hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_14864.1

Complex Portal: CPX-16639

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
PDK1	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1)	5	UniProt NCBI
PDHA2	Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial (EC 1.2.4.1) (PDHE1-A type II)	5	UniProt NCBI
CDO1	Cysteine dioxygenase type 1 (EC 1.13.11.20) (Cysteine dioxygenase type I) (CDO) (CDO-I)	5	UniProt NCBI
PDHX	Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (E3BP) (Lipoyl-containing pyruvate dehydrogenase complex component X) (proX)	5	UniProt NCBI
PDK3	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3)	5	UniProt NCBI
PDK2	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 2) (PDH kinase 2) (PDKII)	5	UniProt NCBI
CA5A	Carbonic anhydrase 5A, mitochondrial (EC 4.2.1.1) (Carbonate dehydratase VA) (Carbonic anhydrase VA) (CA-VA)	5	UniProt NCBI
STAT5A	Signal transducer and activator of transcription 5A	5	UniProt NCBI
DLAT	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2)	5	UniProt NCBI
PDHA1	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I)	5	UniProt NCBI
STAT5B	Signal transducer and activator of transcription 5B	5	UniProt NCBI
PDHB	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1)	5	UniProt NCBI
DLD	Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein)	5	UniProt NCBI
PDK4	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 4)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0006086	2.16042107362e-20	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	acetyl-CoA biosynthetic process from pyruvate
REAC:R-HSA-204174	3.35314310915e-20	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	Regulation of pyruvate dehydrogenase (PDH) complex
GO:0006085	1.16511970707e-17	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	acetyl-CoA biosynthetic process
REAC:R-HSA-70268	1.51972522737e-17	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	Pyruvate metabolism
REAC:R-HSA-5362517	1.00075662284e-16	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	Signaling by Retinoic Acid
GO:0006084	7.47120768672e-16	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	acetyl-CoA metabolic process
REAC:R-HSA-71406	1.94352538305e-15	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	Pyruvate metabolism and Citric Acid (TCA) cycle
GO:0006790	1.2091003305e-14	0.916666666667	PDHX STAT5A PDHA2 CDO1 PDK2 DLD PDK1 PDK3 STAT5B PDK4 PDHA1	sulfur compound metabolic process
GO:0071616	2.3318613891e-14	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	acyl-CoA biosynthetic process
GO:0035384	2.3318613891e-14	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	thioester biosynthetic process
GO:0034030	1.79492642508e-13	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	ribonucleoside bisphosphate biosynthetic process
GO:0034033	1.79492642508e-13	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	purine nucleoside bisphosphate biosynthetic process
GO:0033866	1.79492642508e-13	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	nucleoside bisphosphate biosynthetic process
GO:0044272	3.03995708229e-12	0.75	PDHX PDHA2 CDO1 PDK2 DLD PDK1 PDK3 PDK4 PDHA1	sulfur compound biosynthetic process
GO:0006637	9.93839335892e-12	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	acyl-CoA metabolic process
GO:0035383	9.93839335892e-12	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	thioester metabolic process
GO:0006090	3.02771250521e-11	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	pyruvate metabolic process
REAC:R-HSA-1428517	3.50064246747e-11	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	The citric acid (TCA) cycle and respiratory electron transport
GO:0033865	6.79253593999e-11	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	nucleoside bisphosphate metabolic process
GO:0033875	6.79253593999e-11	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	ribonucleoside bisphosphate metabolic process
GO:0034032	6.79253593999e-11	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	purine nucleoside bisphosphate metabolic process
GO:0045254	1.49641459906e-10	0.416666666667	PDHA2 PDHA1 DLD PDK2 PDHX	pyruvate dehydrogenase complex
GO:0005967	1.49641459906e-10	0.416666666667	PDHA2 PDHA1 DLD PDK2 PDHX	mitochondrial pyruvate dehydrogenase complex
GO:0006082	4.71897487645e-10	0.916666666667	PDHX STAT5A PDHA2 CDO1 PDK2 DLD PDK1 PDK3 STAT5B PDK4 PDHA1	organic acid metabolic process
REAC:R-HSA-9006931	7.54380692122e-10	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	Signaling by Nuclear Receptors
GO:0009152	3.53732380966e-09	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	purine ribonucleotide biosynthetic process
GO:0009260	5.5682184557e-09	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	ribonucleotide biosynthetic process
GO:0044281	6.18847039317e-09	1.0	PDHX PDK4 STAT5A PDHA2 CDO1 PDK2 DLD PDK1 PDK3 STAT5B CA5A PDHA1	small molecule metabolic process
GO:0046390	7.43142972308e-09	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	ribose phosphate biosynthetic process
GO:0010510	1.30247523495e-08	0.333333333333	PDK1 PDK4 PDK3 PDK2	regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0050812	1.30247523495e-08	0.333333333333	PDK1 PDK4 PDK3 PDK2	regulation of acyl-CoA biosynthetic process
GO:0006164	1.46490726114e-08	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	purine nucleotide biosynthetic process
GO:0072522	1.81422984589e-08	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	purine-containing compound biosynthetic process
GO:0009165	3.4679734842e-08	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	nucleotide biosynthetic process
GO:1901293	4.04536841229e-08	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	nucleoside phosphate biosynthetic process
GO:0004740	6.50952358374e-08	0.333333333333	PDK1 PDK4 PDK3 PDK2	pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005759	8.62844122725e-08	0.75	PDHX PDHA2 PDK2 DLD PDK1 PDK3 PDK4 CA5A PDHA1	mitochondrial matrix
GO:0004738	1.9520016395e-07	0.333333333333	PDHA2 PDHA1 DLD PDHX	pyruvate dehydrogenase activity
REAC:R-HSA-389661	8.872476815e-07	0.333333333333	PDHA2 PDHA1 DLD PDHX	Glyoxylate metabolism and glycine degradation
GO:0009150	9.54487941926e-07	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	purine ribonucleotide metabolic process
GO:0009259	1.22696128729e-06	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	ribonucleotide metabolic process
GO:0019693	1.64154591282e-06	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	ribose phosphate metabolic process
GO:0042762	2.72801663605e-06	0.333333333333	PDK1 PDK4 PDK3 PDK2	regulation of sulfur metabolic process
GO:0019752	3.51536431778e-06	0.75	PDHX PDHA2 CDO1 PDK2 DLD PDK1 PDK3 PDK4 PDHA1	carboxylic acid metabolic process
GO:0043436	4.36967122655e-06	0.75	PDHX PDHA2 CDO1 PDK2 DLD PDK1 PDK3 PDK4 PDHA1	oxoacid metabolic process
GO:0006163	4.48143197489e-06	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	purine nucleotide metabolic process
GO:0072521	6.22177083106e-06	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	purine-containing compound metabolic process
GO:0032787	8.6901264272e-06	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	monocarboxylic acid metabolic process
GO:0009117	9.38177227364e-06	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	nucleotide metabolic process
REAC:R-HSA-1430728	9.54512572104e-06	0.833333333333	PDHX PDHA2 CDO1 PDK2 DLD PDK1 PDK3 PDK4 CA5A PDHA1	Metabolism
GO:0006753	1.05091615037e-05	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	nucleoside phosphate metabolic process
KEGG:05415	1.08715773114e-05	0.416666666667	PDHA2 PDHA1 PDK4 PDK3 PDK2	Diabetic cardiomyopathy
GO:0090407	1.19721461508e-05	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	organophosphate biosynthetic process
GO:1900371	1.76932944819e-05	0.333333333333	PDK1 PDK4 PDK3 PDK2	regulation of purine nucleotide biosynthetic process
GO:0030808	1.76932944819e-05	0.333333333333	PDK1 PDK4 PDK3 PDK2	regulation of nucleotide biosynthetic process
KEGG:00785	1.78131689489e-05	0.25	PDHA2 DLD PDHA1	Lipoic acid metabolism
GO:0055086	2.72571169816e-05	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	nucleobase-containing small molecule metabolic process
GO:1901137	3.26519892096e-05	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	carbohydrate derivative biosynthetic process
REAC:R-HSA-162582	3.49306745288e-05	0.833333333333	PDHX STAT5A PDHA2 STAT5B PDK2 DLD PDK1 PDK3 PDK4 PDHA1	Signal Transduction
WP:WP3925	5.40165743302e-05	0.333333333333	PDHX PDK4 DLD PDHA1	Amino acid metabolism
WP:WP4206	5.58837700991e-05	0.25	PDK1 PDHA1 PDHA2	Hereditary leiomyomatosis and renal cell carcinoma pathway
WP:WP581	7.54223504265e-05	0.25	PDK1 STAT5A STAT5B	EPO receptor signaling
GO:0019694	8.45465618902e-05	0.25	CDO1 STAT5A STAT5B	alkanesulfonate metabolic process
GO:0019530	8.45465618902e-05	0.25	CDO1 STAT5A STAT5B	taurine metabolic process
KEGG:01210	8.81389481283e-05	0.25	PDHA2 DLD PDHA1	2-Oxocarboxylic acid metabolism
KEGG:00020	8.81389481283e-05	0.25	PDHA2 DLD PDHA1	Citrate cycle (TCA cycle)
HP:0500184	0.000245230427941	0.25	PDHX DLD PDHA1	Abnormal CSF amino acid concentration
KEGG:00620	0.000266306300111	0.25	PDHA2 DLD PDHA1	Pyruvate metabolism
HP:0500183	0.000297642203506	0.25	PDHX DLD PDHA1	Abnormal CSF carboxylic acid concentration
GO:0043604	0.000345466902291	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	amide biosynthetic process
WP:WP5220	0.000444083318466	0.25	PDHX DLD PDHA1	Metabolic reprogramming in pancreatic cancer
WP:WP528	0.000721004071068	0.166666666667	PDHA2 PDHA1	Acetylcholine synthesis
KEGG:00010	0.000808975683474	0.25	PDHA2 DLD PDHA1	Glycolysis / Gluconeogenesis
GO:0019637	0.000841511667133	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	organophosphate metabolic process
GO:1990204	0.000916596208509	0.416666666667	PDHA2 PDHA1 DLD PDK2 PDHX	oxidoreductase complex
REAC:R-HSA-71291	0.000953931557146	0.416666666667	PDHA2 PDHA1 DLD PDHX CDO1	Metabolism of amino acids and derivatives
REAC:R-HSA-9645135	0.0010067301791	0.166666666667	STAT5B STAT5A	STAT5 Activation
KEGG:05230	0.00102232737685	0.25	PDK1 PDHA1 PDHA2	Central carbon metabolism in cancer
GO:0016903	0.0011716924702	0.333333333333	PDHA2 PDHA1 DLD PDHX	oxidoreductase activity, acting on the aldehyde or oxo group of donors
GO:1901135	0.00143537696373	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	carbohydrate derivative metabolic process
REAC:R-HSA-9027283	0.00167711816531	0.166666666667	STAT5B STAT5A	Erythropoietin activates STAT5
WP:WP4255	0.00229784798254	0.25	PDK1 STAT5A STAT5B	Non small cell lung cancer
GO:0005739	0.00256288759943	0.75	PDHX PDHA2 PDK2 DLD PDK1 PDK3 PDK4 CA5A PDHA1	mitochondrion
GO:1901566	0.00258049027569	0.75	PDHX PDHA2 CDO1 PDK2 DLD PDK1 PDK3 PDK4 PDHA1	organonitrogen compound biosynthetic process
WP:WP5050	0.00323712429647	0.166666666667	PDK1 PDHA1	TCA cycle in senescence
KEGG:04066	0.00329805128323	0.25	PDK1 PDHA1 PDHA2	HIF-1 signaling pathway
GO:0043603	0.00342715213249	0.666666666667	PDHX PDHA2 PDHA1 PDK2 DLD PDK1 PDK3 PDK4	amide metabolic process
REAC:R-HSA-9020958	0.00351873541523	0.166666666667	STAT5B STAT5A	Interleukin-21 signaling
KEGG:01200	0.00382022960876	0.25	PDHA2 DLD PDHA1	Carbon metabolism
HP:0001942	0.00391845182455	0.333333333333	PDHX DLD CA5A PDHA1	Metabolic acidosis
GO:0010906	0.00467600047806	0.333333333333	PDK1 PDK4 PDK3 PDK2	regulation of glucose metabolic process
REAC:R-HSA-9702518	0.00468950688317	0.166666666667	STAT5B STAT5A	STAT5 activation downstream of FLT3 ITD mutants
REAC:R-HSA-8985947	0.00468950688317	0.166666666667	STAT5B STAT5A	Interleukin-9 signaling
WP:WP5063	0.00474345148572	0.166666666667	STAT5B STAT5A	FOXP3 in COVID 19
WP:WP5355	0.00486593783382	0.25	CDO1 DLD PDHA1	Metabolic Epileptic Disorders
HP:0003112	0.00488811606811	0.333333333333	PDHX DLD CA5A PDHA1	Abnormal circulating amino acid concentration
GO:0019217	0.00539667722951	0.333333333333	PDK1 PDK4 PDK3 PDK2	regulation of fatty acid metabolic process
GO:1900542	0.00578662173363	0.333333333333	PDK1 PDK4 PDK3 PDK2	regulation of purine nucleotide metabolic process
REAC:R-HSA-2586552	0.00602661540197	0.166666666667	STAT5B STAT5A	Signaling by Leptin
REAC:R-HSA-9020558	0.00602661540197	0.166666666667	STAT5B STAT5A	Interleukin-2 signaling
GO:0006140	0.0061972303267	0.333333333333	PDK1 PDK4 PDK3 PDK2	regulation of nucleotide metabolic process
WP:WP22	0.00653424765261	0.166666666667	STAT5B STAT5A	IL 9 signaling pathway
WP:WP2453	0.00860873064398	0.166666666667	PDHA1 DLD	TCA cycle and deficiency of pyruvate dehydrogenase complex PDHc
HP:0004366	0.00951807865021	0.25	PDHX DLD PDHA1	Abnormality of glycolysis
HP:0003542	0.00951807865021	0.25	PDHX DLD PDHA1	Increased serum pyruvate
HP:0500231	0.00963903005133	0.166666666667	PDHX PDHA1	Abnormal CSF pyruvate family amino acid concentration
WP:WP205	0.00975211067197	0.166666666667	STAT5B STAT5A	IL 7 signaling pathway
HP:0003128	0.00993946722714	0.333333333333	PDHX DLD CA5A PDHA1	Lactic acidosis
REAC:R-HSA-1170546	0.0110336806298	0.166666666667	STAT5B STAT5A	Prolactin receptor signaling
REAC:R-HSA-9703648	0.0130338557741	0.166666666667	STAT5B STAT5A	Signaling by FLT3 ITD and TKD mutants
REAC:R-HSA-8983432	0.0130338557741	0.166666666667	STAT5B STAT5A	Interleukin-15 signaling
KEGG:01100	0.0145002901226	0.5	PDHA2 PDHX CDO1 DLD PDHA1 CA5A	Metabolic pathways
HP:0002151	0.0148695868168	0.333333333333	PDHX DLD CA5A PDHA1	Increased serum lactate
HP:0003348	0.0154358507084	0.25	PDHX CA5A PDHA1	Hyperalaninemia
HP:0010915	0.0162132209896	0.25	PDHX CA5A PDHA1	Abnormal circulating pyruvate family amino acid concentration
HP:0010916	0.0162132209896	0.25	PDHX CA5A PDHA1	Abnormal circulating alanine concentration
REAC:R-HSA-9703465	0.0200246560632	0.166666666667	STAT5B STAT5A	Signaling by FLT3 fusion proteins
REAC:R-HSA-1839117	0.0200246560632	0.166666666667	STAT5B STAT5A	Signaling by cytosolic FGFR1 fusion mutants
HP:0011013	0.020489144511	0.25	PDHX DLD PDHA1	Abnormal circulating carbohydrate concentration
WP:WP4149	0.0214336297964	0.166666666667	STAT5B STAT5A	White fat cell differentiation
REAC:R-HSA-9670439	0.0226842574326	0.166666666667	STAT5B STAT5A	Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
REAC:R-HSA-9669938	0.0226842574326	0.166666666667	STAT5B STAT5A	Signaling by KIT in disease
WP:WP3972	0.0232091738468	0.166666666667	STAT5B STAT5A	PDGFR beta pathway
HP:0033108	0.0244001944621	0.25	PDHX CA5A PDHA1	Abnormal circulating proteinogenic amino acid derivative concentration
REAC:R-HSA-9006335	0.028496101667	0.166666666667	STAT5B STAT5A	Signaling by Erythropoietin
HP:0002928	0.0288643583102	0.166666666667	PDHX PDHA1	Decreased activity of the pyruvate dehydrogenase complex
WP:WP5358	0.0289539561012	0.166666666667	STAT5B STAT5A	JAK STAT signaling in the regulation of Beta cells
GO:0010565	0.0292731057087	0.333333333333	PDK1 PDK4 PDK3 PDK2	regulation of cellular ketone metabolic process
GO:0097411	0.0309012475255	0.166666666667	PDK1 PDK3	hypoxia-inducible factor-1alpha signaling pathway
WP:WP127	0.0331313049516	0.166666666667	STAT5B STAT5A	IL 5 signaling pathway
REAC:R-HSA-982772	0.0349632924576	0.166666666667	STAT5B STAT5A	Growth hormone receptor signaling
WP:WP49	0.0375857505732	0.166666666667	STAT5B STAT5A	IL 2 signaling pathway
REAC:R-HSA-8854691	0.0384420778088	0.166666666667	STAT5B STAT5A	Interleukin-20 family signaling
WP:WP2203	0.0399166444664	0.166666666667	STAT5B STAT5A	Thymic stromal lymphopoietin TSLP signaling pathway
REAC:R-HSA-9705462	0.0420840222149	0.166666666667	STAT5B STAT5A	Inactivation of CSF3 (G-CSF) signaling
REAC:R-HSA-9682385	0.0458889002508	0.166666666667	STAT5B STAT5A	FLT3 signaling in disease
REAC:R-HSA-1839124	0.0458889002508	0.166666666667	STAT5B STAT5A	FGFR1 mutant receptor activation
CORUM:2013	0.0499436884912	0.0833333333333	STAT5B	STAT5B homodimer complex
CORUM:2023	0.0499436884912	0.0833333333333	STAT5A	STAT5A homodimer complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
PDHA1	PDHB	1.0	0.958	structurally_consistent (dimer)
STAT5A	PDHA1	1.0	0.158
STAT5A	DLAT	1.0	0.086
DLAT	DLD	1.0	0.514
PDK3	STAT5A	1.0	0.03
PDHA1	DLAT	1.0	0.718
PDHB	DLAT	1.0	0.694
PDK3	DLAT	0.999	0.118	structurally_consistent (dimer)
STAT5A	PDHB	0.999	0.124
PDK1	PDK2	0.999	0.058	structurally_consistent (dimer)
PDHB	DLD	0.999	0.66
PDK3	PDK1	0.999	0.278	structurally_consistent (dimer)
PDHX	DLD	0.999	0.436	structurally_consistent (dimer)
STAT5A	PDHX	0.999	0.04
PDK3	PDHB	0.999	0.124	structurally_consistent (dimer)
STAT5A	STAT5B	0.999	0.768	structurally_consistent (dimer)
PDHA1	DLD	0.998	0.766
PDHX	PDHA1	0.998	0.684
PDK3	PDHX	0.998	0.06	structurally_consistent (dimer)
PDHX	DLAT	0.997	0.652
PDK3	PDHA1	0.997	0.18	structurally_consistent (dimer)
PDHA1	PDK2	0.996	0.204
PDK3	PDK2	0.996	0.088	structurally_consistent (dimer)
PDK1	PDHA1	0.996	0.29
PDK2	DLAT	0.994	0.236	structurally_consistent (dimer)
PDHX	PDK2	0.994	0.07
STAT5B	PDHX	0.993	0.078
PDHX	PDHB	0.991	0.568
STAT5B	PDHA1	0.989	0.11
PDK4	PDK3	0.987		structurally_consistent (dimer)
PDK3	PDHA2	0.986		structurally_consistent (dimer)
PDK1	PDHX	0.984	0.218
STAT5B	PDHB	0.981	0.086
PDK1	PDHB	0.964	0.429538461538
PDHB	PDK2	0.957	0.354	structurally_consistent (dimer)
PDHA1	CA5A	0.947
PDK3	DLD	0.947	0.12	structurally_consistent (dimer)
CDO1	PDHX	0.931
PDK4	PDK2	0.927		mutually_exclusive (Q15120)
PDK2	DLD	0.927	0.191076923077	structurally_consistent (Q15120)
PDK1	DLAT	0.924	0.3708
STAT5B	DLAT	0.88	0.092
CDO1	PDHA1	0.873
CDO1	DLAT	0.851
PDHA2	PDHB	0.844		structurally_consistent (dimer)
DLAT	CA5A	0.816
PDK3	STAT5B	0.789	0.024
PDK4	PDK1	0.713
CDO1	PDHB	0.676
PDHB	CA5A	0.647
PDHA2	DLAT	0.587		structurally_consistent (Q15120)
PDHA2	PDHX	0.505
PDHX	CA5A	0.469
STAT5B	DLD	0.435	0.044
PDHA2	DLD	0.403
PDHA2	PDHA1	0.313		mutually_exclusive (P11177)
STAT5A	PDK2	0.239	0.110288
PDK1	DLD	0.23	0.533217391304
PDHA2	PDK1	0.168		structurally_consistent (Q15120)
STAT5B	PDK2	0.143	0.06
PDHA2	PDK2	0.143		structurally_consistent (Q15120)
STAT5A	DLD	0.049	0.052
DLD	CA5A	0.033
PDK4	PDHA1	0.007		structurally_consistent (dimer)
PDK4	DLAT	0.005
PDK4	DLD	0.004		structurally_consistent (Q15120)
CDO1	DLD	0.001

Related Complexes

Genename	Complexes
PDK1	huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
PDHA2	huMAP3_02577.1 huMAP3_11877.1 huMAP3_12045.1 huMAP3_12248.1 huMAP3_13797.1 huMAP3_13948.1 huMAP3_14339.1 huMAP3_14864.1
CDO1	huMAP3_02075.1 huMAP3_02434.1 huMAP3_05902.1 huMAP3_10055.1 huMAP3_12553.1 huMAP3_14864.1
PDHX	huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
PDK3	huMAP3_00016.1 huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
PDK2	huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
CA5A	huMAP3_11377.1 huMAP3_11473.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_12936.1 huMAP3_14339.1 huMAP3_14864.1 huMAP3_15110.1
STAT5A	huMAP3_03752.1 huMAP3_05442.1 huMAP3_07514.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
DLAT	huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
PDHA1	huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
STAT5B	huMAP3_03752.1 huMAP3_04704.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
PDHB	huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
DLD	huMAP3_04997.1 huMAP3_07213.1 huMAP3_10702.1 huMAP3_11548.1 huMAP3_11871.1 huMAP3_12248.1 huMAP3_14864.1
PDK4	huMAP3_00016.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_14864.1

Complex Portal: CPX-16639