hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14877.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MCM8 | DNA helicase MCM8 (EC 3.6.4.12) (Minichromosome maintenance 8) | 5 | UniProt NCBI |
| MCM9 | DNA helicase MCM9 (hMCM9) (EC 3.6.4.12) (Mini-chromosome maintenance deficient domain-containing protein 1) (Minichromosome maintenance 9) | 5 | UniProt NCBI |
| HORMAD2 | HORMA domain-containing protein 2 | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0032406 | 0.00140460216025 | 0.666666666667 | MCM9 MCM8 | MutLbeta complex binding |
| GO:0032408 | 0.00140460216025 | 0.666666666667 | MCM9 MCM8 | MutSbeta complex binding |
| GO:0097362 | 0.00140460216025 | 0.666666666667 | MCM9 MCM8 | MCM8-MCM9 complex |
| GO:0036298 | 0.00140460216025 | 0.666666666667 | MCM9 MCM8 | recombinational interstrand cross-link repair |
| GO:0070716 | 0.00140460216025 | 0.666666666667 | MCM9 MCM8 | mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication |
| HP:0008232 | 0.00513122551172 | 0.666666666667 | MCM9 MCM8 | Elevated circulating follicle stimulating hormone level |
| WP:WP5316 | 0.00929774738496 | 0.666666666667 | MCM9 MCM8 | Primary ovarian insufficiency |
| HP:0030346 | 0.0180650213362 | 0.666666666667 | MCM9 MCM8 | Abnormal circulating follicle-stimulating hormone concentration |
| HP:0000837 | 0.0194392651505 | 0.666666666667 | MCM9 MCM8 | Increased circulating gonadotropin level |
| WP:WP4352 | 0.0243888015773 | 0.666666666667 | MCM9 MCM8 | Ciliary landscape |
| GO:0032407 | 0.0294899169624 | 0.666666666667 | MCM9 MCM8 | MutSalpha complex binding |
| HP:0030338 | 0.0429026841472 | 0.666666666667 | MCM9 MCM8 | Abnormal circulating gonadotropin concentration |
| HP:0010514 | 0.047155317063 | 0.666666666667 | MCM9 MCM8 | Hyperpituitarism |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MCM9 | MCM8 | 0.999 | 0.058 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| MCM9 | HORMAD2 | 0.934 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| MCM8 | HORMAD2 | 0.387 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes