hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_15027.1
Complex Portal: CPX-13776
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| OAZ3 | Ornithine decarboxylase antizyme 3 (AZ3) (ODC-Az 3) | 5 | UniProt NCBI |
| OAZ2 | Ornithine decarboxylase antizyme 2 (AZ2) (ODC-Az 2) | 4 | UniProt NCBI |
| CORO7 | Coronin-7 (Crn7) (70 kDa WD repeat tumor rejection antigen homolog) | 5 | UniProt NCBI |
| OAZ1 | Ornithine decarboxylase antizyme 1 (AZ1) (ODC-Az) | 5 | UniProt NCBI |
| FOXA1 | Hepatocyte nuclear factor 3-alpha (HNF-3-alpha) (HNF-3A) (Forkhead box protein A1) (Transcription factor 3A) (TCF-3A) | 5 | UniProt NCBI |
| AZIN2 | Antizyme inhibitor 2 (AzI2) (Arginine decarboxylase) (ADC) (ARGDC) (Ornithine decarboxylase-like protein) (ODC-like protein) (ornithine decarboxylase paralog) (ODC-p) | 5 | UniProt NCBI |
| AZIN1 | Antizyme inhibitor 1 (AZI) (AZI1) (Ornithine decarboxylase antizyme inhibitor) | 5 | UniProt NCBI |
| ODC1 | Ornithine decarboxylase (ODC) (EC 4.1.1.17) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0042979 | 1.89092208334e-13 | 0.714285714286 | OAZ3 AZIN2 AZIN1 OAZ2 OAZ1 | ornithine decarboxylase regulator activity |
| REAC:R-HSA-351202 | 2.78333848342e-09 | 0.714285714286 | OAZ3 AZIN2 AZIN1 OAZ2 OAZ1 | Metabolism of polyamines |
| REAC:R-HSA-350562 | 8.15870186193e-07 | 0.571428571429 | OAZ3 AZIN1 OAZ2 OAZ1 | Regulation of ornithine decarboxylase (ODC) |
| GO:0006595 | 9.20349554216e-07 | 0.571428571429 | AZIN2 AZIN1 OAZ2 OAZ1 | polyamine metabolic process |
| GO:1902267 | 3.36420143768e-06 | 0.428571428571 | OAZ3 AZIN1 AZIN2 | regulation of polyamine transmembrane transport |
| GO:0008073 | 3.36420143768e-06 | 0.428571428571 | OAZ3 OAZ2 OAZ1 | ornithine decarboxylase inhibitor activity |
| REAC:R-HSA-71291 | 1.97586030962e-05 | 0.714285714286 | OAZ3 AZIN2 AZIN1 OAZ2 OAZ1 | Metabolism of amino acids and derivatives |
| GO:1902047 | 6.72425931667e-05 | 0.428571428571 | OAZ3 AZIN1 AZIN2 | polyamine transmembrane transport |
| GO:0006576 | 0.000210494508038 | 0.571428571429 | AZIN2 AZIN1 OAZ2 OAZ1 | biogenic amine metabolic process |
| GO:0006596 | 0.00040312426486 | 0.428571428571 | AZIN2 OAZ1 AZIN1 | polyamine biosynthetic process |
| GO:0015846 | 0.00040312426486 | 0.428571428571 | OAZ3 AZIN1 AZIN2 | polyamine transport |
| GO:0009308 | 0.000657005257405 | 0.571428571429 | AZIN2 AZIN1 OAZ2 OAZ1 | amine metabolic process |
| GO:0042176 | 0.00235878261657 | 0.714285714286 | OAZ3 AZIN2 AZIN1 OAZ2 OAZ1 | regulation of protein catabolic process |
| GO:0042401 | 0.00516068999797 | 0.428571428571 | AZIN2 OAZ1 AZIN1 | biogenic amine biosynthetic process |
| GO:0009309 | 0.00593357407009 | 0.428571428571 | AZIN2 OAZ1 AZIN1 | amine biosynthetic process |
| GO:0042978 | 0.00983221512175 | 0.285714285714 | AZIN2 AZIN1 | ornithine decarboxylase activator activity |
| GO:1902269 | 0.00983221512175 | 0.285714285714 | AZIN2 AZIN1 | positive regulation of polyamine transmembrane transport |
| GO:0033387 | 0.0294899169624 | 0.285714285714 | AZIN2 AZIN1 | putrescine biosynthetic process from ornithine |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| AZIN1 | OAZ3 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| OAZ3 | ODC1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| AZIN1 | OAZ1 | 0.999 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () | ||
| AZIN2 | OAZ2 | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| AZIN1 | OAZ2 | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| FOXA1 | AZIN2 | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| AZIN2 | OAZ1 | 0.992 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| AZIN2 | CORO7 | 0.907 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| AZIN1 | ODC1 | 0.906 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | ||
| OAZ1 | ODC1 | 0.828 | hein_WMM hein () | ||
| OAZ1 | OAZ2 | 0.77 | bioplex_WMM bioplex3_WMM WMM_only | ||
| FOXA1 | OAZ2 | 0.572 | bioplex_WMM bioplex3_WMM WMM_only | ||
| FOXA1 | OAZ1 | 0.502 | bioplex_WMM bioplex3_WMM WMM_only | ||
| FOXA1 | CORO7 | 0.172 | 0.082 | bioplex_WMM bioplex3_WMM WMM_only | |
| CORO7 | OAZ2 | 0.172 | bioplex_WMM bioplex3_WMM WMM_only | ||
| OAZ1 | CORO7 | 0.164 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes