hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14972.1
Confidence: Medium  
ProteinsGenename | Protein Name | Uniprot Annotation Score | Links |
---|---|---|---|
SMC3 | Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP) | 5 | UniProt   NCBI |
STAG1 | Cohesin subunit SA-1 (SCC3 homolog 1) (Stromal antigen 1) | 5 | UniProt   NCBI |
USP13 | Ubiquitin carboxyl-terminal hydrolase 13 (EC 3.4.19.12) (Deubiquitinating enzyme 13) (Isopeptidase T-3) (ISOT-3) (Ubiquitin thioesterase 13) (Ubiquitin-specific-processing protease 13) | 5 | UniProt   NCBI |
CDCA5 | Sororin (Cell division cycle-associated protein 5) (p35) | 5 | UniProt   NCBI |
SOCS1 | Suppressor of cytokine signaling 1 (SOCS-1) (JAK-binding protein) (JAB) (STAT-induced STAT inhibitor 1) (SSI-1) (Tec-interacting protein 3) (TIP-3) | 5 | UniProt   NCBI |
TRIM38 | E3 ubiquitin-protein ligase TRIM38 (EC 2.3.2.27) (RING finger protein 15) (Tripartite motif-containing protein 38) (Zinc finger protein RoRet) | 5 | UniProt   NCBI |
SMC1A | Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8) | 5 | UniProt   NCBI |
WAPL | Wings apart-like protein homolog (Friend of EBNA2 protein) (WAPL cohesin release factor) | 5 | UniProt   NCBI |
RAD21 | Double-strand-break repair protein rad21 homolog (hHR21) (Nuclear matrix protein 1) (NXP-1) (SCC1 homolog) [Cleaved into: 64-kDa C-terminal product (64-kDa carboxy-terminal product) (65-kDa carboxy-terminal product)] | 5 | UniProt   NCBI |
REC8 | Meiotic recombination protein REC8 homolog (Cohesin Rec8p) | 5 | UniProt   NCBI |
SMC1B | Structural maintenance of chromosomes protein 1B (SMC protein 1B) (SMC-1-beta) (SMC-1B) | 5 | UniProt   NCBI |
STAG2 | Cohesin subunit SA-2 (SCC3 homolog 2) (Stromal antigen 2) | 5 | UniProt   NCBI |
Enrichments
Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
---|---|---|---|---|
  REAC:R-HSA-2468052 | 9.14389528121e-19 | 0.583333333333 | STAG2 RAD21 WAPL SMC1A CDCA5 SMC3 STAG1 | Establishment of Sister Chromatid Cohesion |
  WP:WP5117 | 8.80373824974e-18 | 0.666666666667 | SMC1A STAG2 SMC1B RAD21 WAPL REC8 CDCA5 SMC3 | Cohesin complex Cornelia de Lange syndrome |
  GO:0008278 | 1.12232336732e-17 | 0.583333333333 | STAG2 SMC1B RAD21 STAG1 REC8 SMC1A SMC3 | cohesin complex |
  GO:0007062 | 1.43923650771e-16 | 0.75 | STAG2 SMC1B RAD21 WAPL REC8 SMC1A CDCA5 SMC3 STAG1 | sister chromatid cohesion |
  REAC:R-HSA-2470946 | 3.89418980802e-15 | 0.5 | STAG2 RAD21 WAPL SMC1A SMC3 STAG1 | Cohesin Loading onto Chromatin |
  REAC:R-HSA-68884 | 3.17874905907e-14 | 0.5 | STAG2 RAD21 WAPL SMC1A SMC3 STAG1 | Mitotic Telophase/Cytokinesis |
  GO:0034085 | 2.86713318474e-13 | 0.5 | STAG2 RAD21 WAPL SMC1A SMC3 STAG1 | establishment of sister chromatid cohesion |
  KEGG:04110 | 2.67655723613e-12 | 0.666666666667 | STAG2 SMC1B RAD21 WAPL SMC1A CDCA5 SMC3 STAG1 | Cell cycle |
  REAC:R-HSA-1221632 | 3.68943379334e-12 | 0.583333333333 | STAG2 SMC1B RAD21 STAG1 REC8 SMC1A SMC3 | Meiotic synapsis |
  CORUM:165 | 1.58451975055e-11 | 0.333333333333 | SMC3 RAD21 SMC1A STAG1 | Cohesin-SA1 complex |
  CORUM:163 | 1.58451975055e-11 | 0.333333333333 | SMC3 STAG2 SMC1A RAD21 | Cohesin-SA2 complex |
  CORUM:64 | 1.58451975055e-11 | 0.333333333333 | SMC3 STAG2 SMC1A RAD21 | Cohesin-SA2 complex |
  CORUM:63 | 1.58451975055e-11 | 0.333333333333 | SMC3 RAD21 SMC1A STAG1 | Cohesin-SA1 complex |
  CORUM:166 | 1.58451975055e-11 | 0.333333333333 | SMC3 STAG2 SMC1A RAD21 | Cohesin-SA2 complex |
  CORUM:164 | 1.58451975055e-11 | 0.333333333333 | SMC3 RAD21 SMC1A STAG1 | Cohesin-SA1 complex |
  CORUM:282 | 3.77295906343e-11 | 0.416666666667 | SMC3 RAD21 STAG2 SMC1A STAG1 | SNF2h-cohesin-NuRD complex |
  GO:0030892 | 4.27717811223e-11 | 0.416666666667 | SMC3 RAD21 STAG2 SMC1A STAG1 | mitotic cohesin complex |
  REAC:R-HSA-1500620 | 1.10445917456e-10 | 0.583333333333 | STAG2 SMC1B RAD21 STAG1 REC8 SMC1A SMC3 | Meiosis |
  GO:0034087 | 1.49641459906e-10 | 0.416666666667 | SMC3 RAD21 STAG2 SMC1A STAG1 | establishment of mitotic sister chromatid cohesion |
  CORUM:1856 | 2.37469785827e-10 | 0.333333333333 | SMC3 RAD21 CDCA5 SMC1A | Sororin-cohesin complex |
  CORUM:5432 | 2.37469785827e-10 | 0.333333333333 | SMC3 RAD21 CDCA5 SMC1A | Sororin-cohesin complex |
  REAC:R-HSA-1474165 | 2.67722036017e-10 | 0.583333333333 | STAG2 SMC1B RAD21 STAG1 REC8 SMC1A SMC3 | Reproduction |
  REAC:R-HSA-2500257 | 4.65339397163e-10 | 0.583333333333 | STAG2 RAD21 WAPL SMC1A CDCA5 SMC3 STAG1 | Resolution of Sister Chromatid Cohesion |
  GO:0007064 | 1.00397029501e-09 | 0.5 | STAG2 RAD21 STAG1 SMC1A CDCA5 SMC3 | mitotic sister chromatid cohesion |
  REAC:R-HSA-69242 | 3.24843757227e-09 | 0.583333333333 | STAG2 RAD21 WAPL SMC1A CDCA5 SMC3 STAG1 | S Phase |
  REAC:R-HSA-2467813 | 9.12713045845e-09 | 0.583333333333 | STAG2 RAD21 WAPL SMC1A CDCA5 SMC3 STAG1 | Separation of Sister Chromatids |
  GO:0030893 | 1.30247523495e-08 | 0.333333333333 | SMC3 SMC1B SMC1A RAD21 | meiotic cohesin complex |
  REAC:R-HSA-68877 | 1.37488946018e-08 | 0.583333333333 | STAG2 RAD21 WAPL SMC1A CDCA5 SMC3 STAG1 | Mitotic Prometaphase |
  WP:WP5402 | 2.00344528638e-08 | 0.416666666667 | WAPL SMC3 RAD21 SMC1A STAG1 | 10q22q23 copy number variation |
  WP:WP179 | 2.27857026239e-08 | 0.5 | STAG2 SMC1B RAD21 STAG1 SMC1A SMC3 | Cell cycle |
  WP:WP4240 | 3.03289036018e-08 | 0.333333333333 | SMC3 RAD21 SMC1A STAG1 | Regulation of sister chromatid separation at the metaphase anaphase transition |
  REAC:R-HSA-1640170 | 3.28161591598e-08 | 0.75 | STAG2 SMC1B RAD21 WAPL REC8 SMC1A CDCA5 SMC3 STAG1 | Cell Cycle |
  REAC:R-HSA-68882 | 3.53568206441e-08 | 0.583333333333 | STAG2 RAD21 WAPL SMC1A CDCA5 SMC3 STAG1 | Mitotic Anaphase |
  REAC:R-HSA-2555396 | 3.64862986234e-08 | 0.583333333333 | STAG2 RAD21 WAPL SMC1A CDCA5 SMC3 STAG1 | Mitotic Metaphase and Anaphase |
  CORUM:6303 | 1.02854698163e-07 | 0.25 | SMC3 SMC1A RAD21 | DDX11-RAD21-SMC1A-SMC3 complex |
  HP:0007665 | 2.70432723782e-07 | 0.333333333333 | SMC3 STAG2 SMC1A RAD21 | Curly eyelashes |
  REAC:R-HSA-3108214 | 4.91479389223e-07 | 0.416666666667 | SMC3 RAD21 STAG2 SMC1A STAG1 | SUMOylation of DNA damage response and repair proteins |
  GO:0051276 | 6.22447483704e-07 | 0.75 | STAG2 SMC1B RAD21 WAPL REC8 SMC1A CDCA5 SMC3 STAG1 | chromosome organization |
  GO:0051177 | 9.10136169988e-07 | 0.333333333333 | SMC3 REC8 SMC1A RAD21 | meiotic sister chromatid cohesion |
  GO:0000280 | 9.79117854744e-07 | 0.666666666667 | STAG2 RAD21 WAPL REC8 SMC1A CDCA5 SMC3 STAG1 | nuclear division |
  REAC:R-HSA-68886 | 1.66043296349e-06 | 0.583333333333 | STAG2 RAD21 WAPL SMC1A CDCA5 SMC3 STAG1 | M Phase |
  GO:0048285 | 2.49167254818e-06 | 0.666666666667 | STAG2 RAD21 WAPL REC8 SMC1A CDCA5 SMC3 STAG1 | organelle fission |
  GO:0000775 | 2.62269869309e-06 | 0.583333333333 | STAG2 RAD21 WAPL SMC1A CDCA5 SMC3 STAG1 | chromosome, centromeric region |
  WP:WP5118 | 8.12215593207e-06 | 0.25 | SMC3 SMC1A RAD21 | SMC1 SMC3 role in DNA damage Cornelia de Lange Syndrome |
  REAC:R-HSA-9018519 | 9.38364951029e-06 | 0.416666666667 | SMC3 RAD21 STAG2 SMC1A STAG1 | Estrogen-dependent gene expression |
  REAC:R-HSA-69278 | 1.38320086857e-05 | 0.583333333333 | STAG2 RAD21 WAPL SMC1A CDCA5 SMC3 STAG1 | Cell Cycle, Mitotic |
  GO:0034089 | 2.11464090368e-05 | 0.25 | SMC3 SMC1A RAD21 | establishment of meiotic sister chromatid cohesion |
  REAC:R-HSA-3108232 | 2.80596997275e-05 | 0.416666666667 | SMC3 RAD21 STAG2 SMC1A STAG1 | SUMO E3 ligases SUMOylate target proteins |
  REAC:R-HSA-2990846 | 3.27884818011e-05 | 0.416666666667 | SMC3 RAD21 STAG2 SMC1A STAG1 | SUMOylation |
  CORUM:5241 | 3.75927585468e-05 | 0.166666666667 | SMC3 SMC1A | SMC1-SMC3 complex |
  KEGG:04114 | 5.95814893286e-05 | 0.333333333333 | SMC3 SMC1B SMC1A REC8 | Oocyte meiosis |
  HP:0000413 | 6.12437724416e-05 | 0.333333333333 | SMC3 STAG2 SMC1A RAD21 | Atresia of the external auditory canal |
  REAC:R-HSA-8939211 | 6.16623690022e-05 | 0.416666666667 | SMC3 RAD21 STAG2 SMC1A STAG1 | ESR-mediated signaling |
  HP:0010880 | 6.64268470182e-05 | 0.333333333333 | SMC3 RAD21 SMC1A STAG1 | Increased nuchal translucency |
  GO:0000070 | 7.12067693186e-05 | 0.5 | STAG2 STAG1 WAPL SMC1A CDCA5 SMC3 | mitotic sister chromatid segregation |
  GO:0098687 | 7.97133413669e-05 | 0.583333333333 | STAG2 RAD21 WAPL SMC1A CDCA5 SMC3 STAG1 | chromosomal region |
  HP:0010300 | 9.65187935018e-05 | 0.25 | SMC3 SMC1A RAD21 | Abnormally low-pitched voice |
  GO:0016363 | 0.000111752036542 | 0.416666666667 | SMC3 RAD21 STAG2 SMC1A STAG1 | nuclear matrix |
  HP:0000667 | 0.000159547189976 | 0.25 | SMC3 SMC1A RAD21 | Phthisis bulbi |
  HP:0000965 | 0.000190319755488 | 0.333333333333 | SMC3 RAD21 SMC1A STAG1 | Cutis marmorata |
  HP:0002580 | 0.000199341834895 | 0.25 | SMC3 SMC1A RAD21 | Volvulus |
  GO:0022402 | 0.000242088014925 | 0.75 | STAG2 SMC1B RAD21 WAPL REC8 SMC1A CDCA5 SMC3 STAG1 | cell cycle process |
  REAC:R-HSA-9006931 | 0.000258680240964 | 0.416666666667 | SMC3 RAD21 STAG2 SMC1A STAG1 | Signaling by Nuclear Receptors |
  GO:0000819 | 0.000262895752201 | 0.5 | STAG2 STAG1 WAPL SMC1A CDCA5 SMC3 | sister chromatid segregation |
  HP:0000372 | 0.000355635335442 | 0.333333333333 | SMC3 STAG2 SMC1A RAD21 | Abnormality of the auditory canal |
  GO:0034399 | 0.000377757337158 | 0.416666666667 | SMC3 RAD21 STAG2 SMC1A STAG1 | nuclear periphery |
  HP:0010034 | 0.000423748232485 | 0.25 | SMC3 SMC1A RAD21 | Short 1st metacarpal |
  HP:0000776 | 0.000458637348666 | 0.333333333333 | SMC3 STAG2 SMC1A RAD21 | Congenital diaphragmatic hernia |
  HPA:0381213 | 0.000490617564454 | 0.416666666667 | WAPL RAD21 STAG2 CDCA5 SMC1A | placenta; syncytiotrophoblasts - cell body[High] |
  GO:0097431 | 0.000526240365093 | 0.333333333333 | SMC3 STAG2 SMC1A STAG1 | mitotic spindle pole |
  GO:0140014 | 0.000547076685223 | 0.5 | STAG2 STAG1 WAPL SMC1A CDCA5 SMC3 | mitotic nuclear division |
  HP:0000499 | 0.000808350017095 | 0.416666666667 | SMC3 RAD21 STAG2 SMC1A STAG1 | Abnormal eyelash morphology |
  GO:0098813 | 0.000823663501892 | 0.5 | STAG2 STAG1 WAPL SMC1A CDCA5 SMC3 | nuclear chromosome segregation |
  HP:0009660 | 0.000883061311279 | 0.25 | SMC3 SMC1A RAD21 | Short phalanx of the thumb |
  HP:0025667 | 0.000902577245435 | 0.333333333333 | SMC3 RAD21 SMC1A STAG1 | Fetal neck anomaly |
  HP:0010026 | 0.00100301497426 | 0.25 | SMC3 SMC1A RAD21 | Aplasia/Hypoplasia of the 1st metacarpal |
  HP:0000775 | 0.00106171686102 | 0.333333333333 | SMC3 STAG2 SMC1A RAD21 | Abnormality of the diaphragm |
  HP:0010009 | 0.00127439453065 | 0.25 | SMC3 SMC1A RAD21 | Abnormal 1st metacarpal morphology |
  HP:0000527 | 0.00144157700124 | 0.333333333333 | SMC3 RAD21 SMC1A STAG1 | Long eyelashes |
  HP:0002557 | 0.00176645141874 | 0.25 | SMC3 SMC1A RAD21 | Hypoplastic nipples |
  HPA:0381212 | 0.0017854271666 | 0.416666666667 | WAPL RAD21 STAG2 CDCA5 SMC1A | placenta; syncytiotrophoblasts - cell body[>=Medium] |
  GO:0007049 | 0.00215586789473 | 0.75 | STAG2 SMC1B RAD21 WAPL REC8 SMC1A CDCA5 SMC3 STAG1 | cell cycle |
  HP:0009658 | 0.00215603467286 | 0.25 | SMC3 SMC1A RAD21 | Aplasia/Hypoplasia of the phalanges of the thumb |
  HP:0009623 | 0.00237054180605 | 0.25 | SMC3 SMC1A RAD21 | Proximal placement of thumb |
  HP:0012165 | 0.00237054180605 | 0.25 | SMC3 SMC1A RAD21 | Oligodactyly |
  HP:0000059 | 0.00237054180605 | 0.25 | SMC3 SMC1A RAD21 | Hypoplastic labia majora |
  HP:0008850 | 0.00259874717395 | 0.25 | SMC3 SMC1A RAD21 | Severe postnatal growth retardation |
  HP:0000294 | 0.00309941878508 | 0.333333333333 | SMC3 STAG2 SMC1A RAD21 | Low anterior hairline |
  HPA:0381211 | 0.00331986693212 | 0.416666666667 | WAPL RAD21 STAG2 CDCA5 SMC1A | placenta; syncytiotrophoblasts - cell body[>=Low] |
  HP:0012881 | 0.00365683799616 | 0.25 | SMC3 SMC1A RAD21 | Abnormal labia majora morphology |
  HPA:0380203 | 0.00366589471813 | 0.333333333333 | WAPL STAG2 SMC1A RAD21 | placenta; endothelial cells[High] |
  GO:0007059 | 0.00459564402739 | 0.5 | STAG2 STAG1 WAPL SMC1A CDCA5 SMC3 | chromosome segregation |
  HP:0009603 | 0.00496715447073 | 0.25 | SMC3 SMC1A RAD21 | Deviation of the thumb |
  HPA:0570731 | 0.00526588106599 | 1.0 | RAD21 STAG2 TRIM38 STAG1 WAPL REC8 CDCA5 SMC1A SMC3 USP13 SMC1B SOCS1 | testis; Leydig cells[>=Low] |
  GO:0072686 | 0.00532847031908 | 0.416666666667 | WAPL SMC3 STAG2 SMC1A STAG1 | mitotic spindle |
  GO:0005694 | 0.00547580699774 | 0.75 | STAG2 SMC1B RAD21 WAPL REC8 SMC1A CDCA5 SMC3 STAG1 | chromosome |
  HP:0004209 | 0.00581330319618 | 0.416666666667 | SMC3 RAD21 STAG2 SMC1A STAG1 | Clinodactyly of the 5th finger |
  HP:0009179 | 0.00589395695828 | 0.416666666667 | SMC3 RAD21 STAG2 SMC1A STAG1 | Deviation of the 5th finger |
  HPA:0600432 | 0.00593011389229 | 0.833333333333 | RAD21 STAG2 TRIM38 STAG1 WAPL CDCA5 SMC1A SMC3 USP13 SOCS1 | tonsil; germinal center cells[>=Medium] |
  GO:1903047 | 0.00613972575076 | 0.583333333333 | STAG2 RAD21 WAPL SMC1A CDCA5 SMC3 STAG1 | mitotic cell cycle process |
  HP:0000319 | 0.00633783529234 | 0.333333333333 | SMC3 STAG2 SMC1A RAD21 | Smooth philtrum |
  HP:0000498 | 0.00655592688799 | 0.25 | SMC3 SMC1A RAD21 | Blepharitis |
  HP:0006709 | 0.00655592688799 | 0.25 | SMC3 SMC1A RAD21 | Aplasia/Hypoplasia of the nipples |
  GO:0090307 | 0.00662921233348 | 0.333333333333 | SMC3 STAG2 SMC1A STAG1 | mitotic spindle assembly |
  HP:0000664 | 0.00734770461419 | 0.333333333333 | SMC3 RAD21 SMC1A STAG1 | Synophrys |
  HP:0040019 | 0.0083204048504 | 0.416666666667 | SMC3 RAD21 STAG2 SMC1A STAG1 | Finger clinodactyly |
  HP:0000066 | 0.00897310858416 | 0.25 | SMC3 SMC1A RAD21 | Labial hypoplasia |
  HP:0002219 | 0.00950243261287 | 0.333333333333 | SMC3 RAD21 SMC1A STAG1 | Facial hypertrichosis |
  GO:0003682 | 0.00994730706433 | 0.5 | STAG2 RAD21 SMC1A REC8 CDCA5 STAG1 | chromatin binding |
  HP:5200005 | 0.0100844972532 | 0.25 | SMC3 SMC1A RAD21 | Abnormal pitch |
  HP:0002553 | 0.0101634770492 | 0.333333333333 | SMC3 STAG2 SMC1A RAD21 | Highly arched eyebrow |
  HP:0012815 | 0.011283279923 | 0.25 | SMC3 SMC1A RAD21 | Hypoplastic female external genitalia |
  HP:0007598 | 0.011283279923 | 0.25 | SMC3 SMC1A RAD21 | Bilateral single transverse palmar creases |
  HP:0000954 | 0.0115869131251 | 0.333333333333 | SMC3 RAD21 SMC1A STAG1 | Single transverse palmar crease |
  HPA:0380202 | 0.0117697845694 | 0.333333333333 | WAPL STAG2 SMC1A RAD21 | placenta; endothelial cells[>=Medium] |
  HP:0000599 | 0.0134280866901 | 0.333333333333 | SMC3 STAG2 SMC1A RAD21 | Abnormality of the frontal hairline |
  HPA:0440000 | 0.0135591317262 | 0.916666666667 | RAD21 STAG2 TRIM38 STAG1 WAPL REC8 CDCA5 SMC1A SMC3 USP13 SOCS1 | skeletal muscle |
  HPA:0440341 | 0.0135591317262 | 0.916666666667 | RAD21 STAG2 TRIM38 STAG1 WAPL REC8 CDCA5 SMC1A SMC3 USP13 SOCS1 | skeletal muscle; myocytes[>=Low] |
  HP:5200010 | 0.0154358507084 | 0.25 | SMC3 SMC1A RAD21 | Abnormal Intonation |
  HP:0004207 | 0.0156675831928 | 0.416666666667 | SMC3 RAD21 STAG2 SMC1A STAG1 | Abnormal 5th finger morphology |
  HP:0001629 | 0.0163797743271 | 0.416666666667 | SMC3 RAD21 STAG2 SMC1A STAG1 | Ventricular septal defect |
  HP:0002020 | 0.0163797743271 | 0.416666666667 | SMC3 RAD21 STAG2 SMC1A STAG1 | Gastroesophageal reflux |
  HPA:0600431 | 0.0177482371047 | 0.916666666667 | RAD21 STAG2 TRIM38 STAG1 WAPL REC8 CDCA5 SMC1A SMC3 USP13 SOCS1 | tonsil; germinal center cells[>=Low] |
  HP:0000058 | 0.0178446007592 | 0.25 | SMC3 SMC1A RAD21 | Abnormal labia morphology |
  HP:0010438 | 0.0178802786685 | 0.416666666667 | SMC3 RAD21 STAG2 SMC1A STAG1 | Abnormal ventricular septum morphology |
  HPA:0020052 | 0.018422832107 | 0.916666666667 | RAD21 STAG2 TRIM38 STAG1 WAPL REC8 CDCA5 SMC1A SMC3 USP13 SOCS1 | adrenal gland; glandular cells[>=Medium] |
  HP:0004097 | 0.0184699572828 | 0.416666666667 | SMC3 RAD21 STAG2 SMC1A STAG1 | Deviation of finger |
  HP:0001770 | 0.0206351046979 | 0.333333333333 | SMC3 RAD21 SMC1A STAG1 | Toe syndactyly |
  HPA:0381202 | 0.0206923872087 | 0.333333333333 | WAPL STAG2 CDCA5 SMC1A | placenta; hofbauer cells[>=Medium] |
  HP:0001360 | 0.0214248804903 | 0.25 | RAD21 SMC1A STAG2 | Holoprosencephaly |
  HP:0002974 | 0.0214248804903 | 0.25 | SMC3 SMC1A RAD21 | Radioulnar synostosis |
  WP:WP3995 | 0.0214336297964 | 0.166666666667 | SMC3 RAD21 | Prion disease pathway |
  HP:0003042 | 0.0223883756371 | 0.25 | SMC3 SMC1A RAD21 | Elbow dislocation |
  GO:0000278 | 0.0224381008462 | 0.583333333333 | STAG2 RAD21 WAPL SMC1A CDCA5 SMC3 STAG1 | mitotic cell cycle |
  HP:0002507 | 0.0231020257076 | 0.166666666667 | STAG2 SMC1A | Semilobar holoprosencephaly |
  HP:0009484 | 0.023275281563 | 0.416666666667 | SMC3 RAD21 STAG2 SMC1A STAG1 | Deviation of the hand or of fingers of the hand |
  HP:0031434 | 0.0233800178976 | 0.25 | SMC3 SMC1A RAD21 | Abnormal prosody |
  HP:0010490 | 0.023433093799 | 0.333333333333 | SMC3 RAD21 SMC1A STAG1 | Abnormality of the palmar creases |
  HP:0002827 | 0.0238544992853 | 0.333333333333 | SMC3 STAG2 SMC1A RAD21 | Hip dislocation |
  HP:0004404 | 0.0238544992853 | 0.333333333333 | SMC3 RAD21 SMC1A STAG1 | Abnormal nipple morphology |
  HPA:0380201 | 0.0240309040332 | 0.333333333333 | WAPL STAG2 SMC1A RAD21 | placenta; endothelial cells[>=Low] |
  HP:0001956 | 0.0244001944621 | 0.25 | SMC3 SMC1A RAD21 | Truncal obesity |
  HP:0030084 | 0.0249933507733 | 0.416666666667 | SMC3 RAD21 STAG2 SMC1A STAG1 | Clinodactyly |
  HPA:0130202 | 0.0250839734571 | 0.75 | RAD21 STAG2 TRIM38 STAG1 WAPL SMC1A REC8 SMC3 SOCS1 | colon; endothelial cells[>=Medium] |
  HP:0001018 | 0.0255962049694 | 0.333333333333 | SMC3 RAD21 SMC1A STAG1 | Abnormal palmar dermatoglyphics |
  GO:0044877 | 0.0279514329114 | 0.666666666667 | STAG2 SMC3 STAG1 REC8 CDCA5 SMC1A RAD21 USP13 | protein-containing complex binding |
  HP:0009811 | 0.0288673565228 | 0.333333333333 | SMC3 RAD21 SMC1A STAG1 | Abnormality of the elbow |
  HPA:0330000 | 0.0289462270069 | 0.916666666667 | RAD21 STAG2 TRIM38 STAG1 WAPL REC8 CDCA5 SMC1A SMC3 USP13 SOCS1 | oral mucosa |
  HPA:0330221 | 0.0289462270069 | 0.916666666667 | RAD21 STAG2 TRIM38 STAG1 WAPL REC8 CDCA5 SMC1A SMC3 USP13 SOCS1 | oral mucosa; squamous epithelial cells[>=Low] |
  HP:0030310 | 0.0323727565724 | 0.25 | SMC3 SMC1A RAD21 | Upper extremity joint dislocation |
  HPA:0381201 | 0.0327973671375 | 0.333333333333 | WAPL STAG2 CDCA5 SMC1A | placenta; hofbauer cells[>=Low] |
  HP:0000729 | 0.0341530666059 | 0.416666666667 | SMC3 RAD21 STAG2 SMC1A STAG1 | Autistic behavior |
  HP:0000998 | 0.0346163885867 | 0.333333333333 | SMC3 RAD21 SMC1A STAG1 | Hypertrichosis |
  HPA:0570813 | 0.0347082956399 | 0.5 | SMC1B RAD21 WAPL SMC1A SMC3 STAG1 | testis; spermatogonia cells[High] |
  HP:0002983 | 0.0349293405607 | 0.25 | SMC3 SMC1A RAD21 | Micromelia |
  HP:0008628 | 0.0352625662553 | 0.166666666667 | RAD21 STAG2 | Abnormality of the stapes |
  HP:0000003 | 0.0390078981561 | 0.25 | SMC3 SMC1A RAD21 | Multicystic kidney dysplasia |
  HPA:0310000 | 0.0408905983538 | 0.916666666667 | RAD21 STAG2 TRIM38 STAG1 WAPL REC8 CDCA5 SMC1A SMC3 USP13 SOCS1 | lymph node |
  HP:0009553 | 0.0418043896955 | 0.333333333333 | SMC3 STAG2 SMC1A RAD21 | Abnormality of the hairline |
  HPA:0310431 | 0.0421415086946 | 0.833333333333 | STAG2 TRIM38 STAG1 WAPL REC8 CDCA5 SMC1A SMC3 USP13 SOCS1 | lymph node; germinal center cells[>=Low] |
  HP:0002230 | 0.0433879456849 | 0.25 | SMC3 SMC1A RAD21 | Generalized hirsutism |
  HP:0000676 | 0.0433879456849 | 0.25 | STAG1 SMC1A STAG2 | Abnormality of the incisor |
  HP:0034058 | 0.0464725841336 | 0.333333333333 | SMC3 RAD21 SMC1A STAG1 | Abnormal fetal morphology |
  HPA:0030072 | 0.0478087747402 | 0.666666666667 | RAD21 STAG2 TRIM38 STAG1 WAPL SMC1A SMC3 SOCS1 | appendix; lymphoid tissue[>=Medium] |
  HPA:0160052 | 0.0484016362547 | 0.833333333333 | STAG2 SOCS1 RAD21 WAPL REC8 SMC1A CDCA5 STAG1 USP13 TRIM38 | endometrium 1; glandular cells[>=Medium] |
  HP:0200055 | 0.0497145292647 | 0.25 | SMC3 SMC1A RAD21 | Small hand |
  HP:0000202 | 0.0499410973404 | 0.416666666667 | SMC3 RAD21 STAG2 SMC1A STAG1 | Orofacial cleft |
Edges
Protein 1 | Protein 2 | Score | ProteomeHD |
---|---|---|---|
 STAG1 |  RAD21 | 1.0 | 0.542           |
 RAD21 |  STAG2 | 1.0 | 0.52           |
 SMC3 |  RAD21 | 1.0 | 0.688           |
 SMC3 |  SMC1A | 0.999 | 0.938           |
 STAG1 |  STAG2 | 0.999 | 0.6           |
 REC8 |  SMC1B | 0.999 |            |
 SMC1A |  RAD21 | 0.999 | 0.694           |
 SMC3 |  CDCA5 | 0.999 | 0.444           |
 SMC3 |  STAG1 | 0.999 | 0.5           |
 RAD21 |  SMC1B | 0.998 |            |
 SMC3 |  STAG2 | 0.998 | 0.624           |
 CDCA5 |  RAD21 | 0.998 | 0.224           |
 CDCA5 |  SMC1A | 0.997 | 0.336           |
 STAG1 |  SMC1A | 0.997 | 0.564           |
 SMC1A |  STAG2 | 0.997 | 0.63           |
 USP13 |  REC8 | 0.997 |            |
 WAPL |  RAD21 | 0.995 | 0.182           |
 SMC1A |  REC8 | 0.994 |            |
 STAG1 |  WAPL | 0.994 | 0.108           |
 SMC3 |  REC8 | 0.993 |            |
 STAG1 |  USP13 | 0.99 | 0.122           |
 SMC3 |  SMC1B | 0.99 |            |
 CDCA5 |  SMC1B | 0.988 |            |
 RAD21 |  REC8 | 0.987 |            |
 WAPL |  STAG2 | 0.987 | 0.488           |
 CDCA5 |  STAG2 | 0.986 | 0.122           |
 USP13 |  STAG2 | 0.983 | 0.088           |
 USP13 |  RAD21 | 0.981 | 0.072           |
 SMC1A |  SMC1B | 0.963 |            |
 CDCA5 |  WAPL | 0.934 | 0.086           |
 STAG1 |  CDCA5 | 0.932 | 0.134           |
 USP13 |  WAPL | 0.914 | 0.134           |
 SMC1A |  TRIM38 | 0.898 | 0.14           |
 SMC3 |  USP13 | 0.897 | 0.284           |
 SMC3 |  WAPL | 0.891 | 0.332           |
 SMC3 |  TRIM38 | 0.888 | 0.142           |
 USP13 |  SOCS1 | 0.869 |            |
 SMC1B |  STAG2 | 0.813 |            |
 USP13 |  SMC1A | 0.804 | 0.168           |
 CDCA5 |  TRIM38 | 0.796 | 0.054           |
 USP13 |  TRIM38 | 0.796 | 0.094           |
 STAG2 |  TRIM38 | 0.796 | 0.096           |
 RAD21 |  TRIM38 | 0.796 | 0.048           |
 USP13 |  CDCA5 | 0.781 | 0.072           |
 STAG1 |  TRIM38 | 0.781 | 0.134           |
 WAPL |  TRIM38 | 0.781 | 0.076           |
 SMC1A |  WAPL | 0.756 | 0.35           |
 USP13 |  SMC1B | 0.754 |            |
 STAG1 |  SMC1B | 0.422 |            |
 WAPL |  SMC1B | 0.187 |            |
 REC8 |  STAG2 | 0.17 |            |
 SMC3 |  SOCS1 | 0.021 |            |
 SMC1A |  SOCS1 | 0.016 |            |
 WAPL |  REC8 | 0.006 |            |
Related Complexes
Genename | Complexes |
---|---|
SMC3 | huMAP3_00229.1 huMAP3_14972.1 |
STAG1 | huMAP3_00229.1 huMAP3_14972.1 |
USP13 | huMAP3_00229.1 huMAP3_14972.1 |
CDCA5 | huMAP3_00229.1 huMAP3_14972.1 |
SOCS1 | huMAP3_14972.1 |
TRIM38 | huMAP3_01656.1 huMAP3_11457.1 huMAP3_14663.1 huMAP3_14736.1 huMAP3_14972.1 huMAP3_15109.1 |
SMC1A | huMAP3_00229.1 huMAP3_14972.1 |
WAPL | huMAP3_00229.1 huMAP3_14972.1 |
RAD21 | huMAP3_00229.1 huMAP3_14972.1 |
REC8 | huMAP3_00229.1 huMAP3_14972.1 |
SMC1B | huMAP3_00229.1 huMAP3_14972.1 |
STAG2 | huMAP3_00229.1 huMAP3_14972.1 |