hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_14977.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PDE4D | 3',5'-cyclic-AMP phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43) (cAMP-specific phosphodiesterase 4D) | 5 | UniProt NCBI |
| ITPKB | Inositol-trisphosphate 3-kinase B (EC 2.7.1.127) (Inositol 1,4,5-trisphosphate 3-kinase B) (IP3 3-kinase B) (IP3K B) (InsP 3-kinase B) | 5 | UniProt NCBI |
| PDE4A | 3',5'-cyclic-AMP phosphodiesterase 4A (EC 3.1.4.53) (DPDE2) (PDE46) (cAMP-specific phosphodiesterase 4A) | 5 | UniProt NCBI |
| PDE4B | 3',5'-cyclic-AMP phosphodiesterase 4B (EC 3.1.4.53) (DPDE4) (PDE32) (cAMP-specific phosphodiesterase 4B) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP5294 | 3.38413923581e-07 | 0.75 | PDE4A PDE4D PDE4B | Sildenafil treatment |
| WP:WP4222 | 2.94331624137e-06 | 0.75 | PDE4A PDE4D PDE4B | Phosphodiesterases in neuronal function |
| KEGG:05032 | 1.71467161414e-05 | 0.75 | PDE4A PDE4D PDE4B | Morphine addiction |
| WP:WP35 | 2.64882854506e-05 | 0.75 | PDE4A PDE4D PDE4B | G protein signaling pathways |
| KEGG:04928 | 3.1411932255e-05 | 0.75 | PDE4A PDE4D PDE4B | Parathyroid hormone synthesis, secretion and action |
| KEGG:00230 | 5.19578118732e-05 | 0.75 | PDE4A PDE4D PDE4B | Purine metabolism |
| GO:0030552 | 6.34131776058e-05 | 0.75 | PDE4A PDE4D PDE4B | cAMP binding |
| GO:0004115 | 8.45465618902e-05 | 0.75 | PDE4A PDE4D PDE4B | 3',5'-cyclic-AMP phosphodiesterase activity |
| KEGG:04024 | 0.000219642829889 | 0.75 | PDE4A PDE4D PDE4B | cAMP signaling pathway |
| GO:0004114 | 0.000261258639543 | 0.75 | PDE4A PDE4D PDE4B | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| GO:0030551 | 0.000313494264121 | 0.75 | PDE4A PDE4D PDE4B | cyclic nucleotide binding |
| GO:0004112 | 0.000313494264121 | 0.75 | PDE4A PDE4D PDE4B | cyclic-nucleotide phosphodiesterase activity |
| REAC:R-HSA-180024 | 0.00194479046925 | 0.5 | PDE4A PDE4D | DARPP-32 events |
| KEGG:01100 | 0.00275730008049 | 1.0 | ITPKB PDE4B PDE4D PDE4A | Metabolic pathways |
| GO:1901898 | 0.0028092043205 | 0.5 | PDE4B PDE4D | negative regulation of relaxation of cardiac muscle |
| GO:0008081 | 0.0131184183431 | 0.75 | PDE4A PDE4D PDE4B | phosphoric diester hydrolase activity |
| WP:WP289 | 0.0214906806331 | 0.5 | PDE4B PDE4D | Myometrial relaxation and contraction pathways |
| GO:1901897 | 0.0280843539964 | 0.5 | PDE4B PDE4D | regulation of relaxation of cardiac muscle |
| GO:1901078 | 0.0280843539964 | 0.5 | PDE4B PDE4D | negative regulation of relaxation of muscle |
| REAC:R-HSA-111885 | 0.0305753786405 | 0.5 | PDE4A PDE4D | Opioid Signalling |
| REAC:R-HSA-418555 | 0.0425656343513 | 0.5 | PDE4A PDE4D | G alpha (s) signalling events |
| CORUM:518 | 0.049938562206 | 0.25 | PDE4D | AKAP250-PKA-PDE4D complex |
| CORUM:6046 | 0.049938562206 | 0.25 | PDE4B | PDE4B-DISC1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PDE4D | PDE4B | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| PDE4D | PDE4A | 0.997 | hein_WMM bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PDE4D | ITPKB | 0.894 | hein_WMM hein () | |
| PDE4A | PDE4B | 0.688 | bioplex3_WMM WMM_only | |
| PDE4A | ITPKB | 0.681 | hein_WMM hein () |
Related Complexes