hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14959.1
Complex Portal: CPX-24647
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PHKG1 | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHK-gamma-M) (EC 2.7.11.19) (Phosphorylase kinase subunit gamma-1) (Serine/threonine-protein kinase PHKG1) (EC 2.7.11.1, EC 2.7.11.26) | 5 | UniProt NCBI |
| PHKB | Phosphorylase b kinase regulatory subunit beta (Phosphorylase kinase subunit beta) | 5 | UniProt NCBI |
| PHKG2 | Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (PHK-gamma-LT) (PHK-gamma-T) (EC 2.7.11.19) (PSK-C3) (Phosphorylase kinase subunit gamma-2) | 5 | UniProt NCBI |
| UCK1 | Uridine-cytidine kinase 1 (UCK 1) (EC 2.7.1.48) (Cytidine monophosphokinase 1) (Uridine monophosphokinase 1) | 5 | UniProt NCBI |
| PHKA1 | Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (Phosphorylase kinase alpha M subunit) | 5 | UniProt NCBI |
| ARL5A | ADP-ribosylation factor-like protein 5A | 4 | UniProt NCBI |
| PHKA2 | Phosphorylase b kinase regulatory subunit alpha, liver isoform (Phosphorylase kinase alpha L subunit) | 5 | UniProt NCBI |
| UCKL1 | Uridine-cytidine kinase-like 1 (EC 2.7.1.48) | 5 | UniProt NCBI |
| SLC35G1 | Solute carrier family 35 member G1 (Partner of STIM1) (Transmembrane protein 20) | 5 | UniProt NCBI |
| UPRT | Uracil phosphoribosyltransferase homolog | 5 | UniProt NCBI |
| MPPED1 | Metallophosphoesterase domain-containing protein 1 (EC 3.1.-.-) (Adult brain protein 239) (239AB) | 3 | UniProt NCBI |
| CTCFL | Transcriptional repressor CTCFL (Brother of the regulator of imprinted sites) (CCCTC-binding factor) (CTCF paralog) (CTCF-like protein) (Cancer/testis antigen 27) (CT27) (Zinc finger protein CTCF-T) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6640 | 2.10621603952e-08 | 0.272727272727 | PHKB PHKG1 PHKA1 | Phosphorylase kinase complex |
| REAC:R-HSA-70221 | 3.20574028812e-08 | 0.363636363636 | PHKB PHKG1 PHKA2 PHKA1 | Glycogen breakdown (glycogenolysis) |
| REAC:R-HSA-8982491 | 4.74416423111e-07 | 0.363636363636 | PHKB PHKG1 PHKA2 PHKA1 | Glycogen metabolism |
| WP:WP500 | 1.18218385631e-06 | 0.363636363636 | PHKB PHKG1 PHKA2 PHKA1 | Glycogen synthesis and degradation |
| KEGG:04922 | 2.39101786449e-05 | 0.363636363636 | PHKB PHKG1 PHKA2 PHKA1 | Glucagon signaling pathway |
| HP:0009051 | 3.51428278464e-05 | 0.272727272727 | PHKB PHKA2 PHKA1 | Increased muscle glycogen content |
| GO:0005964 | 6.34131776058e-05 | 0.272727272727 | PHKB PHKA2 PHKA1 | phosphorylase kinase complex |
| HP:0012269 | 6.43756062764e-05 | 0.272727272727 | PHKB PHKA2 PHKA1 | Abnormal muscle glycogen content |
| KEGG:04910 | 8.45363771108e-05 | 0.363636363636 | PHKB PHKG1 PHKA2 PHKA1 | Insulin signaling pathway |
| KEGG:04020 | 0.000292141090125 | 0.363636363636 | PHKB PHKG1 PHKA2 PHKA1 | Calcium signaling pathway |
| HP:0002913 | 0.000850644000044 | 0.272727272727 | PHKB PHKA2 PHKA1 | Myoglobinuria |
| HP:0034370 | 0.00438027839181 | 0.272727272727 | PHKB PHKA2 PHKA1 | Abnormal muscle tissue metabolite concentration |
| REAC:R-HSA-71387 | 0.00713630299376 | 0.363636363636 | PHKB PHKG1 PHKA2 PHKA1 | Metabolism of carbohydrates |
| REAC:R-HSA-73614 | 0.00731130585838 | 0.181818181818 | UCK1 UCKL1 | Pyrimidine salvage |
| HP:0100607 | 0.0213888128664 | 0.181818181818 | PHKB PHKA2 | Dysmenorrhea |
| KEGG:00240 | 0.0255324045641 | 0.181818181818 | UCK1 UCKL1 | Pyrimidine metabolism |
| REAC:R-HSA-8956321 | 0.0278014860056 | 0.181818181818 | UCK1 UCKL1 | Nucleotide salvage |
| HP:0012028 | 0.0498048563326 | 0.181818181818 | PHKB PHKA2 | Hepatocellular adenoma |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PHKG2 | PHKA2 | 1.0 | 0.25 |
mutually_exclusive (Q16816)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| UPRT | UCKL1 | 1.0 | 0.216 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| PHKG2 | PHKB | 1.0 | 0.188 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 boldt_WMM | |
| PHKB | PHKA2 | 1.0 | 0.24 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| PHKG2 | PHKA1 | 1.0 | 0.084 |
mutually_exclusive (Q16816)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 boldt_WMM |
| PHKG1 | PHKG2 | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 | |
| UPRT | UCK1 | 0.999 | 0.082 |
structurally_consistent (Q9NWZ5)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| PHKA1 | PHKA2 | 0.997 | 0.054 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PHKA2 | MPPED1 | 0.997 | 0.12 |
mutually_exclusive (P15735)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| PHKG1 | PHKA2 | 0.997 |
mutually_exclusive (P15735)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PHKG2 | MPPED1 | 0.995 | 0.13 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| PHKB | MPPED1 | 0.994 | 0.05 |
structurally_consistent (P46019)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| UPRT | MPPED1 | 0.993 | 0.074 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| UCKL1 | UCK1 | 0.993 | 0.15 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM WMM_only |
| PHKA1 | MPPED1 | 0.988 | 0.104 |
mutually_exclusive (P15735)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PHKB | PHKA1 | 0.981 | 0.146 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only boldt_WMM | |
| UCKL1 | MPPED1 | 0.979 | 0.08 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PHKA2 | ARL5A | 0.888 | 0.054 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PHKG2 | SLC35G1 | 0.872 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| UCK1 | MPPED1 | 0.842 | 0.058 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PHKG2 | CTCFL | 0.81 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| PHKG1 | PHKB | 0.799 | bioplex_WMM bioplex3_WMM WMM_only | ||
| PHKG1 | PHKA1 | 0.799 |
mutually_exclusive (P15735)
structurally_consistent (dimer) |
bioplex_WMM bioplex3_WMM WMM_only | |
| PHKA2 | UCKL1 | 0.463 | 0.07 | bioplex_WMM bioplex3_WMM WMM_only | |
| PHKA1 | UCKL1 | 0.417 | 0.066 | bioplex_WMM bioplex3_WMM WMM_only | |
| PHKB | UPRT | 0.263 | 0.064 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| PHKG2 | UPRT | 0.242 | 0.083 | bioplex_WMM bioplex3_WMM WMM_only | |
| PHKA2 | UPRT | 0.215 | 0.112 | bioplex_WMM bioplex3_WMM WMM_only | |
| PHKA1 | UPRT | 0.188 | 0.034 | bioplex_WMM bioplex3_WMM WMM_only | |
| PHKB | UCKL1 | 0.178 | 0.044 | bioplex_WMM bioplex3_WMM WMM_only | |
| PHKG2 | UCKL1 | 0.113 | 0.066 | bioplex_WMM bioplex3_WMM WMM_only | |
| PHKA2 | UCK1 | 0.087 | 0.046 |
mutually_exclusive (O15442)
|
bioplex_WMM bioplex3_WMM WMM_only |
| PHKA1 | UCK1 | 0.073 | 0.062 | bioplex_WMM bioplex3_WMM WMM_only | |
| PHKB | UCK1 | 0.07 | 0.08 | bioplex_WMM bioplex3_WMM WMM_only | |
| PHKG2 | UCK1 | 0.068 | 0.062 |
mutually_exclusive (O15442)
|
bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes