hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_14986.1
Complex Portal: CPX-13174
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| RETNLB | Resistin-like beta (Colon and small intestine-specific cysteine-rich protein) (Colon carcinoma-related gene protein) (Cysteine-rich secreted protein A12-alpha-like 1) (Cysteine-rich secreted protein FIZZ2) (RELMbeta) | 4 | UniProt NCBI |
| SYTL2 | Synaptotagmin-like protein 2 (Breast cancer-associated antigen SGA-72M) (Exophilin-4) | 5 | UniProt NCBI |
| SYTL1 | Synaptotagmin-like protein 1 (Exophilin-7) (Protein JFC1) | 5 | UniProt NCBI |
| RPH3AL | Rab effector Noc2 (No C2 domains protein) (Rabphilin-3A-like protein) | 5 | UniProt NCBI |
| MLPH | Melanophilin (Exophilin-3) (Slp homolog lacking C2 domains a) (SlaC2-a) (Synaptotagmin-like protein 2a) | 5 | UniProt NCBI |
| SYTL3 | Synaptotagmin-like protein 3 (Exophilin-6) | 4 | UniProt NCBI |
| RAB27B | Ras-related protein Rab-27B (EC 3.6.5.2) (C25KG) | 5 | UniProt NCBI |
| SYTL4 | Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin) | 5 | UniProt NCBI |
| RAB3C | Ras-related protein Rab-3C | 5 | UniProt NCBI |
| RAB27A | Ras-related protein Rab-27A (Rab-27) (EC 3.6.5.2) (GTP-binding protein Ram) | 5 | UniProt NCBI |
| SYTL5 | Synaptotagmin-like protein 5 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2291 | 3.43339439334e-25 | 0.818181818182 | SYTL5 RAB27A SYTL2 SYTL1 RAB27B RPH3AL SYTL4 SYTL3 MLPH | Deregulation of Rab and Rab effector genes in bladder cancer |
| GO:0006887 | 1.10876421172e-10 | 0.818181818182 | SYTL5 RAB27A SYTL2 SYTL1 RAB3C RAB27B RPH3AL SYTL4 SYTL3 | exocytosis |
| GO:0070382 | 1.96782831071e-10 | 0.727272727273 | SYTL5 SYTL2 SYTL3 RAB3C RAB27B RAB27A SYTL4 SYTL1 | exocytic vesicle |
| GO:0042043 | 3.28685663218e-09 | 0.454545454545 | SYTL2 SYTL4 SYTL1 SYTL5 SYTL3 | neurexin family protein binding |
| GO:0030133 | 5.51913306535e-08 | 0.727272727273 | SYTL5 SYTL2 SYTL3 RAB3C RAB27B RAB27A SYTL4 SYTL1 | transport vesicle |
| GO:0032940 | 7.74147145625e-08 | 0.818181818182 | SYTL5 RAB27A SYTL2 SYTL1 RAB3C RAB27B RPH3AL SYTL4 SYTL3 | secretion by cell |
| GO:0046903 | 1.78613433781e-07 | 0.818181818182 | SYTL5 RAB27A SYTL2 SYTL1 RAB3C RAB27B RPH3AL SYTL4 SYTL3 | secretion |
| GO:0140352 | 1.85047804154e-07 | 0.818181818182 | SYTL5 RAB27A SYTL2 SYTL1 RAB3C RAB27B RPH3AL SYTL4 SYTL3 | export from cell |
| CORUM:6307 | 0.000102551658964 | 0.181818181818 | RAB27A SYTL3 | RAB27A-SLP3-KLC1 transport complex |
| GO:0042470 | 0.000108961008888 | 0.363636363636 | RAB27A SYTL2 SYTL1 RAB27B | melanosome |
| GO:0048770 | 0.000108961008888 | 0.363636363636 | RAB27A SYTL2 SYTL1 RAB27B | pigment granule |
| GO:0016192 | 0.00017702999991 | 0.818181818182 | SYTL5 RAB27A SYTL2 SYTL1 RAB3C RAB27B RPH3AL SYTL4 SYTL3 | vesicle-mediated transport |
| GO:0099503 | 0.000323004977546 | 0.727272727273 | SYTL5 SYTL2 SYTL3 RAB3C RAB27B RAB27A SYTL4 SYTL1 | secretory vesicle |
| GO:0017157 | 0.000936281597731 | 0.454545454545 | RAB27A RPH3AL RAB3C RAB27B SYTL4 | regulation of exocytosis |
| HP:0002220 | 0.00143002591111 | 0.181818181818 | RAB27A MLPH | Melanin pigment aggregation in hair shafts |
| REAC:R-HSA-8873719 | 0.00303340299354 | 0.272727272727 | RAB3C RAB27B RAB27A | RAB geranylgeranylation |
| HP:0002218 | 0.00476283944706 | 0.181818181818 | RAB27A MLPH | Silver-gray hair |
| HP:0007443 | 0.0133195302426 | 0.181818181818 | RAB27A MLPH | Partial albinism |
| REAC:R-HSA-9007101 | 0.0160674755621 | 0.272727272727 | RAB27A SYTL1 RAB27B | Rab regulation of trafficking |
| GO:0006810 | 0.0267944704247 | 0.909090909091 | SYTL5 RAB27A SYTL2 SYTL1 RAB3C RAB27B RPH3AL SYTL4 SYTL3 MLPH | transport |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| SYTL1 | RAB27B | 1.0 | 0.122 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SYTL2 | RAB27B | 0.999 | 0.118 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RPH3AL | RAB27A | 0.999 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| RAB27B | SYTL4 | 0.999 | 0.31 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| RAB27B | SYTL5 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| SYTL3 | RAB27A | 0.998 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| RAB27A | SYTL5 | 0.998 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| SYTL4 | RAB27A | 0.997 | 0.212 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SYTL1 | RAB27A | 0.995 | 0.08 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SYTL2 | RAB27A | 0.995 | 0.074 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RPH3AL | RAB27B | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| SYTL3 | RAB27B | 0.991 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| MLPH | RAB27A | 0.985 | 0.05 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| RAB27B | RAB27A | 0.973 | 0.37 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| MLPH | RAB27B | 0.968 | 0.156 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SYTL2 | SYTL1 | 0.913 | 0.124 | bioplex_WMM bioplex3_WMM WMM_only | |
| SYTL1 | RPH3AL | 0.907 | bioplex_WMM bioplex3_WMM WMM_only | ||
| RPH3AL | SYTL5 | 0.907 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SYTL2 | RPH3AL | 0.907 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SYTL2 | SYTL3 | 0.907 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SYTL2 | SYTL5 | 0.907 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SYTL3 | SYTL5 | 0.907 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SYTL1 | SYTL5 | 0.907 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SYTL1 | SYTL3 | 0.907 | bioplex_WMM bioplex3_WMM WMM_only | ||
| RAB3C | SYTL4 | 0.902 | bioplex3_WMM WMM_only | ||
| RPH3AL | SYTL3 | 0.9 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SYTL2 | SYTL4 | 0.872 | 0.14 | bioplex_WMM bioplex3_WMM WMM_only | |
| SYTL1 | SYTL4 | 0.872 | 0.108 | bioplex_WMM bioplex3_WMM WMM_only | |
| RPH3AL | SYTL4 | 0.843 | bioplex_WMM bioplex3_WMM WMM_only | ||
| SYTL3 | SYTL4 | 0.843 | bioplex_WMM bioplex3_WMM WMM_only | ||
| RAB27A | RETNLB | 0.833 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| SYTL4 | SYTL5 | 0.683 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MLPH | SYTL5 | 0.656 | bioplex3_WMM WMM_only | ||
| RPH3AL | MLPH | 0.64 | bioplex3_WMM WMM_only | ||
| MLPH | SYTL3 | 0.64 | bioplex3_WMM WMM_only | ||
| MLPH | SYTL4 | 0.633 | 0.172 | bioplex3_WMM WMM_only | |
| SYTL1 | MLPH | 0.578 | 0.134 | bioplex3_WMM WMM_only | |
| SYTL2 | MLPH | 0.578 | 0.18 | bioplex3_WMM WMM_only | |
| SYTL1 | RETNLB | 0.415 | bioplex3_WMM WMM_only | ||
| SYTL5 | RETNLB | 0.415 | bioplex3_WMM WMM_only | ||
| SYTL4 | RETNLB | 0.415 | bioplex3_WMM WMM_only | ||
| RPH3AL | RETNLB | 0.415 | bioplex3_WMM WMM_only | ||
| SYTL3 | RETNLB | 0.415 | bioplex3_WMM WMM_only | ||
| SYTL2 | RETNLB | 0.415 | bioplex3_WMM WMM_only | ||
| RAB27B | RETNLB | 0.278 | bioplex3_WMM WMM_only | ||
| MLPH | RETNLB | 0.146 | bioplex3_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| RETNLB | huMAP3_11606.1 huMAP3_14631.1 huMAP3_14986.1 huMAP3_15324.1 |
| SYTL2 | huMAP3_01476.1 huMAP3_14986.1 |
| SYTL1 | huMAP3_01476.1 huMAP3_14986.1 |
| RPH3AL | huMAP3_01476.1 huMAP3_14986.1 |
| MLPH | huMAP3_01476.1 huMAP3_07691.1 huMAP3_12772.1 huMAP3_14986.1 |
| SYTL3 | huMAP3_01476.1 huMAP3_14986.1 |
| RAB27B | huMAP3_01476.1 huMAP3_11660.1 huMAP3_14986.1 |
| SYTL4 | huMAP3_01476.1 huMAP3_11860.1 huMAP3_14986.1 |
| RAB3C | huMAP3_01223.1 huMAP3_10379.1 huMAP3_11094.1 huMAP3_11626.1 huMAP3_11860.1 huMAP3_13741.1 huMAP3_14479.1 huMAP3_14986.1 |
| RAB27A | huMAP3_01476.1 huMAP3_14986.1 |
| SYTL5 | huMAP3_01476.1 huMAP3_14986.1 |