hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_14922.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| KRT76 | Keratin, type II cytoskeletal 2 oral (Cytokeratin-2P) (CK-2P) (K2P) (Keratin-76) (K76) (Type-II keratin Kb9) | 5 | UniProt NCBI |
| KRT78 | Keratin, type II cytoskeletal 78 (Cytokeratin-78) (CK-78) (Keratin-5b) (Keratin-78) (K78) (Type-II keratin Kb40) | 5 | UniProt NCBI |
| KRT77 | Keratin, type II cytoskeletal 1b (Cytokeratin-1B) (CK-1B) (Keratin-77) (K77) (Type-II keratin Kb39) | 5 | UniProt NCBI |
| KRT3 | Keratin, type II cytoskeletal 3 (65 kDa cytokeratin) (Cytokeratin-3) (CK-3) (Keratin-3) (K3) (Type-II keratin Kb3) | 5 | UniProt NCBI |
| KRT14 | Keratin, type I cytoskeletal 14 (Cytokeratin-14) (CK-14) (Keratin-14) (K14) | 5 | UniProt NCBI |
| KRT16 | Keratin, type I cytoskeletal 16 (Cytokeratin-16) (CK-16) (Keratin-16) (K16) | 5 | UniProt NCBI |
| KRT6C | Keratin, type II cytoskeletal 6C (Cytokeratin-6C) (CK-6C) (Cytokeratin-6E) (CK-6E) (Keratin K6h) (Keratin-6C) (K6C) (Type-II keratin Kb12) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0045095 | 8.51367930471e-13 | 1.0 | KRT6C KRT78 KRT14 KRT16 KRT77 KRT76 | keratin filament |
| REAC:R-HSA-6809371 | 1.35674515979e-12 | 1.0 | KRT6C KRT78 KRT14 KRT16 KRT77 KRT76 | Formation of the cornified envelope |
| REAC:R-HSA-6805567 | 1.6297614669e-12 | 1.0 | KRT6C KRT78 KRT14 KRT16 KRT77 KRT76 | Keratinization |
| GO:0045109 | 1.02087272278e-11 | 1.0 | KRT6C KRT78 KRT14 KRT16 KRT77 KRT76 | intermediate filament organization |
| GO:0045104 | 7.52838076699e-11 | 1.0 | KRT6C KRT78 KRT14 KRT16 KRT77 KRT76 | intermediate filament cytoskeleton organization |
| GO:0045103 | 8.48945065214e-11 | 1.0 | KRT6C KRT78 KRT14 KRT16 KRT77 KRT76 | intermediate filament-based process |
| GO:0005882 | 2.5125586413e-10 | 1.0 | KRT6C KRT78 KRT14 KRT16 KRT77 KRT76 | intermediate filament |
| GO:0031424 | 1.09837878454e-09 | 0.833333333333 | KRT6C KRT16 KRT77 KRT76 KRT78 | keratinization |
| GO:0045111 | 2.8187089442e-09 | 1.0 | KRT6C KRT78 KRT14 KRT16 KRT77 KRT76 | intermediate filament cytoskeleton |
| GO:0008544 | 9.10987309576e-08 | 1.0 | KRT6C KRT78 KRT14 KRT16 KRT77 KRT76 | epidermis development |
| GO:0030216 | 1.2932381028e-06 | 0.833333333333 | KRT6C KRT16 KRT77 KRT76 KRT78 | keratinocyte differentiation |
| GO:0030280 | 2.88146527749e-06 | 0.666666666667 | KRT6C KRT77 KRT76 KRT78 | structural constituent of skin epidermis |
| GO:0009913 | 5.98689150865e-06 | 0.833333333333 | KRT6C KRT16 KRT77 KRT76 KRT78 | epidermal cell differentiation |
| REAC:R-HSA-1266738 | 7.19708522974e-06 | 1.0 | KRT6C KRT78 KRT14 KRT16 KRT77 KRT76 | Developmental Biology |
| GO:0030855 | 7.45589404554e-06 | 1.0 | KRT6C KRT78 KRT14 KRT16 KRT77 KRT76 | epithelial cell differentiation |
| GO:0043588 | 1.41932757568e-05 | 0.833333333333 | KRT6C KRT16 KRT77 KRT76 KRT78 | skin development |
| GO:0099513 | 2.68096414183e-05 | 1.0 | KRT6C KRT78 KRT14 KRT16 KRT77 KRT76 | polymeric cytoskeletal fiber |
| GO:0005198 | 8.67131099651e-05 | 1.0 | KRT6C KRT78 KRT14 KRT16 KRT77 KRT76 | structural molecule activity |
| GO:0060429 | 0.000106925679478 | 1.0 | KRT6C KRT78 KRT14 KRT16 KRT77 KRT76 | epithelium development |
| GO:0099512 | 0.000149286254074 | 1.0 | KRT6C KRT78 KRT14 KRT16 KRT77 KRT76 | supramolecular fiber |
| GO:0099081 | 0.000160956821667 | 1.0 | KRT6C KRT78 KRT14 KRT16 KRT77 KRT76 | supramolecular polymer |
| GO:0097435 | 0.000245671465297 | 1.0 | KRT6C KRT78 KRT14 KRT16 KRT77 KRT76 | supramolecular fiber organization |
| GO:0099080 | 0.00221939891188 | 1.0 | KRT6C KRT78 KRT14 KRT16 KRT77 KRT76 | supramolecular complex |
| HP:0000982 | 0.00378495258144 | 0.5 | KRT14 KRT16 KRT6C | Palmoplantar keratoderma |
| HP:0007446 | 0.00388470114881 | 0.333333333333 | KRT14 KRT16 | Palmoplantar blistering |
| GO:0009888 | 0.00398264360229 | 1.0 | KRT6C KRT78 KRT14 KRT16 KRT77 KRT76 | tissue development |
| HP:0000972 | 0.00561569644834 | 0.5 | KRT14 KRT16 KRT6C | Palmoplantar hyperkeratosis |
| HP:0010765 | 0.00577679393552 | 0.5 | KRT14 KRT16 KRT6C | Palmar hyperkeratosis |
| HP:0007556 | 0.0059409259996 | 0.5 | KRT14 KRT16 KRT6C | Plantar hyperkeratosis |
| GO:0007010 | 0.00907384039353 | 1.0 | KRT6C KRT78 KRT14 KRT16 KRT77 KRT76 | cytoskeleton organization |
| KEGG:05150 | 0.00918692149975 | 0.333333333333 | KRT14 KRT16 | Staphylococcus aureus infection |
| HP:0100872 | 0.0126844263563 | 0.5 | KRT14 KRT16 KRT6C | Abnormality of the plantar skin of foot |
| HPA:0461451 | 0.0244436645586 | 0.5 | KRT14 KRT78 KRT6C | skin 1; hair follicles[>=Low] |
| HP:0033800 | 0.0272311241025 | 0.333333333333 | KRT14 KRT16 | Blistering by anatomical location |
| KEGG:04915 | 0.0299366365218 | 0.333333333333 | KRT14 KRT16 | Estrogen signaling pathway |
| HP:0002745 | 0.0349615340576 | 0.333333333333 | KRT6C KRT16 | Oral leukoplakia |
| HP:0025125 | 0.0349615340576 | 0.333333333333 | KRT6C KRT16 | White lesion of the oral mucosa |
| HP:0000962 | 0.0365652768554 | 0.5 | KRT14 KRT16 KRT6C | Hyperkeratosis |
| HP:0001805 | 0.037751561683 | 0.333333333333 | KRT14 KRT16 | Onychogryposis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| KRT3 | KRT16 | 0.936 | 0.312 | youn_WMM gupta_WMM WMM_only boldt_WMM |
| KRT76 | KRT3 | 0.929 | gupta_WMM WMM_only boldt_WMM | |
| KRT16 | KRT6C | 0.921 | youn_WMM gupta_WMM WMM_only boldt_WMM | |
| KRT78 | KRT16 | 0.918 | 0.366 | youn_WMM WMM_only boldt_WMM |
| KRT3 | KRT6C | 0.906 | youn_WMM gupta_WMM WMM_only boldt_WMM | |
| KRT77 | KRT16 | 0.902 | 0.446 | youn_WMM fraction boldt_WMM |
| KRT78 | KRT3 | 0.892 | 0.294 | youn_WMM WMM_only boldt_WMM |
| KRT77 | KRT3 | 0.881 | 0.158 | youn_WMM WMM_only boldt_WMM |
| KRT78 | KRT6C | 0.868 | youn_WMM WMM_only boldt_WMM | |
| KRT77 | KRT6C | 0.855 | youn_WMM WMM_only boldt_WMM | |
| KRT78 | KRT77 | 0.855 | 0.376 | youn_WMM WMM_only boldt_WMM |
| KRT78 | KRT14 | 0.807 | 0.474 | youn_WMM WMM_only boldt_WMM |
| KRT6C | KRT14 | 0.765 | youn_WMM gupta_WMM WMM_only boldt_WMM | |
| KRT76 | KRT78 | 0.761 | WMM_only boldt_WMM | |
| KRT77 | KRT14 | 0.639 | 0.476 | youn_WMM WMM_only boldt_WMM |
| KRT16 | KRT14 | 0.336 | 0.524 | youn_WMM gupta_WMM WMM_only boldt_WMM |
| KRT76 | KRT16 | 0.169 | gupta_WMM WMM_only boldt_WMM | |
| KRT76 | KRT6C | 0.077 | gupta_WMM WMM_only boldt_WMM | |
| KRT3 | KRT14 | 0.068 | 0.55 | youn_WMM gupta_WMM WMM_only boldt_WMM |
| KRT76 | KRT77 | 0.03 | fraction boldt_WMM | |
| KRT76 | KRT14 | 0.029 | gupta_WMM WMM_only boldt_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| KRT76 | huMAP3_13431.1 huMAP3_14922.1 huMAP3_15329.1 |
| KRT78 | huMAP3_13431.1 huMAP3_14922.1 huMAP3_15329.1 |
| KRT77 | huMAP3_13431.1 huMAP3_14922.1 huMAP3_15329.1 |
| KRT3 | huMAP3_13431.1 huMAP3_14922.1 huMAP3_15329.1 |
| KRT14 | huMAP3_14922.1 huMAP3_15329.1 |
| KRT16 | huMAP3_13431.1 huMAP3_14922.1 huMAP3_15329.1 |
| KRT6C | huMAP3_13431.1 huMAP3_14922.1 huMAP3_15329.1 |