hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14902.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CEP290 | Centrosomal protein of 290 kDa (Cep290) (Bardet-Biedl syndrome 14 protein) (Cancer/testis antigen 87) (CT87) (Nephrocystin-6) (Tumor antigen se2-2) | 5 | UniProt NCBI |
| CEP104 | Centrosomal protein of 104 kDa (Cep104) | 5 | UniProt NCBI |
| CCP110 | Centriolar coiled-coil protein of 110 kDa (Centrosomal protein of 110 kDa) (CP110) (Cep110) | 5 | UniProt NCBI |
| KIF24 | Kinesin-like protein KIF24 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6594 | 5.12628525639e-06 | 0.5 | CCP110 CEP290 | CCP110-CEP290 complex |
| WP:WP4656 | 1.99075136102e-05 | 0.75 | CEP104 CEP290 CCP110 | Joubert syndrome |
| GO:0005814 | 0.000130712993938 | 1.0 | KIF24 CEP104 CEP290 CCP110 | centriole |
| REAC:R-HSA-5620912 | 0.000181248084935 | 0.75 | CCP110 CEP290 KIF24 | Anchoring of the basal body to the plasma membrane |
| REAC:R-HSA-5617833 | 0.00153910156762 | 0.75 | CCP110 CEP290 KIF24 | Cilium Assembly |
| REAC:R-HSA-1852241 | 0.00474364374959 | 0.75 | CCP110 CEP290 KIF24 | Organelle biogenesis and maintenance |
| WP:WP5234 | 0.00722934152515 | 0.5 | CEP104 CEP290 | Bardet Biedl syndrome |
| HP:0002419 | 0.018706736024 | 0.5 | CEP104 CEP290 | Molar tooth sign on MRI |
| REAC:R-HSA-380259 | 0.0218635493976 | 0.5 | CCP110 CEP290 | Loss of Nlp from mitotic centrosomes |
| REAC:R-HSA-380284 | 0.0218635493976 | 0.5 | CCP110 CEP290 | Loss of proteins required for interphase microtubule organization from the centrosome |
| REAC:R-HSA-8854518 | 0.0239057396727 | 0.5 | CCP110 CEP290 | AURKA Activation by TPX2 |
| WP:WP4803 | 0.030443565418 | 0.5 | CEP104 CEP290 | Ciliopathies |
| REAC:R-HSA-380287 | 0.0305753786405 | 0.5 | CCP110 CEP290 | Centrosome maturation |
| REAC:R-HSA-380270 | 0.0305753786405 | 0.5 | CCP110 CEP290 | Recruitment of mitotic centrosome proteins and complexes |
| REAC:R-HSA-2565942 | 0.0346321697685 | 0.5 | CCP110 CEP290 | Regulation of PLK1 Activity at G2/M Transition |
| HP:0002876 | 0.0391604009626 | 0.5 | CEP104 CEP290 | Episodic tachypnea |
| REAC:R-HSA-380320 | 0.0407325822829 | 0.5 | CCP110 CEP290 | Recruitment of NuMA to mitotic centrosomes |
| CORUM:6597 | 0.049938562206 | 0.25 | CEP290 | CEP290-IQCB1 complex |
| CORUM:6598 | 0.049938562206 | 0.25 | CEP290 | CC2D2A-CEP290 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CCP110 | CEP290 | 0.993 | 0.189529204785 | hein_WMM bioplex_WMM bioplex3_WMM gupta () boldt hein () gupta_WMM boldt_WMM |
| CCP110 | CEP104 | 0.933 | hein_WMM gupta () hein () gupta_WMM | |
| CCP110 | KIF24 | 0.921 | hein_WMM bioplex3_HEK293 bioplex3_WMM boldt_WMM WMM_only | |
| CEP104 | KIF24 | 0.343 | hein_WMM hein () | |
| CEP290 | CEP104 | 0.079 | gupta_WMM WMM_only gupta () |
Related Complexes