hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_14934.1

Complex Portal: CPX-19821

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
GSTM4	Glutathione S-transferase Mu 4 (EC 2.5.1.18) (GST class-mu 4) (GST-Mu2) (GSTM4-4) (Leukotriene C4 synthase GSTM4) (EC 4.4.1.20)	5	UniProt NCBI
PPP1R13B	Apoptosis-stimulating of p53 protein 1 (Protein phosphatase 1 regulatory subunit 13B)	5	UniProt NCBI
UCP1	Mitochondrial brown fat uncoupling protein 1 (UCP 1) (Solute carrier family 25 member 7) (Thermogenin)	5	UniProt NCBI
ARFGAP1	ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein)	5	UniProt NCBI
GSTM1	Glutathione S-transferase Mu 1 (EC 2.5.1.18) (GST HB subunit 4) (GST class-mu 1) (GSTM1-1) (GSTM1a-1a) (GSTM1b-1b) (GTH4)	5	UniProt NCBI
GSTM5	Glutathione S-transferase Mu 5 (EC 2.5.1.18) (GST class-mu 5) (GSTM5-5)	5	UniProt NCBI
RASSF9	Ras association domain-containing protein 9 (PAM COOH-terminal interactor protein 1) (P-CIP1) (Peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor)	4	UniProt NCBI
GSTM3	Glutathione S-transferase Mu 3 (EC 2.5.1.18) (GST class-mu 3) (GSTM3-3) (hGSTM3-3)	5	UniProt NCBI
GSTM2	Glutathione S-transferase Mu 2 (EC 2.5.1.18) (GST class-mu 2) (GSTM2-2)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-156590	4.30104656022e-10	0.625	GSTM1 GSTM3 GSTM4 GSTM2 GSTM5	Glutathione conjugation
KEGG:00480	1.04967378663e-09	0.625	GSTM1 GSTM3 GSTM4 GSTM2 GSTM5	Glutathione metabolism
KEGG:05204	1.42096473e-09	0.625	GSTM1 GSTM3 GSTM4 GSTM2 GSTM5	Chemical carcinogenesis - DNA adducts
KEGG:00982	1.56569247718e-09	0.625	GSTM1 GSTM3 GSTM4 GSTM2 GSTM5	Drug metabolism - cytochrome P450
KEGG:00980	2.47643117257e-09	0.625	GSTM1 GSTM3 GSTM4 GSTM2 GSTM5	Metabolism of xenobiotics by cytochrome P450
KEGG:00983	4.77064270497e-09	0.625	GSTM1 GSTM3 GSTM4 GSTM2 GSTM5	Drug metabolism - other enzymes
KEGG:01524	5.97551490727e-09	0.625	GSTM1 GSTM3 GSTM4 GSTM2 GSTM5	Platinum drug resistance
GO:0004364	1.32402198725e-08	0.625	GSTM1 GSTM3 GSTM4 GSTM2 GSTM5	glutathione transferase activity
REAC:R-HSA-156580	5.09241824227e-08	0.625	GSTM1 GSTM3 GSTM4 GSTM2 GSTM5	Phase II - Conjugation of compounds
KEGG:05418	8.20570400711e-08	0.625	GSTM1 GSTM3 GSTM4 GSTM2 GSTM5	Fluid shear stress and atherosclerosis
WP:WP2884	1.21196313963e-07	0.625	GSTM1 GSTM3 GSTM4 GSTM2 GSTM5	NRF2 pathway
GO:0006749	1.39614322074e-07	0.625	GSTM1 GSTM3 GSTM4 GSTM2 GSTM5	glutathione metabolic process
WP:WP702	3.11975587845e-07	0.625	GSTM1 GSTM3 GSTM4 GSTM2 GSTM5	Metapathway biotransformation Phase I and II
GO:0043295	3.86287613381e-07	0.5	GSTM1 GSTM4 GSTM2 GSTM3	glutathione binding
KEGG:05225	3.86417821983e-07	0.625	GSTM1 GSTM3 GSTM4 GSTM2 GSTM5	Hepatocellular carcinoma
KEGG:05207	4.37918004052e-07	0.625	GSTM1 GSTM3 GSTM4 GSTM2 GSTM5	Chemical carcinogenesis - receptor activation
GO:1900750	6.06890408176e-07	0.5	GSTM1 GSTM4 GSTM2 GSTM3	oligopeptide binding
KEGG:05208	1.28681623759e-06	0.625	GSTM1 GSTM3 GSTM4 GSTM2 GSTM5	Chemical carcinogenesis - reactive oxygen species
GO:0016765	1.4351743773e-06	0.625	GSTM1 GSTM3 GSTM4 GSTM2 GSTM5	transferase activity, transferring alkyl or aryl (other than methyl) groups
REAC:R-HSA-211859	1.88211567699e-06	0.625	GSTM1 GSTM3 GSTM4 GSTM2 GSTM5	Biological oxidations
GO:0018916	5.38272230028e-06	0.375	GSTM1 GSTM2 GSTM3	nitrobenzene metabolic process
GO:0042178	5.61890325943e-06	0.5	GSTM1 GSTM4 GSTM2 GSTM3	xenobiotic catabolic process
WP:WP2882	7.0345751751e-06	0.625	GSTM1 GSTM3 GSTM4 GSTM2 GSTM5	Nuclear receptors meta pathway
GO:0045171	1.12211617261e-05	0.625	GSTM1 GSTM3 GSTM4 GSTM2 GSTM5	intercellular bridge
GO:0070458	5.37995977657e-05	0.375	GSTM1 GSTM2 GSTM3	cellular detoxification of nitrogen compound
GO:0051410	5.37995977657e-05	0.375	GSTM1 GSTM2 GSTM3	detoxification of nitrogen compound
KEGG:05200	6.65080913942e-05	0.625	GSTM1 GSTM3 GSTM4 GSTM2 GSTM5	Pathways in cancer
GO:0006575	8.28776104718e-05	0.625	GSTM1 GSTM3 GSTM4 GSTM2 GSTM5	cellular modified amino acid metabolic process
GO:0072341	0.00123045452734	0.5	GSTM1 GSTM4 GSTM2 GSTM3	modified amino acid binding
TF:M07247_1	0.00176352609787	0.5	GSTM5 PPP1R13B GSTM2 GSTM1	Factor: CLOCK; motif: CCACSTGW; match class: 1
GO:0042537	0.00300428100757	0.375	GSTM1 GSTM2 GSTM3	benzene-containing compound metabolic process
GO:0006790	0.0032118325422	0.625	GSTM1 GSTM3 GSTM4 GSTM2 GSTM5	sulfur compound metabolic process
WP:WP100	0.00324014777067	0.25	GSTM1 GSTM2	Glutathione metabolism
GO:0006805	0.00402583472149	0.5	GSTM1 GSTM4 GSTM2 GSTM3	xenobiotic metabolic process
HPA:0570741	0.00610236666365	0.875	ARFGAP1 PPP1R13B GSTM1 GSTM4 GSTM5 GSTM2 RASSF9	testis; cells in seminiferous ducts[>=Low]
GO:0042759	0.00712601113833	0.375	GSTM1 GSTM4 GSTM2	long-chain fatty acid biosynthetic process
GO:0071466	0.0100133115528	0.5	GSTM1 GSTM4 GSTM2 GSTM3	cellular response to xenobiotic stimulus
KEGG:01100	0.0120498549077	0.625	GSTM1 GSTM3 GSTM4 GSTM2 GSTM5	Metabolic pathways
HPA:0180052	0.024892450361	1.0	GSTM3 ARFGAP1 PPP1R13B GSTM1 GSTM4 GSTM5 GSTM2 RASSF9	epididymis; glandular cells[>=Medium]
GO:0009410	0.0281979257523	0.5	GSTM1 GSTM4 GSTM2 GSTM3	response to xenobiotic stimulus
GO:1901681	0.0290088602918	0.5	GSTM1 GSTM4 GSTM2 GSTM3	sulfur compound binding
GO:1990748	0.0450022850424	0.375	GSTM1 GSTM2 GSTM3	cellular detoxification
TF:M06731	0.0487399472212	0.375	GSTM1 GSTM2 GSTM5	Factor: znf302; motif: NGGGCATGSTGM

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
GSTM4	GSTM2	1.0	0.114		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
GSTM3	GSTM2	1.0	0.516	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
GSTM4	GSTM3	0.999	0.172		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
GSTM5	GSTM2	0.999			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
GSTM5	GSTM3	0.999			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
GSTM4	GSTM5	0.999			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
GSTM5	ARFGAP1	0.995			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
PPP1R13B	GSTM3	0.991	0.046		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
GSTM1	GSTM2	0.984	0.108	mutually_exclusive (P21266) structurally_consistent (dimer)	bioplex3_WMM bioplex3_HCT116 WMM_only
GSTM1	GSTM5	0.972			bioplex3_WMM bioplex3_HCT116 WMM_only
GSTM3	ARFGAP1	0.948	0.022		bioplex_WMM bioplex3_WMM youn_WMM WMM_only
PPP1R13B	GSTM2	0.917	0.036		bioplex_WMM bioplex3_WMM WMM_only
GSTM4	ARFGAP1	0.913	0.024		bioplex_WMM bioplex3_WMM WMM_only
PPP1R13B	RASSF9	0.908		mutually_exclusive (P62140)	bioplex3_HEK293 bioplex3_WMM WMM_only
GSTM2	ARFGAP1	0.867	0.014		bioplex_WMM bioplex3_WMM WMM_only
GSTM1	UCP1	0.855			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
PPP1R13B	GSTM4	0.827	0.05		bioplex_WMM bioplex3_WMM WMM_only
GSTM4	GSTM1	0.633	0.286		bioplex3_WMM WMM_only
GSTM1	ARFGAP1	0.388	0.064		bioplex3_WMM WMM_only
GSTM1	GSTM3	0.23	0.168	mutually_exclusive (P28161) structurally_consistent (dimer)	bioplex3_WMM WMM_only
PPP1R13B	ARFGAP1	0.017	0.106		youn_WMM WMM_only

Related Complexes

Genename	Complexes
GSTM4	huMAP3_01673.1 huMAP3_14934.1
PPP1R13B	huMAP3_00020.1 huMAP3_06304.1 huMAP3_06341.1 huMAP3_08482.1 huMAP3_08717.1 huMAP3_09354.1 huMAP3_09633.1 huMAP3_09755.1 huMAP3_10148.1 huMAP3_10901.1 huMAP3_14504.1 huMAP3_14934.1
UCP1	huMAP3_13858.1 huMAP3_14934.1
ARFGAP1	huMAP3_05105.1 huMAP3_05120.1 huMAP3_05849.1 huMAP3_08320.1 huMAP3_09403.1 huMAP3_10876.1 huMAP3_14934.1
GSTM1	huMAP3_01673.1 huMAP3_13858.1 huMAP3_14934.1
GSTM5	huMAP3_01673.1 huMAP3_14445.1 huMAP3_14656.1 huMAP3_14934.1
RASSF9	huMAP3_14504.1 huMAP3_14934.1
GSTM3	huMAP3_01673.1 huMAP3_14934.1
GSTM2	huMAP3_01673.1 huMAP3_14934.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_14934.1

Complex Portal: CPX-19821