hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_14916.1
Complex Portal: CPX-15460
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PHKG1 | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHK-gamma-M) (EC 2.7.11.19) (Phosphorylase kinase subunit gamma-1) (Serine/threonine-protein kinase PHKG1) (EC 2.7.11.1, EC 2.7.11.26) | 5 | UniProt NCBI |
| RPS6KA1 | Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1) | 5 | UniProt NCBI |
| ZDHHC11 | Palmitoyltransferase ZDHHC11 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 11) (DHHC-11) (Zinc finger protein 399) | 5 | UniProt NCBI |
| MAPK1 | Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2) | 5 | UniProt NCBI |
| PTPRR | Receptor-type tyrosine-protein phosphatase R (R-PTP-R) (EC 3.1.3.48) (Ch-1PTPase) (NC-PTPCOM1) (Protein-tyrosine phosphatase PCPTP1) | 5 | UniProt NCBI |
| CUEDC1 | CUE domain-containing protein 1 | 3 | UniProt NCBI |
| MAPK3 | Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1) | 5 | UniProt NCBI |
| IRGC | Interferon-inducible GTPase 5 (EC 3.6.5.-) (Immunity-related GTPase cinema 1) | 4 | UniProt NCBI |
| RFFL | E3 ubiquitin-protein ligase rififylin (EC 2.3.2.27) (Caspase regulator CARP2) (Caspases-8 and -10-associated RING finger protein 2) (CARP-2) (FYVE-RING finger protein Sakura) (Fring) (RING finger and FYVE-like domain-containing protein 1) (RING finger protein 189) (RING finger protein 34-like) (RING-type E3 ubiquitin transferase rififylin) | 5 | UniProt NCBI |
| RPS6KA2 | Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3) | 5 | UniProt NCBI |
| RPS6KA3 | Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-444257 | 9.33368537808e-10 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | RSK activation |
| REAC:R-HSA-881907 | 4.83918061893e-08 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | Gastrin-CREB signalling pathway via PKC and MAPK |
| REAC:R-HSA-198753 | 1.58873212508e-07 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | ERK/MAPK targets |
| REAC:R-HSA-442742 | 1.94114532425e-07 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling |
| WP:WP4877 | 2.95554457269e-07 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | Host pathogen interaction of human coronaviruses MAPK signaling |
| REAC:R-HSA-450282 | 7.25322049724e-07 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | MAPK targets/ Nuclear events mediated by MAP kinases |
| KEGG:04720 | 1.73110640111e-06 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | Long-term potentiation |
| REAC:R-HSA-199920 | 1.94746021672e-06 | 0.3 | RPS6KA2 RPS6KA1 RPS6KA3 | CREB phosphorylation |
| REAC:R-HSA-198725 | 8.3042930256e-06 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | Nuclear Events (kinase and transcription factor activation) |
| KEGG:04914 | 9.48615060545e-06 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | Progesterone-mediated oocyte maturation |
| REAC:R-HSA-450294 | 9.63815355783e-06 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | MAP kinase activation |
| KEGG:04010 | 1.4458134091e-05 | 0.5 | PTPRR RPS6KA3 RPS6KA1 RPS6KA2 MAPK3 | MAPK signaling pathway |
| REAC:R-HSA-448424 | 1.46096587181e-05 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | Interleukin-17 signaling |
| KEGG:04722 | 2.1141162511e-05 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | Neurotrophin signaling pathway |
| REAC:R-HSA-438064 | 2.12861862485e-05 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | Post NMDA receptor activation events |
| KEGG:04114 | 2.4757954581e-05 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | Oocyte meiosis |
| KEGG:05135 | 3.70889874115e-05 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | Yersinia infection |
| REAC:R-HSA-442755 | 4.11757689433e-05 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | Activation of NMDA receptors and postsynaptic events |
| REAC:R-HSA-975871 | 4.55060268174e-05 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | MyD88 cascade initiated on plasma membrane |
| REAC:R-HSA-168142 | 4.55060268174e-05 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | Toll Like Receptor 10 (TLR10) Cascade |
| REAC:R-HSA-168176 | 4.55060268174e-05 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | Toll Like Receptor 5 (TLR5) Cascade |
| REAC:R-HSA-975138 | 5.01675451915e-05 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| REAC:R-HSA-975155 | 5.26275998716e-05 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | MyD88 dependent cascade initiated on endosome |
| REAC:R-HSA-168181 | 5.26275998716e-05 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| REAC:R-HSA-168138 | 6.33783538488e-05 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | Toll Like Receptor 9 (TLR9) Cascade |
| REAC:R-HSA-168164 | 6.93299198151e-05 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | Toll Like Receptor 3 (TLR3) Cascade |
| WP:WP3915 | 7.0000159691e-05 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | Angiopoietin like protein 8 regulatory pathway |
| REAC:R-HSA-166166 | 7.56889212085e-05 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | MyD88-independent TLR4 cascade |
| REAC:R-HSA-937061 | 7.56889212085e-05 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | TRIF(TICAM1)-mediated TLR4 signaling |
| REAC:R-HSA-166058 | 8.24732991588e-05 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | MyD88:MAL(TIRAP) cascade initiated on plasma membrane |
| REAC:R-HSA-168188 | 8.24732991588e-05 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | Toll Like Receptor TLR6:TLR2 Cascade |
| REAC:R-HSA-181438 | 8.9701360476e-05 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | Toll Like Receptor 2 (TLR2) Cascade |
| REAC:R-HSA-168179 | 8.9701360476e-05 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | Toll Like Receptor TLR1:TLR2 Cascade |
| REAC:R-HSA-187037 | 8.9701360476e-05 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | Signaling by NTRK1 (TRKA) |
| REAC:R-HSA-2559582 | 8.9701360476e-05 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | Senescence-Associated Secretory Phenotype (SASP) |
| KEGG:04150 | 0.00010183820007 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | mTOR signaling pathway |
| REAC:R-HSA-373760 | 0.000109836051439 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | L1CAM interactions |
| GO:0004711 | 0.000115261178119 | 0.3 | RPS6KA2 RPS6KA1 RPS6KA3 | ribosomal protein S6 kinase activity |
| KEGG:05207 | 0.000149659664551 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | Chemical carcinogenesis - receptor activation |
| REAC:R-HSA-166520 | 0.000171787831512 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | Signaling by NTRKs |
| WP:WP481 | 0.000173534462234 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | Insulin signaling |
| WP:WP437 | 0.000178433597202 | 0.4 | PTPRR RPS6KA3 RPS6KA1 RPS6KA2 | EGF EGFR signaling pathway |
| REAC:R-HSA-166016 | 0.00023302848949 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | Toll Like Receptor 4 (TLR4) Cascade |
| WP:WP4566 | 0.000238756251955 | 0.3 | RPS6KA2 RPS6KA1 MAPK3 | Translation inhibitors in chronically activated PDGFRA cells |
| REAC:R-HSA-416476 | 0.000299946729968 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | G alpha (q) signalling events |
| REAC:R-HSA-168898 | 0.000414096364321 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | Toll-like Receptor Cascades |
| WP:WP304 | 0.000464750478504 | 0.3 | RPS6KA3 RPS6KA1 MAPK3 | Kit receptor signaling pathway |
| REAC:R-HSA-112314 | 0.000634112853678 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | Neurotransmitter receptors and postsynaptic signal transmission |
| REAC:R-HSA-437239 | 0.000832877998849 | 0.3 | RPS6KA2 RPS6KA1 RPS6KA3 | Recycling pathway of L1 |
| REAC:R-HSA-2559583 | 0.0009525163043 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | Cellular Senescence |
| WP:WP5353 | 0.00143474462389 | 0.3 | RPS6KA3 RPS6KA1 MAPK3 | A network map of Macrophage stimulating protein MSP signaling |
| KEGG:04931 | 0.00170732395933 | 0.3 | RPS6KA2 RPS6KA1 RPS6KA3 | Insulin resistance |
| REAC:R-HSA-112315 | 0.001716945174 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | Transmission across Chemical Synapses |
| WP:WP477 | 0.00233501936937 | 0.3 | RPS6KA2 RPS6KA1 RPS6KA3 | Cytoplasmic ribosomal proteins |
| WP:WP4321 | 0.00267240243426 | 0.3 | RPS6KA2 RPS6KA1 RPS6KA3 | Thermogenesis |
| WP:WP2380 | 0.00658064183178 | 0.3 | RPS6KA3 RPS6KA1 MAPK3 | Brain derived neurotrophic factor BDNF signaling pathway |
| REAC:R-HSA-112316 | 0.00779952004401 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | Neuronal System |
| KEGG:04714 | 0.0152810112528 | 0.3 | RPS6KA2 RPS6KA1 RPS6KA3 | Thermogenesis |
| REAC:R-HSA-388396 | 0.0176009385409 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | GPCR downstream signalling |
| WP:WP127 | 0.0190825311458 | 0.2 | RPS6KA1 MAPK3 | IL 5 signaling pathway |
| REAC:R-HSA-449147 | 0.0236575158663 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | Signaling by Interleukins |
| WP:WP382 | 0.0281880329148 | 0.3 | PTPRR MAPK3 RPS6KA3 | MAPK signaling pathway |
| WP:WP2332 | 0.0287758668954 | 0.2 | RPS6KA1 MAPK3 | Interleukin 11 signaling pathway |
| REAC:R-HSA-372790 | 0.0291774485596 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | Signaling by GPCR |
| REAC:R-HSA-9006934 | 0.0331471231971 | 0.4 | RPS6KA2 RPS6KA3 RPS6KA1 MAPK3 | Signaling by Receptor Tyrosine Kinases |
| CORUM:6801 | 0.0499436884912 | 0.1 | MAPK3 | VEGFR2-S1PR3-ERK1/2-PKC-alpha complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RPS6KA3 | RPS6KA2 | 0.999 |
mutually_exclusive (P28482)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| MAPK1 | MAPK3 | 0.999 | 0.446 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM |
| RPS6KA3 | RPS6KA1 | 0.998 | 0.154 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| MAPK1 | RPS6KA3 | 0.996 | 0.164 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| RPS6KA1 | RPS6KA2 | 0.992 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | ||
| CUEDC1 | MAPK3 | 0.98 | 0.147119047619 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| MAPK1 | PTPRR | 0.977 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MAPK1 | RPS6KA1 | 0.975 | 0.124 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 fraction | |
| MAPK3 | RPS6KA2 | 0.959 |
mutually_exclusive (P28482)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| MAPK1 | RPS6KA2 | 0.948 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| CUEDC1 | MAPK1 | 0.942 | 0.162 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ZDHHC11 | MAPK3 | 0.937 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PHKG1 | RPS6KA1 | 0.934 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| RFFL | MAPK3 | 0.914 | 0.11 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 |
| ZDHHC11 | MAPK1 | 0.88 |
mutually_exclusive (P27361)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| RFFL | MAPK1 | 0.871 | 0.114 |
mutually_exclusive (P27361)
|
bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 |
| IRGC | RPS6KA1 | 0.861 | bioplex3_HEK293 bioplex () bioplex_WMM | ||
| IRGC | RPS6KA2 | 0.827 | bioplex3_HEK293 bioplex () bioplex_WMM | ||
| RPS6KA3 | MAPK3 | 0.793 | 0.224 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| RPS6KA1 | MAPK3 | 0.531 | 0.128392857143 | bioplex3_HEK293 bioplex3_WMM fraction | |
| IRGC | RPS6KA3 | 0.215 | bioplex3_HEK293 bioplex () bioplex_WMM | ||
| PTPRR | MAPK3 | 0.162 |
mutually_exclusive (P28482)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CUEDC1 | RPS6KA1 | 0.094 | 0.046 | bioplex3_WMM WMM_only | |
| PHKG1 | RPS6KA2 | 0.078 | bioplex3_WMM WMM_only | ||
| PHKG1 | RPS6KA3 | 0.076 | bioplex3_WMM WMM_only | ||
| CUEDC1 | RPS6KA3 | 0.062 | 0.046 | bioplex3_WMM WMM_only | |
| CUEDC1 | RPS6KA2 | 0.058 | bioplex3_WMM WMM_only | ||
| PHKG1 | MAPK1 | 0.04 | bioplex3_WMM WMM_only | ||
| IRGC | MAPK3 | 0.021 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PHKG1 | MAPK3 | 0.021 | bioplex3_WMM WMM_only | ||
| MAPK1 | IRGC | 0.019 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes