hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_14946.1

Complex Portal: CPX-18296

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
IL25	Interleukin-25 (IL-25) (Interleukin-17E) (IL-17E)	5	UniProt NCBI
WNT5A	Protein Wnt-5a	5	UniProt NCBI
WNT16	Protein Wnt-16	5	UniProt NCBI
ICAM4	Intercellular adhesion molecule 4 (ICAM-4) (Landsteiner-Wiener blood group glycoprotein) (LW blood group protein) (CD antigen CD242)	5	UniProt NCBI
CALR	Calreticulin (CRP55) (Calregulin) (Endoplasmic reticulum resident protein 60) (ERp60) (HACBP) (grp60)	5	UniProt NCBI
PDIA3	Protein disulfide-isomerase A3 (EC 5.3.4.1) (58 kDa glucose-regulated protein) (58 kDa microsomal protein) (p58) (Disulfide isomerase ER-60) (Endoplasmic reticulum resident protein 57) (ER protein 57) (ERp57) (Endoplasmic reticulum resident protein 60) (ER protein 60) (ERp60)	5	UniProt NCBI
PDIA6	Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7)	5	UniProt NCBI
INHA	Inhibin alpha chain	5	UniProt NCBI
JMJD8	JmjC domain-containing protein 8 (Jumonji domain-containing protein 8)	5	UniProt NCBI
UGGT1	UDP-glucose:glycoprotein glucosyltransferase 1 (UGT1) (hUGT1) (EC 2.4.1.-) (UDP--Glc:glycoprotein glucosyltransferase) (UDP-glucose ceramide glucosyltransferase-like 1)	5	UniProt NCBI
WNT7A	Protein Wnt-7a	5	UniProt NCBI
LYPD6B	Ly6/PLAUR domain-containing protein 6B	4	UniProt NCBI
SELENOF	Selenoprotein F (15 kDa selenoprotein)	5	UniProt NCBI
WNT7B	Protein Wnt-7b	5	UniProt NCBI
WNT2	Protein Wnt-2 (Int-1-like protein 1) (Int-1-related protein) (IRP)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-3238698	5.32569561001e-09	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	WNT ligand biogenesis and trafficking
WP:WP4150	1.15195269037e-08	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	Wnt signaling in kidney disease
KEGG:05217	6.79862735109e-08	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	Basal cell carcinoma
KEGG:04916	5.59304035007e-07	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	Melanogenesis
WP:WP4336	6.53300869811e-07	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	ncRNAs involved in Wnt signaling in hepatocellular carcinoma
GO:0005788	8.17786857446e-07	0.571428571429	WNT7A JMJD8 PDIA6 SELENOF UGGT1 CALR WNT7B WNT5A	endoplasmic reticulum lumen
REAC:R-HSA-373080	1.02204474161e-06	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	Class B/2 (Secretin family receptors)
WP:WP4258	1.1720613694e-06	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	lncRNA in canonical Wnt signaling and colorectal cancer
WP:WP399	2.20331637955e-06	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	Wnt signaling pathway and pluripotency
GO:0005109	2.53614215253e-06	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	frizzled binding
WP:WP3931	3.01269502789e-06	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	Embryonic stem cell pluripotency pathways
WP:WP710	3.16797231232e-06	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	DNA damage response only ATM dependent
WP:WP428	3.16797231232e-06	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	Wnt signaling
WP:WP4787	3.32955252714e-06	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	Osteoblast differentiation and related diseases
KEGG:04550	3.60182034629e-06	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	Signaling pathways regulating pluripotency of stem cells
KEGG:04934	4.42108881111e-06	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	Cushing syndrome
KEGG:05224	4.78751264698e-06	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	Breast cancer
KEGG:05226	5.59268101328e-06	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	Gastric cancer
KEGG:04390	9.61933640181e-06	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	Hippo signaling pathway
KEGG:04150	1.02955842764e-05	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	mTOR signaling pathway
KEGG:04310	1.10090338857e-05	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	Wnt signaling pathway
WP:WP4239	1.21749845878e-05	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	Epithelial to mesenchymal transition in colorectal cancer
WP:WP4262	1.26440394591e-05	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	Breast cancer pathway
KEGG:05225	1.47207435303e-05	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	Hepatocellular carcinoma
KEGG:05205	2.881699953e-05	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	Proteoglycans in cancer
GO:0005125	6.85170376658e-05	0.428571428571	WNT2 WNT7B WNT7A INHA WNT16 WNT5A	cytokine activity
GO:0030545	0.000188819894903	0.5	WNT2 WNT7B WNT7A INHA LYPD6B WNT16 WNT5A	signaling receptor regulator activity
WP:WP2059	0.000196231064938	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	Alzheimer 39 s disease and miRNA effects
WP:WP5124	0.000196231064938	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	Alzheimer 39 s disease
KEGG:05165	0.000305498995647	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	Human papillomavirus infection
REAC:R-HSA-500792	0.000453113091535	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	GPCR ligand binding
WP:WP2848	0.000524223951036	0.214285714286	WNT2 WNT5A WNT7B	Pluripotent stem cell differentiation pathway
KEGG:05010	0.000619849706697	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	Alzheimer disease
KEGG:05022	0.00160480541157	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	Pathways of neurodegeneration - multiple diseases
REAC:R-HSA-195721	0.00162131816748	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	Signaling by WNT
GO:0002088	0.00170838115144	0.285714285714	WNT7B WNT2 WNT5A WNT7A	lens development in camera-type eye
GO:0005102	0.00178116614782	0.642857142857	WNT2 ICAM4 WNT7A IL25 WNT7B INHA CALR WNT16 WNT5A	signaling receptor binding
WP:WP5087	0.00200803183248	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	Pleural mesothelioma
KEGG:05200	0.00229394532617	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	Pathways in cancer
GO:0043010	0.00239350832216	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	camera-type eye development
GO:0045165	0.00430397386964	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	cell fate commitment
GO:0048018	0.00487898165326	0.428571428571	WNT2 WNT7B WNT7A INHA WNT16 WNT5A	receptor ligand activity
GO:0030546	0.00532506117966	0.428571428571	WNT2 WNT7B WNT7A INHA WNT16 WNT5A	signaling receptor activator activity
REAC:R-HSA-372790	0.00848857338745	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	Signaling by GPCR
GO:0001654	0.0116557875545	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	eye development
GO:0150063	0.0128244142912	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	visual system development
GO:0048880	0.0140841279252	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	sensory system development
KEGG:04141	0.0221517001131	0.214285714286	CALR PDIA6 UGGT1	Protein processing in endoplasmic reticulum
GO:0001664	0.0280950171166	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	G protein-coupled receptor binding
WP:WP3613	0.0294217529211	0.142857142857	CALR PDIA6	Photodynamic therapy induced unfolded protein response
GO:0061642	0.0426062655276	0.142857142857	WNT5A WNT7B	chemoattraction of axon
GO:0003408	0.0426062655276	0.142857142857	WNT5A WNT16	optic cup formation involved in camera-type eye development
GO:0060070	0.0490014689508	0.357142857143	WNT7B WNT2 WNT5A WNT7A WNT16	canonical Wnt signaling pathway
CORUM:5217	0.0499958217778	0.0714285714286	CALR	Calreticulin homo-oligomer complex
CORUM:3115	0.0499958217778	0.0714285714286	ICAM4	ITGA2B-ITGB3-ICAM4 complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
CALR	PDIA3	0.999	0.796	structurally_consistent (dimer)
WNT7B	WNT7A	0.995		structurally_consistent (dimer)
SELENOF	UGGT1	0.992	0.57
WNT5A	WNT16	0.986	0.038	structurally_consistent (dimer)
SELENOF	WNT7A	0.985
WNT5A	WNT7A	0.984		structurally_consistent (P56706)
CALR	UGGT1	0.976	0.532
CALR	WNT7A	0.974
PDIA6	WNT16	0.972
WNT5A	SELENOF	0.964	0.066
CALR	INHA	0.945
PDIA3	LYPD6B	0.945
CALR	WNT2	0.942
JMJD8	PDIA6	0.937
PDIA3	INHA	0.935
CALR	PDIA6	0.928
IL25	UGGT1	0.921
UGGT1	WNT7A	0.917
ICAM4	SELENOF	0.914
IL25	SELENOF	0.912
CALR	IL25	0.912
IL25	PDIA3	0.906
CALR	WNT16	0.882	0.068
JMJD8	PDIA3	0.877	0.088	structurally_consistent (dimer)
PDIA3	WNT7A	0.868
ICAM4	UGGT1	0.863
UGGT1	LYPD6B	0.863
WNT2	WNT16	0.849		mutually_exclusive (P41221)
SELENOF	LYPD6B	0.845
WNT16	LYPD6B	0.835
CALR	LYPD6B	0.816
WNT5A	UGGT1	0.814	0.18
SELENOF	WNT16	0.805	0.034
CALR	JMJD8	0.805	0.11	structurally_consistent (P30101)
WNT16	UGGT1	0.766	0.082
CALR	SELENOF	0.756	0.172
WNT5A	PDIA3	0.63	0.126
WNT16	WNT7A	0.614
CALR	ICAM4	0.596
PDIA3	WNT16	0.551	0.084
CALR	WNT5A	0.546	0.158
PDIA6	WNT7A	0.472
UGGT1	INHA	0.464
WNT5A	PDIA6	0.446
JMJD8	UGGT1	0.398	0.066
WNT5A	WNT7B	0.281		mixed_interface
ICAM4	WNT5A	0.238
WNT2	PDIA3	0.227
JMJD8	WNT16	0.225
WNT7B	PDIA3	0.161
JMJD8	SELENOF	0.15	0.052
PDIA6	UGGT1	0.126
WNT2	UGGT1	0.121
PDIA6	INHA	0.113
CALR	WNT7B	0.102
ICAM4	PDIA6	0.084
PDIA3	UGGT1	0.079	0.684
WNT7B	PDIA6	0.077
WNT2	SELENOF	0.077
JMJD8	WNT5A	0.06	0.068
WNT2	PDIA6	0.059
WNT7B	SELENOF	0.055
PDIA3	PDIA6	0.053
WNT7B	UGGT1	0.052
PDIA6	SELENOF	0.047
SELENOF	INHA	0.042
PDIA3	SELENOF	0.039	0.258
IL25	PDIA6	0.038
ICAM4	PDIA3	0.031
WNT7B	WNT16	0.026		mutually_exclusive (P41221)
ICAM4	WNT16	0.01
PDIA6	LYPD6B	0.004

Related Complexes

Genename	Complexes
IL25	huMAP3_03816.1 huMAP3_06527.1 huMAP3_09635.1 huMAP3_10009.1 huMAP3_14946.1
WNT5A	huMAP3_02658.1 huMAP3_12557.1 huMAP3_14946.1
WNT16	huMAP3_08541.1 huMAP3_08720.1 huMAP3_09427.1 huMAP3_10495.1 huMAP3_14946.1
ICAM4	huMAP3_02655.1 huMAP3_06073.1 huMAP3_06610.1 huMAP3_10732.1 huMAP3_11143.1 huMAP3_14946.1
CALR	huMAP3_00241.1 huMAP3_14354.1 huMAP3_14946.1
PDIA3	huMAP3_04186.1 huMAP3_06291.1 huMAP3_07216.1 huMAP3_07251.1 huMAP3_10036.1 huMAP3_10241.1 huMAP3_13812.1 huMAP3_14946.1
PDIA6	huMAP3_04662.1 huMAP3_06321.1 huMAP3_08720.1 huMAP3_10680.1 huMAP3_11117.1 huMAP3_14271.1 huMAP3_14946.1
INHA	huMAP3_13812.1 huMAP3_14354.1 huMAP3_14946.1
JMJD8	huMAP3_01006.1 huMAP3_10968.1 huMAP3_11546.1 huMAP3_14946.1
UGGT1	huMAP3_08545.1 huMAP3_10740.1 huMAP3_12557.1 huMAP3_14946.1
WNT7A	huMAP3_13291.1 huMAP3_13527.1 huMAP3_14946.1
LYPD6B	huMAP3_14946.1
SELENOF	huMAP3_05548.1 huMAP3_08814.1 huMAP3_09703.1 huMAP3_11091.1 huMAP3_12557.1 huMAP3_14946.1
WNT7B	huMAP3_02823.1 huMAP3_10551.1 huMAP3_10977.1 huMAP3_12285.1 huMAP3_13291.1 huMAP3_13527.1 huMAP3_14946.1
WNT2	huMAP3_00467.1 huMAP3_05496.1 huMAP3_06836.1 huMAP3_11188.1 huMAP3_14676.1 huMAP3_14946.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_14946.1

Complex Portal: CPX-18296