hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_15036.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PHKG1 | Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHK-gamma-M) (EC 2.7.11.19) (Phosphorylase kinase subunit gamma-1) (Serine/threonine-protein kinase PHKG1) (EC 2.7.11.1, EC 2.7.11.26) | 5 | UniProt NCBI |
| PHKB | Phosphorylase b kinase regulatory subunit beta (Phosphorylase kinase subunit beta) | 5 | UniProt NCBI |
| PHKG2 | Phosphorylase b kinase gamma catalytic chain, liver/testis isoform (PHK-gamma-LT) (PHK-gamma-T) (EC 2.7.11.19) (PSK-C3) (Phosphorylase kinase subunit gamma-2) | 5 | UniProt NCBI |
| PHKA1 | Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (Phosphorylase kinase alpha M subunit) | 5 | UniProt NCBI |
| ARL5A | ADP-ribosylation factor-like protein 5A | 4 | UniProt NCBI |
| PHKA2 | Phosphorylase b kinase regulatory subunit alpha, liver isoform (Phosphorylase kinase alpha L subunit) | 5 | UniProt NCBI |
| SLC35G1 | Solute carrier family 35 member G1 (Partner of STIM1) (Transmembrane protein 20) | 5 | UniProt NCBI |
| MPPED1 | Metallophosphoesterase domain-containing protein 1 (EC 3.1.-.-) (Adult brain protein 239) (239AB) | 3 | UniProt NCBI |
| CTCFL | Transcriptional repressor CTCFL (Brother of the regulator of imprinted sites) (CCCTC-binding factor) (CTCF paralog) (CTCF-like protein) (Cancer/testis antigen 27) (CT27) (Zinc finger protein CTCF-T) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-70221 | 5.59299191682e-09 | 0.5 | PHKA2 PHKB PHKG1 PHKA1 | Glycogen breakdown (glycogenolysis) |
| CORUM:6640 | 9.82248594942e-09 | 0.375 | PHKB PHKG1 PHKA1 | Phosphorylase kinase complex |
| REAC:R-HSA-8982491 | 8.29203003935e-08 | 0.5 | PHKA2 PHKB PHKG1 PHKA1 | Glycogen metabolism |
| WP:WP500 | 2.20384027668e-07 | 0.5 | PHKA2 PHKB PHKG1 PHKA1 | Glycogen synthesis and degradation |
| KEGG:04922 | 4.99807549086e-06 | 0.5 | PHKA2 PHKB PHKG1 PHKA1 | Glucagon signaling pathway |
| HP:0009051 | 1.11166732967e-05 | 0.375 | PHKB PHKA1 PHKA2 | Increased muscle glycogen content |
| KEGG:04910 | 1.77704272335e-05 | 0.5 | PHKA2 PHKB PHKG1 PHKA1 | Insulin signaling pathway |
| HP:0012269 | 2.03701052291e-05 | 0.375 | PHKB PHKA1 PHKA2 | Abnormal muscle glycogen content |
| GO:0005964 | 2.15253635486e-05 | 0.375 | PHKB PHKA1 PHKA2 | phosphorylase kinase complex |
| KEGG:04020 | 6.18791607025e-05 | 0.5 | PHKA2 PHKB PHKG1 PHKA1 | Calcium signaling pathway |
| HP:0002913 | 0.00026978847357 | 0.375 | PHKB PHKA1 PHKA2 | Myoglobinuria |
| REAC:R-HSA-71387 | 0.00129598700925 | 0.5 | PHKA2 PHKB PHKG1 PHKA1 | Metabolism of carbohydrates |
| HP:0034370 | 0.00139331307601 | 0.375 | PHKB PHKA1 PHKA2 | Abnormal muscle tissue metabolite concentration |
| HP:0100607 | 0.0101490036868 | 0.25 | PHKB PHKA2 | Dysmenorrhea |
| HP:0012028 | 0.0236486099347 | 0.25 | PHKB PHKA2 | Hepatocellular adenoma |
| HP:0003546 | 0.0285778201567 | 0.375 | PHKB PHKA1 PHKA2 | Exercise intolerance |
| GO:0004689 | 0.0393180950424 | 0.25 | PHKA2 PHKA1 | phosphorylase kinase activity |
| HP:0003326 | 0.0418334319246 | 0.375 | PHKB PHKA1 PHKA2 | Myalgia |
| HP:0003162 | 0.0427341718023 | 0.25 | PHKB PHKA2 | Fasting hypoglycemia |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PHKG2 | PHKA2 | 1.0 | 0.25 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| PHKG2 | PHKB | 1.0 | 0.188 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 boldt_WMM |
| PHKB | PHKA2 | 1.0 | 0.24 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| PHKG2 | PHKA1 | 1.0 | 0.084 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 boldt_WMM |
| PHKG1 | PHKG2 | 0.999 | bioplex3_HEK293 bioplex () bioplex3_WMM bioplex3_HCT116 | |
| PHKA1 | PHKA2 | 0.997 | 0.054 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| PHKA2 | MPPED1 | 0.997 | 0.12 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| PHKG1 | PHKA2 | 0.997 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PHKG2 | MPPED1 | 0.995 | 0.13 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| PHKB | MPPED1 | 0.994 | 0.05 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| PHKA1 | MPPED1 | 0.988 | 0.104 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| PHKB | PHKA1 | 0.981 | 0.146 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only boldt_WMM |
| PHKA2 | ARL5A | 0.888 | 0.054 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| PHKG2 | SLC35G1 | 0.872 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PHKG2 | CTCFL | 0.81 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| PHKG1 | PHKA1 | 0.799 | bioplex_WMM bioplex3_WMM WMM_only | |
| PHKG1 | PHKB | 0.799 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes