hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_15038.1
Complex Portal: CPX-21992
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| OIP5 | Protein Mis18-beta (Cancer/testis antigen 86) (CT86) (Opa-interacting protein 5) (OIP-5) | 5 | UniProt NCBI |
| MIS18BP1 | Mis18-binding protein 1 (Kinetochore-associated protein KNL-2 homolog) (HsKNL-2) (P243) | 5 | UniProt NCBI |
| HJURP | Holliday junction recognition protein (14-3-3-associated AKT substrate) (Fetal liver-expressing gene 1 protein) (Up-regulated in lung cancer 9) | 5 | UniProt NCBI |
| CENPA | Histone H3-like centromeric protein A (Centromere autoantigen A) (Centromere protein A) (CENP-A) | 5 | UniProt NCBI |
| MIS18A | Protein Mis18-alpha (FAPP1-associated protein 1) | 5 | UniProt NCBI |
| CCDC170 | Coiled-coil domain-containing protein 170 | 5 | UniProt NCBI |
| G0S2 | G0/G1 switch protein 2 (G0/G1 switch regulatory protein 2) (Putative lymphocyte G0/G1 switch gene) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-606279 | 1.17788247364e-09 | 0.833333333333 | MIS18A OIP5 CENPA MIS18BP1 HJURP | Deposition of new CENPA-containing nucleosomes at the centromere |
| REAC:R-HSA-774815 | 1.17788247364e-09 | 0.833333333333 | MIS18A OIP5 CENPA MIS18BP1 HJURP | Nucleosome assembly |
| CORUM:6434 | 4.67737426163e-09 | 0.5 | OIP5 MIS18BP1 MIS18A | MIS18 complex |
| GO:0031055 | 1.38095933257e-08 | 0.666666666667 | MIS18A OIP5 CENPA HJURP | chromatin remodeling at centromere |
| GO:0034080 | 1.38095933257e-08 | 0.666666666667 | MIS18A OIP5 CENPA HJURP | CENP-A containing chromatin assembly |
| REAC:R-HSA-73886 | 5.01457145565e-08 | 0.833333333333 | MIS18A OIP5 CENPA MIS18BP1 HJURP | Chromosome Maintenance |
| GO:0034508 | 2.35782092708e-06 | 0.666666666667 | MIS18A OIP5 CENPA HJURP | centromere complex assembly |
| CORUM:7413 | 1.70876175213e-05 | 0.333333333333 | HJURP CENPA | CENP-A-histone H4 heterodimer- HJURP complex |
| GO:0000775 | 0.000122353943136 | 0.833333333333 | MIS18A OIP5 CENPA MIS18BP1 HJURP | chromosome, centromeric region |
| REAC:R-HSA-1640170 | 0.000178011057657 | 0.833333333333 | MIS18A OIP5 CENPA MIS18BP1 HJURP | Cell Cycle |
| CORUM:7388 | 0.00112572613738 | 0.333333333333 | HJURP CENPA | CENP-A nucleosomal complex |
| GO:0098687 | 0.00141530580053 | 0.833333333333 | MIS18A OIP5 CENPA MIS18BP1 HJURP | chromosomal region |
| GO:0065004 | 0.0112661365493 | 0.666666666667 | MIS18A OIP5 CENPA HJURP | protein-DNA complex assembly |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MIS18A | OIP5 | 1.0 | 0.292 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| MIS18BP1 | MIS18A | 1.0 | 0.282 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| MIS18BP1 | OIP5 | 0.999 | 0.194 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM | |
| CENPA | HJURP | 0.998 | 0.156 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () | |
| MIS18A | CCDC170 | 0.958 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| OIP5 | G0S2 | 0.954 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| HJURP | MIS18A | 0.931 | 0.22 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CENPA | OIP5 | 0.926 | 0.106 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CENPA | MIS18A | 0.922 | 0.116 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MIS18A | G0S2 | 0.847 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| MIS18BP1 | CCDC170 | 0.172 | bioplex_WMM bioplex3_WMM WMM_only | ||
| HJURP | MIS18BP1 | 0.137 | 0.078 | bioplex_WMM bioplex3_WMM WMM_only | |
| HJURP | OIP5 | 0.116 | 0.17 | bioplex_WMM bioplex3_WMM WMM_only | |
| OIP5 | CCDC170 | 0.047 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
Related Complexes