hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14952.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ABCC2 | ATP-binding cassette sub-family C member 2 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (Canalicular multidrug resistance protein) (Canalicular multispecific organic anion transporter 1) (Multidrug resistance-associated protein 2) | 5 | UniProt NCBI |
| CLCN4 | H(+)/Cl(-) exchange transporter 4 (Chloride channel protein 4) (ClC-4) (Chloride transporter ClC-4) | 5 | UniProt NCBI |
| CLCN5 | H(+)/Cl(-) exchange transporter 5 (Chloride channel protein 5) (ClC-5) (Chloride transporter ClC-5) | 5 | UniProt NCBI |
| TMEM9B | Transmembrane protein 9B | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-2672351 | 0.0212029570934 | 0.5 | CLCN4 CLCN5 | Stimuli-sensing channels |
| KEGG:04613 | 0.0272860662684 | 0.5 | CLCN4 CLCN5 | Neutrophil extracellular trap formation |
| REAC:R-HSA-382551 | 0.0342552713859 | 0.75 | CLCN5 ABCC2 CLCN4 | Transport of small molecules |
| GO:0015103 | 0.0378152735667 | 0.75 | CLCN5 ABCC2 CLCN4 | inorganic anion transmembrane transporter activity |
| REAC:R-HSA-5679001 | 0.0499436884912 | 0.25 | ABCC2 | Defective ABCC2 causes DJS |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CLCN5 | TMEM9B | 0.999 | 0.174 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CLCN4 | TMEM9B | 0.982 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ABCC2 | TMEM9B | 0.971 | 0.042 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| CLCN4 | CLCN5 | 0.633 | bioplex3_WMM WMM_only | |
| ABCC2 | CLCN4 | 0.269 | bioplex3_WMM WMM_only | |
| ABCC2 | CLCN5 | 0.188 | 0.108 | bioplex3_WMM WMM_only |
Related Complexes