hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_15070.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| FANCB | Fanconi anemia group B protein (Protein FACB) (Fanconi anemia-associated polypeptide of 95 kDa) (FAAP95) | 5 | UniProt NCBI |
| FANCL | E3 ubiquitin-protein ligase FANCL (EC 2.3.2.27) (Fanconi anemia group L protein) (Fanconi anemia-associated polypeptide of 43 kDa) (FAAP43) (RING-type E3 ubiquitin transferase FANCL) | 5 | UniProt NCBI |
| FANCC | Fanconi anemia group C protein (Protein FACC) | 5 | UniProt NCBI |
| IL6R | Interleukin-6 receptor subunit alpha (IL-6 receptor subunit alpha) (IL-6R subunit alpha) (IL-6R-alpha) (IL-6RA) (IL-6R 1) (Membrane glycoprotein 80) (gp80) (CD antigen CD126) [Cleaved into: Soluble interleukin-6 receptor subunit alpha (sIL6R)] | 5 | UniProt NCBI |
| FAAP100 | Fanconi anemia core complex-associated protein 100 (Fanconi anemia-associated protein of 100 kDa) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:245 | 2.68437430602e-11 | 0.8 | FAAP100 FANCB FANCC FANCL | FA core complex (Fanconi anemia core complex) |
| CORUM:1624 | 2.68437430602e-11 | 0.8 | FAAP100 FANCB FANCC FANCL | FA core complex (Fanconi anemia core complex) |
| CORUM:6884 | 4.831609132e-11 | 0.8 | FAAP100 FANCB FANCC FANCL | Fanconi anemia FAAP100 complex |
| CORUM:6885 | 2.80233355908e-09 | 0.6 | FANCB FAAP100 FANCL | L-B-P100 subcomplex |
| REAC:R-HSA-6783310 | 2.23277738459e-08 | 0.8 | FAAP100 FANCB FANCC FANCL | Fanconi Anemia Pathway |
| KEGG:03460 | 2.69964987601e-08 | 0.8 | FAAP100 FANCB FANCC FANCL | Fanconi anemia pathway |
| GO:0043240 | 6.50952358374e-08 | 0.8 | FAAP100 FANCB FANCC FANCL | Fanconi anaemia nuclear complex |
| CORUM:1152 | 9.80414034403e-08 | 0.6 | FANCB FANCC FANCL | FA complex (Fanconi anemia complex) |
| CORUM:2739 | 3.36038420171e-07 | 0.6 | FANCB FANCC FANCL | FA complex (Fanconi anemia complex) |
| WP:WP4946 | 1.05784593025e-06 | 0.8 | FAAP100 FANCB FANCC FANCL | DNA repair pathways full network |
| GO:0036297 | 5.37501604002e-06 | 0.8 | FAAP100 FANCB FANCC FANCL | interstrand cross-link repair |
| GO:0006513 | 1.95582475037e-05 | 0.8 | FAAP100 FANCB FANCC FANCL | protein monoubiquitination |
| HP:0005522 | 2.02378479708e-05 | 0.6 | FANCB FANCC FANCL | Pyridoxine-responsive sideroblastic anemia |
| HP:0010469 | 2.32711338381e-05 | 0.6 | FANCB FANCC FANCL | Absent testis |
| HP:0003974 | 2.65928487324e-05 | 0.6 | FANCB FANCC FANCL | Absent radius |
| HP:0009822 | 3.02160410061e-05 | 0.6 | FANCB FANCC FANCL | Aplasia involving forearm bones |
| HP:0003953 | 3.02160410061e-05 | 0.6 | FANCB FANCC FANCL | Absent forearm bone |
| HP:0100867 | 3.84190241496e-05 | 0.6 | FANCB FANCC FANCL | Duodenal stenosis |
| HP:0010293 | 3.84190241496e-05 | 0.6 | FANCB FANCC FANCL | Aplasia/Hypoplasia of the uvula |
| HP:0012848 | 3.84190241496e-05 | 0.6 | FANCB FANCC FANCL | Small intestinal stenosis |
| HP:0002245 | 4.3024884775e-05 | 0.6 | FANCB FANCC FANCL | Meckel diverticulum |
| HP:0100760 | 4.3024884775e-05 | 0.6 | FANCB FANCC FANCL | Clubbing of toes |
| HP:0100587 | 5.33104781094e-05 | 0.6 | FANCB FANCC FANCL | Abnormal preputium morphology |
| HP:0001924 | 6.51146833402e-05 | 0.6 | FANCB FANCC FANCL | Sideroblastic anemia |
| HP:0001549 | 0.000101951828436 | 0.6 | FANCB FANCC FANCL | Abnormal ileum morphology |
| REAC:R-HSA-73894 | 0.000150476434856 | 0.8 | FAAP100 FANCB FANCC FANCL | DNA Repair |
| HP:0000813 | 0.000186036891494 | 0.6 | FANCB FANCC FANCL | Bicornuate uterus |
| CORUM:1625 | 0.000204640425412 | 0.4 | FANCB FANCC | FA core complex (Fanconi anemia core complex) |
| HP:0007874 | 0.000226687892301 | 0.6 | FANCB FANCC FANCL | Almond-shaped palpebral fissure |
| HP:0100026 | 0.000241447043353 | 0.6 | FANCB FANCC FANCL | Arteriovenous malformation |
| HP:0003022 | 0.000272856062575 | 0.6 | FANCB FANCC FANCL | Hypoplasia of the ulna |
| HP:0003220 | 0.000289531742257 | 0.6 | FANCB FANCC FANCL | Abnormality of chromosome stability |
| HP:0009777 | 0.000306872067377 | 0.6 | FANCB FANCC FANCL | Absent thumb |
| HP:0200005 | 0.000306872067377 | 0.6 | FANCB FANCC FANCL | Abnormal shape of the palpebral fissure |
| HP:0006495 | 0.000343598217885 | 0.6 | FANCB FANCC FANCL | Aplasia/Hypoplasia of the ulna |
| HP:0007565 | 0.00038313758832 | 0.6 | FANCB FANCC FANCL | Multiple cafe-au-lait spots |
| CORUM:248 | 0.000490935356523 | 0.4 | FANCL FANCC | BRAFT complex |
| HP:0001199 | 0.000545165611301 | 0.6 | FANCB FANCC FANCL | Triphalangeal thumb |
| HP:0000072 | 0.000598637712806 | 0.6 | FANCB FANCC FANCL | Hydroureter |
| HP:0009821 | 0.000715820213284 | 0.6 | FANCB FANCC FANCL | Forearm undergrowth |
| HP:0006501 | 0.000747323545163 | 0.6 | FANCB FANCC FANCL | Aplasia/Hypoplasia of the radius |
| CORUM:244 | 0.000749834781753 | 0.4 | FANCL FANCC | BRAFT complex |
| HP:0008572 | 0.000882551573811 | 0.6 | FANCB FANCC FANCL | External ear malformation |
| HP:0009380 | 0.000918726168333 | 0.6 | FANCB FANCC FANCL | Aplasia of the fingers |
| HP:0002246 | 0.00103313648748 | 0.6 | FANCB FANCC FANCL | Abnormal duodenum morphology |
| HP:0009824 | 0.00103313648748 | 0.6 | FANCB FANCC FANCL | Upper limb undergrowth |
| HP:0005344 | 0.00111444304982 | 0.6 | FANCB FANCC FANCL | Abnormal carotid artery morphology |
| HP:0002575 | 0.00128959418368 | 0.6 | FANCB FANCC FANCL | Tracheoesophageal fistula |
| HP:0000027 | 0.00138364241778 | 0.6 | FANCB FANCC FANCL | Azoospermia |
| HP:0006503 | 0.00143232921071 | 0.6 | FANCB FANCC FANCL | Aplasia/hypoplasia involving forearm bones |
| HP:0011893 | 0.00202472104006 | 0.8 | FANCB IL6R FANCC FANCL | Abnormal leukocyte count |
| HP:0012745 | 0.00217228548395 | 0.6 | FANCB FANCC FANCL | Short palpebral fissure |
| HP:0008669 | 0.00251341867689 | 0.6 | FANCB FANCC FANCL | Abnormal spermatogenesis |
| HP:0002863 | 0.00251341867689 | 0.6 | FANCB FANCC FANCL | Myelodysplasia |
| HP:0010161 | 0.00258565436429 | 0.6 | FANCB FANCC FANCL | Abnormal toe phalanx morphology |
| HP:0001053 | 0.00258565436429 | 0.6 | FANCB FANCC FANCL | Hypopigmented skin patches |
| HP:0000957 | 0.00296757123606 | 0.6 | FANCB FANCC FANCL | Cafe-au-lait spot |
| HP:0000453 | 0.00304819040973 | 0.6 | FANCB FANCC FANCL | Choanal atresia |
| HP:0008055 | 0.00304819040973 | 0.6 | FANCB FANCC FANCL | Aplasia/Hypoplasia affecting the uvea |
| HP:0008053 | 0.00304819040973 | 0.6 | FANCB FANCC FANCL | Aplasia/Hypoplasia of the iris |
| HP:0002414 | 0.00313025086245 | 0.6 | FANCB FANCC FANCL | Spina bifida |
| HP:0001217 | 0.00321376516039 | 0.6 | FANCB FANCC FANCL | Clubbing |
| HP:0000415 | 0.00374608473288 | 0.6 | FANCB FANCC FANCL | Abnormality of the choanae |
| HP:0008062 | 0.00384012735324 | 0.6 | FANCB FANCC FANCL | Aplasia/Hypoplasia affecting the anterior segment of the eye |
| HP:0000324 | 0.00393572415664 | 0.6 | FANCB FANCC FANCL | Facial asymmetry |
| HP:0010301 | 0.00403288766139 | 0.6 | FANCB FANCC FANCL | Spinal dysraphism |
| HP:0009601 | 0.00413163038045 | 0.6 | FANCB FANCC FANCL | Aplasia/Hypoplasia of the thumb |
| HP:0002023 | 0.00423196482148 | 0.6 | FANCB FANCC FANCL | Anal atresia |
| HP:0000010 | 0.00486809738821 | 0.6 | FANCB FANCC FANCL | Recurrent urinary tract infections |
| HP:0004362 | 0.00497992365102 | 0.6 | FANCB FANCC FANCL | Abnormal enteric ganglion morphology |
| HP:0002251 | 0.00497992365102 | 0.6 | FANCB FANCC FANCL | Aganglionic megacolon |
| HP:0031105 | 0.00497992365102 | 0.6 | FANCB FANCC FANCL | Abnormal uterus morphology |
| HP:0009892 | 0.00499516489297 | 0.4 | FANCB FANCL | Anotia |
| HP:0025028 | 0.00509344150575 | 0.6 | FANCB FANCC FANCL | Abnormal enteric nervous system morphology |
| HP:0012331 | 0.00509344150575 | 0.6 | FANCB FANCC FANCL | Abnormal autonomic nervous system morphology |
| HP:0025633 | 0.00509344150575 | 0.6 | FANCB FANCC FANCL | Abnormal ureter morphology |
| HP:0040071 | 0.00520866341226 | 0.6 | FANCB FANCC FANCL | Abnormal morphology of ulna |
| HP:0001882 | 0.00532560182507 | 0.6 | FANCB FANCC FANCL | Leukopenia |
| HP:0001881 | 0.00535529637799 | 0.8 | FANCB IL6R FANCC FANCL | Abnormal leukocyte morphology |
| HP:0010987 | 0.00535529637799 | 0.8 | FANCB IL6R FANCC FANCL | Abnormal cellular immune system morphology |
| HP:0012041 | 0.0054442691934 | 0.6 | FANCB FANCC FANCL | Decreased fertility in males |
| HP:0011017 | 0.00586253468833 | 0.8 | FANCB IL6R FANCC FANCL | Abnormal cellular physiology |
| HP:0032251 | 0.00595043700131 | 0.8 | FANCB IL6R FANCC FANCL | Abnormal immune system morphology |
| HP:0003221 | 0.00672241921037 | 0.4 | FANCL FANCC | Chromosomal breakage induced by crosslinking agents |
| HP:0025354 | 0.00703354264141 | 0.8 | FANCB IL6R FANCC FANCL | Abnormal cellular phenotype |
| HP:0002778 | 0.00714993467587 | 0.6 | FANCB FANCC FANCL | Abnormal tracheal morphology |
| HP:0001646 | 0.00744020362032 | 0.6 | FANCB FANCC FANCL | Abnormal aortic valve morphology |
| HP:0012145 | 0.00758822304307 | 0.6 | FANCB FANCC FANCL | Abnormality of multiple cell lineages in the bone marrow |
| HP:0008517 | 0.00768171284681 | 0.4 | FANCB FANCL | Aplasia/Hypoplasia of the sacrum |
| HP:0010468 | 0.00819982205473 | 0.6 | FANCB FANCC FANCL | Aplasia/Hypoplasia of the testes |
| HP:0001562 | 0.00884324759031 | 0.6 | FANCB FANCC FANCL | Oligohydramnios |
| HP:0001636 | 0.00934717745 | 0.6 | FANCB FANCC FANCL | Tetralogy of Fallot |
| HP:0000340 | 0.00986978571312 | 0.6 | FANCB FANCC FANCL | Sloping forehead |
| HP:0010972 | 0.00986978571312 | 0.6 | FANCB FANCC FANCL | Anemia of inadequate production |
| HP:0000172 | 0.010048196591 | 0.6 | FANCB FANCC FANCL | Abnormal uvula morphology |
| HP:0045058 | 0.0105962255115 | 0.6 | FANCB FANCC FANCL | Abnormality of the testis size |
| HP:0001034 | 0.0109723643764 | 0.6 | FANCB FANCC FANCL | Hypermelanotic macule |
| HP:0000268 | 0.0115529971699 | 0.6 | FANCB FANCC FANCL | Dolichocephaly |
| HP:0009602 | 0.0115529971699 | 0.6 | FANCB FANCC FANCL | Abnormality of thumb phalanx |
| HP:0005561 | 0.0117509702765 | 0.6 | FANCB FANCC FANCL | Abnormal bone marrow cell morphology |
| HP:0000104 | 0.0125653330708 | 0.6 | FANCB FANCC FANCL | Renal agenesis |
| HP:0002818 | 0.0132000411118 | 0.6 | FANCB FANCC FANCL | Abnormal morphology of the radius |
| HP:0034915 | 0.0132000411118 | 0.6 | FANCB FANCC FANCL | Abnormal anus morphology |
| HP:0001010 | 0.0134162347773 | 0.6 | FANCB FANCC FANCL | Hypopigmentation of the skin |
| HP:0006101 | 0.0136347609231 | 0.6 | FANCB FANCC FANCL | Finger syndactyly |
| HP:0000483 | 0.0152307762491 | 0.6 | FANCB FANCC FANCL | Astigmatism |
| HP:0000025 | 0.015708466597 | 0.6 | FANCB FANCC FANCL | Functional abnormality of male internal genitalia |
| HP:0040072 | 0.0164434381168 | 0.6 | FANCB FANCC FANCL | Abnormal forearm bone morphology |
| HP:0002973 | 0.0166933934022 | 0.6 | FANCB FANCC FANCL | Abnormal forearm morphology |
| HP:0007400 | 0.0169458512751 | 0.6 | FANCB FANCC FANCL | Irregular hyperpigmentation |
| HP:0004378 | 0.0169458512751 | 0.6 | FANCB FANCC FANCL | Abnormality of the anus |
| HP:0002031 | 0.0177183615034 | 0.6 | FANCB FANCC FANCL | Abnormal esophagus morphology |
| HP:0012733 | 0.0177183615034 | 0.6 | FANCB FANCC FANCL | Macule |
| HP:0001770 | 0.0204610424355 | 0.6 | FANCB FANCC FANCL | Toe syndactyly |
| HP:0000130 | 0.0216322462269 | 0.6 | FANCB FANCC FANCL | Abnormality of the uterus |
| HP:0100542 | 0.021931816569 | 0.6 | FANCB FANCC FANCL | Abnormal localization of kidney |
| HP:0009826 | 0.021931816569 | 0.6 | FANCB FANCC FANCL | Limb undergrowth |
| HP:0002032 | 0.0224351839587 | 0.4 | FANCB FANCL | Esophageal atresia |
| HP:0001710 | 0.0228469664256 | 0.6 | FANCB FANCC FANCL | Conotruncal defect |
| HP:0002827 | 0.0228469664256 | 0.6 | FANCB FANCC FANCL | Hip dislocation |
| HP:0002244 | 0.0247523208233 | 0.6 | FANCB FANCC FANCL | Abnormal small intestine morphology |
| HP:0003026 | 0.0247523208233 | 0.6 | FANCB FANCC FANCL | Short long bone |
| HP:0000520 | 0.0250797490255 | 0.6 | FANCB FANCC FANCL | Proptosis |
| HP:0100736 | 0.0264180981427 | 0.6 | FANCB FANCC FANCL | Abnormal soft palate morphology |
| HP:0011563 | 0.0274522626574 | 0.6 | FANCB FANCC FANCL | Abnormal ventriculoarterial connection |
| HP:0006824 | 0.0278028388098 | 0.6 | FANCB FANCC FANCL | Cranial nerve paralysis |
| HP:0031910 | 0.0285128446266 | 0.6 | FANCB FANCC FANCL | Abnormal cranial nerve physiology |
| HP:0011545 | 0.0285128446266 | 0.6 | FANCB FANCC FANCL | Abnormal connection of the cardiac segments |
| HP:0000144 | 0.0296001658067 | 0.6 | FANCB FANCC FANCL | Decreased fertility |
| HP:0012874 | 0.0307145475304 | 0.6 | FANCB FANCC FANCL | Abnormal male reproductive system physiology |
| HP:0000568 | 0.0314726608058 | 0.6 | FANCB FANCC FANCL | Microphthalmia |
| HP:0002719 | 0.0315799854248 | 0.8 | FANCB IL6R FANCC FANCL | Recurrent infections |
| HP:0001639 | 0.0342232629352 | 0.6 | FANCB FANCC FANCL | Hypertrophic cardiomyopathy |
| HP:0002270 | 0.0346287076763 | 0.6 | FANCB FANCC FANCL | Abnormality of the autonomic nervous system |
| HP:0002823 | 0.0354490916891 | 0.6 | FANCB FANCC FANCL | Abnormal femur morphology |
| HP:0200007 | 0.0362822138687 | 0.6 | FANCB FANCC FANCL | Abnormal size of the palpebral fissures |
| HP:0045005 | 0.0375559878492 | 0.6 | FANCB FANCC FANCL | Neural tube defect |
| HP:0410043 | 0.0375559878492 | 0.6 | FANCB FANCC FANCL | Abnormal neural tube morphology |
| HP:0002143 | 0.0384213686055 | 0.6 | FANCB FANCC FANCL | Abnormal spinal cord morphology |
| HP:0004377 | 0.0384213686055 | 0.6 | FANCB FANCC FANCL | Hematological neoplasm |
| HP:0001537 | 0.0388589537734 | 0.6 | FANCB FANCC FANCL | Umbilical hernia |
| HP:0032101 | 0.0401462542927 | 0.8 | FANCB IL6R FANCC FANCL | Unusual infection |
| HP:0000953 | 0.0401914297306 | 0.6 | FANCB FANCC FANCL | Hyperpigmentation of the skin |
| HP:0001551 | 0.0410962983883 | 0.6 | FANCB FANCC FANCL | Abnormal umbilicus morphology |
| HP:0040012 | 0.0425110382594 | 0.4 | FANCL FANCC | Chromosome breakage |
| HP:0030311 | 0.043417085174 | 0.6 | FANCB FANCC FANCL | Lower extremity joint dislocation |
| HP:0100887 | 0.043417085174 | 0.6 | FANCB FANCC FANCL | Abnormality of globe size |
| WP:WP5316 | 0.0477224874935 | 0.4 | FANCL FANCC | Primary ovarian insufficiency |
| HP:0007700 | 0.0488237559993 | 0.6 | FANCB FANCC FANCL | Ocular anterior segment dysgenesis |
| HP:0000582 | 0.0488237559993 | 0.6 | FANCB FANCC FANCL | Upslanted palpebral fissure |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| FANCL | FAAP100 | 0.995 | 0.175 | hein_WMM bioplex_WMM bioplex3_WMM boldt hein () boldt_WMM |
| FAAP100 | FANCB | 0.994 | 0.124 | hein_WMM bioplex_WMM bioplex3_WMM boldt hein () boldt_WMM |
| FANCL | FANCC | 0.994 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FANCB | FANCC | 0.993 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FANCL | FANCB | 0.991 | 0.226 | hein_WMM bioplex_WMM bioplex3_WMM boldt hein () boldt_WMM |
| IL6R | FANCL | 0.96 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| IL6R | FANCB | 0.96 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| IL6R | FAAP100 | 0.811 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes