hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_15090.1
Confidence: Medium
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ARRB1 | Beta-arrestin-1 (Arrestin beta-1) (Non-visual arrestin-2) | 5 | UniProt NCBI |
| ARRB2 | Beta-arrestin-2 (Arrestin beta-2) (Non-visual arrestin-3) | 5 | UniProt NCBI |
| ARR3 | Arrestin-C (Cone arrestin) (C-arrestin) (cArr) (Retinal cone arrestin-3) (X-arrestin) | 5 | UniProt NCBI |
| NOLC1 | Nucleolar and coiled-body phosphoprotein 1 (140 kDa nucleolar phosphoprotein) (Nopp140) (Hepatitis C virus NS5A-transactivated protein 13) (HCV NS5A-transactivated protein 13) (Nucleolar 130 kDa protein) (Nucleolar phosphoprotein p130) | 5 | UniProt NCBI |
| SAG | S-arrestin (48 kDa protein) (Retinal S-antigen) (S-AG) (Rod photoreceptor arrestin) | 5 | UniProt NCBI |
| PLEKHA2 | Pleckstrin homology domain-containing family A member 2 (PH domain-containing family A member 2) (Tandem PH domain-containing protein 2) (TAPP-2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0002031 | 3.22863876272e-05 | 0.75 | ARRB1 ARR3 ARRB2 | G protein-coupled receptor internalization |
| GO:0002029 | 8.45465618902e-05 | 0.75 | ARRB1 ARR3 ARRB2 | desensitization of G protein-coupled receptor signaling pathway |
| GO:0022401 | 0.000109904886398 | 0.75 | ARRB1 ARR3 ARRB2 | negative adaptation of signaling pathway |
| GO:0023058 | 0.000109904886398 | 0.75 | ARRB1 ARR3 ARRB2 | adaptation of signaling pathway |
| WP:WP4941 | 0.000535373329556 | 0.5 | ARRB1 ARRB2 | GPR143 in melanocytes and retinal pigment epithelium cells |
| REAC:R-HSA-5635838 | 0.000798898068561 | 0.5 | ARRB1 ARRB2 | Activation of SMO |
| WP:WP4871 | 0.00126323103486 | 0.5 | ARRB1 ARRB2 | Kisspeptin kisspeptin receptor system in the ovary |
| WP:WP4249 | 0.00169541860832 | 0.5 | ARRB1 ARRB2 | Hedgehog signaling pathway |
| KEGG:04340 | 0.00247340401034 | 0.5 | ARRB1 ARRB2 | Hedgehog signaling pathway |
| KEGG:04929 | 0.00247340401034 | 0.5 | ARRB1 ARRB2 | GnRH secretion |
| REAC:R-HSA-2122948 | 0.00282403231951 | 0.5 | ARRB1 ARRB2 | Activated NOTCH1 Transmits Signal to the Nucleus |
| REAC:R-HSA-456926 | 0.00359044851421 | 0.5 | ARRB1 ARRB2 | Thrombin signalling through proteinase activated receptors (PARs) |
| GO:0045744 | 0.0037914498893 | 0.75 | ARRB1 ARR3 ARRB2 | negative regulation of G protein-coupled receptor signaling pathway |
| REAC:R-HSA-6802948 | 0.00444848198459 | 0.5 | ARRB1 ARRB2 | Signaling by high-kinase activity BRAF mutants |
| WP:WP5094 | 0.00561306746582 | 0.5 | ARRB1 ARRB2 | Orexin receptor pathway |
| KEGG:05032 | 0.0056793701001 | 0.5 | ARRB1 ARRB2 | Morphine addiction |
| REAC:R-HSA-5674135 | 0.00573491177379 | 0.5 | ARRB1 ARRB2 | MAP2K and MAPK activation |
| REAC:R-HSA-9656223 | 0.006081926491 | 0.5 | ARRB1 ARRB2 | Signaling by RAF1 mutants |
| WP:WP2355 | 0.00703973989842 | 0.5 | ARRB1 ARRB2 | Corticotropin releasing hormone signaling pathway |
| REAC:R-HSA-6802949 | 0.00718390333861 | 0.5 | ARRB1 ARRB2 | Signaling by RAS mutants |
| REAC:R-HSA-9649948 | 0.00718390333861 | 0.5 | ARRB1 ARRB2 | Signaling downstream of RAS mutants |
| REAC:R-HSA-6802955 | 0.00718390333861 | 0.5 | ARRB1 ARRB2 | Paradoxical activation of RAF signaling by kinase inactive BRAF |
| REAC:R-HSA-6802946 | 0.00718390333861 | 0.5 | ARRB1 ARRB2 | Signaling by moderate kinase activity BRAF mutants |
| KEGG:04740 | 0.00826911293642 | 0.5 | ARRB1 ARRB2 | Olfactory transduction |
| KEGG:04928 | 0.00847251296121 | 0.5 | ARRB1 ARRB2 | Parathyroid hormone synthesis, secretion and action |
| WP:WP4659 | 0.0138131669346 | 0.5 | ARRB1 ARRB2 | Gastrin signaling pathway |
| KEGG:04926 | 0.014352694406 | 0.5 | ARRB1 ARRB2 | Relaxin signaling pathway |
| KEGG:04728 | 0.014619629343 | 0.5 | ARRB1 ARRB2 | Dopaminergic synapse |
| REAC:R-HSA-6802952 | 0.0157112703152 | 0.5 | ARRB1 ARRB2 | Signaling by BRAF and RAF1 fusions |
| WP:WP536 | 0.015715675352 | 0.5 | ARRB1 ARRB2 | Calcium regulation in cardiac cells |
| GO:0031701 | 0.0168521501606 | 0.5 | ARRB1 ARRB2 | angiotensin receptor binding |
| REAC:R-HSA-1980143 | 0.0174510452107 | 0.5 | ARRB1 ARRB2 | Signaling by NOTCH1 |
| WP:WP3929 | 0.0183400443465 | 0.5 | ARRB1 ARRB2 | Chemokine signaling pathway |
| WP:WP289 | 0.0214906806331 | 0.5 | ARRB1 ARRB2 | Myometrial relaxation and contraction pathways |
| KEGG:04062 | 0.0237566589162 | 0.5 | ARRB1 ARRB2 | Chemokine signaling pathway |
| CORUM:1297 | 0.0249718442456 | 0.25 | ARRB2 | MKK4-ARRB2-ASK1 complex |
| REAC:R-HSA-6802957 | 0.0253175164514 | 0.5 | ARRB1 ARRB2 | Oncogenic MAPK signaling |
| REAC:R-HSA-5632684 | 0.0297941212351 | 0.5 | ARRB1 ARRB2 | Hedgehog 'on' state |
| KEGG:05207 | 0.0326315237827 | 0.5 | ARRB1 ARRB2 | Chemical carcinogenesis - receptor activation |
| REAC:R-HSA-418555 | 0.0425656343513 | 0.5 | ARRB1 ARRB2 | G alpha (s) signalling events |
| REAC:R-HSA-8856825 | 0.0444386798825 | 0.5 | ARRB1 ARRB2 | Cargo recognition for clathrin-mediated endocytosis |
| GO:0031623 | 0.0449670283878 | 0.75 | ARRB1 ARR3 ARRB2 | receptor internalization |
| CORUM:1298 | 0.049938562206 | 0.25 | ARRB2 | MKK4-ARRB2-JNK3 complex |
| CORUM:6805 | 0.049938562206 | 0.25 | ARRB2 | S1PR1-beta-arrestin 2 complex, ApoM(+)HDL-S1P stimulated |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ARRB1 | SAG | 0.999 | 0.22 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| NOLC1 | ARRB1 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ARRB2 | ARRB1 | 0.986 | 0.124 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| ARRB2 | ARR3 | 0.973 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ARRB2 | NOLC1 | 0.932 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| NOLC1 | PLEKHA2 | 0.927 | bioplex3_HEK293 bioplex3_WMM WMM_only boldt_WMM | |
| NOLC1 | SAG | 0.751 | bioplex_WMM bioplex3_WMM WMM_only | |
| ARR3 | ARRB1 | 0.53 | bioplex_WMM bioplex3_WMM WMM_only | |
| ARRB2 | SAG | 0.213 | 0.14 | bioplex_WMM bioplex3_WMM WMM_only |
| ARR3 | NOLC1 | 0.193 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes