hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_14953.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| JAK3 | Tyrosine-protein kinase JAK3 (EC 2.7.10.2) (Janus kinase 3) (JAK-3) (Leukocyte janus kinase) (L-JAK) | 5 | UniProt NCBI |
| RPS6KB1 | Ribosomal protein S6 kinase beta-1 (S6K-beta-1) (S6K1) (EC 2.7.11.1) (70 kDa ribosomal protein S6 kinase 1) (P70S6K1) (p70-S6K 1) (Ribosomal protein S6 kinase I) (Serine/threonine-protein kinase 14A) (p70 ribosomal S6 kinase alpha) (p70 S6 kinase alpha) (p70 S6K-alpha) (p70 S6KA) | 5 | UniProt NCBI |
| PLCE1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (EC 3.1.4.11) (Pancreas-enriched phospholipase C) (Phosphoinositide phospholipase C-epsilon-1) (Phospholipase C-epsilon-1) (PLC-epsilon-1) | 5 | UniProt NCBI |
| MAP4K2 | Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (B lymphocyte serine/threonine-protein kinase) (Germinal center kinase) (GC kinase) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein) | 5 | UniProt NCBI |
| MASTL | Serine/threonine-protein kinase greatwall (GW) (GWL) (hGWL) (EC 2.7.11.1) (Microtubule-associated serine/threonine-protein kinase-like) (MAST-L) | 5 | UniProt NCBI |
| DELE1 | DAP3-binding cell death enhancer 1 (DAP3-binding cell death enhancer 1, long form) (DELE1(L)) (Death ligand signal enhancer) [Cleaved into: DAP3-binding cell death enhancer 1 short form (DELE1(S)) (S-DELE1)] | 5 | UniProt NCBI |
| EIF2AK1 | Eukaryotic translation initiation factor 2-alpha kinase 1 (EC 2.7.11.1) (Heme-controlled repressor) (HCR) (Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase) (Heme-regulated inhibitor) (hHRI) (Hemin-sensitive initiation factor 2-alpha kinase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP49 | 0.00933842806825 | 0.285714285714 | JAK3 RPS6KB1 | IL 2 signaling pathway |
| WP:WP395 | 0.0190579984179 | 0.285714285714 | JAK3 RPS6KB1 | IL 4 signaling pathway |
| GO:0004672 | 0.0241566055694 | 0.714285714286 | JAK3 MAP4K2 EIF2AK1 MASTL RPS6KB1 | protein kinase activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| EIF2AK1 | DELE1 | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PLCE1 | MASTL | 0.904 | bioplex3_WMM WMM_only | |
| JAK3 | MASTL | 0.904 | 0.102 | bioplex3_WMM WMM_only |
| EIF2AK1 | RPS6KB1 | 0.904 | 0.076 | bioplex3_WMM WMM_only |
| EIF2AK1 | MAP4K2 | 0.904 | 0.094 | bioplex3_WMM WMM_only |
| JAK3 | PLCE1 | 0.902 | bioplex3_WMM WMM_only | |
| EIF2AK1 | PLCE1 | 0.902 | bioplex3_WMM WMM_only | |
| EIF2AK1 | JAK3 | 0.902 | 0.104 | bioplex3_WMM WMM_only |
| JAK3 | RPS6KB1 | 0.902 | 0.082 | bioplex3_WMM WMM_only |
| RPS6KB1 | PLCE1 | 0.902 | bioplex3_WMM WMM_only | |
| MAP4K2 | PLCE1 | 0.902 | bioplex3_WMM WMM_only | |
| MAP4K2 | JAK3 | 0.902 | 0.06 | bioplex3_WMM WMM_only |
| RPS6KB1 | MASTL | 0.892 | 0.086 | bioplex3_WMM WMM_only |
| MAP4K2 | MASTL | 0.892 | 0.056 | bioplex3_WMM WMM_only |
| EIF2AK1 | MASTL | 0.868 | 0.098 | bioplex3_WMM boldt WMM_only boldt_WMM |
| MAP4K2 | RPS6KB1 | 0.717 | 0.062 | bioplex3_WMM WMM_only |
Related Complexes