hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_15022.1

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
CPSF4	Cleavage and polyadenylation specificity factor subunit 4 (Cleavage and polyadenylation specificity factor 30 kDa subunit) (CPSF 30 kDa subunit) (NS1 effector domain-binding protein 1) (Neb-1) (No arches homolog)	5	UniProt NCBI
PUF60	Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (FUSE-binding protein-interacting repressor) (FBP-interacting repressor) (Ro-binding protein 1) (RoBP1) (Siah-binding protein 1) (Siah-BP1)	5	UniProt NCBI
PRPF38B	Pre-mRNA-splicing factor 38B (Sarcoma antigen NY-SAR-27)	3	UniProt NCBI
JMJD6	Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (EC 1.14.11.-) (Histone arginine demethylase JMJD6) (JmjC domain-containing protein 6) (Jumonji domain-containing protein 6) (Lysyl-hydroxylase JMJD6) (Peptide-lysine 5-dioxygenase JMJD6) (Phosphatidylserine receptor) (Protein PTDSR)	5	UniProt NCBI
CPSF2	Cleavage and polyadenylation specificity factor subunit 2 (Cleavage and polyadenylation specificity factor 100 kDa subunit) (CPSF 100 kDa subunit)	5	UniProt NCBI
PHRF1	PHD and RING finger domain-containing protein 1	4	UniProt NCBI
DDX41	Probable ATP-dependent RNA helicase DDX41 (EC 3.6.4.13) (DEAD box protein 41) (DEAD box protein abstrakt homolog)	5	UniProt NCBI
MAPKAPK2	MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC 2.7.11.1)	5	UniProt NCBI
WDR33	pre-mRNA 3' end processing protein WDR33 (WD repeat-containing protein 33) (WD repeat-containing protein of 146 kDa)	5	UniProt NCBI
PRPF38A	Pre-mRNA-splicing factor 38A	5	UniProt NCBI
SFSWAP	Splicing factor, suppressor of white-apricot homolog (Splicing factor, arginine/serine-rich 8) (Suppressor of white apricot protein homolog)	4	UniProt NCBI
RSRC2	Arginine/serine-rich coiled-coil protein 2	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-72203	9.39234395669e-06	0.5	PUF60 CPSF2 DDX41 CPSF4 WDR33 PRPF38A	Processing of Capped Intron-Containing Pre-mRNA
REAC:R-HSA-8953854	8.35887689953e-05	0.583333333333	PUF60 MAPKAPK2 CPSF2 DDX41 CPSF4 WDR33 PRPF38A	Metabolism of RNA
GO:0016071	8.77764780154e-05	0.666666666667	SFSWAP PUF60 CPSF2 WDR33 MAPKAPK2 JMJD6 DDX41 PRPF38A	mRNA metabolic process
REAC:R-HSA-77595	0.00011054301717	0.25	CPSF4 CPSF2 WDR33	Processing of Intronless Pre-mRNAs
GO:0006397	0.00011209194969	0.583333333333	SFSWAP PUF60 CPSF2 WDR33 JMJD6 DDX41 PRPF38A	mRNA processing
HPA:0050012	0.000265489407334	0.666666666667	SFSWAP PUF60 RSRC2 CPSF2 WDR33 MAPKAPK2 JMJD6 DDX41	breast; adipocytes[>=Medium]
REAC:R-HSA-75067	0.000332450747125	0.25	CPSF4 CPSF2 WDR33	Processing of Capped Intronless Pre-mRNA
CORUM:1144	0.000375413311943	0.166666666667	CPSF4 CPSF2	Cleavage and polyadenylation factor (CPSF)
REAC:R-HSA-159231	0.000953957738129	0.25	CPSF4 CPSF2 WDR33	Transport of Mature mRNA Derived from an Intronless Transcript
REAC:R-HSA-159234	0.00103297641469	0.25	CPSF4 CPSF2 WDR33	Transport of Mature mRNAs Derived from Intronless Transcripts
KEGG:03015	0.00256393573202	0.25	CPSF4 CPSF2 WDR33	mRNA surveillance pathway
REAC:R-HSA-72187	0.00294346432773	0.25	CPSF4 CPSF2 WDR33	mRNA 3'-end processing
REAC:R-HSA-73856	0.00443895830613	0.25	CPSF4 CPSF2 WDR33	RNA Polymerase II Transcription Termination
HPA:0010012	0.00533216257335	0.666666666667	SFSWAP PUF60 RSRC2 CPSF2 WDR33 MAPKAPK2 JMJD6 DDX41	adipose tissue; adipocytes[>=Medium]
GO:0003723	0.00557948368627	0.75	RSRC2 WDR33 PUF60 CPSF2 CPSF4 JMJD6 DDX41 PRPF38A PRPF38B	RNA binding
KEGG:03040	0.00660131488073	0.25	PUF60 PRPF38A PRPF38B	Spliceosome
REAC:R-HSA-72202	0.00877436243362	0.25	CPSF4 CPSF2 WDR33	Transport of Mature Transcript to Cytoplasm
WP:WP411	0.0138055940905	0.25	CPSF4 CPSF2 SFSWAP	mRNA processing
GO:0005847	0.0142868257683	0.25	CPSF4 CPSF2 WDR33	mRNA cleavage and polyadenylation specificity factor complex
GO:0005849	0.0278917334495	0.25	CPSF4 CPSF2 WDR33	mRNA cleavage factor complex
HPA:0050011	0.0290038954755	0.666666666667	SFSWAP PUF60 RSRC2 CPSF2 WDR33 MAPKAPK2 JMJD6 DDX41	breast; adipocytes[>=Low]
GO:0006396	0.0335230566464	0.583333333333	SFSWAP PUF60 CPSF2 WDR33 JMJD6 DDX41 PRPF38A	RNA processing

Edges

Protein 1	Protein 2	Score	ProteomeHD
CPSF4	WDR33	1.0	0.428
CPSF4	CPSF2	1.0	0.714
CPSF2	WDR33	1.0	0.53
JMJD6	SFSWAP	0.998	0.054
CPSF4	JMJD6	0.998	0.054
JMJD6	PHRF1	0.998	0.05
JMJD6	RSRC2	0.997	0.036
JMJD6	PRPF38A	0.996	0.088
PUF60	JMJD6	0.993	0.126
CPSF4	MAPKAPK2	0.981	0.024
MAPKAPK2	RSRC2	0.979	0.018
JMJD6	PRPF38B	0.968	0.05
MAPKAPK2	SFSWAP	0.966	0.032
DDX41	PRPF38B	0.919	0.12
CPSF4	SFSWAP	0.894	0.21
WDR33	JMJD6	0.881	0.064
CPSF2	JMJD6	0.818	0.07
PHRF1	PRPF38A	0.806	0.104
JMJD6	DDX41	0.71	0.092
PHRF1	RSRC2	0.646	0.076
RSRC2	SFSWAP	0.62	0.068
WDR33	PHRF1	0.572	0.256
RSRC2	PRPF38B	0.572	0.068
PHRF1	DDX41	0.565	0.108
PHRF1	SFSWAP	0.564	0.124
CPSF4	RSRC2	0.55	0.246
CPSF4	PHRF1	0.535	0.174
CPSF2	SFSWAP	0.52	0.356
WDR33	DDX41	0.51	0.07
WDR33	RSRC2	0.481	0.098
RSRC2	PRPF38A	0.458	0.1
PRPF38A	PRPF38B	0.445	0.342
PRPF38A	DDX41	0.411	0.478
CPSF2	DDX41	0.37	0.612
DDX41	SFSWAP	0.358	0.128
PRPF38B	SFSWAP	0.352	0.088
CPSF2	RSRC2	0.312	0.112
PHRF1	PRPF38B	0.3	0.158
CPSF2	PRPF38B	0.283	0.216
WDR33	PUF60	0.233	0.306
RSRC2	DDX41	0.22	0.044
PRPF38A	SFSWAP	0.22	0.194
WDR33	PRPF38B	0.21	0.172
WDR33	PRPF38A	0.19	0.364
CPSF4	PRPF38A	0.159	0.576
PUF60	PHRF1	0.154	0.492
WDR33	SFSWAP	0.123	0.08
PUF60	PRPF38A	0.117	0.564
CPSF2	PHRF1	0.093	0.22
PUF60	SFSWAP	0.086	0.193333333333
PUF60	RSRC2	0.085	0.19
CPSF4	PRPF38B	0.072	0.2
CPSF2	PRPF38A	0.054	0.7
PUF60	PRPF38B	0.04	0.128
CPSF4	PUF60	0.022	0.474
MAPKAPK2	PRPF38B	0.022	0.048
MAPKAPK2	PRPF38A	0.018	0.024
CPSF2	PUF60	0.016	0.56
PHRF1	MAPKAPK2	0.015	0.048
CPSF4	DDX41	0.013	0.224
PUF60	DDX41	0.013	0.532
WDR33	MAPKAPK2	0.01	0.022
CPSF2	MAPKAPK2	0.009	0.012
PUF60	MAPKAPK2	0.004	0.066
MAPKAPK2	DDX41	0.003	0.024

Related Complexes

Genename	Complexes
CPSF4	huMAP3_00102.1 huMAP3_09096.1 huMAP3_09559.1 huMAP3_10074.1 huMAP3_11757.1 huMAP3_15022.1
PUF60	huMAP3_00347.1 huMAP3_05316.1 huMAP3_05421.1 huMAP3_06487.1 huMAP3_07096.1 huMAP3_08265.1 huMAP3_08305.1 huMAP3_08675.1 huMAP3_08947.1 huMAP3_09450.1 huMAP3_09621.1 huMAP3_09943.1 huMAP3_10010.1 huMAP3_10250.1 huMAP3_11073.1 huMAP3_11453.1 huMAP3_12815.1 huMAP3_13567.1 huMAP3_13743.1 huMAP3_15022.1 huMAP3_15349.1
PRPF38B	huMAP3_02280.1 huMAP3_02831.1 huMAP3_03250.1 huMAP3_10352.1 huMAP3_11073.1 huMAP3_11453.1 huMAP3_13567.1 huMAP3_15022.1
JMJD6	huMAP3_00347.1 huMAP3_01539.1 huMAP3_04407.1 huMAP3_05316.1 huMAP3_06487.1 huMAP3_07096.1 huMAP3_07703.1 huMAP3_08305.1 huMAP3_08947.1 huMAP3_09450.1 huMAP3_09943.1 huMAP3_10010.1 huMAP3_10074.1 huMAP3_10250.1 huMAP3_11073.1 huMAP3_11453.1 huMAP3_13567.1 huMAP3_15022.1
CPSF2	huMAP3_00102.1 huMAP3_09096.1 huMAP3_11757.1 huMAP3_15022.1
PHRF1	huMAP3_00347.1 huMAP3_01759.1 huMAP3_05316.1 huMAP3_06386.1 huMAP3_06487.1 huMAP3_07124.1 huMAP3_08305.1 huMAP3_08715.1 huMAP3_09607.1 huMAP3_09943.1 huMAP3_10010.1 huMAP3_10162.1 huMAP3_10250.1 huMAP3_11453.1 huMAP3_13567.1 huMAP3_14051.1 huMAP3_15022.1
DDX41	huMAP3_01761.1 huMAP3_05063.1 huMAP3_06342.1 huMAP3_07833.1 huMAP3_09943.1 huMAP3_10010.1 huMAP3_10250.1 huMAP3_11453.1 huMAP3_13567.1 huMAP3_13726.1 huMAP3_15022.1
MAPKAPK2	huMAP3_01525.1 huMAP3_04030.1 huMAP3_05536.1 huMAP3_07206.1 huMAP3_07964.1 huMAP3_08407.1 huMAP3_10074.1 huMAP3_10583.1 huMAP3_11114.1 huMAP3_11371.1 huMAP3_11575.1 huMAP3_14776.1 huMAP3_15022.1
WDR33	huMAP3_00102.1 huMAP3_09096.1 huMAP3_11757.1 huMAP3_15022.1
PRPF38A	huMAP3_01539.1 huMAP3_02972.1 huMAP3_04839.1 huMAP3_07703.1 huMAP3_08305.1 huMAP3_08947.1 huMAP3_09450.1 huMAP3_09639.1 huMAP3_10063.1 huMAP3_10074.1 huMAP3_10359.1 huMAP3_11021.1 huMAP3_11453.1 huMAP3_13567.1 huMAP3_15022.1
SFSWAP	huMAP3_06117.1 huMAP3_07703.1 huMAP3_09343.1 huMAP3_10074.1 huMAP3_10345.1 huMAP3_11453.1 huMAP3_13347.1 huMAP3_13567.1 huMAP3_13743.1 huMAP3_15022.1
RSRC2	huMAP3_01525.1 huMAP3_05536.1 huMAP3_07703.1 huMAP3_08042.1 huMAP3_08290.1 huMAP3_10074.1 huMAP3_10583.1 huMAP3_11575.1 huMAP3_13273.1 huMAP3_15022.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_15022.1