hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_14975.1
Complex Portal: CPX-22865
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PIGL | N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase (EC 3.5.1.89) (Phosphatidylinositol-glycan biosynthesis class L protein) (PIG-L) | 5 | UniProt NCBI |
| PAQR7 | Membrane progestin receptor alpha (mPR alpha) (Membrane progesterone P4 receptor alpha) (Membrane progesterone receptor alpha) (Progesterone and adipoQ receptor family member 7) (Progestin and adipoQ receptor family member 7) (Progestin and adipoQ receptor family member VII) | 4 | UniProt NCBI |
| CALCRL | Calcitonin gene-related peptide type 1 receptor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) | 5 | UniProt NCBI |
| SMIM20 | Small integral membrane protein 20 (Mitochondrial translation regulation assembly intermediate of cytochrome c oxidase protein of 7 kDa) (MITRAC7) [Cleaved into: Phoenixin-14 (PNX-14); Phoenixin-20 (PNX-20)] | 5 | UniProt NCBI |
| LPAR2 | Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4) | 5 | UniProt NCBI |
| RAMP1 | Receptor activity-modifying protein 1 (Calcitonin-receptor-like receptor activity-modifying protein 1) (CRLR activity-modifying protein 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1300 | 1.70876175213e-05 | 0.333333333333 | RAMP1 CALCRL | CRLR-RAMP1 complex |
| CORUM:1301 | 1.70876175213e-05 | 0.333333333333 | RAMP1 CALCRL | CRLR-RAMP1 complex |
| REAC:R-HSA-419812 | 0.000541723162524 | 0.333333333333 | RAMP1 CALCRL | Calcitonin-like ligand receptors |
| WP:WP2197 | 0.0023190863075 | 0.333333333333 | RAMP1 CALCRL | Endothelin pathways |
| GO:0001635 | 0.00702301080125 | 0.333333333333 | RAMP1 CALCRL | calcitonin gene-related peptide receptor activity |
| GO:1990406 | 0.00702301080125 | 0.333333333333 | RAMP1 CALCRL | CGRP receptor complex |
| REAC:R-HSA-500792 | 0.0134812218215 | 0.5 | LPAR2 CALCRL RAMP1 | GPCR ligand binding |
| GO:0097644 | 0.0210651876021 | 0.333333333333 | RAMP1 CALCRL | calcitonin family binding |
| GO:1990408 | 0.0210651876021 | 0.333333333333 | RAMP1 CALCRL | calcitonin gene-related peptide receptor signaling pathway |
| KEGG:04270 | 0.0325874784997 | 0.333333333333 | RAMP1 CALCRL | Vascular smooth muscle contraction |
| GO:0097642 | 0.042122686785 | 0.333333333333 | RAMP1 CALCRL | calcitonin family receptor activity |
| GO:1903439 | 0.042122686785 | 0.333333333333 | RAMP1 CALCRL | calcitonin family receptor complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| PIGL | LPAR2 | 0.991 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| CALCRL | RAMP1 | 0.989 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| LPAR2 | PAQR7 | 0.977 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SMIM20 | CALCRL | 0.902 | bioplex3_WMM WMM_only | ||
| SMIM20 | PIGL | 0.902 | bioplex3_WMM WMM_only | ||
| PIGL | CALCRL | 0.902 | bioplex3_WMM WMM_only | ||
| PIGL | PAQR7 | 0.722 | bioplex3_WMM WMM_only |
Related Complexes