hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_14864.1

Complex Portal: CPX-16639

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
PDK1	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1)	5	UniProt NCBI
PDHA2	Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial (EC 1.2.4.1) (PDHE1-A type II)	5	UniProt NCBI
CDO1	Cysteine dioxygenase type 1 (EC 1.13.11.20) (Cysteine dioxygenase type I) (CDO) (CDO-I)	5	UniProt NCBI
PDHX	Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (E3BP) (Lipoyl-containing pyruvate dehydrogenase complex component X) (proX)	5	UniProt NCBI
PDK3	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3)	5	UniProt NCBI
PDK2	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 2) (PDH kinase 2) (PDKII)	5	UniProt NCBI
CA5A	Carbonic anhydrase 5A, mitochondrial (EC 4.2.1.1) (Carbonate dehydratase VA) (Carbonic anhydrase VA) (CA-VA)	5	UniProt NCBI
STAT5A	Signal transducer and activator of transcription 5A	5	UniProt NCBI
DLAT	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2)	5	UniProt NCBI
PDHA1	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I)	5	UniProt NCBI
STAT5B	Signal transducer and activator of transcription 5B	5	UniProt NCBI
PDHB	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1)	5	UniProt NCBI
DLD	Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein)	5	UniProt NCBI
PDK4	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 4)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0006086	2.16042107362e-20	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	acetyl-CoA biosynthetic process from pyruvate
REAC:R-HSA-204174	3.35314310915e-20	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	Regulation of pyruvate dehydrogenase (PDH) complex
GO:0006085	1.16511970707e-17	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	acetyl-CoA biosynthetic process
REAC:R-HSA-70268	1.51972522737e-17	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	Pyruvate metabolism
REAC:R-HSA-5362517	1.00075662284e-16	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	Signaling by Retinoic Acid
GO:0006084	7.47120768672e-16	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	acetyl-CoA metabolic process
REAC:R-HSA-71406	1.94352538305e-15	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	Pyruvate metabolism and Citric Acid (TCA) cycle
GO:0006790	1.2091003305e-14	0.916666666667	STAT5B PDHX PDK2 PDK1 DLD PDHA2 PDHA1 PDK3 CDO1 PDK4 STAT5A	sulfur compound metabolic process
GO:0071616	2.3318613891e-14	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	acyl-CoA biosynthetic process
GO:0035384	2.3318613891e-14	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	thioester biosynthetic process
GO:0034030	1.79492642508e-13	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	ribonucleoside bisphosphate biosynthetic process
GO:0034033	1.79492642508e-13	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	purine nucleoside bisphosphate biosynthetic process
GO:0033866	1.79492642508e-13	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	nucleoside bisphosphate biosynthetic process
GO:0044272	3.03995708229e-12	0.75	PDHX PDK2 PDK1 PDHA2 PDHA1 PDK3 CDO1 PDK4 DLD	sulfur compound biosynthetic process
GO:0006637	9.93839335892e-12	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	acyl-CoA metabolic process
GO:0035383	9.93839335892e-12	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	thioester metabolic process
GO:0006090	3.02771250521e-11	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	pyruvate metabolic process
REAC:R-HSA-1428517	3.50064246747e-11	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	The citric acid (TCA) cycle and respiratory electron transport
GO:0033865	6.79253593999e-11	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	nucleoside bisphosphate metabolic process
GO:0033875	6.79253593999e-11	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	ribonucleoside bisphosphate metabolic process
GO:0034032	6.79253593999e-11	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	purine nucleoside bisphosphate metabolic process
GO:0045254	1.49641459906e-10	0.416666666667	PDK2 PDHA1 DLD PDHA2 PDHX	pyruvate dehydrogenase complex
GO:0005967	1.49641459906e-10	0.416666666667	PDK2 PDHA1 DLD PDHA2 PDHX	mitochondrial pyruvate dehydrogenase complex
GO:0006082	4.71897487645e-10	0.916666666667	STAT5B PDHX PDK2 PDK1 DLD PDHA2 PDHA1 PDK3 CDO1 PDK4 STAT5A	organic acid metabolic process
REAC:R-HSA-9006931	7.54380692122e-10	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	Signaling by Nuclear Receptors
GO:0009152	3.53732380966e-09	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	purine ribonucleotide biosynthetic process
GO:0009260	5.5682184557e-09	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	ribonucleotide biosynthetic process
GO:0044281	6.18847039317e-09	1.0	STAT5B PDHX PDK2 PDK1 STAT5A PDHA2 PDHA1 PDK3 DLD CDO1 PDK4 CA5A	small molecule metabolic process
GO:0046390	7.43142972308e-09	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	ribose phosphate biosynthetic process
GO:0010510	1.30247523495e-08	0.333333333333	PDK1 PDK4 PDK2 PDK3	regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0050812	1.30247523495e-08	0.333333333333	PDK1 PDK4 PDK2 PDK3	regulation of acyl-CoA biosynthetic process
GO:0006164	1.46490726114e-08	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	purine nucleotide biosynthetic process
GO:0072522	1.81422984589e-08	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	purine-containing compound biosynthetic process
GO:0009165	3.4679734842e-08	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	nucleotide biosynthetic process
GO:1901293	4.04536841229e-08	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	nucleoside phosphate biosynthetic process
GO:0004740	6.50952358374e-08	0.333333333333	PDK1 PDK4 PDK2 PDK3	pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005759	8.62844122725e-08	0.75	PDHX PDK2 PDK1 PDHA2 PDHA1 PDK3 CA5A PDK4 DLD	mitochondrial matrix
GO:0004738	1.9520016395e-07	0.333333333333	PDHA1 DLD PDHA2 PDHX	pyruvate dehydrogenase activity
REAC:R-HSA-389661	8.872476815e-07	0.333333333333	PDHA1 DLD PDHA2 PDHX	Glyoxylate metabolism and glycine degradation
GO:0009150	9.54487941926e-07	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	purine ribonucleotide metabolic process
GO:0009259	1.22696128729e-06	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	ribonucleotide metabolic process
GO:0019693	1.64154591282e-06	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	ribose phosphate metabolic process
GO:0042762	2.72801663605e-06	0.333333333333	PDK1 PDK4 PDK2 PDK3	regulation of sulfur metabolic process
GO:0019752	3.51536431778e-06	0.75	PDHX PDK2 PDK1 PDHA2 PDHA1 PDK3 CDO1 PDK4 DLD	carboxylic acid metabolic process
GO:0043436	4.36967122655e-06	0.75	PDHX PDK2 PDK1 PDHA2 PDHA1 PDK3 CDO1 PDK4 DLD	oxoacid metabolic process
GO:0006163	4.48143197489e-06	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	purine nucleotide metabolic process
GO:0072521	6.22177083106e-06	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	purine-containing compound metabolic process
GO:0032787	8.6901264272e-06	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	monocarboxylic acid metabolic process
GO:0009117	9.38177227364e-06	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	nucleotide metabolic process
REAC:R-HSA-1430728	9.54512572104e-06	0.833333333333	PDHX PDK2 PDK1 DLD PDHA2 PDHA1 PDK3 CDO1 PDK4 CA5A	Metabolism
GO:0006753	1.05091615037e-05	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	nucleoside phosphate metabolic process
KEGG:05415	1.08715773114e-05	0.416666666667	PDK3 PDK4 PDHA1 PDHA2 PDK2	Diabetic cardiomyopathy
GO:0090407	1.19721461508e-05	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	organophosphate biosynthetic process
GO:1900371	1.76932944819e-05	0.333333333333	PDK1 PDK4 PDK2 PDK3	regulation of purine nucleotide biosynthetic process
GO:0030808	1.76932944819e-05	0.333333333333	PDK1 PDK4 PDK2 PDK3	regulation of nucleotide biosynthetic process
KEGG:00785	1.78131689489e-05	0.25	PDHA1 PDHA2 DLD	Lipoic acid metabolism
GO:0055086	2.72571169816e-05	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	nucleobase-containing small molecule metabolic process
GO:1901137	3.26519892096e-05	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	carbohydrate derivative biosynthetic process
REAC:R-HSA-162582	3.49306745288e-05	0.833333333333	STAT5B STAT5A PDK2 PDK1 DLD PDHA2 PDHA1 PDK3 PDK4 PDHX	Signal Transduction
WP:WP3925	5.40165743302e-05	0.333333333333	PDHA1 PDK4 PDHX DLD	Amino acid metabolism
WP:WP4206	5.58837700991e-05	0.25	PDK1 PDHA2 PDHA1	Hereditary leiomyomatosis and renal cell carcinoma pathway
WP:WP581	7.54223504265e-05	0.25	PDK1 STAT5A STAT5B	EPO receptor signaling
GO:0019694	8.45465618902e-05	0.25	STAT5B CDO1 STAT5A	alkanesulfonate metabolic process
GO:0019530	8.45465618902e-05	0.25	STAT5B CDO1 STAT5A	taurine metabolic process
KEGG:01210	8.81389481283e-05	0.25	PDHA1 PDHA2 DLD	2-Oxocarboxylic acid metabolism
KEGG:00020	8.81389481283e-05	0.25	PDHA1 PDHA2 DLD	Citrate cycle (TCA cycle)
HP:0500184	0.000245230427941	0.25	PDHA1 PDHX DLD	Abnormal CSF amino acid concentration
KEGG:00620	0.000266306300111	0.25	PDHA1 PDHA2 DLD	Pyruvate metabolism
HP:0500183	0.000297642203506	0.25	PDHA1 PDHX DLD	Abnormal CSF carboxylic acid concentration
GO:0043604	0.000345466902291	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	amide biosynthetic process
WP:WP5220	0.000444083318466	0.25	PDHA1 PDHX DLD	Metabolic reprogramming in pancreatic cancer
WP:WP528	0.000721004071068	0.166666666667	PDHA1 PDHA2	Acetylcholine synthesis
KEGG:00010	0.000808975683474	0.25	PDHA1 PDHA2 DLD	Glycolysis / Gluconeogenesis
GO:0019637	0.000841511667133	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	organophosphate metabolic process
GO:1990204	0.000916596208509	0.416666666667	PDK2 PDHA1 DLD PDHA2 PDHX	oxidoreductase complex
REAC:R-HSA-71291	0.000953931557146	0.416666666667	PDHX PDHA1 DLD PDHA2 CDO1	Metabolism of amino acids and derivatives
REAC:R-HSA-9645135	0.0010067301791	0.166666666667	STAT5B STAT5A	STAT5 Activation
KEGG:05230	0.00102232737685	0.25	PDK1 PDHA2 PDHA1	Central carbon metabolism in cancer
GO:0016903	0.0011716924702	0.333333333333	PDHA1 DLD PDHA2 PDHX	oxidoreductase activity, acting on the aldehyde or oxo group of donors
GO:1901135	0.00143537696373	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	carbohydrate derivative metabolic process
REAC:R-HSA-9027283	0.00167711816531	0.166666666667	STAT5B STAT5A	Erythropoietin activates STAT5
WP:WP4255	0.00229784798254	0.25	PDK1 STAT5A STAT5B	Non small cell lung cancer
GO:0005739	0.00256288759943	0.75	PDHX PDK2 PDK1 PDHA2 PDHA1 PDK3 CA5A PDK4 DLD	mitochondrion
GO:1901566	0.00258049027569	0.75	PDHX PDK2 PDK1 PDHA2 PDHA1 PDK3 CDO1 PDK4 DLD	organonitrogen compound biosynthetic process
WP:WP5050	0.00323712429647	0.166666666667	PDK1 PDHA1	TCA cycle in senescence
KEGG:04066	0.00329805128323	0.25	PDK1 PDHA2 PDHA1	HIF-1 signaling pathway
GO:0043603	0.00342715213249	0.666666666667	PDHX PDK3 PDK1 PDHA2 PDK4 PDHA1 PDK2 DLD	amide metabolic process
REAC:R-HSA-9020958	0.00351873541523	0.166666666667	STAT5B STAT5A	Interleukin-21 signaling
KEGG:01200	0.00382022960876	0.25	PDHA1 PDHA2 DLD	Carbon metabolism
HP:0001942	0.00391845182455	0.333333333333	PDHA1 DLD PDHX CA5A	Metabolic acidosis
GO:0010906	0.00467600047806	0.333333333333	PDK1 PDK4 PDK2 PDK3	regulation of glucose metabolic process
REAC:R-HSA-9702518	0.00468950688317	0.166666666667	STAT5B STAT5A	STAT5 activation downstream of FLT3 ITD mutants
REAC:R-HSA-8985947	0.00468950688317	0.166666666667	STAT5B STAT5A	Interleukin-9 signaling
WP:WP5063	0.00474345148572	0.166666666667	STAT5B STAT5A	FOXP3 in COVID 19
WP:WP5355	0.00486593783382	0.25	PDHA1 CDO1 DLD	Metabolic Epileptic Disorders
HP:0003112	0.00488811606811	0.333333333333	PDHA1 DLD PDHX CA5A	Abnormal circulating amino acid concentration
GO:0019217	0.00539667722951	0.333333333333	PDK1 PDK4 PDK2 PDK3	regulation of fatty acid metabolic process
GO:1900542	0.00578662173363	0.333333333333	PDK1 PDK4 PDK2 PDK3	regulation of purine nucleotide metabolic process
REAC:R-HSA-2586552	0.00602661540197	0.166666666667	STAT5B STAT5A	Signaling by Leptin
REAC:R-HSA-9020558	0.00602661540197	0.166666666667	STAT5B STAT5A	Interleukin-2 signaling
GO:0006140	0.0061972303267	0.333333333333	PDK1 PDK4 PDK2 PDK3	regulation of nucleotide metabolic process
WP:WP22	0.00653424765261	0.166666666667	STAT5B STAT5A	IL 9 signaling pathway
WP:WP2453	0.00860873064398	0.166666666667	PDHA1 DLD	TCA cycle and deficiency of pyruvate dehydrogenase complex PDHc
HP:0004366	0.00951807865021	0.25	PDHA1 PDHX DLD	Abnormality of glycolysis
HP:0003542	0.00951807865021	0.25	PDHA1 PDHX DLD	Increased serum pyruvate
HP:0500231	0.00963903005133	0.166666666667	PDHA1 PDHX	Abnormal CSF pyruvate family amino acid concentration
WP:WP205	0.00975211067197	0.166666666667	STAT5B STAT5A	IL 7 signaling pathway
HP:0003128	0.00993946722714	0.333333333333	PDHA1 DLD PDHX CA5A	Lactic acidosis
REAC:R-HSA-1170546	0.0110336806298	0.166666666667	STAT5B STAT5A	Prolactin receptor signaling
REAC:R-HSA-9703648	0.0130338557741	0.166666666667	STAT5B STAT5A	Signaling by FLT3 ITD and TKD mutants
REAC:R-HSA-8983432	0.0130338557741	0.166666666667	STAT5B STAT5A	Interleukin-15 signaling
KEGG:01100	0.0145002901226	0.5	PDHX PDHA2 PDHA1 CA5A CDO1 DLD	Metabolic pathways
HP:0002151	0.0148695868168	0.333333333333	PDHA1 DLD PDHX CA5A	Increased serum lactate
HP:0003348	0.0154358507084	0.25	PDHA1 PDHX CA5A	Hyperalaninemia
HP:0010915	0.0162132209896	0.25	PDHA1 PDHX CA5A	Abnormal circulating pyruvate family amino acid concentration
HP:0010916	0.0162132209896	0.25	PDHA1 PDHX CA5A	Abnormal circulating alanine concentration
REAC:R-HSA-9703465	0.0200246560632	0.166666666667	STAT5B STAT5A	Signaling by FLT3 fusion proteins
REAC:R-HSA-1839117	0.0200246560632	0.166666666667	STAT5B STAT5A	Signaling by cytosolic FGFR1 fusion mutants
HP:0011013	0.020489144511	0.25	PDHA1 PDHX DLD	Abnormal circulating carbohydrate concentration
WP:WP4149	0.0214336297964	0.166666666667	STAT5B STAT5A	White fat cell differentiation
REAC:R-HSA-9670439	0.0226842574326	0.166666666667	STAT5B STAT5A	Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
REAC:R-HSA-9669938	0.0226842574326	0.166666666667	STAT5B STAT5A	Signaling by KIT in disease
WP:WP3972	0.0232091738468	0.166666666667	STAT5B STAT5A	PDGFR beta pathway
HP:0033108	0.0244001944621	0.25	PDHA1 PDHX CA5A	Abnormal circulating proteinogenic amino acid derivative concentration
REAC:R-HSA-9006335	0.028496101667	0.166666666667	STAT5B STAT5A	Signaling by Erythropoietin
HP:0002928	0.0288643583102	0.166666666667	PDHA1 PDHX	Decreased activity of the pyruvate dehydrogenase complex
WP:WP5358	0.0289539561012	0.166666666667	STAT5B STAT5A	JAK STAT signaling in the regulation of Beta cells
GO:0010565	0.0292731057087	0.333333333333	PDK1 PDK4 PDK2 PDK3	regulation of cellular ketone metabolic process
GO:0097411	0.0309012475255	0.166666666667	PDK1 PDK3	hypoxia-inducible factor-1alpha signaling pathway
WP:WP127	0.0331313049516	0.166666666667	STAT5B STAT5A	IL 5 signaling pathway
REAC:R-HSA-982772	0.0349632924576	0.166666666667	STAT5B STAT5A	Growth hormone receptor signaling
WP:WP49	0.0375857505732	0.166666666667	STAT5B STAT5A	IL 2 signaling pathway
REAC:R-HSA-8854691	0.0384420778088	0.166666666667	STAT5B STAT5A	Interleukin-20 family signaling
WP:WP2203	0.0399166444664	0.166666666667	STAT5B STAT5A	Thymic stromal lymphopoietin TSLP signaling pathway
REAC:R-HSA-9705462	0.0420840222149	0.166666666667	STAT5B STAT5A	Inactivation of CSF3 (G-CSF) signaling
REAC:R-HSA-9682385	0.0458889002508	0.166666666667	STAT5B STAT5A	FLT3 signaling in disease
REAC:R-HSA-1839124	0.0458889002508	0.166666666667	STAT5B STAT5A	FGFR1 mutant receptor activation
CORUM:2013	0.0499436884912	0.0833333333333	STAT5B	STAT5B homodimer complex
CORUM:2023	0.0499436884912	0.0833333333333	STAT5A	STAT5A homodimer complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
PDHA1	PDHB	1.0	0.958	structurally_consistent (dimer)
STAT5A	PDHA1	1.0	0.158
STAT5A	DLAT	1.0	0.086
DLAT	DLD	1.0	0.514
PDK3	STAT5A	1.0	0.03
PDHA1	DLAT	1.0	0.718
PDHB	DLAT	1.0	0.694
PDK3	DLAT	0.999	0.118	structurally_consistent (dimer)
STAT5A	PDHB	0.999	0.124
PDK1	PDK2	0.999	0.058	structurally_consistent (dimer)
PDHB	DLD	0.999	0.66
PDK3	PDK1	0.999	0.278	structurally_consistent (dimer)
PDHX	DLD	0.999	0.436	structurally_consistent (dimer)
STAT5A	PDHX	0.999	0.04
PDK3	PDHB	0.999	0.124	structurally_consistent (dimer)
STAT5A	STAT5B	0.999	0.768	structurally_consistent (dimer)
PDHA1	DLD	0.998	0.766
PDHX	PDHA1	0.998	0.684
PDK3	PDHX	0.998	0.06	structurally_consistent (dimer)
PDHX	DLAT	0.997	0.652
PDK3	PDHA1	0.997	0.18	structurally_consistent (dimer)
PDHA1	PDK2	0.996	0.204
PDK3	PDK2	0.996	0.088	structurally_consistent (dimer)
PDK1	PDHA1	0.996	0.29
PDK2	DLAT	0.994	0.236	structurally_consistent (dimer)
PDHX	PDK2	0.994	0.07
STAT5B	PDHX	0.993	0.078
PDHX	PDHB	0.991	0.568
STAT5B	PDHA1	0.989	0.11
PDK4	PDK3	0.987		structurally_consistent (dimer)
PDK3	PDHA2	0.986		structurally_consistent (dimer)
PDK1	PDHX	0.984	0.218
STAT5B	PDHB	0.981	0.086
PDK1	PDHB	0.964	0.429538461538
PDHB	PDK2	0.957	0.354	structurally_consistent (dimer)
PDHA1	CA5A	0.947
PDK3	DLD	0.947	0.12	structurally_consistent (dimer)
CDO1	PDHX	0.931
PDK4	PDK2	0.927		mutually_exclusive (Q15120)
PDK2	DLD	0.927	0.191076923077	structurally_consistent (Q15120)
PDK1	DLAT	0.924	0.3708
STAT5B	DLAT	0.88	0.092
CDO1	PDHA1	0.873
CDO1	DLAT	0.851
PDHA2	PDHB	0.844		structurally_consistent (dimer)
DLAT	CA5A	0.816
PDK3	STAT5B	0.789	0.024
PDK4	PDK1	0.713
CDO1	PDHB	0.676
PDHB	CA5A	0.647
PDHA2	DLAT	0.587		structurally_consistent (Q15120)
PDHA2	PDHX	0.505
PDHX	CA5A	0.469
STAT5B	DLD	0.435	0.044
PDHA2	DLD	0.403
PDHA2	PDHA1	0.313		mutually_exclusive (P11177)
STAT5A	PDK2	0.239	0.110288
PDK1	DLD	0.23	0.533217391304
PDHA2	PDK1	0.168		structurally_consistent (Q15120)
STAT5B	PDK2	0.143	0.06
PDHA2	PDK2	0.143		structurally_consistent (Q15120)
STAT5A	DLD	0.049	0.052
DLD	CA5A	0.033
PDK4	PDHA1	0.007		structurally_consistent (dimer)
PDK4	DLAT	0.005
PDK4	DLD	0.004		structurally_consistent (Q15120)
CDO1	DLD	0.001

Related Complexes

Genename	Complexes
PDK1	huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
PDHA2	huMAP3_02577.1 huMAP3_11877.1 huMAP3_12045.1 huMAP3_12248.1 huMAP3_13797.1 huMAP3_13948.1 huMAP3_14339.1 huMAP3_14864.1
CDO1	huMAP3_02075.1 huMAP3_02434.1 huMAP3_05902.1 huMAP3_10055.1 huMAP3_12553.1 huMAP3_14864.1
PDHX	huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
PDK3	huMAP3_00016.1 huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
PDK2	huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
CA5A	huMAP3_11377.1 huMAP3_11473.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_12936.1 huMAP3_14339.1 huMAP3_14864.1 huMAP3_15110.1
STAT5A	huMAP3_03752.1 huMAP3_05442.1 huMAP3_07514.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
DLAT	huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
PDHA1	huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
STAT5B	huMAP3_03752.1 huMAP3_04704.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
PDHB	huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
DLD	huMAP3_04997.1 huMAP3_07213.1 huMAP3_10702.1 huMAP3_11548.1 huMAP3_11871.1 huMAP3_12248.1 huMAP3_14864.1
PDK4	huMAP3_00016.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_14864.1

Complex Portal: CPX-16639