hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14882.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TUBGCP3 | Gamma-tubulin complex component 3 (GCP-3) (hGCP3) (Gamma-ring complex protein 104 kDa) (h104p) (hGrip104) (Spindle pole body protein Spc98 homolog) (hSpc98) | 5 | UniProt NCBI |
| MZT2B | Mitotic-spindle organizing protein 2B (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B) | 4 | UniProt NCBI |
| TUBGCP6 | Gamma-tubulin complex component 6 (GCP-6) | 5 | UniProt NCBI |
| MZT1 | Mitotic-spindle organizing protein 1 (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1) | 5 | UniProt NCBI |
| CPED1 | Cadherin-like and PC-esterase domain-containing protein 1 | 3 | UniProt NCBI |
| NEDD1 | Protein NEDD1 (Neural precursor cell expressed developmentally down-regulated protein 1) (NEDD-1) | 5 | UniProt NCBI |
| TUBG2 | Tubulin gamma-2 chain (Gamma-2-tubulin) | 5 | UniProt NCBI |
| TXNDC12 | Thioredoxin domain-containing protein 12 (EC 1.8.4.2) (Endoplasmic reticulum resident protein 18) (ER protein 18) (ERp18) (Endoplasmic reticulum resident protein 19) (ER protein 19) (ERp19) (Thioredoxin-like protein p19) (hTLP19) | 5 | UniProt NCBI |
| TUBGCP4 | Gamma-tubulin complex component 4 (GCP-4) (hGCP4) (Gamma-ring complex protein 76 kDa) (h76p) (hGrip76) | 5 | UniProt NCBI |
| TUBGCP2 | Gamma-tubulin complex component 2 (GCP-2) (hGCP2) (Gamma-ring complex protein 103 kDa) (h103p) (hGrip103) (Spindle pole body protein Spc97 homolog) (hSpc97) | 5 | UniProt NCBI |
| TUBG1 | Tubulin gamma-1 chain (Gamma-1-tubulin) (Gamma-tubulin complex component 1) (GCP-1) | 5 | UniProt NCBI |
| MZT2A | Mitotic-spindle organizing protein 2A (Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2A) | 4 | UniProt NCBI |
| LGALS3BP | Galectin-3-binding protein (Basement membrane autoantigen p105) (Lectin galactoside-binding soluble 3-binding protein) (Mac-2-binding protein) (MAC2BP) (Mac-2 BP) (Tumor-associated antigen 90K) | 5 | UniProt NCBI |
| NME7 | Nucleoside diphosphate kinase homolog 7 (NDK 7) (NDP kinase homolog 7) (3'-5' exonuclease NME7) (EC 3.1.-.-) (Protein kinase NME7) (EC 2.7.-.-) (nm23-H7) | 5 | UniProt NCBI |
| TAS2R41 | Taste receptor type 2 member 41 (T2R41) (Taste receptor type 2 member 59) (T2R59) | 3 | UniProt NCBI |
| TUBGCP5 | Gamma-tubulin complex component 5 (GCP-5) | 5 | UniProt NCBI |
| MCTP2 | Multiple C2 and transmembrane domain-containing protein 2 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-380287 | 5.99810383272e-20 | 0.6875 | TUBGCP5 MZT2B TUBG2 NEDD1 TUBGCP4 NME7 TUBGCP6 MZT1 MZT2A TUBGCP3 TUBGCP2 | Centrosome maturation |
| REAC:R-HSA-380270 | 5.99810383272e-20 | 0.6875 | TUBGCP5 MZT2B TUBG2 NEDD1 TUBGCP4 NME7 TUBGCP6 MZT1 MZT2A TUBGCP3 TUBGCP2 | Recruitment of mitotic centrosome proteins and complexes |
| GO:0000930 | 1.65701101415e-19 | 0.5625 | TUBGCP5 MZT2B TUBG2 MZT2A TUBGCP3 TUBGCP6 MZT1 TUBGCP4 TUBGCP2 | gamma-tubulin complex |
| REAC:R-HSA-380320 | 3.19600363489e-19 | 0.6875 | TUBGCP5 MZT2B TUBG2 NEDD1 TUBGCP4 NME7 TUBGCP6 MZT1 MZT2A TUBGCP3 TUBGCP2 | Recruitment of NuMA to mitotic centrosomes |
| REAC:R-HSA-69275 | 1.52404414494e-15 | 0.6875 | TUBGCP5 MZT2B TUBG2 NEDD1 TUBGCP4 NME7 TUBGCP6 MZT1 MZT2A TUBGCP3 TUBGCP2 | G2/M Transition |
| REAC:R-HSA-453274 | 1.71547082424e-15 | 0.6875 | TUBGCP5 MZT2B TUBG2 NEDD1 TUBGCP4 NME7 TUBGCP6 MZT1 MZT2A TUBGCP3 TUBGCP2 | Mitotic G2-G2/M phases |
| REAC:R-HSA-68877 | 2.16524952622e-15 | 0.6875 | TUBGCP5 MZT2B TUBG2 NEDD1 TUBGCP4 NME7 TUBGCP6 MZT1 MZT2A TUBGCP3 TUBGCP2 | Mitotic Prometaphase |
| CORUM:6893 | 3.57556175758e-14 | 0.3125 | TUBGCP6 TUBGCP5 TUBGCP2 TUBGCP3 TUBGCP4 | Gamma-tubulin complex |
| GO:0000931 | 8.28185622893e-13 | 0.375 | TUBGCP5 MZT2B TUBGCP6 MZT2A MZT1 TUBGCP4 | gamma-tubulin ring complex |
| GO:0007020 | 2.1748721647e-12 | 0.5 | TUBGCP5 TUBGCP2 TUBG2 NEDD1 TUBGCP3 TUBGCP6 MZT1 TUBGCP4 | microtubule nucleation |
| REAC:R-HSA-68886 | 4.42370056809e-12 | 0.6875 | TUBGCP5 MZT2B TUBG2 NEDD1 TUBGCP4 NME7 TUBGCP6 MZT1 MZT2A TUBGCP3 TUBGCP2 | M Phase |
| WP:WP4940 | 1.10095816548e-11 | 0.3125 | TUBGCP6 TUBGCP5 TUBGCP2 TUBGCP3 TUBGCP4 | 15q11 2 copy number variation syndrome |
| GO:0000923 | 3.93311793334e-11 | 0.3125 | TUBGCP6 TUBGCP5 TUBGCP2 TUBGCP3 TUBGCP4 | equatorial microtubule organizing center |
| REAC:R-HSA-69278 | 1.28499766811e-10 | 0.6875 | TUBGCP5 MZT2B TUBG2 NEDD1 TUBGCP4 NME7 TUBGCP6 MZT1 MZT2A TUBGCP3 TUBGCP2 | Cell Cycle, Mitotic |
| GO:0046785 | 3.87628142721e-10 | 0.5 | TUBGCP5 TUBGCP2 TUBG2 NEDD1 TUBGCP3 TUBGCP6 MZT1 TUBGCP4 | microtubule polymerization |
| REAC:R-HSA-1640170 | 1.22887830347e-09 | 0.6875 | TUBGCP5 MZT2B TUBG2 NEDD1 TUBGCP4 NME7 TUBGCP6 MZT1 MZT2A TUBGCP3 TUBGCP2 | Cell Cycle |
| GO:0043015 | 5.18624588901e-09 | 0.375 | TUBGCP5 TUBGCP2 TUBGCP6 NEDD1 TUBGCP3 TUBGCP4 | gamma-tubulin binding |
| GO:0031109 | 5.64411912976e-09 | 0.5 | TUBGCP5 TUBGCP2 TUBG2 NEDD1 TUBGCP3 TUBGCP6 MZT1 TUBGCP4 | microtubule polymerization or depolymerization |
| GO:0005813 | 3.0489684284e-08 | 0.6875 | TUBGCP5 MZT2B TUBG2 NEDD1 TUBGCP4 NME7 TUBGCP6 MZT1 MZT2A TUBGCP3 TUBGCP2 | centrosome |
| GO:0051011 | 3.10137235014e-08 | 0.3125 | TUBGCP6 TUBGCP5 TUBGCP2 TUBGCP3 TUBGCP4 | microtubule minus-end binding |
| GO:0005815 | 1.93135215228e-07 | 0.6875 | TUBGCP5 MZT2B TUBG2 NEDD1 TUBGCP4 NME7 TUBGCP6 MZT1 MZT2A TUBGCP3 TUBGCP2 | microtubule organizing center |
| GO:0051258 | 6.2637418744e-07 | 0.5 | TUBGCP5 TUBGCP2 TUBG2 NEDD1 TUBGCP3 TUBGCP6 MZT1 TUBGCP4 | protein polymerization |
| WP:WP3998 | 2.42163926002e-06 | 0.3125 | TUBGCP6 TUBGCP5 TUBGCP2 TUBGCP3 TUBGCP4 | Prader Willi and Angelman syndrome |
| GO:0007051 | 9.49559443304e-06 | 0.4375 | TUBGCP5 TUBGCP2 TUBG2 TUBGCP3 TUBGCP6 MZT1 TUBGCP4 | spindle organization |
| GO:0015630 | 2.69028633435e-05 | 0.6875 | TUBGCP5 MZT2B TUBG2 NEDD1 TUBGCP4 NME7 TUBGCP6 MZT1 MZT2A TUBGCP3 TUBGCP2 | microtubule cytoskeleton |
| GO:0051225 | 3.76857388203e-05 | 0.375 | TUBGCP5 TUBGCP2 TUBGCP6 TUBGCP3 MZT1 TUBGCP4 | spindle assembly |
| GO:0031122 | 4.16803583941e-05 | 0.3125 | TUBGCP6 TUBGCP5 TUBGCP2 TUBGCP3 TUBGCP4 | cytoplasmic microtubule organization |
| GO:0032153 | 8.1010625854e-05 | 0.3125 | TUBGCP6 TUBGCP5 TUBGCP2 TUBGCP3 TUBGCP4 | cell division site |
| CORUM:3714 | 0.000153131458895 | 0.125 | TUBGCP3 TUBGCP2 | Pericentrin-GCP complex |
| GO:0051321 | 0.000492342215894 | 0.375 | TUBGCP5 TUBGCP2 TUBGCP6 TUBGCP3 TUBG2 TUBGCP4 | meiotic cell cycle |
| GO:0000226 | 0.000803539414011 | 0.5 | TUBGCP5 TUBGCP2 TUBG2 NEDD1 TUBGCP3 TUBGCP6 MZT1 TUBGCP4 | microtubule cytoskeleton organization |
| GO:0007059 | 0.0011635946678 | 0.4375 | TUBGCP5 TUBGCP2 TUBG2 TUBGCP3 TUBGCP6 MZT1 TUBGCP4 | chromosome segregation |
| GO:0005856 | 0.00205044865822 | 0.6875 | TUBGCP5 MZT2B TUBG2 NEDD1 TUBGCP4 NME7 TUBGCP6 MZT1 MZT2A TUBGCP3 TUBGCP2 | cytoskeleton |
| GO:0097435 | 0.00394883308508 | 0.5 | TUBGCP5 TUBGCP2 TUBG2 NEDD1 TUBGCP3 TUBGCP6 MZT1 TUBGCP4 | supramolecular fiber organization |
| GO:0007017 | 0.0113864236528 | 0.5 | TUBGCP5 TUBGCP2 TUBG2 NEDD1 TUBGCP3 TUBGCP6 MZT1 TUBGCP4 | microtubule-based process |
| GO:0000278 | 0.015593607012 | 0.5 | TUBGCP5 TUBGCP2 TUBG2 NEDD1 TUBGCP3 TUBGCP6 MZT1 TUBGCP4 | mitotic cell cycle |
| GO:0015631 | 0.02214743869 | 0.375 | TUBGCP5 TUBGCP2 TUBGCP6 NEDD1 TUBGCP3 TUBGCP4 | tubulin binding |
| GO:0005819 | 0.0249176349592 | 0.375 | MZT2B TUBG2 MZT2A NEDD1 MZT1 TUBGCP3 | spindle |
| GO:0140694 | 0.0290489459853 | 0.375 | TUBGCP5 TUBGCP2 TUBGCP6 TUBGCP3 MZT1 TUBGCP4 | non-membrane-bounded organelle assembly |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| TUBGCP2 | TUBGCP5 | 1.0 | 0.264 |
| TUBG1 | TUBGCP5 | 1.0 | 0.208 |
| TUBGCP3 | TUBGCP5 | 1.0 | 0.19 |
| TUBGCP6 | TUBGCP5 | 1.0 | 0.258 |
| TUBGCP4 | TUBGCP5 | 1.0 | 0.06 |
| TUBGCP3 | MZT1 | 1.0 | 0.204 |
| TUBGCP5 | MZT2A | 1.0 | 0.072 |
| MZT2B | TUBGCP6 | 1.0 | 0.092 |
| TUBGCP2 | TUBGCP6 | 1.0 | 0.156 |
| TUBGCP4 | TUBGCP6 | 1.0 | 0.148 |
| NME7 | TUBGCP5 | 1.0 | 0.112 |
| MZT2B | TUBGCP2 | 1.0 | 0.604 |
| TUBGCP2 | NME7 | 1.0 | 0.082 |
| MZT2B | TUBG1 | 1.0 | 0.738 |
| TUBG2 | TUBG1 | 1.0 | |
| TUBG1 | MZT2A | 1.0 | 0.084 |
| TUBGCP6 | MZT2A | 0.999 | 0.168 |
| TUBGCP4 | MZT2A | 0.999 | 0.108 |
| TUBGCP3 | TUBGCP6 | 0.999 | 0.098 |
| TUBGCP3 | MZT2A | 0.999 | 0.092 |
| MZT2B | TUBGCP5 | 0.999 | 0.148 |
| TUBG2 | TUBGCP5 | 0.999 | |
| TUBGCP2 | MZT2A | 0.999 | 0.072 |
| NME7 | TUBGCP6 | 0.999 | 0.086 |
| MZT2B | MZT2A | 0.999 | 0.072 |
| TUBG1 | TUBGCP6 | 0.999 | 0.152 |
| TUBG2 | TUBGCP2 | 0.999 | |
| TUBG2 | TUBGCP6 | 0.999 | |
| TUBGCP4 | TUBG1 | 0.999 | 0.346 |
| TUBGCP3 | TUBG2 | 0.999 | |
| NME7 | MZT2A | 0.999 | 0.162 |
| TUBGCP4 | NME7 | 0.999 | 0.114 |
| TUBGCP3 | NME7 | 0.999 | 0.068 |
| TUBGCP3 | MZT2B | 0.999 | 0.22 |
| MZT2B | TUBG2 | 0.999 | |
| TUBGCP3 | TUBGCP2 | 0.999 | 0.684 |
| TUBG2 | MZT2A | 0.999 | |
| MZT1 | TUBG1 | 0.999 | 0.192 |
| TUBG2 | TUBGCP4 | 0.999 | |
| MZT2B | TUBGCP4 | 0.999 | 0.302 |
| MZT2B | NME7 | 0.999 | 0.034 |
| MZT1 | NEDD1 | 0.999 | 0.08 |
| TUBGCP3 | TUBGCP4 | 0.999 | 0.108 |
| MZT1 | TUBGCP6 | 0.998 | 0.152 |
| MZT1 | TUBGCP4 | 0.998 | 0.112 |
| TUBG1 | NME7 | 0.998 | 0.03 |
| MZT1 | TUBGCP5 | 0.998 | 0.184 |
| TUBGCP4 | TUBGCP2 | 0.998 | 0.266 |
| TUBGCP3 | TUBG1 | 0.998 | 0.64 |
| NEDD1 | TUBGCP2 | 0.998 | 0.08 |
| MZT1 | TUBGCP2 | 0.998 | 0.214 |
| MZT2B | MZT1 | 0.998 | 0.114 |
| TUBG2 | NME7 | 0.998 | |
| MZT1 | MZT2A | 0.998 | 0.1 |
| TUBG1 | TUBGCP2 | 0.998 | 0.93 |
| NEDD1 | TUBGCP6 | 0.997 | 0.1 |
| MZT1 | NME7 | 0.997 | 0.074 |
| NEDD1 | TUBGCP5 | 0.997 | 0.084 |
| MZT2B | NEDD1 | 0.997 | 0.04 |
| TUBG1 | LGALS3BP | 0.995 | 0.178 |
| NEDD1 | TUBGCP4 | 0.994 | 0.108 |
| MZT2A | LGALS3BP | 0.994 | 0.048 |
| TUBGCP3 | NEDD1 | 0.993 | 0.182 |
| TUBGCP6 | LGALS3BP | 0.992 | 0.104 |
| TUBGCP5 | LGALS3BP | 0.987 | 0.106 |
| NEDD1 | TUBG1 | 0.986 | 0.134 |
| TXNDC12 | MZT2A | 0.983 | 0.06 |
| NEDD1 | MZT2A | 0.983 | 0.098 |
| TUBGCP6 | TXNDC12 | 0.98 | 0.074 |
| NEDD1 | NME7 | 0.979 | 0.042 |
| TUBGCP2 | LGALS3BP | 0.97 | 0.076 |
| NME7 | LGALS3BP | 0.964 | 0.064 |
| TXNDC12 | TUBGCP5 | 0.963 | 0.082 |
| TUBGCP4 | LGALS3BP | 0.956 | 0.054 |
| MZT2B | LGALS3BP | 0.947 | 0.03 |
| MZT2B | TXNDC12 | 0.926 | 0.06 |
| TUBG1 | TXNDC12 | 0.922 | 0.12 |
| TUBGCP3 | LGALS3BP | 0.916 | 0.162 |
| TUBGCP4 | TXNDC12 | 0.904 | 0.03 |
| TUBGCP5 | MCTP2 | 0.904 | 0.11 |
| TUBGCP3 | TXNDC12 | 0.898 | 0.034 |
| TUBGCP2 | TXNDC12 | 0.887 | 0.032 |
| TUBGCP6 | MCTP2 | 0.875 | 0.098 |
| TXNDC12 | CPED1 | 0.867 | |
| TAS2R41 | TXNDC12 | 0.85 | |
| NME7 | TXNDC12 | 0.824 | 0.05 |
| MZT1 | LGALS3BP | 0.818 | 0.120285714286 |
| NEDD1 | LGALS3BP | 0.811 | 0.034 |
| TUBGCP4 | MCTP2 | 0.696 | 0.076 |
| TUBG1 | MCTP2 | 0.696 | 0.154 |
| TUBGCP2 | MCTP2 | 0.654 | 0.08 |
| MZT1 | TUBG2 | 0.502 | |
| NME7 | MCTP2 | 0.401 | 0.122 |
| TUBGCP3 | MCTP2 | 0.19 | 0.072 |
| NEDD1 | TUBG2 | 0.143 | |
| NEDD1 | TXNDC12 | 0.029 | 0.026 |
| TAS2R41 | LGALS3BP | 0.009 | |
| CPED1 | LGALS3BP | 0.008 | |
| NEDD1 | MCTP2 | 0.006 | 0.112 |
| TUBG2 | LGALS3BP | 0.001 | |
| TXNDC12 | LGALS3BP | 0.001 | 0.054 |
Related Complexes