hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_15011.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EFNB2 | Ephrin-B2 (EPH-related receptor tyrosine kinase ligand 5) (LERK-5) (HTK ligand) (HTK-L) | 5 | UniProt NCBI |
| PLEKHN1 | Pleckstrin homology domain-containing family N member 1 (PH domain-containing family N member 1) (Cardiolipin and phosphatidic acid-binding protein) | 5 | UniProt NCBI |
| DIP2A | Disco-interacting protein 2 homolog A (DIP2 homolog A) (EC 6.2.1.1) | 5 | UniProt NCBI |
| FAM171A2 | Protein FAM171A2 | 3 | UniProt NCBI |
| EFNB1 | Ephrin-B1 (EFL-3) (ELK ligand) (ELK-L) (EPH-related receptor tyrosine kinase ligand 2) (LERK-2) [Cleaved into: Ephrin-B1 C-terminal fragment (Ephrin-B1 CTF); Ephrin-B1 intracellular domain (Ephrin-B1 ICD)] | 5 | UniProt NCBI |
| SELE | E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E) | 5 | UniProt NCBI |
| SDC3 | Syndecan-3 (SYND3) | 5 | UniProt NCBI |
| EPHB3 | Ephrin type-B receptor 3 (EC 2.7.10.1) (EPH-like tyrosine kinase 2) (EPH-like kinase 2) (Embryonic kinase 2) (EK2) (hEK2) (Tyrosine-protein kinase TYRO6) | 5 | UniProt NCBI |
| DIP2B | Disco-interacting protein 2 homolog B (DIP2 homolog B) | 4 | UniProt NCBI |
| PHLPP1 | PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-3928664 | 2.1343196228e-05 | 0.333333333333 | EFNB2 EPHB3 EFNB1 | Ephrin signaling |
| REAC:R-HSA-3928662 | 0.000319346916738 | 0.333333333333 | EFNB2 EPHB3 EFNB1 | EPHB-mediated forward signaling |
| REAC:R-HSA-3928665 | 0.000500428099492 | 0.333333333333 | EFNB2 EPHB3 EFNB1 | EPH-ephrin mediated repulsion of cells |
| REAC:R-HSA-2682334 | 0.00330724658913 | 0.333333333333 | EFNB2 EPHB3 EFNB1 | EPH-Ephrin signaling |
| KEGG:04360 | 0.00465104570603 | 0.333333333333 | EFNB2 EPHB3 EFNB1 | Axon guidance |
| WP:WP4561 | 0.00991991165725 | 0.222222222222 | EFNB2 EFNB1 | Cell migration and invasion through p75NTR |
| GO:0048667 | 0.0236571498744 | 0.555555555556 | DIP2B DIP2A EFNB2 EPHB3 EFNB1 | cell morphogenesis involved in neuron differentiation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| EFNB2 | EFNB1 | 0.993 | 0.122 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM |
| PHLPP1 | EFNB1 | 0.992 | 0.174 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| EFNB1 | DIP2A | 0.991 | 0.084 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| EFNB2 | SDC3 | 0.986 | 0.134 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| FAM171A2 | EFNB1 | 0.986 | 0.144 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| EFNB1 | DIP2B | 0.986 | 0.128 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| PLEKHN1 | EFNB1 | 0.983 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| EFNB2 | DIP2A | 0.977 | 0.054 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| EPHB3 | EFNB2 | 0.977 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM | |
| EFNB2 | DIP2B | 0.972 | 0.08 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| EFNB2 | FAM171A2 | 0.954 | 0.088 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM gupta_WMM |
| FAM171A2 | DIP2B | 0.947 | 0.066 | bioplex_WMM bioplex3_WMM WMM_only |
| DIP2B | DIP2A | 0.929 | 0.462 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| DIP2A | SELE | 0.926 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| FAM171A2 | DIP2A | 0.917 | 0.05 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| PHLPP1 | DIP2B | 0.907 | 0.094 | bioplex_WMM bioplex3_WMM WMM_only |
| DIP2B | SELE | 0.879 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| EFNB2 | PHLPP1 | 0.838 | 0.098 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PHLPP1 | DIP2A | 0.821 | 0.07 | bioplex_WMM bioplex3_WMM WMM_only |
| PHLPP1 | FAM171A2 | 0.797 | 0.07 | bioplex_WMM bioplex3_WMM WMM_only |
| EPHB3 | EFNB1 | 0.65 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| PLEKHN1 | FAM171A2 | 0.586 | bioplex3_WMM WMM_only | |
| PLEKHN1 | DIP2A | 0.586 | bioplex3_WMM WMM_only | |
| PLEKHN1 | DIP2B | 0.41 | bioplex3_WMM WMM_only | |
| PLEKHN1 | PHLPP1 | 0.388 | bioplex3_WMM WMM_only | |
| EPHB3 | SDC3 | 0.378 | bioplex_WMM bioplex3_WMM WMM_only | |
| EPHB3 | DIP2B | 0.358 | bioplex_WMM bioplex3_WMM WMM_only | |
| EPHB3 | PHLPP1 | 0.3 | bioplex_WMM bioplex3_WMM WMM_only | |
| SDC3 | FAM171A2 | 0.228 | 0.104 | bioplex_WMM bioplex3_WMM WMM_only |
| SDC3 | DIP2B | 0.215 | 0.042 | bioplex_WMM bioplex3_WMM WMM_only |
| SDC3 | PHLPP1 | 0.215 | 0.124 | bioplex_WMM bioplex3_WMM WMM_only |
| PLEKHN1 | EFNB2 | 0.214 | bioplex3_WMM WMM_only | |
| SDC3 | EFNB1 | 0.16 | 0.086 | bioplex_WMM bioplex3_WMM WMM_only |
| EPHB3 | PLEKHN1 | 0.131 | bioplex3_WMM WMM_only | |
| EPHB3 | DIP2A | 0.131 | bioplex_WMM bioplex3_WMM WMM_only | |
| EPHB3 | FAM171A2 | 0.119 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only | |
| SDC3 | DIP2A | 0.08 | 0.078 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes