List of Gene Names or Uniprot ACCs (ex. OFD1 PCM1 Q1MSJ5):

Enrichment (ex. cilium):

Protein (ex. Centrosomal protein):

Complex: huMAP3_15095.1

Confidence: Medium   ?

Proteins

Genename	Protein Name	Uniprot Annotation Score	Links
AEBP2	Zinc finger protein AEBP2 (Adipocyte enhancer-binding protein 2) (AE-binding protein 2)	5	UniProt   NCBI
IL1A	Interleukin-1 alpha (IL-1 alpha) (Hematopoietin-1)	5	UniProt   NCBI
PHF1	PHD finger protein 1 (Protein PHF1) (hPHF1) (Polycomb-like protein 1) (hPCl1)	5	UniProt   NCBI
SMARCA1	Probable global transcription activator SNF2L1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA1) (Nucleosome-remodeling factor subunit SNF2L) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1)	5	UniProt   NCBI
EED	Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1)	5	UniProt   NCBI
PHF19	PHD finger protein 19 (Polycomb-like protein 3) (hPCL3)	5	UniProt   NCBI
EZH1	Histone-lysine N-methyltransferase EZH1 (EC 2.1.1.356) (ENX-2) (Enhancer of zeste homolog 1)	5	UniProt   NCBI
BPTF	Nucleosome-remodeling factor subunit BPTF (Bromodomain and PHD finger-containing transcription factor) (Fetal Alz-50 clone 1 protein) (Fetal Alzheimer antigen)	5	UniProt   NCBI
SUZ12	Polycomb protein SUZ12 (Chromatin precipitated E2F target 9 protein) (ChET 9 protein) (Joined to JAZF1 protein) (Suppressor of zeste 12 protein homolog)	5	UniProt   NCBI
JARID2	Protein Jumonji (Jumonji/ARID domain-containing protein 2)	5	UniProt   NCBI
BAZ2A	Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3)	5	UniProt   NCBI
EZH2	Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)	5	UniProt   NCBI
EPOP	Elongin BC and Polycomb repressive complex 2-associated protein (Proline-rich protein 28)	4	UniProt   NCBI
LCOR	Ligand-dependent corepressor (LCoR) (Mblk1-related protein 2)	5	UniProt   NCBI
MTF2	Metal-response element-binding transcription factor 2 (Metal regulatory transcription factor 2) (Metal-response element DNA-binding protein M96) (Polycomb-like protein 2) (hPCl2)	5	UniProt   NCBI
SKIDA1	SKI/DACH domain-containing protein 1 (Protein DLN-1)	3	UniProt   NCBI
MAMDC4	Apical endosomal glycoprotein (MAM domain-containing protein 4)	4	UniProt   NCBI



Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:03083	1.89460161373e-20	0.6875	EED PHF1 AEBP2 JARID2 SUZ12 EZH2 MTF2 EZH1 EPOP LCOR PHF19	Polycomb repressive complex
GO:0035098	1.6033625463e-17	0.5	EED PHF1 AEBP2 SUZ12 EZH2 MTF2 EZH1 PHF19	ESC/E(Z) complex
WP:WP2916	5.13961414928e-16	0.4375	EED AEBP2 JARID2 SUZ12 EZH1 MTF2 EZH2	Interactome of polycomb repressive complex 2 PRC2
GO:0035097	1.83946540652e-13	0.5625	EED PHF1 AEBP2 JARID2 SUZ12 EZH2 MTF2 EZH1 PHF19	histone methyltransferase complex
REAC:R-HSA-212300	2.0958003515e-13	0.5	EED PHF1 AEBP2 JARID2 PHF19 MTF2 EZH2 SUZ12	PRC2 methylates histones and DNA
GO:0031519	1.44979606596e-12	0.5	EED PHF1 AEBP2 SUZ12 EZH2 MTF2 EZH1 PHF19	PcG protein complex
GO:0034708	5.17400923255e-12	0.5625	EED PHF1 AEBP2 JARID2 SUZ12 EZH2 MTF2 EZH1 PHF19	methyltransferase complex
REAC:R-HSA-212165	1.03696998599e-11	0.5625	EED PHF1 AEBP2 JARID2 PHF19 MTF2 EZH2 BAZ2A SUZ12	Epigenetic regulation of gene expression
CORUM:7304	4.35354440333e-11	0.25	EED EZH2 PHF19 SUZ12	HIC1-PCL3L-PCR2 complex
CORUM:974	2.17534197696e-10	0.25	EED EZH2 AEBP2 SUZ12	EED-EZH2 complex
CORUM:6910	4.89338390935e-08	0.1875	EED PHF19 EZH2	EED-EZH2-PHF19 complex
GO:0001222	2.35735070203e-07	0.375	MTF2 SUZ12 LCOR EED EZH2 PHF1	transcription corepressor binding
CORUM:105	4.88685573808e-07	0.1875	EED SUZ12 EZH2	Polycomb repressive complex 2 (PRC 2)
GO:0003682	1.80767791828e-06	0.5625	EED PHF19 JARID2 SUZ12 EZH2 MTF2 EZH1 EPOP PHF1	chromatin binding
HP:0001814	1.16859593737e-05	0.1875	EED SUZ12 EZH2	Deep-set nails
WP:WP2853	1.2545328391e-05	0.3125	MTF2 BPTF EZH2 AEBP2 JARID2	Endoderm differentiation
GO:0001221	2.28951247902e-05	0.375	MTF2 SUZ12 LCOR EED EZH2 PHF1	transcription coregulator binding
CORUM:5502	5.10764421909e-05	0.125	EED EZH2	EED-EZH-YY1 polycomb complex
CORUM:5521	5.10764421909e-05	0.125	EED EZH2	EED-EZH polycomb complex
GO:0042054	5.25426436672e-05	0.3125	EED JARID2 SUZ12 EZH2 EZH1	histone methyltransferase activity
GO:0042393	5.30409513575e-05	0.4375	MTF2 PHF19 BPTF PHF1 EZH1 BAZ2A SUZ12	histone binding
WP:WP2369	5.72708031456e-05	0.25	EED EZH2 AEBP2 EZH1	Histone modifications
GO:0140513	6.81182444162e-05	0.6875	JARID2 EED AEBP2 SUZ12 BPTF PHF19 EZH2 MTF2 EZH1 BAZ2A PHF1	nuclear protein-containing complex
GO:0006338	0.00014700323847	0.5	JARID2 MTF2 BPTF PHF1 EZH2 EZH1 BAZ2A PHF19	chromatin remodeling
CORUM:1177	0.000153131458895	0.125	EED EZH2	Polycomb repressive complex 4
CORUM:7375	0.000153131458895	0.125	EZH2 SUZ12	BRD7-EZH2-SUZ12 complex
REAC:R-HSA-3214841	0.000218667387422	0.25	EED EZH2 AEBP2 SUZ12	PKMTs methylate histone lysines
HP:0010300	0.00025589262046	0.1875	EED SUZ12 EZH2	Abnormally low-pitched voice
GO:0035064	0.000266559099471	0.3125	MTF2 BPTF PHF1 SUZ12 PHF19	methylated histone binding
GO:0140034	0.000312850704938	0.3125	MTF2 BPTF PHF1 SUZ12 PHF19	methylation-dependent protein binding
WP:WP5366	0.000333493826818	0.25	EED JARID2 SUZ12 EZH1	NF1 copy number variation syndrome
HP:0001816	0.000422821089101	0.1875	EED SUZ12 EZH2	Thin nail
GO:0006325	0.000429031780815	0.5	JARID2 MTF2 BPTF PHF1 EZH2 EZH1 BAZ2A PHF19	chromatin organization
WP:WP4204	0.000478028477874	0.1875	EED SUZ12 EZH2	Tumor suppressor activity of SMARCB1
GO:0140030	0.000511602982281	0.375	MTF2 PHF19 BPTF PHF1 BAZ2A SUZ12	modification-dependent protein binding
WP:WP4553	0.000583216073111	0.1875	EED SUZ12 EZH2	FBXL10 enhancement of MAP ERK signaling in diffuse large B cell lymphoma
REAC:R-HSA-74160	0.000625063376807	0.5625	EED PHF1 AEBP2 JARID2 PHF19 MTF2 EZH2 BAZ2A SUZ12	Gene expression (Transcription)
HP:0002002	0.000720329231936	0.25	EED EZH2 SUZ12 JARID2	Deep philtrum
GO:0008276	0.000793086713427	0.3125	EED JARID2 SUZ12 EZH2 EZH1	protein methyltransferase activity
GO:0046976	0.0010743908712	0.1875	EZH1 EZH2 JARID2	histone H3K27 methyltransferase activity
GO:1990234	0.00132340310675	0.5625	EED PHF1 AEBP2 JARID2 SUZ12 EZH2 MTF2 EZH1 PHF19	transferase complex
GO:0071824	0.00135185037983	0.5	JARID2 MTF2 BPTF PHF1 EZH2 EZH1 BAZ2A PHF19	protein-DNA complex organization
HP:0011304	0.00156621497503	0.25	EED EZH2 SUZ12 BPTF	Broad thumb
REAC:R-HSA-8953750	0.0018450565582	0.1875	EED SUZ12 EZH2	Transcriptional Regulation by E2F6
GO:1902494	0.0020932348776	0.6875	JARID2 EED AEBP2 SUZ12 BPTF PHF19 EZH2 MTF2 EZH1 BAZ2A PHF1	catalytic complex
HP:0001852	0.00219412890528	0.25	EED EZH2 SUZ12 BPTF	Sandal gap
HP:0009768	0.00353501189279	0.25	EED EZH2 SUZ12 BPTF	Broad phalanges of the hand
GO:0010468	0.00420237990638	0.875	SKIDA1 IL1A JARID2 EED AEBP2 BPTF PHF19 EZH2 MTF2 EZH1 EPOP LCOR BAZ2A PHF1	regulation of gene expression
HP:0001176	0.00466597362099	0.1875	EED SUZ12 EZH2	Large hands
HP:0001769	0.00466597362099	0.1875	EED SUZ12 EZH2	Broad foot
GO:0010556	0.00638472598999	0.875	SKIDA1 IL1A JARID2 EED AEBP2 BPTF PHF19 EZH2 MTF2 EZH1 EPOP LCOR BAZ2A PHF1	regulation of macromolecule biosynthetic process
HP:0001500	0.0074113228079	0.25	EED EZH2 SUZ12 BPTF	Broad finger
GO:0031326	0.00857934397984	0.875	SKIDA1 IL1A JARID2 EED AEBP2 BPTF PHF19 EZH2 MTF2 EZH1 EPOP LCOR BAZ2A PHF1	regulation of cellular biosynthetic process
HP:0006009	0.00873919683708	0.25	EED EZH2 SUZ12 BPTF	Broad phalanx
REAC:R-HSA-8943724	0.00888428125138	0.1875	EED SUZ12 EZH2	Regulation of PTEN gene transcription
GO:0009889	0.00928831362461	0.875	SKIDA1 IL1A JARID2 EED AEBP2 BPTF PHF19 EZH2 MTF2 EZH1 EPOP LCOR BAZ2A PHF1	regulation of biosynthetic process
REAC:R-HSA-2559583	0.00944621415808	0.25	EED EZH2 IL1A SUZ12	Cellular Senescence
HP:0001548	0.00964346335526	0.1875	EED SUZ12 EZH2	Overgrowth
HP:0005622	0.0102353320438	0.25	EED EZH2 SUZ12 BPTF	Broad long bones
REAC:R-HSA-9710421	0.0108985733495	0.1875	EED SUZ12 EZH2	Defective pyroptosis
GO:0008134	0.0114326741454	0.4375	EED SUZ12 LCOR MTF2 EZH2 BAZ2A PHF1	transcription factor binding
GO:0006355	0.0115370464873	0.75	SKIDA1 EED AEBP2 BPTF PHF19 EZH2 MTF2 EZH1 EPOP LCOR BAZ2A PHF1	regulation of DNA-templated transcription
GO:2001141	0.0123556667956	0.75	SKIDA1 EED AEBP2 BPTF PHF19 EZH2 MTF2 EZH1 EPOP LCOR BAZ2A PHF1	regulation of RNA biosynthetic process
GO:0006351	0.0197251377193	0.75	SKIDA1 EED AEBP2 BPTF PHF19 EZH2 MTF2 EZH1 EPOP LCOR BAZ2A PHF1	DNA-templated transcription
GO:0008168	0.0198667870779	0.3125	EED JARID2 SUZ12 EZH2 EZH1	methyltransferase activity
GO:0032774	0.0222553679442	0.75	SKIDA1 EED AEBP2 BPTF PHF19 EZH2 MTF2 EZH1 EPOP LCOR BAZ2A PHF1	RNA biosynthetic process
HP:5200005	0.0265121239957	0.1875	EED SUZ12 EZH2	Abnormal pitch
GO:0016741	0.026641919839	0.3125	EED JARID2 SUZ12 EZH2 EZH1	transferase activity, transferring one-carbon groups
GO:0140993	0.0320920386818	0.3125	EED JARID2 SUZ12 EZH2 EZH1	histone modifying activity
GO:0040029	0.0320920386818	0.3125	MTF2 EZH1 EZH2 PHF19 BAZ2A	epigenetic regulation of gene expression
HP:0000995	0.034804535539	0.1875	EED SUZ12 EZH2	Melanocytic nevus
HP:0000337	0.0359081822028	0.25	EED EZH2 SUZ12 JARID2	Broad forehead
HP:0009602	0.0359081822028	0.25	EED EZH2 SUZ12 BPTF	Abnormality of thumb phalanx
REAC:R-HSA-9645723	0.0360585105265	0.1875	EED SUZ12 EZH2	Diseases of programmed cell death
HP:0005616	0.0366445831328	0.1875	EED SUZ12 EZH2	Accelerated skeletal maturation
WP:WP2857	0.0367893044399	0.1875	JARID2 AEBP2 MTF2	Mesodermal commitment pathway
REAC:R-HSA-4839726	0.0378308672918	0.25	EED EZH2 AEBP2 SUZ12	Chromatin organization
REAC:R-HSA-3247509	0.0378308672918	0.25	EED EZH2 AEBP2 SUZ12	Chromatin modifying enzymes
HP:5200010	0.0405142617991	0.1875	EED SUZ12 EZH2	Abnormal Intonation
GO:0044877	0.0406629564176	0.5625	EED PHF19 JARID2 SUZ12 EZH2 MTF2 EZH1 EPOP PHF1	protein-containing complex binding
GO:0051252	0.0407627055642	0.75	SKIDA1 EED AEBP2 BPTF PHF19 EZH2 MTF2 EZH1 EPOP LCOR BAZ2A PHF1	regulation of RNA metabolic process
WP:WP4239	0.0412073545689	0.1875	EED SUZ12 EZH2	Epithelial to mesenchymal transition in colorectal cancer



Edges

Protein 1	Protein 2	Score ?	ProteomeHD?
EED	EZH2	1.0	0.15
SUZ12	EZH2	1.0	0.632
EED	SUZ12	1.0	0.482
AEBP2	SUZ12	1.0	0.158
AEBP2	EED	1.0	0.132
PHF1	EED	1.0	0.146
EZH2	EPOP	1.0
PHF1	SUZ12	1.0	0.198
PHF19	EED	0.999	0.146
PHF19	EZH1	0.999	0.126
PHF19	SUZ12	0.999	0.088
AEBP2	EZH2	0.999	0.136
PHF1	EPOP	0.999
PHF1	EZH2	0.999	0.162
PHF19	EZH2	0.999	0.158
SUZ12	EPOP	0.999
AEBP2	JARID2	0.998	0.116
AEBP2	EZH1	0.998	0.14
JARID2	EZH2	0.998	0.066
EED	EPOP	0.998
PHF19	EPOP	0.997
EZH1	SUZ12	0.997	0.218
PHF1	EZH1	0.996	0.096
SUZ12	JARID2	0.993	0.22
AEBP2	EPOP	0.991
EED	MTF2	0.991	0.26
PHF1	AEBP2	0.99	0.076
SUZ12	MTF2	0.989	0.234
SUZ12	SKIDA1	0.988
EED	EZH1	0.988	0.394
JARID2	EPOP	0.986
PHF1	LCOR	0.986
MTF2	SKIDA1	0.984
PHF1	JARID2	0.984	0.076
EZH1	JARID2	0.982	0.08
EZH1	MTF2	0.982	0.282
EZH2	MTF2	0.979	0.112
EZH1	EPOP	0.977
PHF1	MAMDC4	0.976
PHF19	AEBP2	0.976	0.106
PHF19	MTF2	0.975	0.08
BAZ2A	EED	0.975	0.114
EED	JARID2	0.974	0.11
PHF1	PHF19	0.971	0.104
EZH1	EZH2	0.965	0.344
EZH1	SKIDA1	0.962
EED	SKIDA1	0.954
PHF19	JARID2	0.953	0.108
PHF1	MTF2	0.95	0.114
AEBP2	MTF2	0.946	0.226
EPOP	MTF2	0.944
EZH2	SKIDA1	0.937
SMARCA1	BPTF	0.933	0.214
BPTF	EZH1	0.922	0.234
LCOR	SUZ12	0.915
PHF19	SKIDA1	0.905
BPTF	AEBP2	0.891	0.102
BPTF	SUZ12	0.888	0.15
BPTF	MTF2	0.884	0.236
BPTF	EZH2	0.883	0.076
JARID2	MTF2	0.879	0.098
BPTF	IL1A	0.859
BPTF	EED	0.858	0.232
SMARCA1	EED	0.831	0.068
SMARCA1	SUZ12	0.82	0.044
SMARCA1	AEBP2	0.817	0.086
SMARCA1	EZH2	0.711	0.05
LCOR	EPOP	0.658
LCOR	EZH1	0.625
LCOR	EED	0.588
LCOR	EZH2	0.567
BPTF	PHF19	0.492	0.128
BPTF	JARID2	0.467	0.062
SMARCA1	EZH1	0.379	0.14
BPTF	EPOP	0.356
SMARCA1	JARID2	0.317	0.1
BPTF	PHF1	0.312	0.094
SMARCA1	MTF2	0.272	0.12
LCOR	JARID2	0.164
SMARCA1	IL1A	0.157
LCOR	MTF2	0.143
LCOR	AEBP2	0.143
LCOR	PHF19	0.143
BAZ2A	SUZ12	0.101	0.168
SMARCA1	PHF19	0.078	0.124
BAZ2A	MTF2	0.076	0.112
SMARCA1	SKIDA1	0.054
SMARCA1	EPOP	0.026
SMARCA1	PHF1	0.025	0.146
BAZ2A	EZH1	0.02	0.084
BPTF	BAZ2A	0.009	0.186
SMARCA1	BAZ2A	0.009	0.058





Related Complexes

Genename	Complexes
AEBP2	huMAP3_04977.1 huMAP3_06942.1 huMAP3_13482.1 huMAP3_15095.1 huMAP3_15128.1
IL1A	huMAP3_13482.1 huMAP3_14567.1 huMAP3_15095.1
PHF1	huMAP3_02446.1 huMAP3_06942.1 huMAP3_13482.1 huMAP3_15095.1 huMAP3_15128.1
SMARCA1	huMAP3_00206.1 huMAP3_00746.1 huMAP3_06728.1 huMAP3_07299.1 huMAP3_08549.1 huMAP3_08906.1 huMAP3_09198.1 huMAP3_09499.1 huMAP3_10118.1 huMAP3_10472.1 huMAP3_13482.1 huMAP3_13516.1 huMAP3_14567.1 huMAP3_15095.1 huMAP3_15128.1
EED	huMAP3_04977.1 huMAP3_06942.1 huMAP3_13482.1 huMAP3_15095.1 huMAP3_15128.1
PHF19	huMAP3_03842.1 huMAP3_04977.1 huMAP3_06942.1 huMAP3_13482.1 huMAP3_15095.1 huMAP3_15128.1
EZH1	huMAP3_04977.1 huMAP3_06942.1 huMAP3_13482.1 huMAP3_15095.1 huMAP3_15128.1
BPTF	huMAP3_00206.1 huMAP3_00746.1 huMAP3_06728.1 huMAP3_07299.1 huMAP3_08833.1 huMAP3_08906.1 huMAP3_09198.1 huMAP3_09499.1 huMAP3_10472.1 huMAP3_10593.1 huMAP3_13482.1 huMAP3_14567.1 huMAP3_15095.1 huMAP3_15128.1
SUZ12	huMAP3_04977.1 huMAP3_06942.1 huMAP3_13482.1 huMAP3_15095.1 huMAP3_15128.1
JARID2	huMAP3_04977.1 huMAP3_06942.1 huMAP3_13482.1 huMAP3_15095.1 huMAP3_15128.1
BAZ2A	huMAP3_04197.1 huMAP3_12761.1 huMAP3_13327.1 huMAP3_13406.1 huMAP3_15095.1
EZH2	huMAP3_04977.1 huMAP3_06942.1 huMAP3_13482.1 huMAP3_15095.1 huMAP3_15128.1
EPOP	huMAP3_04977.1 huMAP3_06942.1 huMAP3_13482.1 huMAP3_15095.1 huMAP3_15128.1
LCOR	huMAP3_02446.1 huMAP3_06942.1 huMAP3_13482.1 huMAP3_15095.1 huMAP3_15128.1
MTF2	huMAP3_04977.1 huMAP3_06942.1 huMAP3_13482.1 huMAP3_15095.1 huMAP3_15128.1
SKIDA1	huMAP3_04977.1 huMAP3_06942.1 huMAP3_13482.1 huMAP3_15095.1 huMAP3_15128.1
MAMDC4	huMAP3_02446.1 huMAP3_06942.1 huMAP3_12479.1 huMAP3_15092.1 huMAP3_15095.1