hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_15082.1

Confidence: Medium

Genename	Protein Name	Uniprot Annotation Score	Links
AP3B1	AP-3 complex subunit beta-1 (Adaptor protein complex AP-3 subunit beta-1) (Adaptor-related protein complex 3 subunit beta-1) (Beta-3A-adaptin) (Clathrin assembly protein complex 3 beta-1 large chain)	5	UniProt NCBI
EPB41L3	Band 4.1-like protein 3 (4.1B) (Differentially expressed in adenocarcinoma of the lung protein 1) (DAL-1) (Erythrocyte membrane protein band 4.1-like 3) [Cleaved into: Band 4.1-like protein 3, N-terminally processed]	5	UniProt NCBI
AP3M2	AP-3 complex subunit mu-2 (Adaptor-related protein complex 3 subunit mu-2) (Clathrin assembly protein assembly protein complex 3 mu-2 medium chain) (Clathrin coat assembly protein AP47 homolog 2) (Clathrin coat-associated protein AP47 homolog 2) (Golgi adaptor AP-1 47 kDa protein homolog 2) (HA1 47 kDa subunit homolog 2) (Mu3B-adaptin) (P47B)	5	UniProt NCBI
RNF167	E3 ubiquitin-protein ligase RNF167 (EC 2.3.2.27) (RING finger protein 167)	5	UniProt NCBI
AP3M1	AP-3 complex subunit mu-1 (AP-3 adaptor complex mu3A subunit) (Adaptor-related protein complex 3 subunit mu-1) (Mu-adaptin 3A) (Mu3A-adaptin)	5	UniProt NCBI
AP3S1	AP-3 complex subunit sigma-1 (AP-3 complex subunit sigma-3A) (Adaptor-related protein complex 3 subunit sigma-1) (Clathrin-associated/assembly/adaptor protein, small 3) (Sigma-3A-adaptin) (Sigma3A-adaptin) (Sigma-adaptin 3a)	5	UniProt NCBI
AP3D1	AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adaptor-related protein complex 3 subunit delta-1) (Delta-adaptin)	5	UniProt NCBI
AP3S2	AP-3 complex subunit sigma-2 (AP-3 complex subunit sigma-3B) (Adaptor-related protein complex 3 subunit sigma-2) (Sigma-3B-adaptin) (Sigma3B-adaptin) (Sigma-adaptin 3b)	5	UniProt NCBI
AP3B2	AP-3 complex subunit beta-2 (Adaptor protein complex AP-3 subunit beta-2) (Adaptor-related protein complex 3 subunit beta-2) (Beta-3B-adaptin) (Clathrin assembly protein complex 3 beta-2 large chain) (Neuron-specific vesicle coat protein beta-NAP)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:59	1.03551099145e-22	0.777777777778	AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	AP3 adaptor complex
GO:0035654	6.37874770736e-20	0.777777777778	AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	clathrin-coated vesicle cargo loading, AP-3-mediated
GO:0035652	6.37874770736e-20	0.777777777778	AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	clathrin-coated vesicle cargo loading
CORUM:652	6.65712841923e-19	0.777777777778	AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	AP3-BLOC1 complex
GO:0030123	2.2957989982e-18	0.777777777778	AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	AP-3 adaptor complex
GO:0099517	2.02729844503e-15	0.777777777778	AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	synaptic vesicle transport along microtubule
GO:0099514	2.02729844503e-15	0.777777777778	AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	synaptic vesicle cytoskeletal transport
GO:0048490	2.02729844503e-15	0.777777777778	AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	anterograde synaptic vesicle transport
GO:0035459	1.67252034433e-13	0.777777777778	AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	vesicle cargo loading
GO:0048489	2.14056921207e-13	0.777777777778	AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	synaptic vesicle transport
GO:0030119	4.27502542025e-13	0.777777777778	AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	AP-type membrane coat adaptor complex
GO:0097479	6.54364059016e-13	0.777777777778	AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	synaptic vesicle localization
GO:0016183	1.13455325e-12	0.555555555556	AP3M2 AP3D1 AP3B2 AP3S2 AP3S1	synaptic vesicle coating
GO:0047496	1.42823098688e-12	0.777777777778	AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	vesicle transport along microtubule
GO:0008089	1.71367145396e-12	0.777777777778	AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	anterograde axonal transport
KEGG:04142	4.51750771777e-12	0.777777777778	AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	Lysosome
GO:0098930	1.12332805817e-11	0.777777777778	AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	axonal transport
GO:0070142	2.38147473756e-11	0.555555555556	AP3M2 AP3D1 AP3B2 AP3S2 AP3S1	synaptic vesicle budding
GO:0016185	2.38147473756e-11	0.555555555556	AP3M2 AP3D1 AP3B2 AP3S2 AP3S1	synaptic vesicle budding from presynaptic endocytic zone membrane
GO:0008088	2.44789974494e-11	0.777777777778	AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	axo-dendritic transport
GO:0099518	3.50553764221e-11	0.777777777778	AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	vesicle cytoskeletal trafficking
GO:0072384	8.41812224316e-11	0.777777777778	AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	organelle transport along microtubule
GO:0048475	3.69169326631e-10	0.777777777778	AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	coated membrane
GO:0030117	3.69169326631e-10	0.777777777778	AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	membrane coat
GO:0010970	9.16611298037e-09	0.777777777778	AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	transport along microtubule
GO:1903232	9.69205058567e-09	0.555555555556	AP3S1 AP3D1 AP3B1 AP3S2 AP3M1	melanosome assembly
GO:0099111	2.12346122825e-08	0.777777777778	AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	microtubule-based transport
GO:0060155	2.30028568441e-08	0.555555555556	AP3S1 AP3D1 AP3B1 AP3S2 AP3M1	platelet dense granule organization
GO:0051650	4.13097422297e-08	0.777777777778	AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	establishment of vesicle localization
GO:0030705	5.08812294015e-08	0.777777777778	AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	cytoskeleton-dependent intracellular transport
GO:0051648	5.30075618599e-08	0.777777777778	AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	vesicle localization
WP:WP5408	2.15894894111e-07	0.444444444444	AP3M2 AP3D1 AP3B2 AP3S1	15q25 copy number variation
GO:0006901	3.65797757329e-07	0.555555555556	AP3M2 AP3D1 AP3B2 AP3S2 AP3S1	vesicle coating
GO:0032438	4.24700324456e-07	0.555555555556	AP3S1 AP3D1 AP3B1 AP3S2 AP3M1	melanosome organization
GO:0048753	4.24700324456e-07	0.555555555556	AP3S1 AP3D1 AP3B1 AP3S2 AP3M1	pigment granule organization
GO:0051640	4.64100334321e-07	0.888888888889	RNF167 AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	organelle localization
GO:0033363	5.6520432225e-07	0.555555555556	AP3S1 AP3D1 AP3B1 AP3S2 AP3M1	secretory granule organization
GO:0005769	1.18578965312e-06	0.777777777778	AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	early endosome
GO:0007018	1.21708292868e-06	0.777777777778	AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	microtubule-based movement
GO:0048488	1.37354375265e-06	0.555555555556	AP3M2 AP3D1 AP3B2 AP3S2 AP3S1	synaptic vesicle endocytosis
GO:0140238	1.37354375265e-06	0.555555555556	AP3M2 AP3D1 AP3B2 AP3S2 AP3S1	presynaptic endocytosis
GO:0016050	1.57096856529e-06	0.777777777778	AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	vesicle organization
GO:0036465	3.54809247849e-06	0.555555555556	AP3M2 AP3D1 AP3B2 AP3S2 AP3S1	synaptic vesicle recycling
GO:0033059	3.90200898242e-06	0.555555555556	AP3S1 AP3D1 AP3B1 AP3S2 AP3M1	cellular pigmentation
GO:0051656	1.02573864666e-05	0.777777777778	AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	establishment of organelle localization
GO:0005768	1.27256183285e-05	0.888888888889	RNF167 AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	endosome
GO:0006900	1.56328999739e-05	0.555555555556	AP3M2 AP3D1 AP3B2 AP3S2 AP3S1	vesicle budding from membrane
GO:0043473	1.67785355241e-05	0.555555555556	AP3S1 AP3D1 AP3B1 AP3S2 AP3M1	pigmentation
CORUM:2308	2.73623797451e-05	0.222222222222	AP3S1 AP3D1	AP3D1-AP3S1 complex
CORUM:2307	2.73623797451e-05	0.222222222222	AP3D1 AP3S2	AP3D1-AP3S2 complex
GO:0099504	0.000107075384876	0.555555555556	AP3M2 AP3D1 AP3B2 AP3S2 AP3S1	synaptic vesicle cycle
GO:0099003	0.000123522310574	0.555555555556	AP3M2 AP3D1 AP3B2 AP3S2 AP3S1	vesicle-mediated transport in synapse
GO:0007017	0.000875288134912	0.777777777778	AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	microtubule-based process
GO:0010256	0.00268822918493	0.666666666667	AP3S1 AP3B1 EPB41L3 AP3S2 AP3D1 AP3M1	endomembrane system organization
HP:0011125	0.00306165140522	0.222222222222	AP3D1 AP3B1	Abnormality of dermal melanosomes
GO:0006897	0.00346340802694	0.666666666667	AP3M2 AP3M1 AP3S1 AP3S2 AP3D1 AP3B2	endocytosis
GO:0098796	0.00630695715281	0.777777777778	AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	membrane protein complex
GO:0031410	0.0109403276913	0.888888888889	RNF167 AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	cytoplasmic vesicle
GO:0097708	0.0110977854262	0.888888888889	RNF167 AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	intracellular vesicle
GO:0061024	0.0123653327439	0.666666666667	AP3S1 EPB41L3 AP3M2 AP3S2 AP3D1 AP3B2	membrane organization
GO:0098657	0.0171338571064	0.666666666667	AP3M2 AP3M1 AP3S1 AP3S2 AP3D1 AP3B2	import into cell
GO:0046907	0.0187458905152	0.777777777778	AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	intracellular transport
GO:0016192	0.0208703166512	0.777777777778	AP3S1 AP3B1 AP3S2 AP3B2 AP3M2 AP3D1 AP3M1	vesicle-mediated transport
HP:0001022	0.0366109494459	0.222222222222	AP3D1 AP3B1	Albinism

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
AP3M1	AP3S1	1.0	0.522	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction
AP3S1	AP3B2	1.0	0.054	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116
AP3M1	AP3B2	1.0	0.044	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116
AP3B1	AP3S1	1.0	0.262	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction
AP3B1	AP3M1	1.0	0.782	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM
AP3M1	AP3D1	1.0	0.794	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction
AP3M2	AP3S1	1.0	0.166	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction
AP3S1	AP3D1	0.999	0.482	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction
AP3S1	RNF167	0.999	0.044	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
AP3B1	AP3M2	0.999	0.28	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction
EPB41L3	AP3M2	0.998		bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only
AP3M2	AP3M1	0.998	0.636	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM
EPB41L3	AP3B1	0.996		bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only
EPB41L3	AP3M1	0.995		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
AP3M2	AP3D1	0.995	0.604	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction
AP3B1	AP3D1	0.993	0.806	bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM fraction treiber_WMM
AP3M1	AP3S2	0.991	0.068	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM
AP3B1	AP3B2	0.991	0.04	bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
AP3M2	AP3B2	0.98	0.036	bioplex_WMM bioplex3_WMM WMM_only
AP3M2	AP3S2	0.978	0.074	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
EPB41L3	AP3D1	0.971		bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only
AP3S1	AP3S2	0.94	0.064	bioplex_WMM bioplex3_WMM youn_WMM WMM_only
AP3D1	AP3S2	0.938	0.136	bioplex_WMM bioplex3_WMM youn_WMM WMM_only
AP3D1	AP3B2	0.921	0.038	bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
EPB41L3	AP3B2	0.913		bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
EPB41L3	AP3S1	0.859		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
AP3B1	RNF167	0.849	0.106	bioplex_WMM bioplex3_WMM WMM_only
AP3B1	AP3S2	0.834	0.066	bioplex_WMM bioplex3_WMM youn_WMM WMM_only
AP3B2	RNF167	0.749	0.022	bioplex_WMM bioplex3_WMM WMM_only
AP3M2	RNF167	0.747	0.064	bioplex_WMM bioplex3_WMM WMM_only
AP3S2	AP3B2	0.747	0.06	bioplex_WMM bioplex3_WMM WMM_only
EPB41L3	AP3S2	0.741		bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only
AP3D1	RNF167	0.667	0.102	bioplex_WMM bioplex3_WMM WMM_only
AP3M1	RNF167	0.622	0.094	bioplex_WMM bioplex3_WMM WMM_only
AP3S2	RNF167	0.121	0.066	bioplex_WMM bioplex3_WMM WMM_only
EPB41L3	RNF167	0.008		bioplex_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
AP3B1	huMAP3_03149.1 huMAP3_03536.1 huMAP3_04281.1 huMAP3_06230.1 huMAP3_11077.1 huMAP3_11493.1 huMAP3_12157.1 huMAP3_12325.1 huMAP3_12813.1 huMAP3_13727.1 huMAP3_13786.1 huMAP3_14281.1 huMAP3_15082.1
EPB41L3	huMAP3_00103.1 huMAP3_07467.1 huMAP3_08647.1 huMAP3_09803.1 huMAP3_11077.1 huMAP3_11121.1 huMAP3_11493.1 huMAP3_12157.1 huMAP3_12325.1 huMAP3_12813.1 huMAP3_12829.1 huMAP3_14281.1 huMAP3_15082.1
AP3M2	huMAP3_03149.1 huMAP3_04148.1 huMAP3_04238.1 huMAP3_11493.1 huMAP3_12157.1 huMAP3_12325.1 huMAP3_12813.1 huMAP3_13727.1 huMAP3_14281.1 huMAP3_15082.1
RNF167	huMAP3_03536.1 huMAP3_04969.1 huMAP3_05469.1 huMAP3_05839.1 huMAP3_06650.1 huMAP3_07176.1 huMAP3_08379.1 huMAP3_09767.1 huMAP3_12157.1 huMAP3_12660.1 huMAP3_13197.1 huMAP3_13699.1 huMAP3_14844.1 huMAP3_15082.1
AP3M1	huMAP3_03149.1 huMAP3_04148.1 huMAP3_04238.1 huMAP3_11493.1 huMAP3_12157.1 huMAP3_12325.1 huMAP3_12813.1 huMAP3_13727.1 huMAP3_14281.1 huMAP3_15082.1
AP3S1	huMAP3_03149.1 huMAP3_03536.1 huMAP3_04238.1 huMAP3_06230.1 huMAP3_12157.1 huMAP3_12325.1 huMAP3_12813.1 huMAP3_15082.1
AP3D1	huMAP3_03149.1 huMAP3_03536.1 huMAP3_04238.1 huMAP3_06230.1 huMAP3_11493.1 huMAP3_12157.1 huMAP3_12325.1 huMAP3_12813.1 huMAP3_13727.1 huMAP3_14281.1 huMAP3_15082.1
AP3S2	huMAP3_03149.1 huMAP3_03809.1 huMAP3_04148.1 huMAP3_04238.1 huMAP3_06631.1 huMAP3_07739.1 huMAP3_11493.1 huMAP3_12157.1 huMAP3_12325.1 huMAP3_12813.1 huMAP3_13727.1 huMAP3_14281.1 huMAP3_15082.1
AP3B2	huMAP3_03149.1 huMAP3_03536.1 huMAP3_04238.1 huMAP3_06230.1 huMAP3_11493.1 huMAP3_12157.1 huMAP3_12325.1 huMAP3_12813.1 huMAP3_13727.1 huMAP3_14281.1 huMAP3_15082.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_15082.1