004 | 0.162           |
 SSBP1 |  CHD1L | 0.004 | 0.18           |
 RPA1 |  CLEC1B | 0.004 |            |
 PNKP |  SSBP1 | 0.003 | 0.048           |
 XRCC6 |  CLEC1B | 0.002 |            |
 TDP1 |  SSBP1 | 0.001 | 0.046           |
 XRCC5 |  CLEC1B | 0.001 |            |
 SSRP1 |  SSBP1 | 0.001 | 0.214           |
Related Complexes