hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14870.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| IRAK2 | Interleukin-1 receptor-associated kinase-like 2 (IRAK-2) | 5 | UniProt NCBI |
| GLOD4 | Glyoxalase domain-containing protein 4 | 4 | UniProt NCBI |
| TIRAP | Toll/interleukin-1 receptor domain-containing adapter protein (TIR domain-containing adapter protein) (Adaptor protein Wyatt) (MyD88 adapter-like protein) (MyD88-2) | 5 | UniProt NCBI |
| MYD88 | Myeloid differentiation primary response protein MyD88 | 5 | UniProt NCBI |
| ARMCX6 | Protein ARMCX6 | 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4136 | 6.56805473695e-06 | 0.6 | MYD88 IRAK2 TIRAP | Fibrin complement receptor 3 signaling pathway |
| REAC:R-HSA-166058 | 0.000427893420445 | 0.6 | MYD88 IRAK2 TIRAP | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-168188 | 0.000427893420445 | 0.6 | MYD88 IRAK2 TIRAP | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-168179 | 0.000455699137987 | 0.6 | MYD88 IRAK2 TIRAP | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-181438 | 0.000455699137987 | 0.6 | MYD88 IRAK2 TIRAP | Toll Like Receptor 2 (TLR2) Cascade |
| KEGG:05152 | 0.000467209213785 | 0.6 | MYD88 IRAK2 TIRAP | Tuberculosis |
| REAC:R-HSA-166016 | 0.000932817738425 | 0.6 | MYD88 IRAK2 TIRAP | Toll Like Receptor 4 (TLR4) Cascade |
| REAC:R-HSA-5602498 | 0.0013810496636 | 0.4 | MYD88 TIRAP | MyD88 deficiency (TLR2/4) |
| REAC:R-HSA-5603041 | 0.0013810496636 | 0.4 | MYD88 TIRAP | IRAK4 deficiency (TLR2/4) |
| REAC:R-HSA-168898 | 0.00143724099843 | 0.6 | MYD88 IRAK2 TIRAP | Toll-like Receptor Cascades |
| WP:WP3851 | 0.00175902717245 | 0.4 | MYD88 TIRAP | TLR4 signaling and tolerance |
| WP:WP3858 | 0.00205749802636 | 0.4 | MYD88 TIRAP | Toll like receptor signaling related to MyD88 |
| WP:WP4496 | 0.00254884296025 | 0.4 | MYD88 IRAK2 | Signal transduction through IL1R |
| WP:WP2637 | 0.00528162918062 | 0.4 | MYD88 IRAK2 | Interleukin 1 IL 1 structural pathway |
| REAC:R-HSA-5260271 | 0.00531742996423 | 0.4 | MYD88 TIRAP | Diseases of Immune System |
| REAC:R-HSA-5602358 | 0.00531742996423 | 0.4 | MYD88 TIRAP | Diseases associated with the TLR signaling cascade |
| WP:WP195 | 0.00659312941575 | 0.4 | MYD88 IRAK2 | IL 1 signaling pathway |
| GO:0034142 | 0.00683974211741 | 0.6 | MYD88 IRAK2 TIRAP | toll-like receptor 4 signaling pathway |
| KEGG:05133 | 0.00771708586936 | 0.4 | MYD88 TIRAP | Pertussis |
| WP:WP2324 | 0.010328593539 | 0.4 | MYD88 TIRAP | AGE RAGE pathway |
| GO:0140895 | 0.011813517648 | 0.6 | MYD88 IRAK2 TIRAP | cell surface toll-like receptor signaling pathway |
| KEGG:05235 | 0.0142114773497 | 0.4 | MYD88 TIRAP | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| KEGG:04064 | 0.0142114773497 | 0.4 | MYD88 TIRAP | NF-kappa B signaling pathway |
| KEGG:04620 | 0.0168082536599 | 0.4 | MYD88 TIRAP | Toll-like receptor signaling pathway |
| GO:0002752 | 0.0176256341648 | 0.6 | MYD88 IRAK2 TIRAP | cell surface pattern recognition receptor signaling pathway |
| WP:WP75 | 0.0197951791935 | 0.4 | MYD88 TIRAP | Toll like receptor signaling pathway |
| KEGG:04936 | 0.0340898047114 | 0.4 | MYD88 TIRAP | Alcoholic liver disease |
| GO:0002220 | 0.039797089625 | 0.6 | MYD88 IRAK2 TIRAP | innate immune response activating cell surface receptor signaling pathway |
| GO:0008063 | 0.0468008499735 | 0.4 | MYD88 IRAK2 | Toll signaling pathway |
| KEGG:05161 | 0.0484667159694 | 0.4 | MYD88 TIRAP | Hepatitis B |
| REAC:R-HSA-168142 | 0.0499330761364 | 0.4 | MYD88 IRAK2 | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-975871 | 0.0499330761364 | 0.4 | MYD88 IRAK2 | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-168176 | 0.0499330761364 | 0.4 | MYD88 IRAK2 | Toll Like Receptor 5 (TLR5) Cascade |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TIRAP | IRAK2 | 0.997 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MYD88 | ARMCX6 | 0.996 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MYD88 | TIRAP | 0.995 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MYD88 | IRAK2 | 0.904 | bioplex3_WMM WMM_only | |
| MYD88 | GLOD4 | 0.825 | bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes