hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14895.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SH2D3C | SH2 domain-containing protein 3C (Cas/HEF1-associated signal transducer) (Chat-H) (Novel SH2-containing protein 3) (SH2 domain-containing Eph receptor-binding protein 1) (SHEP1) | 5 | UniProt NCBI |
| BCAR3 | Breast cancer anti-estrogen resistance protein 3 (Novel SH2-containing protein 2) (SH2 domain-containing protein 3B) | 5 | UniProt NCBI |
| CTSH | Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H (EC 3.4.22.16); Cathepsin H heavy chain; Cathepsin H light chain] | 5 | UniProt NCBI |
| BCAR1 | Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas) | 5 | UniProt NCBI |
| RASAL1 | RasGAP-activating-like protein 1 (RAS protein activator like 1) (Ras GTPase-activating-like protein) | 5 | UniProt NCBI |
| PCP4 | Calmodulin regulator protein PCP4 (Brain-specific polypeptide PEP-19) (Purkinje cell protein 4) | 5 | UniProt NCBI |
| HTRA3 | Serine protease HTRA3 (EC 3.4.21.-) (High-temperature requirement factor A3) (Pregnancy-related serine protease) | 5 | UniProt NCBI |
| NT5C1A | Cytosolic 5'-nucleotidase 1A (cN1A) (EC 3.1.3.5) (EC 3.1.3.89) (EC 3.1.3.99) (5'-deoxynucleotidase) (Cytosolic 5'-nucleotidase IA) (cN-I) (cN-IA) | 5 | UniProt NCBI |
| HCRTR2 | Orexin receptor type 2 (Ox-2-R) (Ox2-R) (Ox2R) (Hypocretin receptor type 2) | 5 | UniProt NCBI |
| GDPD3 | Lysophospholipase D GDPD3 (EC 3.1.4.-) (Glycerophosphodiester phosphodiesterase 7) (Glycerophosphodiester phosphodiesterase domain-containing protein 3) | 5 | UniProt NCBI |
| NEDD9 | Enhancer of filamentation 1 (hEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (Cas scaffolding protein family member 2) (CASS2) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (Renal carcinoma antigen NY-REN-12) (p105) [Cleaved into: Enhancer of filamentation 1 p55] | 5 | UniProt NCBI |
| ARSF | Arylsulfatase F (ASF) (EC 3.1.6.1) | 4 | UniProt NCBI |
| CREG1 | Protein CREG1 (Cellular repressor of E1A-stimulated genes 1) | 5 | UniProt NCBI |
| OR5F1 | Olfactory receptor 5F1 (Olfactory receptor 11-10) (OR11-10) (Olfactory receptor OR11-167) | 3 | UniProt NCBI |
| SH2D3A | SH2 domain-containing protein 3A (Novel SH2-containing protein 1) | 5 | UniProt NCBI |
| BEX5 | Protein BEX5 (Brain-expressed X-linked protein 5) (NGFRAP1-like protein 1) (Nerve growth factor receptor-associated protein 2) | 5 | UniProt NCBI |
| TRAF3IP2 | E3 ubiquitin ligase TRAF3IP2 (EC 2.3.2.27) (Adapter protein CIKS) (Connection to IKK and SAPK/JNK) (E3 ubiquitin-protein ligase CIKS) (Nuclear factor NF-kappa-B activator 1) (ACT1) (TRAF3-interacting protein 2) | 5 | UniProt NCBI |
| CCDC25 | Coiled-coil domain-containing protein 25 | 5 | UniProt NCBI |
| RFXAP | Regulatory factor X-associated protein (RFX-associated protein) (RFX DNA-binding complex 36 kDa subunit) | 5 | UniProt NCBI |
| AIRE | Autoimmune regulator (Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein) (APECED protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0002728 | 0.0289485521875 | 0.15 | RFXAP TRAF3IP2 AIRE | Chronic mucocutaneous candidiasis |
| KEGG:05340 | 0.0366346690637 | 0.1 | RFXAP AIRE | Primary immunodeficiency |
| CORUM:1985 | 0.0499436884912 | 0.05 | AIRE | AIRE homodimer complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD |
|---|---|---|---|
| BCAR1 | BCAR3 | 1.0 | 0.122 |
| SH2D3C | BCAR1 | 0.999 | 0.094 |
| SH2D3A | RASAL1 | 0.998 | 0.07 |
| BCAR1 | SH2D3A | 0.998 | 0.134 |
| PCP4 | ARSF | 0.996 | |
| BCAR3 | CCDC25 | 0.995 | 0.094 |
| BCAR3 | NEDD9 | 0.994 | 0.156 |
| PCP4 | CREG1 | 0.992 | |
| BCAR1 | TRAF3IP2 | 0.99 | 0.146 |
| NT5C1A | CREG1 | 0.988 | |
| SH2D3A | CREG1 | 0.982 | 0.04 |
| BCAR1 | NEDD9 | 0.976 | 0.152 |
| AIRE | CTSH | 0.975 | |
| PCP4 | GDPD3 | 0.974 | |
| CTSH | GDPD3 | 0.973 | 0.176 |
| NT5C1A | GDPD3 | 0.967 | |
| AIRE | CREG1 | 0.946 | |
| SH2D3C | SH2D3A | 0.946 | 0.07 |
| SH2D3C | BCAR3 | 0.946 | 0.098 |
| PCP4 | CTSH | 0.938 | |
| SH2D3A | BCAR3 | 0.931 | 0.114 |
| SH2D3A | GDPD3 | 0.927 | |
| CTSH | NT5C1A | 0.927 | |
| NT5C1A | HCRTR2 | 0.922 | |
| SH2D3A | RFXAP | 0.92 | 0.05 |
| SH2D3C | TRAF3IP2 | 0.902 | 0.078 |
| BCAR1 | RASAL1 | 0.902 | 0.108 |
| AIRE | GDPD3 | 0.893 | |
| RASAL1 | CREG1 | 0.892 | 0.066 |
| CCDC25 | OR5F1 | 0.886 | |
| CTSH | SH2D3A | 0.873 | 0.054 |
| HTRA3 | SH2D3A | 0.846 | |
| TRAF3IP2 | BEX5 | 0.829 | |
| BCAR1 | CCDC25 | 0.801 | 0.118 |
| CREG1 | GDPD3 | 0.755 | 0.046 |
| CTSH | CREG1 | 0.742 | 0.098 |
| ARSF | CTSH | 0.615 | |
| ARSF | GDPD3 | 0.522 | |
| TRAF3IP2 | BCAR3 | 0.455 | 0.05 |
| SH2D3C | NEDD9 | 0.415 | 0.114 |
| TRAF3IP2 | SH2D3A | 0.405 | 0.062 |
| BCAR1 | CREG1 | 0.401 | 0.066 |
| RASAL1 | GDPD3 | 0.378 | |
| ARSF | CREG1 | 0.332 | |
| SH2D3A | NEDD9 | 0.274 | |
| BCAR1 | RFXAP | 0.274 | 0.112 |
| CTSH | RASAL1 | 0.22 | 0.134 |
| RASAL1 | RFXAP | 0.214 | 0.056 |
| BCAR1 | GDPD3 | 0.188 | 0.136 |
| BCAR1 | CTSH | 0.15 | 0.112 |
| NEDD9 | CCDC25 | 0.143 | 0.032 |
| TRAF3IP2 | NEDD9 | 0.055 | |
| CREG1 | RFXAP | 0.042 | 0.032 |
| GDPD3 | RFXAP | 0.041 | |
| CTSH | RFXAP | 0.026 | 0.086 |
| TRAF3IP2 | CCDC25 | 0.014 | 0.056 |
Related Complexes